text:
Purpose: To determine ocular side effects of vardenafil with special regard to color vision and retinal function.
Methods: This was a single center, randomized, double-blind, placebo-controlled, twofold crossover study with an administration of a single oral dose of two 20 mg tablets of BAY 38–9456 (vardenafil hydrochloride) or corresponding placebo in 24 healthy male subjects. Ocular investigations included Farnsworth–Munsell D100 color vision test, electroretinogram, and basic ophthalmological examinations like visual acuity, visual field, and slit-lamp of anterior segment and fundus.
Results: Compared to placebo, administration of vardenafil hydrochloride lead to a temporary significant increase of Farnsworth–Munsell D100 total error score after 1 and 6 hours as well as in error lines 3 and 4 after 1 hour. Twenty-four hours after administration there was no significant alteration of total error score or of any error line. While latency of electroretinogram b-wave remained unaffected, amplitudes showed a significant decrease compared to placebo 1 hour following administration. While other ocular examinations did not reveal any differences in general some mild to moderate but no serious adverse events have been reported.
Conclusion: Despite temporary changes in retinal function our study reports good tolerability of vardenafil in regard to ocular side effects.
Typical ocular side effects seen under treatment with PDE-5 inhibitors are disturbed color vision and temporary effects on the electroretinogram (ERG), which may be due to the fact that PDE-6, typically located in the eye, is also inhibited to a certain degree by PDE-5 inhibitors;9–14 this may depend on the selectivity of PDE-5 inhibition.15 However, these side effects have been exclusively investigated for sildenafil. Therefore, this study was designed to especially investigate the possible influence of vardenafil-induced PDE-5 inhibition on ocular side effects and the function of the retina.
The primary objective of the study was to investigate the possible influence of a single oral dose of 40 mg of vardenafil on color vision in normal-eyed male subjects measured by performing Farnsworth–Munsell 100 test at 1, 6 and 24 hours after drug administration. Secondary objectives of the study were further investigations of the eye including effects on retinal function as well as the safety and overall tolerability of vardenafil. To our knowledge this is the first investigation on retinal function following vardenafil administration and the first placebo-controlled study on ocular side effects for the use of vardenafil at all.
This was a single-center, randomized, double-blind, placebo-controlled, twofold crossover study with an administration of a single oral dose of a 40 mg BAY 38–9456 (vardenafil hydrochloride) given as 2 tablets of 20 mg in 24 healthy male subjects. The trial was registered at the District Council Cologne, Germany under the registration number BAY 38-9456 / 10197. In detail, demographic features of all subjects are listed in Table 1.
Starting from the time of administration, subsequent investigations of the eye were performed according to the study flowchart (Table 2). Blood drawings were taken for the determination of the plasma concentrations of BAY 38–7268 (free base of BAY 38–9456 vardenafil hydrochloride) and its major active metabolite BAY 44–5576 for population-pharmacokinetics at baseline (at screening) and at certain time intervals after administration of the test drug. Plasma concentrations were measured by using a validated HPLC/MS/MS-assay with limits of quantification of 0.1 μg/L (BAY 38–7268) and 0.5 μg/L (BAY 44–5576), respectively (Table 3).
Abbreviations: ETDRS, Early Treatment of Diabetic Retinopathy Study; ERG, electroretinogram; ECG, electrocardiogram.
Monitoring of safety and tolerability of treatment included subjective parameters like well-being and AEs communicated by the subjects and classified by investigators according to their severity and if AEs were non-serious or serious. Objective parameters were monitored by measurement of heart rate, blood pressure and recording of standard electrocardiogram (ECG). Moreover, blood samples were examined in regard to possible alterations of hematological and clinical chemistry parameters.
Each of the two treatment periods consisted of one profile day and at 24-hours follow-up examination. Subjects were discharged from the study ward about 1–2 hours after the last examination on days 0 and 1, provided there were no medical objections. There was a wash-out phase of at least one week between each of the two periods. For each subject the study ended with the final examination approximately 1–2 weeks after the second study period. The total duration of the study was four months.
Eye-specific inclusion/exclusion criteria were examined for both eyes. However, only one eye was included for study use. The study was conducted in accordance with the Declaration of Helsinki (1964) in the revised version of 1996 (Somerset West) and 2000 (Edinburgh), the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) GCP Guideline (Note for Guidance on Good Clinical Practice) and the German drug law [Arzneimittelgesetz]. The study protocol was approved by the Ethics Committee of the Medical Faculty, University of Cologne. Subjects must have given their written informed consent to participate in the study after receiving adequate previous information.
As test drug vardenafil (free base of BAY 38–9456) was administered orally at dosage of two tablets of 20 mg or corresponding placebo. Medication was given once on day 0 (0d 00) of each study period (Table 2) and in accordance with the randomization list.
In order to detect potential ophthalmological changes, BAY 38–9456 (vardenafil hydrochloride) 40 mg was chosen, which was double the expected highest prescribed future dose. A 40 mg dose had previously been found safe in a number of Phase I studies. The amount of dose in the tablet refers to the free base BAY 38–7268 (vardenafil).
