Daily Papers

Reinforcement learning (RL) is a machine learning paradigm where an autonomous agent learns to make an optimal sequence of decisions by interacting with the underlying environment. The promise demonstrated by RL-guided workflows in unraveling electronic design automation problems has encouraged hardware security researchers to utilize autonomous RL agents in solving domain-specific problems. From the perspective of hardware security, such autonomous agents are appealing as they can generate optimal actions in an unknown adversarial environment. On the other hand, the continued globalization of the integrated circuit supply chain has forced chip fabrication to off-shore, untrustworthy entities, leading to increased concerns about the security of the hardware. Furthermore, the unknown adversarial environment and increasing design complexity make it challenging for defenders to detect subtle modifications made by attackers (a.k.a. hardware Trojans). In this brief, we outline the development of RL agents in detecting hardware Trojans, one of the most challenging hardware security problems. Additionally, we outline potential opportunities and enlist the challenges of applying RL to solve hardware security problems.

Digital technologies have changed the way supply chain operations are structured. In this article, we conduct systematic syntheses of literature on the impact of new technologies on supply chains and the related cyber risks. A taxonomic/cladistic approach is used for the evaluations of progress in the area of supply chain integration in the Industrial Internet of Things and Industry 4.0, with a specific focus on the mitigation of cyber risks. An analytical framework is presented, based on a critical assessment with respect to issues related to new types of cyber risk and the integration of supply chains with new technologies. This paper identifies a dynamic and self-adapting supply chain system supported with Artificial Intelligence and Machine Learning (AI/ML) and real-time intelligence for predictive cyber risk analytics. The system is integrated into a cognition engine that enables predictive cyber risk analytics with real-time intelligence from IoT networks at the edge. This enhances capacities and assist in the creation of a comprehensive understanding of the opportunities and threats that arise when edge computing nodes are deployed, and when AI/ML technologies are migrated to the periphery of IoT networks.

Supply chain management (SCM) involves coordinating the flow of goods, information, and finances across various entities to deliver products efficiently. Effective inventory management is crucial in today's volatile and uncertain world. Previous research has demonstrated the superiority of heuristic methods and reinforcement learning applications in inventory management. However, the application of large language models (LLMs) as autonomous agents in multi-agent systems for inventory management remains underexplored. This study introduces a novel approach using LLMs to manage multi-agent inventory systems. Leveraging their zero-shot learning capabilities, our model, InvAgent, enhances resilience and improves efficiency across the supply chain network. Our contributions include utilizing LLMs for zero-shot learning to enable adaptive and informed decision-making without prior training, providing explainability and clarity through chain-of-thought, and demonstrating dynamic adaptability to varying demand scenarios while reducing costs and preventing stockouts. Extensive evaluations across different scenarios highlight the efficiency of our model in SCM.

Academic and policy proposals on algorithmic accountability often seek to understand algorithmic systems in their socio-technical context, recognising that they are produced by 'many hands'. Increasingly, however, algorithmic systems are also produced, deployed, and used within a supply chain comprising multiple actors tied together by flows of data between them. In such cases, it is the working together of an algorithmic supply chain of different actors who contribute to the production, deployment, use, and functionality that drives systems and produces particular outcomes. We argue that algorithmic accountability discussions must consider supply chains and the difficult implications they raise for the governance and accountability of algorithmic systems. In doing so, we explore algorithmic supply chains, locating them in their broader technical and political economic context and identifying some key features that should be understood in future work on algorithmic governance and accountability (particularly regarding general purpose AI services). To highlight ways forward and areas warranting attention, we further discuss some implications raised by supply chains: challenges for allocating accountability stemming from distributed responsibility for systems between actors, limited visibility due to the accountability horizon, service models of use and liability, and cross-border supply chains and regulatory arbitrage

Supply chain operations traditionally involve a variety of complex decision making problems. Over the last few decades, supply chains greatly benefited from advances in computation, which allowed the transition from manual processing to automation and cost-effective optimization. Nonetheless, business operators still need to spend substantial efforts in explaining and interpreting the optimization outcomes to stakeholders. Motivated by the recent advances in Large Language Models (LLMs), we study how this disruptive technology can help bridge the gap between supply chain automation and human comprehension and trust thereof. We design -- a framework that accepts as input queries in plain text, and outputs insights about the underlying optimization outcomes. Our framework does not forgo the state-of-the-art combinatorial optimization technology, but rather leverages it to quantitatively answer what-if scenarios (e.g., how would the cost change if we used supplier B instead of supplier A for a given demand?). Importantly, our design does not require sending proprietary data over to LLMs, which can be a privacy concern in some circumstances. We demonstrate the effectiveness of our framework on a real server placement scenario within Microsoft's cloud supply chain. Along the way, we develop a general evaluation benchmark, which can be used to evaluate the accuracy of the LLM output in other scenarios.

