Pubmed Text
Collection
Collection of pubmed 2024 papers. • 11 items • Updated
pubMedId stringlengths 5 1.75k | title stringlengths 1 2.03k ⌀ | abstract stringlengths 1 15.7k ⌀ |
|---|---|---|
8070661 | A reevaluation of data from competitive tests shows high levels of heterosis in Drosophila melanogaster. | We have analyzed the results from a range of procedures designed to measure the fitness petitive conditions of inbred strains of Drosophila melanogaster, specifically strains which are homozygous for chromosome 2. All methods show a substantial reduction in fitness, ranging from an estimated 70-80% for single petition ... |
8070662 | A Drosophila third chromosome Minute locus encodes a ribosomal protein. | Minutes (M) are a group of over 50 phenotypically similar Drosophila mutations widely believed to affect ribosomal protein genes. This report describes the characterization of the P element-induced M(3)95A(Plac92) mutation [allelic to M(3)95A]. This mutation can be reversed by the mobilization of the P element, demonst... |
8070664 | Molecular analysis of the Drosophila EGF receptor homolog reveals that several genetically defined classes of alleles cluster in subdomains of the receptor protein. | Mutations in the torpedo gene, which encodes the fruitfly homolog of the epidermal growth factor receptor (DER), disrupt a variety of developmental processes in Drosophila. These include the survival of certain embryonic ectodermal tissues, the proliferation of the imaginal discs, the morphogenesis of several adult ect... |
8070663 | Components acting in localization of bicoid mRNA are conserved among Drosophila species. | Substantial insights into basic strategies for embryonic body patterning have been obtained from genetic analyses of Drosophila melanogaster. This knowledge has been used in parisons to ask if genes and functions are conserved. To begin to ask how highly conserved are the mechanisms of mRNA localization, a process cruc... |
8070665 | Local transposition of P elements in Drosophila melanogaster and recombination between duplicated elements using a site-specific recombinase. | The transposase source delta 2-3(99B) was used to mobilize a P element located at sites on chromosomes X, 2 and 3. The transposition event most frequently recovered was a chromosome with two copies of the P element at or near the original site of insertion. These were easily recognized because the P element carried a h... |
8070666 | Shared sequence variants of Mus spretus LINE-1 elements tracing dispersal to within the last 1 million years. | LINE-1 repetitive sequences contain a record of an evolving population of transposons within the mammalian genome. Of the 100,000 copies of LINE-1 sequences per genome there are many shared sequence variants representing changes occurring within the propagating LINE-1 elements themselves, rather than changes that occur... |
8070667 | Sheep linkage mapping: nineteen linkage groups derived from the analysis of paternal half-sib families. | Nineteen linkage groups containing a total of 52 markers have been identified in the sheep genome after typing large paternal half-sib families. The linkage groups range in size from 2 markers showing no bination to a group containing 6 markers covering approximately 30 cM of the sheep genome. Thirteen of the groups ha... |
8070669 | A ruby in the rubbish: beneficial mutations, deleterious mutations and the evolution of sex. | This study presents a mathematical model in which a single beneficial mutation arises in a very large population that is subject to frequent deleterious mutations. The results suggest that, if the population is sexual, then the deleterious mutations will have little effect on the ultimate fate of the beneficial mutatio... |
8070670 | Oxidative stress-induced apoptosis prevented by Trolox. | The ability of oxidative stress to induce apoptosis (programmed cell death), and the effect of Trolox, a water soluble vitamin E analog, on this induction were studied in vitro in mouse thymocytes. Cells were exposed to oxidative stress by treating them with 0.5-10 microM hydrogen peroxide (H2O2) for 10 min, in phospha... |
8070673 | Membrane changes associated with lysis of red blood cells by hypochlorous acid. | This study was carried out to investigate HOCl-induced lysis of human erythrocytes. Using reagent HOCl with isolated red cells, we showed that the rate of lysis was dependent on the dose of HOCl per red cell rather than on the concentration of oxidant. The process was inhibited by scavengers such as methionine and taur... |
8070668 | The robustness of recombination frequency estimates in intercrosses with dominant markers. | The robustness of the maximum likelihood estimates of bination frequencies has been investigated in double intercrosses plete dominance at both loci. The robustness was investigated with respect to bias in the bination frequency estimates due to: (1) limited sample sizes, (2) heterogeneity in bination frequencies betwe... |
8070676 | Ferrous ion formation by ferrioxamine prepared from aged desferrioxamine: a potential prooxidant property. | The siderophore desferrioxamine (DEFOM) binds ferric ions in a 1:1 ratio resulting in a ferrioxamine plex. When DEFOM is stored or heat degraded, the resulting FOMD undergoes an autoreduction with the transfer of electrons to the bound ferric ions forming ferrous ions which react with Ferrozine to yield a plex absorbin... |
8070672 | Tyrosine attack by free radicals derived from catalytic decomposition of carbon tetrachloride. | The interaction between free radicals derived from the catalytic position of carbon tetrachloride and tyrosine (the N-acetyl tyrosine ethyl ester, ATEE) under anaerobic and aerobic conditions was studied. The structure of the reaction products formed was deciphered by the GLC/MS analysis of their trimethylsilyl derivat... |
8070674 | Magnesium-deficiency potentiates free radical production associated with postischemic injury to rat hearts: vitamin E affords protection. | Preexisting magnesium deficiency may alter the susceptibility of rat hearts to postischemic oxidative injury (free radicals). This was examined in rats maintained for 3 weeks on a magnesium-deficient (Mg-D) diet with or without concurrent vitamin E treatment (1.2 mg/day, SC). Magnesium-sufficient (Mg-S) rats received t... |
8070678 | A comparative study of EPR spin trapping and cytochrome c reduction techniques for the measurement of superoxide anions. | Superoxide anions (O2.-) generated by the reaction of xanthine with xanthine oxidase were measured by the reduction of cytochrome c and by electron paramagnetic resonance (EPR) spectroscopy using the spin trap 5,5-dimethyl-1-pyrroline-N-oxide (DMPO). Studies were performed to determine the relative sensitivities of the... |
8070679 | Lipid peroxidation as molecular mechanism of liver cell injury during reperfusion after ischemia. | The pathophysiological importance of reactive oxygen species has been extensively documented in the pathogenesis of hepatic ischemia-reperfusion injury. Kupffer cells and neutrophils were identified as the dominant sources of the postischemic oxidant stress. To test the hypothesis that a direct free radical-mediated in... |
8070671 | alpha-Phenyl-tert-butyl-nitrone inhibits free radical release in brain concussion. | Traumatic brain injury (TBI) is one of the important causes of mortality and morbidity. The pathogenesis of the underlying brain dysfunction is poorly understood. Recent data have suggested that oxygen free radicals play a key role in the primary and secondary processes of acute TBI. We report direct electron spin reso... |
8070680 | Oxidant-sensitive protein phosphorylation in endothelial cells. | Reactive oxygen is an important regulator of vascular cell biology; however, the mechanisms involved in transducing signals from oxidants in endothelial cells are poorly defined. Because protein phosphorylation is a major mechanism for signal transduction, cultured aortic endothelial cells were exposed to nonlethal con... |
8070677 | In vitro modulation of antioxidant enzyme levels in normal hamster kidney and estrogen-induced hamster kidney tumor. | Antioxidant enzyme (AE) activities were studied in normal hamster kidney proximal tubules and in estrogen-induced hamster kidney cancer. In vivo, kidney tumor had lower activities of manganese superoxide dismutase (MnSOD), copper, zinc superoxide dismutase, catalase, and glutathione peroxidase than kidney proximal tubu... |
8070675 | Comparative toxicity of alkyl-1,4-naphthoquinones in rats: relationship to free radical production in vitro. | 2-Methyl-1,4-naphthoquinone causes haemolysis in vivo. This toxic effect is believed to result from oxidative damage to erythrocytes by "active oxygen" species formed via one-electron reduction of the naphthoquinone by oxyhaemoglobin. In the present investigation, seven 2-alkyl-1,4-naphtoquinones have been studied with... |
8070681 | Membrane peroxidation: inhibiting effects of water-soluble antioxidants on phospholipids of different charge types. | Quantitative kinetic methods of autoxidation are used to determine the antioxidant activities of two water-soluble antioxidatants of the chromanol type, 6-hydroxy-2,5,7, 8-tetramethylchroman-2-carboxylic acid (Trolox) and 6-hydroxy-2,5,7,8- tetramethyl-2-N,N,N-trimethylethanaminium methylbenzene-sulfonate (MDL 73404), ... |
8070682 | Effects of natural antioxidant ginkgo biloba extract (EGB 761) on myocardial ischemia-reperfusion injury. | Recently, it was reported that Ginkgo biloba extract (EGb 761), which is known to have antioxidant properties, also has antiarrhythmic effects on cardiac reperfusion-induced arrhythmias. In the present study, effects of EGb 761 on cardiac ischemia-reperfusion injury were investigated from the point of view of recovery ... |
8070684 | A pulse radiolysis study of one-electron oxidation and .OH radical reaction of a new class of antioxidants: 2,5 dimethylpyrrole--amino acid N-conjugates. | A new class of 2,5 dimethylpyrrole functionalized amino acid and peptide antioxidants has been synthesized. Pulse radiolysis studies have been carried out on pounds to determine their reactivity in one-electron oxidation reactions with Br2- and (SCN)2-, as well as their reactivity toward the water radicals .OH and eaq-... |
8070683 | The increase in vasomotor tone induced by a parenteral lipid emulsion is linked to an inhibition of prostacyclin production. | The aim of the study was to verify whether the infusion of a lipid emulsion causes a rise in vascular pressure related to an imbalance in the production of vasoconstricting and vasodilatating eicosanoids. Segments of umbilical veins were perfused with and without 1.5 microM indomethacin (cyclooxygenase inhibitor) in so... |