Inventory Routing Problem (IRP) is a crucial challenge in supply chain management as it involves optimizing efficient route selection while considering the uncertainty of inventory demand planning. To solve IRPs, usually a two-stage approach is employed, where demand is predicted using machine learning techniques first, and then an optimization algorithm is used to minimize routing costs. Our experiment shows machine learning models fall short of achieving perfect accuracy because inventory levels are influenced by the dynamic business environment, which, in turn, affects the optimization problem in the next stage, resulting in sub-optimal decisions. In this paper, we formulate and propose a decision-focused learning-based approach to solving real-world IRPs. This approach directly integrates inventory prediction and routing optimization within an end-to-end system potentially ensuring a robust supply chain strategy.

Advancement in information and communication technology (ICT) has given rise to explosion of data in every field of operations. Working with the enormous volume of data (or Big Data, as it is popularly known as) for extraction of useful information to support decision making is one of the sources of competitive advantage for organizations today. Enterprises are leveraging the power of analytics in formulating business strategy in every facet of their operations to mitigate business risk. Volatile global market scenario has compelled the organizations to redefine their supply chain management (SCM). In this paper, we have delineated the relevance of Big Data and its importance in managing end to end supply chains for achieving business excellence. A Big Data-centric architecture for SCM has been proposed that exploits the current state of the art technology of data management, analytics and visualization. The security and privacy requirements of a Big Data system have also been highlighted and several mechanisms have been discussed to implement these features in a real world Big Data system deployment in the context of SCM. Some future scope of work has also been pointed out. Keyword: Big Data, Analytics, Cloud, Architecture, Protocols, Supply Chain Management, Security, Privacy.

Printed Circuit Board (PCB) schematic design plays an essential role in all areas of electronic industries. Unlike prior works that focus on digital or analog circuits alone, PCB design must handle heterogeneous digital, analog, and power signals while adhering to real-world IC packages and pin constraints. Automated PCB schematic design remains unexplored due to the scarcity of open-source data and the absence of simulation-based verification. We introduce PCBSchemaGen, the first training-free framework for PCB schematic design that comprises LLM agent and Constraint-guided synthesis. Our approach makes three contributions: 1. an LLM-based code generation paradigm with iterative feedback with domain-specific prompts. 2. a verification framework leveraging a real-world IC datasheet derived Knowledge Graph (KG) and Subgraph Isomorphism encoding pin-role semantics and topological constraints. 3. an extensive experiment on 23 PCB schematic tasks spanning digital, analog, and power domains. Results demonstrate that PCBSchemaGen significantly improves design accuracy and computational efficiency.

Open time-series forecasting (TSF) benchmarks cover retail, energy, weather, and traffic, but supply-chain logistics remains underserved. We introduce ISOMORPH, the first public digital twin of a multi-echelon logistics network with fully interpretable, user-configurable parameters and modular topology, demand process, and control rules. The simulator advances a directed routing graph in discrete time: demand arrives at the destination, is served from stock or recorded as backlog, and triggers replenishment through the network. The state vector tracks per-node on-hand inventory with outstanding orders, in-transit shipments, and a smoothed demand estimate, so the dynamics close as a Markov chain on a tractable state space whose transition kernel acts linearly on the empirical distribution of the state. The released data reproduces the bullwhip effect at empirically consistent magnitudes, and three conservation laws encoded in the Markov chain serve as verification tools when users extend the simulator. We release datasets at two catalogue scales (C=50 and C=200) with six scenario sweeps producing 30 additional rollouts and 20 Latin-hypercube perturbations, exhibiting dynamics absent from fixed TSF benchmarks: variance amplification, cascading bottlenecks, regime shifts, and cross-channel coupling through shared macro shocks. Zero-shot evaluation of four foundation models (Chronos, Moirai, TimesFM, Lag-Llama) shows MASE values exceeding public GIFT-Eval references at low-to-moderate horizons, supporting incorporation into existing benchmarks. The same pairing produces forecast confidence bands via Latin-hypercube perturbation of demand-side knobs, forward UQ from parameter uncertainty unavailable on standard TSF datasets, demonstrating that foundation models can serve as fast surrogates for the digital twin's forward UQ. Code (MIT): https://github.com/tuhinsahai/ISOMORPH.