8070685 | Postischemic inhibition of cerebral cortex pyruvate dehydrogenase. | Postischemic, mitochondrial respiratory impairment can contribute to prolonged intracellular lactic acidosis, secondary tissue deenergization, and neuronal cell death. Specifically, reperfusion-dependent inhibition of pyruvate dehydrogenase (PDH) may determine the degree to which glucose is metabolized aerobically vs. ... |
8070688 | On the use of the quenching of luminol luminescence to evaluate SOD activity. | Addition of horseradish peroxidase to a luminol solution (pH = 9.4) produces a burst of light followed by a steady luminescence that lasts for several minutes. This steady-state luminescence is readily quenched by SOD, with a Q1/2 concentration (the additive concentration needed to decrease by one-half the emitted lumi... |
8070687 | Adenosine deaminase, 5'nucleotidase, xanthine oxidase, superoxide dismutase, and catalase activities in cancerous and noncancerous human bladder tissues. | Activities of adenosine deaminase (ADA), 5'nucleotidase (5NT), xanthine oxidase (XO), superoxide dismutase (SOD), and catalase (CAT) enzymes were measured in cancerous and cancer-free adjacent bladder tissues from 36 patients with bladder cancer and in control bladder tissues from 9 noncancer patients. Increased ADA an... |
8070686 | Influenza virus induces expression of antioxidant genes in human epithelial cells. | Influenza infections cause airway epithelial inflammation and oxidant-mediated damage. In this setting, cellular antioxidant enzymes may protect airway epithelial cells against damage resulting from toxic oxygen radicals produced by activated leukocytes. Therefore, we tested the effect of influenza virus infection, as ... |
8070689 | Effects of reactive oxygen metabolites on norepinephrine-induced vasoconstriction. | Aortic rings, 4 mm in length, were obtained from rats and placed on isometric force transducers in oxygenated Krebs buffer. Following a period of stabilization, the cumulative dose response relationship to norepinephrine was assessed. The vessels were washed and allowed to return to baseline in Krebs buffer containing ... |
8070690 | The correlation between active oxygens scavenging and antioxidative effects of flavonoids. | The abilities of 15 flavonoids as a scavenger of active oxygens (hydroxyl radical and superoxide anion) were studied. Hydroxyl radical (.OH) was generated by the Fenton system, and assayed by the determination of methanesulfonic acid (MSA) formed from the reaction of dimethyl sulfoxide (DMSO) with .OH. (+)-Catechin, (-... |
8070691 | Enhanced urinary spontaneous luminescence in Duchenne muscular dystrophy. | Urinary spontaneous visible luminescence is enhanced in children with Duchenne Muscular Dystrophy (DMD). This result is indicative of systemic oxidative stress in DMD patients. It is proposed that measurement of the urinary luminescence could be employed to follow the progress of the disease, as well as the response of... |
8070692 | Effects of oxygen free radical scavengers on uranium-induced acute renal failure in rats. | Study was made to determine whether oxygen free radicals mediate uranium-induced acute renal failure (ARF). Superoxide dismutase (SOD), a superoxide anion scavenger, did not prevent uranium acetate (UA) (5 mg/kg, i.v.)-induced renal injury 48 h after injection. In contrast, dimethylthiourea (DMTU), a hydroxyl radical s... |
8070693 | Ischemia-induced brain iron delocalization: effect of iron chelators. | Tissue damage in cerebral ischemia may be produced by acidosis-induced delocalization of intracellular iron which acts as a catalyst in oxidative reactions. Acidosis was induced either by homogenization and incubation of rat cortical homogenates in acidified buffers or by submitting hyperglycemic rats plete ischemia, a... |
8070694 | Coinduction of nitric oxide synthesis and intracellular nonheme iron-nitrosyl complexes in murine cytokine-treated fibroblasts. | Murine fibroblasts treated with interferon-gamma plus tumor necrosis factor-alpha plus lipopolysaccharide produce nitrite and EPR-observable intracellular nonheme iron-thiol-dinitrosyl species. Inhibition of .NO synthesis or de novo tetrahydrobiopterin (BH4) synthesis decreases nitrite and the EPR signal. The effects o... |
8070695 | New reactive oxidizing species causes formation of carbon-centered radical adducts in organic extracts of blood following liver transplantation. | alpha-(4-pyridyl-1-oxide)-N-t-butylnitrone (4-POBN) radical adducts from Folch (chloroform:methanol) extraction of blood of transplanted livers exhibited a large 6-line electron paramagnetic resonance (EPR) spectrum. Slow EPR sample preparation involving freezing and thawing prior to extraction over 15 min yielded a sp... |
8070696 | Mutual dependence of growth modifying effects of 4-hydroxynonenal and fetal calf serum in vitro. | Recently, the hypothesis has been put forward that 4-hydroxynonenal (HNE), an aldehydic product of lipid peroxidation, contributes to the mechanisms of oxygen toxicity and to the selective pressure exerted by exposure to hyperoxia. Here it has been studied whether HNE itself is involved in mechanisms that convey increa... |
8070697 | [Comparison of routine semen analysis with results of the hypo-osmotic test and hamster penetration test]. | In the program of semen preparation to intra uterine insemination (IUI) parison of the routine semen analysis with the results of the Hypoosmotic Test (HOS-T) and the Hamster Oocyte Penetration Test (HOP-T) was performed. The positive correlation between the sperm quality and the results of the used tests (HOP and HOS)... |
8070698 | [Ultrasound images of prostate and seminal vesicles in infertile male patients]. | The results of clinical examinations, semen analysis and endosonographic examinations of prostate and seminal vesicles were analysed in 172 male patients treated due to infertility. Ultrasound equipment with transrectal multiplane transducers 6.5 and 7.0 MHz frequency has been used to the evaluation of size, symmetry a... |
8070699 | [Usefulness of diagnostic ultrasonography for evaluation of scrotal organs]. | Scrotal sonography was performed on 172 patients treated for infertility ranging 1-10 years. The results of the sonographic examinations pared with palpations. Pathological deviations were found in 71.5% of patients using sonography and ony 53.5% of patients examined clinically. Our study found varicocele in 55.2% of p... |
8070700 | [Self concept of men from childless married couples after receiving information about sperm value]. | The questionnaire included 220 men from childless married couples who referred to the Department of Reproduction and Andrology of the Medical Academy in Lublin for 4 months in 1992. The treatment period of childlessness in those couples ranged from several months to 17 years. The authors tried to establish if, and to w... |
8070701 | [Seasonal changes in results of semen analysis from male members of an infertile married couple]. | Analysis of 200 semen samples of men from childless couples was performed in order to evaluate the sperm characteristics during the year. Estimated were following features: semen volume, sperm density, motility and percentage of pathological forms. The sperm estimation data obtained from 4 seasons of the year was stati... |
8070702 | [Congenital malformations of the epididymis and vas deferens as reasons for male infertility]. | Between 1966-1991 330 patients where the semen analysis revealed azoospermia and the histopathological examination of biopsy specimen of testis shown retained spermatogenesis and spermiogenesis underwent the surgical intervention. In 80% of cases congenital malformations of epididymis and vas deferens were found. The t... |
8070703 | [Ultrasonographic investigations in diagnosis of congenital malformations of epididymis in cases of azoospermia]. | Between 1984-1991 in 28 patients referred for the surgical treatment for the reason of obstruction of epididymis outlet ducts there was a suspicion of a congenital epididymis malformation put after the physical examination. The ultrasound examination of the scrotum which was performed in all cases revealed the proper v... |
8070704 | [Fertility disturbances in males working as professional computer operators]. | From 2376 patients who were diagnosed as infertile between 1986-1991, 20 puter operator males in the age of 26-40 were chosen (0.8%). Their working time was at least 5 hours daily and they have been working for 2-12 years (mean 7.7 +/- 3.3 years). The mean number of spermatozoa in 1 ml of sperm was 45.5 +/- 23.7 X 10(6... |
8070705 | [Androgens and the brain]. | Recent years investigations provided, that androgens belong to the group of neurosteroids synthetized and metabolized in the brain tissue by both: the cells (neurons and glia) and the white matter. Two basal metabolic pathways of androgens: aromatisation and 5-alpha-reduction probably serve different physiological func... |
8070706 | [Intrauterine insemination as a method of treating male infertility]. | One of the method of treatment of the infertile couple due to the male factor is the Intra Uterine Insemination (IUI). The references on the subject are divergent. This is caused by the lack of the parable classification in patients selection for the treatment, procedure of semen preparation and the results estimation.... |
8070707 | [Observation of some semen parameters in men with varicocele]. | Among 172 examined male patients varicoceles have been found in 57.6% patients. The frequency of varicocele appearance increased according to the fall of sperm concentration. Simple relations between sperm motility and varicocele have not been observed. Larger per cent of pathological sperm forms in patients with varic... |
8070708 | [Remarks on artificial intrauterine insemination of women with abnormal semen]. | Despite of the great deal of publications on artificial insemination the real effectiveness of the procedure is not clearly estimated so far. This is why in the presented paper authors tried to evaluate the effectiveness of the artificial intrauterine insemination with the abnormal sperm which was laboratory classified... |
8070709 | [Comparison between the influence of estradiol benzoate, testosterone propionate and human chorionic gonadotropin on initiation of spermatogenesis in the rat]. | Newborn male rats were injected daily from the 5th to 15th day of life with: EB in doses of 6.2 or 12.5 or 25.0 micrograms and TP in doses of 1.2 or 2.5 or 5.0 mg (experiment 1), and with hCG (experiment 2) in doses of 2.0 or 4.0 or 8.0 I.U. Animals were sacrificed on the 16th day of life, testes and seminal vesicles w... |