Graph Neural Networks (GNNs) have gained traction across different domains such as transportation, bio-informatics, language processing, and computer vision. However, there is a noticeable absence of research on applying GNNs to supply chain networks. Supply chain networks are inherently graph-like in structure, making them prime candidates for applying GNN methodologies. This opens up a world of possibilities for optimizing, predicting, and solving even the most complex supply chain problems. A major setback in this approach lies in the absence of real-world benchmark datasets to facilitate the research and resolution of supply chain problems using GNNs. To address the issue, we present a real-world benchmark dataset for temporal tasks, obtained from one of the leading FMCG companies in Bangladesh, focusing on supply chain planning for production purposes. The dataset includes temporal data as node features to enable sales predictions, production planning, and the identification of factory issues. By utilizing this dataset, researchers can employ GNNs to address numerous supply chain problems, thereby advancing the field of supply chain analytics and planning. Source: https://github.com/CIOL-SUST/SupplyGraph

The last decade has seen widespread adoption of Machine Learning (ML) components in software systems. This has occurred in nearly every domain, from natural language processing to computer vision. These ML components range from relatively simple neural networks to complex and resource-intensive large language models. However, despite this widespread adoption, little is known about the supply chain relationships that produce these models, which can have implications for compliance and security. In this work, we conduct an extensive analysis of 760,460 models and 175,000 datasets mined from the popular model-sharing site Hugging Face. First, we evaluate the current state of documentation in the Hugging Face supply chain, report real-world examples of shortcomings, and offer actionable suggestions for improvement. Next, we analyze the underlying structure of the extant supply chain. Finally, we explore the current licensing landscape against what was reported in prior work and discuss the unique challenges posed in this domain. Our results motivate multiple research avenues, including the need for better license management for ML models/datasets, better support for model documentation, and automated inconsistency checking and validation. We make our research infrastructure and dataset available to facilitate future research.

Generative AI applications, such as ChatGPT or DALL-E, have shown the world their impressive capabilities in generating human-like text or image. Diving deeper, the science stakeholder for those AI applications are Deep Generative Models, a.k.a DGMs, which are designed to learn the underlying distribution of the data and generate new data points that are statistically similar to the original dataset. One critical question is raised: how can we leverage DGMs into morden retail supply chain realm? To address this question, this paper expects to provide a comprehensive review of DGMs and discuss their existing and potential usecases in retail supply chain, by (1) providing a taxonomy and overview of state-of-the-art DGMs and their variants, (2) reviewing existing DGM applications in retail supply chain from a end-to-end view of point, and (3) discussing insights and potential directions on how DGMs can be further utilized on solving retail supply chain problems.

Packaging has become a crucial process due to the paradigm shift of More than Moore. Addressing manufacturing and yield issues is a significant challenge for modern layout algorithms. We propose to use printed circuit board (PCB) placement as a benchmark for the packaging problem. A maximum-margin formulation is devised to improve the separation between nets. Our framework includes seed layout proposals, a coordinate descent-based procedure to optimize routability, and a mixed-integer linear programming method to legalize the layout. We perform an extensive study with 14 PCB designs and an open-source router. We show that the placements produced by NS-place improve routed wirelength by up to 25\%, reduce the number of vias by up to 50\%, and reduce the number of DRVs by 79\% compared to manual and wirelength-minimal placements.

A software supply chain attack is characterized by the injection of malicious code into a software package in order to compromise dependent systems further down the chain. Recent years saw a number of supply chain attacks that leverage the increasing use of open source during software development, which is facilitated by dependency managers that automatically resolve, download and install hundreds of open source packages throughout the software life cycle. This paper presents a dataset of 174 malicious software packages that were used in real-world attacks on open source software supply chains, and which were distributed via the popular package repositories npm, PyPI, and RubyGems. Those packages, dating from November 2015 to November 2019, were manually collected and analyzed. The paper also presents two general attack trees to provide a structured overview about techniques to inject malicious code into the dependency tree of downstream users, and to execute such code at different times and under different conditions. This work is meant to facilitate the future development of preventive and detective safeguards by open source and research communities.