8070711 | [Influence of intratesticular injections of tamoxifen on spermatogenesis and testosterone secretion in the rat]. | Three groups of adult Wistar rats were injected every second day with: 5 or 10 or 20 micrograms of tamoxifen (Tx) to the right testis. Left testis was injected with the same volume of solvent. Control group received the solvent for Tx. Animals were killed after 15 days. Blood samples were taken from heart for testoster... |
8070710 | [Tamoxifen and spermatogenesis in rats subjected to effects of estradiol]. | During 14 subsequent days male Wistar rats received subcutaneously 50 micrograms of EB and different doses of tamoxifen intratesticularly. Action of EB was examined parison with the group, which received the solvent for EB only. EB caused the reduction in the mean testis weight, degenerative changes of germinal cells a... |
8070712 | [Level of zinc and magnesium in semen taken from male partners of married infertile couples]. | There was a preliminary study performed on the differences of zinc and magnesium levels in semen serum from 46 males from the infertile couples. Zinc and magnesium concentration was measured by the use of atomic absorption spectrophotometer. There was no statistically significant differences noticed between the mean co... |
8070713 | [Usefulness of examining gonadotropin hormones and testosterone in men with abnormal semen]. | The aim of the study was to estimate the usefulness of some hormonal investigations in cases of males with abnormalities in semen analysis in the diagnosis of the male factor in the infertile couple. 107 males with the abnormalities in spermiogram underwent the analysis of the blood serum hormonal levels. Estimated was... |
8070714 | [Detection and treatment of hyperprolactinemia in male infertility]. | The role of prolactin in males has not been satisfactorily explained. It has been proved that hyperprolactinemia has a negative effect both on spermiogenesis and spermatogenesis. It is widely known that the secretion of the pituitary hormones is of a pulsating character and occurs in the diurnal rhythm. Therefore, in o... |
8070715 | [Evaluating the effect of smoking tobacco on some semen parameters in men of reproductive age]. | Seminal fluid indexes (sperm count, motility, pH, morphology) were examined in 40 smokers and 30 nonsmokers. The sperm count and motility were lower in smokers. Smokers have also higher incidence of pared to nonsmokers. There was no difference between pH and sperm morphology in smokers and nonsmokers. Additionally, smo... |
8070716 | [Examining the effects of tobacco smoking on levels of certain hormones in serum of young men]. | Dehydroepiandrosterone (DHEA), testosterone (T), 17 beta-estradiol (E), prolactin (PRL) and gonadotropins (FSH, LH) were examined in 30 smokers and 25 nonsmokers. The mean E level was higher in smokers than nonsmokers, whereas the levels of T and DHEA are similar and did not differ significantly in pared to nonsmokers.... |
8070717 | [Histologic evaluation of testis in men with azoospermia in light of hormonal determination]. | The causes of azoospermia may be of varied nature and are often difficult to determine. Generally, there are two morphological-clinical types of azoospermia. The first is due to the occlusion of the outgoing seminal tracts. The second is manifested by the lack of seminiferous epithelium, diagnosed on microscopic examin... |
8070718 | [Eosin and water tests and results of conventional semen analysis]. | Semen analysis was performed in 95 men and the results of routine examination were correlated with two sperm viability tests: eosin (TE) and water test (TW). Results of TE and TW were expressed as a percent of spermatozoa revealing a functional integrity of the cell membrane. Linear regression analysis was used. Patien... |
8070719 | [Reduced-size liver transplants in children]. | Orthotopic liver transplantation is now used for children with end-stage liver disease, but the scarcity of size-matched liver allografts for children has limited its use. Reduced-size liver transplantation, in which only part of the liver is used as a graft, es size disparity and increases significantly the potential ... |
8070720 | [Laparoscopic cholecystectomy using the Hasson trocar]. | Laparoscopic cholecystectomy has e the standard operation for symptomatic gallstone disease. There is general agreement that the advantages of this procedure in selected patients outweigh those of conventional open cholecystectomy. However, technical aspects of the procedure may expose the patient to severe and even pl... |
8070721 | [Invasive papillary thyroid carcinoma]. | Papillary carcinoma, the mon malignant tumor of the thyroid, infrequently invades the upper aerodigestive tract (larynx, pharynx, trachea and esophagus). However, when invasion does occur, it is a source of significant morbidity and excess mortality; the method of treatment is controversial. In our opinion surgery is t... |
8070723 | [Atrial septal aneurysm and paroxysmal atrial fibrillation]. | A 48-year-old man was admitted because of treatment-resistant, paroxysmal atrial fibrillation. Transthoracic, 2-dimensional echocardiography revealed a "mass" within the left atrium, thought to be a tumor. Transesophageal echocardiography showed it to be an atrial septal aneurysm. There is a relationship between atrial... |
8070722 | [Interferon for hemangiomas of infancy]. | Hemangioma, the mon tumor of infancy, is usually harmless. It frequently appears soon after birth, proliferates for 8-18 months, and then slowly regresses over the next 5-8 years, leaving the skin normal or only slightly blemished. However, hemangiomas sometimes cause devastating tissue damage and may be associated wit... |
8070729 | [Attitudes of courts, physicians and psychiatric committees to court-ordered psychiatric hospitalization]. | Legal responsibility for the mentally ill has long been a dilemma. Public opinion with regard to the current law, which holds that the mentally ill are not responsible for their actions, is divided. We assessed 30 cases of psychiatric mitted by court order following a criminal act. No relation was found between the nat... |
8070730 | [The Amsterdam air disaster--management and fate of casualties]. | On Sunday, Oct. 4, 1992, an E1 A1 Boeing cargo plane crashed into a 10-story block of flats in the Bijmermeer, on the outskirts of Amsterdam. About 8 people died at the site of the disaster. 37 patients were treated in local hospitals within 90 minutes of the disaster, 16 of whom were admitted. 3 suffered severe, and 6... |
8070733 | Safety evaluation of lipase G from Penicillium camembertii. | Lipase G, a partial glycerides eliminating enzyme produced by Penicillium camembertii, was subjected to safety evaluation studies to establish its safety when used as a processing aid in the food industry. The toxicological studies on the enzyme included a 90-day gavage study with rats, a mutagenicity study using bacte... |
8070734 | Aluminium uptake from some foods by guinea pigs and the characterization of aluminium in in vivo intestinal digesta by SEC-ICP-MS. | The uptake of ingested aluminium (Al) from food monly consumed in a normal human diet was investigated by feeding five test diets to guinea pigs. Al concentrations were measured in the femur, brain, kidney and upper intestinal contents. Consumption of these diets did not lead to elevated Al levels in brain. Levels of A... |
8070735 | Effect of ammoniation of aflatoxin B1-contaminated cottonseed feedstock on the aflatoxin M1 content of cows' milk and hepatocarcinogenicity in the trout bioassay. | The effectiveness of ammonia in inactivating aflatoxins in contaminated cottonseed was investigated. Two aflatoxin-contaminated cottonseed lots were treated separately using an atmospheric pressure, ambient temperature ammoniation procedure (APAT) or a high pressure, high temperature ammoniation procedure (HPHT), and i... |
8070736 | Transfer of the food mutagen PhIP to foetuses and newborn mice following maternal exposure. | The food mutagen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) is a liver carcinogen in neonatal mice. In this study the transfer of PhIP to foetuses and neonates following a single ip dose (4.7-5.2 mg/kg body weight) to pregnant or lactating C57Bl/6 mice was studied by tissue extraction and HPLC analysis. A t... |
8070737 | Dietary effects on the uptake of benzo[a]pyrene. | It has been established that exposure to polycyclic aromatic hydrocarbons (PAHs), or more specifically benzo[a]pyrene (B[a]P), either by inhalation through cigarette smoking or by contact through occupational exposure of the lungs or skin, can result in cancerous lesions. It appears that the general population consumes... |
8070738 | Effects of beta-carotene and canthaxanthin on liver xenobiotic-metabolizing enzymes in the rat. | The activities of several phase I and phase II xenobiotic-metabolizing enzymes have been measured in liver microsomes and cytosol of male rats that had been fed for 15 days with diets containing beta-carotene or canthaxanthin (300 mg/kg diet) or an excess of vitamin A (70,000 IU/kg diet), or to which beta-carotene had ... |
8070741 | The identification and classification of skin irritation hazard by a human patch test. | There exist various regulatory instruments the purpose of which is to ensure that the intrinsic toxic hazards associated with substances and preparations are identified. In the context of identification of skin irritation potential, the method is normally the Draize test. Guidance notes provided by the OECD and the EEC... |
8070740 | Effects of sustained low-level muscarinic agonism in rats. | Sustained, low level muscarinic activity was induced in rats by feeding the muscarinic agonist and experimental drug candidate CI-969 at 50, 100 and 200 mg/kg body weight/day for 4 wk. Except for urine staining, clinical signs typical of acute high-dose exposure to muscarinic agonists were not observed. A dose-related ... |
8070742 | Effect of Brassica nigra on benzo[a]pyrene mutagenicity. | Male rats were given diets containing Brassica nigra (mustard seed) powder at 0, 1, 5 or 10% for 1 month and then exposed to benzo[a]pyrene (B[a]P. 1 mg by ip injection). The antimutagenic effect due to mustard was assessed by testing the urine of rats fed diets with and without mustard. There was a significant (P < 0.... |
8070739 | Comparison of the hepatic effects of coumarin, 3,4-dimethylcoumarin, dihydrocoumarin and 6-methylcoumarin in the rat. | The mechanism of coumarin-induced hepatotoxicity in the rat has been investigated paring the effects of coumarin with those of three coumarin derivatives, namely 3,4-dihydrocoumarin (DHC), 3,4-dimethylcoumarin (3,4-DMC) and 6-methylcoumarin (6-MC). Male Sprague-Dawley rats were fed either control diet or diets containi... |