Material and product life cycles are based on complex value chains of technology-specific elements. Resource strategy aspects of essential and strategic raw materials have a direct impact on applications of new functionalized materials or the development of novel products. Thus, an urgent challenge of modern materials science is to obtain information about the supply risk and environmental aspects of resource utilization, especially at an early stage of basic research. Combining the fields of materials science, industrial engineering and resource strategy enables a multidisciplinary research approach to identify specific risks within the value chain, aggregated as the so-called resource criticality. Here, we demonstrate a step-by-step criticality assessment in the sector of basic materials research for multifunctional hexagonal manganite YMnO3, which can be a candidate for future electronic systems. Raw material restrictions can be quantitatively identified, even at such an early stage of materials research, from eleven long-term indicators including our new developed Sector Competition Index. This approach for resource strategy for modern material science integrates two objective targets: reduced supply risk and enhanced environmental sustainability of new functionalized materials, showing drawbacks but also benefits towards a sustainable materials research and development.

This study investigates large language model (LLM) -based multi-agent systems (MASs) as a promising approach to inventory management, which is a key component of supply chain management. Although these systems have gained considerable attention for their potential to address the challenges associated with typical inventory management methods, key uncertainties regarding their effectiveness persist. Specifically, it is unclear whether LLM-based MASs can consistently derive optimal ordering policies and adapt to diverse supply chain scenarios. To address these questions, we examine an LLM-based MAS with a fixed-ordering strategy prompt that encodes the stepwise processes of the problem setting and a safe-stock strategy commonly used in inventory management. Our empirical results demonstrate that, even without detailed prompt adjustments, an LLM-based MAS can determine optimal ordering decisions in a restricted scenario. To enhance adaptability, we propose a novel agent called AIM-RM, which leverages similar historical experiences through similarity matching. Our results show that AIM-RM outperforms benchmark methods across various supply chain scenarios, highlighting its robustness and adaptability.

Advancements in high-computing devices increase the necessity for improved and new understanding and development of smart manufacturing factories. Discrete-event models with simulators have been shown to be critical to architect, designing, building, and operating the manufacturing of semiconductor chips. The diffusion, implantation, and lithography machines have intricate processes due to their feedforward and feedback connectivity. The dataset collected from simulations of the factory models holds the promise of generating valuable machine-learning models. As surrogate data-based models, their executions are highly efficient compared to the physics-based counterpart models. For the development of surrogate models, it is beneficial to have publicly available benchmark simulation models that are grounded in factory models that have concise structures and accurate behaviors. Hence, in this research, a dataset is devised and constructed based on a benchmark model of an Intel semiconductor fabrication factory. The model is formalized using the Parallel Discrete-Event System Specification and executed using the DEVS-Suite simulator. The time series dataset is constructed using discrete-event time trajectories. This dataset is further analyzed and used to develop baseline univariate and multivariate machine learning models. The dataset can also be utilized in the machine learning community for behavioral analysis based on formalized and scalable component-based discrete-event models and simulations.

Classical supply chain risk models treat node failures as statistically independent events, systematically underestimating cascade probabilities when supplier dependencies are strongly correlated. At n=40 nodes, the full correlated failure distribution requires O(2^n) classical samples, a regime where exact simulation demands 17.6 TB of memory and over 369,000 hours of computation on a standard workstation. We present QR-SPPS (Quantum-Native Retail Shock Propagation and Policy Stress Simulator), a three-algorithm quantum pipeline implemented using the Qiskit framework with the Aer statevector_simulator backend. First, a 40-node, 4-tier retail supply network is encoded as a 40-qubit Ising Hamiltonian using OpenFermion QubitOperator, where ZZ coupling terms encode correlated cascade probabilities structurally absent from classical Monte Carlo. Second, a hardware-efficient VQE circuit finds the ground-state stress distribution with zero error, detecting entangled cascade failures in 14/40 nodes with max|ΔP|=0.637 versus classical Monte Carlo. Third, we introduce the first application of ADAPT-VQE gradient screening to counterfactual macroeconomic policy evaluation: six crisis interventions are ranked in O(1) Qiskit operator evaluations per policy, a 287x speedup over sequential VQE re-optimisation. Fourth, Density-of-States QPE (DOS-QPE) reconstructs the full eigenspectrum via 32-step Trotter evolution and introduces a novel mapping of the Boltzmann catastrophe probability P_cat(T) to VIX-equivalent market volatility temperature, enabling direct integration into regulatory Value-at-Risk frameworks. Qiskit Aer scaling benchmarks confirm exponential classical intractability at 40 qubits.