8070745 | [Drug dependence and withdrawal in chronic pain patients]. | Drug dependence in "pain patients" usually involves primary headache syndromes with chronicity resulting from the use of analgesic-psychotropic or bination preparations. Since, during the withdrawal phase, enhancement of pain intensity together with other abstinence phenomena are to be expected, hospitalization is usua... |
8070748 | [Optimal or maximum acid inhibition in ulcer therapy? A decision guide for routine general practice based on personal studies]. | The mucosal barrier in the stomach plete only when the mucous layer has e saturated with bicarbonate. The latter arises as a waste product, as it were, of acid production in the parietal cell, but is then actively secreted via the surface epithelial cells and tight junctions. If the acid secretion is inhibited by means... |
8070750 | Dose-dependent testicular toxicity of propylene oxide in rats induced by repeated intraperitoneal injections. | The dose-dependent testicular toxicity of propylene oxide (PO) was evaluated in male Wistar rats when administered by intraperitoneal injections. In 23 mg/kg, 47 mg/kg, and 93 mg/kg groups, PO was given three days a week for six weeks, while PO was given three days a week for two weeks plus once a week after the third ... |
8070751 | Effectiveness of relative low-dose interferon treatment for patients with chronic hepatitis C. | To demonstrate effectiveness by relative low-dose of interferon treatment for patients with chronic hepatitis C, we investigated the histological activity index (HAI) score of liver tissue, hepatitis C virus (HCV) genotype by polymerase chain reaction (PCR) with type-specific primers, HCV RNA levels petitive PCR, serum... |
8070752 | The substitution of troponin in bullfrog and chicken myofibrils by rabbit skeletal troponin, troponin-T and troponin-T1. | The substitution of troponin in bullfrog skeletal myofibrils by rabbit skeletal troponin, troponin T and troponin T1 was examined by the densitometry of the SDS gel-electrophoretic patterns. The troponin in the myofibrils was replaced by the added rabbit skeletal troponin and troponin T (tropomyosin ponent of troponin)... |
8070753 | [Transient and steady-state electroretinograms and visual evoked potentials to pattern and uniform-field stimulation in humans]. | I recorded simultaneously transient and steady-state electroretinograms (ERGs) and visual evoked potentials (VEPs) in response to pattern and uniform-field stimulation in 21 normal subjects, in order to study their physiological characteristics. ERGs and VEPs to pattern stimulation (P-ERGs and P-VEPs, respectively) sho... |
8070758 | [Radioligand binding assay of PHSA receptor on hepatocytes]. | The radioligand binding assay of PHSA receptor on hepatocytes of 7 adults is reported. The presence of PHSA receptor was demonstrated in all the 7 adults, though the individual difference of the Kds and binding capacities among them was distinct with a higher standard derivation. The mean values of the Kds and binding ... |
8070759 | [Effects of zuzhongping on ischemic volume in the rat model of middle cerebral artery occlusion]. | Using the middle cerebral artery occlusion model, we studied the effects of Zuzhongping on experimental focal cerebral ischemia. Twenty-eight adult male Wistar rats were randomly divided into three groups: (1) Zuzhongping group (n = 9), (2) Saline control group (n = 10), and (3) Blank control group (n = 9). Group 1 and... |
8070754 | Transfection of the bcr/abl oncogene into factor-dependent cells by electroporation: acquisition of autonomous proliferation. | In order to clarify the function of P210 bcr/abl oncogene in leukemogenesis, IL-3 dependent murine hematopietic cell line, FDC-P2, was transfected with the plasmid containing cDNA of P210 bcr/abl oncogene (pGD'210) or murine IL-3 (pcDmIL3) by electroporation. Four out of five pGDH210 transfected clones as well as FDC-P... |
8070755 | Reactive hemophagocytic syndrome in childhood--frequent occurrence of atypical mononuclear cells. | Reactive hemophagocytic syndrome, which is characterized by systemic proliferation of benign hemophagocytic histiocytes, usually presents as an acute febrile illness with pancytopenia and hepatosplenomegaly. moner diseases associated with the syndrome are infection and malignant lymphoma. In this report, eight cases of... |
8070760 | [Application of ORM1 phenotyping in forensic science]. | ORM1 is an important genetic marker for both parentage testing and personal identification in forensic science. We have examined the ORM1 phenotypes in the human serum and dried bloodstains using the ULPAGIF method. ORM1 phenotypes were successfully demonstrated from dried bloodstains stored at 4 degrees C and room tem... |
8070761 | [Chemiluminescent immunoassay for anti-granulocyte antibody IgG]. | In this paper is reported solid petitive chemiluminescent immunoassay (CLIA) for anti-granulocyte antibody (AGAb) IgG with N-(4-amiobytul)-N-ethylisoluminol (ABEI) labelled rabbit antibody IgG against peting with the analyte and ABEI-CoCl2-H2O2 as the chemiluminescent system. The absolute limit of detection was 3.0 x 1... |
8070762 | [Facial nerve repairs: a comparative experimental study of epineural and perineural techniques]. | This paper reports parative study results of perineural and epineural techniques in facial nerve (FN) transection injuries of 16 rabbits. We found little difference in recovery of FN function and histology between epineural and perineural repairs. Both epineural and perineural sutures on FN have not yet solved the prob... |
8070756 | Autologous bone marrow transplantation in adults with non-Hodgkin's lymphoma: a Southwest Oncology Group study. | Patients with non-Hodgkin's lymphoma (NHL) who fail conventional chemotherapy have a dismal e. Reports from single institutions utilizing high-dose chemoradiotherapy plus Autologous Bone Marrow Transplantation (ABMT) in this setting suggest three-year disease-free survival between 15-60 per cent. From 1985 to 1989 the ... |
8070764 | [Descriptions of three new species of the genus Delia, anthomyiidae, diptera in Sichuan, China]. | Three new species of the genus Delia distributed in Mountain Emei and Huanglong Canyon have been identified and kept in our Parasitological Laboratory. 1. Delia taonura sp. nov. (Fig 1-3) male: Having no blunt bristles on the 5th sternite and long hairs on posterior part of the cercal plate, the new species is superfic... |
8070763 | [Detection of isoferritin level in breast cancer tissue and serum]. | ELISA (double-determinant) was used to evaluate the isoferritin level in the breast cancer tissue. The isoferritin concentration was measured in cytosol extracts of 25 breast cancer tissues (BCT), 6 cancer surrounding tissues (CST) and 8 normal breast tissues (NBT). With the results of 16,023 +/- 15,732, 2467 +/- 1360 ... |
8070765 | [Characterization of receptor-mediated binding of 99mTc-NGA in vitro]. | This paper reports results of an assay of the binding of 99mTc-galactosylneoglycoalbumin (NGA) and plasma membranes of the rat liver in vitro. The data showed that 99mTc-NGA could be bound to the membrane receptor with high affinity. Specificity and saturability, and that the amount of membrane-bound 99mTc-NGA varied l... |
8070766 | [Quantitative study on cerebral motor cortex structure of kindling rat induced by coriaria lactone]. | Ten male Wistar rats were divided into two groups. The experimental rats were injected with subconvulsive dosage of coriaria lactone (1 mg/kg) intramuscularly every 3.5 days to induce kindling seizures. The controls were injected with normal saline. Cerebral motor cortex of kindling rats was taken at the time between s... |
8070767 | [Synthesis of p-substituted benzoylaminobenzoic acid (methyl esters) and its differentiation induction in activities of human promyelocytic leukemia cells HL-60]. | Sixteen p-substituted benzoylaminobenzoic acids and their methyl esters were synthesized, of which nine were not found in literature. All of the pounds were evaluated for their differentiation induction in activities of human promyelotic leukemia cells HL-60. Compounds III1, III2, III4, and III5 possessed potential act... |
8070768 | [Immunohistochemical observation of anti-human hepatocellular carcinoma monoclonal antibody HL2 in cancers]. | Molecular weight of human hepatocellular carcinoma (HCC)-associated antigen-HL2 antigen was detected to be about 50,000 dalton by SDS-PAGE and Western blot. One hundred and twenty-seven paraffin sections of cancers and pathological liver tissue were tests by ABC immunohistochemical staining. MAb HL2 reacted with 62.7% ... |
8070769 | [Experimental study of Chinese Agkistrodon acutus venom in activation of rabbit platelets in vivo]. | Fourteen Albino rabbits, male and female, were allocated randomly into two groups: control group which had intravenous infusion of normal saline, and experimental group which had intravenous infusion of Chinese Agkistrodon Acutus venom (CAAV) 0.075 mg/kg. Platelet was reduced, plasma PF4 activity and 5-HT concentration... |
8070770 | [Amplification of C-myc oncogene in squamous cell carcinoma of the larynx]. | C-myc amplification in 22 squamous cell carcinomas and 10 normal tissues (control) from the larynx was assessed by dot hybridization technique. Significant amplification of C-myc oncogene was found in malignant tumours pared with the normal tissues. The extent of amplification also correlated with advanced tumour stage... |
8070772 | [Preparation of membrane proteins of Trichinella spiralis larva and application of them in detection with ELISA]. | Membrane proteins of muscle larva of Trichinella spiralis (T.s) were isolated by using the non-ionic detergent Triton X-114. At least ponents in the membrane proteins were separated with SDS-PAGE and then silver nitrate stain. The bands of them were located between 99-18kd MW level. The MW of chief bands were 94, 90, 4... |
8070771 | [Anti-implantation action of nylestriol and its effect on endometrium in rabbits]. | The anti-implantation action of nylestriol in rabbits was studied. Using the method of arresting mitosis by injection of colchicine, we detected the mitosis frequency of endometrial cells. The activities of carbonic anhydrase (CAH), A1P and PAS reaction were observed under light bined with the histochemical method and ... |
8070773 | [Changes in cell spreading area and cell surface morphology of Tca8113 line affected by fibronectin]. | Morphometric changes in cell spreading area and morphological alternation in cell surface of human tongue squamous cancer line Tca8113 on rat-tail collagen substrata supplemented with different concentration of FN and/or anti-FN serum were quantified and observed with cell culture technique as well as light and scannin... |
End of preview. Expand in Data Studio
- Downloads last month
- 34