Open-source EDA shows promising potential in unleashing EDA innovation and lowering the cost of chip design. This paper presents an open-source EDA project, iEDA, aiming for building a basic infrastructure for EDA technology evolution and closing the industrial-academic gap in the EDA area. iEDA now covers the whole flow of physical design (including Floorplan, Placement, CTS, Routing, Timing Optimization etc.), and part of the analysis tools (Static Timing Analysis and Power Analysis). To demonstrate the effectiveness of iEDA, we implement and tape out three chips of different scales (from 700k to 1.5M gates) on different process nodes (110nm and 28nm) with iEDA. iEDA is publicly available from the project home page http://ieda.oscc.cc.

While Large Language Models (LLMs) demonstrate immense potential for automating integrated circuit (IC) development, their practical deployment is fundamentally limited by restricted context windows. Existing context-extension methods struggle to achieve effective semantic modeling and thorough multi-hop reasoning over extensive, intricate circuit specifications. To address this, we introduce ChipMind, a novel knowledge graph-augmented reasoning framework specifically designed for lengthy IC specifications. ChipMind first transforms circuit specifications into a domain-specific knowledge graph ChipKG through the Circuit Semantic-Aware Knowledge Graph Construction methodology. It then leverages the ChipKG-Augmented Reasoning mechanism, combining information-theoretic adaptive retrieval to dynamically trace logical dependencies with intent-aware semantic filtering to prune irrelevant noise, effectively balancing retrieval completeness and precision. Evaluated on an industrial-scale specification reasoning benchmark, ChipMind significantly outperforms state-of-the-art baselines, achieving an average improvement of 34.59% (up to 72.73%). Our framework bridges a critical gap between academic research and practical industrial deployment of LLM-aided Hardware Design (LAD).

Outsourced printed circuit board (PCB) fabrication necessitates increased hardware assurance capabilities. Several assurance techniques based on automated optical inspection (AOI) have been proposed that leverage PCB images acquired using digital cameras. We review state-of-the-art AOI techniques and observe a strong, rapid trend toward machine learning (ML) solutions. These require significant amounts of labeled ground truth data, which is lacking in the publicly available PCB data space. We contribute the FICS PCB Image Collection (FPIC) dataset to address this need. Additionally, we outline new hardware security methodologies enabled by our data set.

The electric vehicle (EV) battery supply chain's vulnerability to disruptions necessitates advanced predictive analytics. We present SHIELD (Schema-based Hierarchical Induction for EV supply chain Disruption), a system integrating Large Language Models (LLMs) with domain expertise for EV battery supply chain risk assessment. SHIELD combines: (1) LLM-driven schema learning to construct a comprehensive knowledge library, (2) a disruption analysis system utilizing fine-tuned language models for event extraction, multi-dimensional similarity matching for schema matching, and Graph Convolutional Networks (GCNs) with logical constraints for prediction, and (3) an interactive interface for visualizing results and incorporating expert feedback to enhance decision-making. Evaluated on 12,070 paragraphs from 365 sources (2022-2023), SHIELD outperforms baseline GCNs and LLM+prompt methods (e.g., GPT-4o) in disruption prediction. These results demonstrate SHIELD's effectiveness in combining LLM capabilities with domain expertise for enhanced supply chain risk assessment.

Integrated circuits are a cornerstone of modern information technology, and analog wave-based architectures could enable fast and efficient processing beyond conventional charge electronics. In magnonics, spin waves provide a highly tunable, compact and energy-efficient medium for on-chip microwave signal transport and processing. However, progress has been limited to isolated elements or short devices, severely limiting the overall functional complexity and scalability. Here we realize the key elements of universal magnonic circuitry, using a single-step direct laser writing process in yttrium iron garnet, and monolithically cascade them in multi-stage programmable devices and networks. Using magneto-optical Kerr effect microscopy, we show efficient spin-wave propagation and preserved phase coherence in waveguide structures for hundreds of wavelengths. In coupled waveguides, we observe complete and periodic power transfer over several coupling lengths, and in phase shifters we achieve arbitrary, tunable phase delays. By cascading these elements, we realize programmable splitters, frequency demultiplexers, and phase-controlled 2x2 routers, where output power and relative phase can be programmed on demand via external fields. Finally, we realize programmable magnonic interferometric meshes for on-chip radio-frequency signal routing, with up to six magnonic inputs and outputs and seven cascaded stages, without the need for intermediate amplification. These direct-write cascaded networks bridge a long-standing gap in magnonic scalability, offering a viable pathway toward integrated, large-scale architectures for both classical and quantum processing.

As the globalization of semiconductor design and manufacturing processes continues, the demand for defect detection during integrated circuit fabrication stages is becoming increasingly critical, playing a significant role in enhancing the yield of semiconductor products. Traditional wafer map defect pattern detection methods involve manual inspection using electron microscopes to collect sample images, which are then assessed by experts for defects. This approach is labor-intensive and inefficient. Consequently, there is a pressing need to develop a model capable of automatically detecting defects as an alternative to manual operations. In this paper, we propose a method that initially employs a pre-trained VAE model to obtain the fault distribution information of the wafer map. This information serves as guidance, combined with the original image set for semi-supervised model training. During the semi-supervised training, we utilize a teacher-student network for iterative learning. The model presented in this paper is validated on the benchmark dataset WM-811K wafer dataset. The experimental results demonstrate superior classification accuracy and detection performance compared to state-of-the-art models, fulfilling the requirements for industrial applications. Compared to the original architecture, we have achieved significant performance improvement.

In the post-pandemic world, manufacturing enterprises face increasing uncertainties, especially with vulnerabilities in global supply chains. Although supply chain management has been extensively studied, the critical influence of decision-makers (DMs) in these systems remains underexplored. This study studies the inventory management problem under risk using the newsvendor model by incorporating DMs risk preferences. By employing the Quantum Monte Carlo (QMC) combined with Quantum Amplitude Estimation (QAE) algorithm, the estimation of probabilities or expectation values can be done more efficiently. This offers near-quadratic speedup compared to classical Monte Carlo methods. Our findings illuminate the intricate relationship between risk-aware decision-making and inventory management, providing essential insights for enhancing supply chain resilience and adaptability in uncertain conditions

Large language models (LLMs) have shown promise in complex reasoning and tool-based decision making, motivating their application to real-world supply chain management. However, supply chain workflows require reliable long-horizon, multi-step orchestration grounded in domain-specific procedures, which remains challenging for current models. To systematically evaluate LLM performance in this setting, we introduce SupChain-Bench, a unified real-world benchmark that assesses both supply chain domain knowledge and long-horizon tool-based orchestration grounded in standard operating procedures (SOPs). Our experiments reveal substantial gaps in execution reliability across models. We further propose SupChain-ReAct, an SOP-free framework that autonomously synthesizes executable procedures for tool use, achieving the strongest and most consistent tool-calling performance. Our work establishes a principled benchmark for studying reliable long-horizon orchestration in real-world operational settings and highlights significant room for improvement in LLM-based supply chain agents.

In the dynamic landscape of Industry 4.0, achieving efficiency, precision, and adaptability is essential to optimize manufacturing operations. Industries suffer due to supply chain disruptions caused by anomalies, which are being detected by current AI models but leaving domain experts uncertain without deeper insights into these anomalies. Additionally, operational inefficiencies persist due to inaccurate production forecasts and the limited effectiveness of traditional AI models for processing complex sensor data. Despite these advancements, existing systems lack the seamless integration of these capabilities needed to create a truly unified solution for enhancing production and decision-making. We propose SmartPilot, a neurosymbolic, multiagent CoPilot designed for advanced reasoning and contextual decision-making to address these challenges. SmartPilot processes multimodal sensor data and is compact to deploy on edge devices. It focuses on three key tasks: anomaly prediction, production forecasting, and domain-specific question answering. By bridging the gap between AI capabilities and real-world industrial needs, SmartPilot empowers industries with intelligent decision-making and drives transformative innovation in manufacturing. The demonstration video, datasets, and supplementary materials are available at https://github.com/ChathurangiShyalika/SmartPilot.

Drug shortages pose critical risks to patient care and healthcare systems worldwide, yet the effectiveness of regulatory interventions remains poorly understood due to information asymmetries in pharmaceutical supply chains. We propose ShortageSim, addresses this challenge by providing the first simulation framework that evaluates the impact of regulatory interventions on competition dynamics under information asymmetry. Using Large Language Model (LLM)-based agents, the framework models the strategic decisions of drug manufacturers and institutional buyers, in response to shortage alerts given by the regulatory agency. Unlike traditional game theory models that assume perfect rationality and complete information, ShortageSim simulates heterogeneous interpretations on regulatory announcements and the resulting decisions. Experiments on self-processed dataset of historical shortage events show that ShortageSim reduces the resolution lag for production disruption cases by up to 84\%, achieving closer alignment to real-world trajectories than the zero-shot baseline. Our framework confirms the effect of regulatory alert in addressing shortages and introduces a new method for understanding competition in multi-stage environments under uncertainty. We open-source ShortageSim and a dataset of 2,925 FDA shortage events, providing a novel framework for future research on policy design and testing in supply chains under information asymmetry.