Scotopic and photopic ERG measurements were performed according to International Society for Clinical Electrophysiology of Vision (ISCEV) standards.17 ERGs were recorded by Amplaid MK15 evoked potential system (Amplaid USA Inc., Rolling Meadows, IL, USA) connected to corneal jet electrodes. Following dark adaptation of 30 minutes ERGs were recorded according to single flash stimulation with constant luminance stimulus (cds/m2) of 2.4 cds/m2 (no background illumination) and 5.0 cds/m2 (additional background illumination of 20 cd/m2).
Concentration measurements of BAY 38–7268 and BAY 44–5576 in plasma indicated subject compliance. Moreover, urine probes were taken at baseline to detect possible drug abuse (opiates, amphetamines, barbiturates, cannabis, benzodiazepines, cocaine-metabolites) which would have led to exclusion of the subject.
The statistical evaluation was performed using SAS software package (version 6; SAS Institute Inc., Cary, NC, USA). All data were listed and trial summary tables were provided. Exploratory statistical tests were performed to compare the visual function tests following BAY 38–9456 and placebo, respectively. Quantitative target variables were subjected to an analysis of covariance (ANCOVA) with the factors: treatment, period, subject, sequence, time, and the interactions period*time, treatment*time and the baseline value as a covariate.
BAY 38–9456 40 mg (vardenafil hydrochloride) was generally well tolerated. Adverse events were more common in subjects receiving active BAY 38–9456 (vardenafil hydrochloride) when compared to those receiving placebo. The most frequently reported adverse event in each treatment group was “headache”. The intensity of all adverse events was reported as “mild” or “moderate” and the relationship to study drug was “possible” in all cases. All adverse events had resolved by the end of the study while there was no evidence for a serious adverse event at any time (Table 4).
Abbreviation: COSTART, coding symbols for a thesaurus of adverse reaction terms.
The color discrimination error score of the Farnsworth–Munsell test was the primary variable for the assessment of the visual function. The most pronounced differences between the two treatment groups were observed for total error score 1 and 6 hours after drug administration, and for error score lines 3, and 4 one hour after drug administration, indicating an impairment of color discrimination particularly in representing color vision of blue/green and purple. Minor differences were still present after 6 hours affecting error score lines 1, 3, and 4. There were no differences after 24 hours between active and placebo (Tables 5 and 6).
Abbreviations: ANCOVA, analysis of covariance; LS-mean, least squared mean.
In comparison to screening ERG with b-wave amplitude of 225±91 μV (2.4 cds/m2), in ERG after 1 hour 20 minutes with active treatment b-wave amplitude was reduced by 15% compared to a reduction of 10% observed with placebo. While there was no relevant difference in b-wave amplitude between the treatment groups after 6 hours 20 minutes, there were again differences between active and placebo after 24 hours (Table 7a).
Notes: Amplitudes of b-wave show significant reductions even after 24 hours in treatment arm while a-waves remain unaffected.
Compared to a baseline value of 92±41 μV (5 cds/m2), b-wave amplitude was reduced by 27% after 1 hour 20 minutes with active treatment while placebo group showed a reduction of 12%. A less prominent amplitude reduction was still present after 6 hours 20 minutes with active treatment. At 24 hours, the amplitude had nearly returned to baseline values; however, there was still a difference between active and placebo after 24 hours (Table 7b).
The ANCOVA for the observations of a-wave and b-wave revealed a significant influence of the factor treatment on the amplitude of the a-wave, 2.4 cds/m2 (P=0.0152), as well as on the amplitude of the b-wave, 2.4 cds/m2 (P=0.0302) and 5 cds/m2 (P=0.0028). Moreover, a significant influence of time on the amplitude of the b-wave, 2.4 cds/m2 (P=0.0170) and 5 cds/m2 (P=0.0020), was observed. The b-wave amplitude increased with time after administration of active treatment or placebo.
There were no relevant differences between active and placebo in regard to ERG latency for neither a-wave nor b-wave at any time up to 24 hours after drug administration.
Other ophthalmological examinations like visual acuity, refraction, intraocular pressure, Humphrey 30-2 visual field test, Amsler grid field test, slit-lamp, and funduscopy did not reveal any significant differences between the two treatment groups (Supplementary materials).
Many investigations have been performed on ocular side effects of PDE-5 inhibitors, especially for the use of its best-known representative sildenafil citrate.18–22 In regard to visual function, visual acuity, visual fields, and contrast sensitivity remained unaffected while a temporary impairment of color discrimination represents a definitive effect.
Moreover, ERG measurements showed reductions of the b-wave amplitude with no relevant effects on a-wave amplitude which predominantly recovered after 24 hours. There were no relevant differences between active and placebo in regard to ERG latency at any time up to 24 hours following drug administration. Studies on retinal function after sildenafil administration show a complete recovery of all ERG parameters within 24 hours.9,13 However, as we found a mild reduction of the b-wave amplitude even 24 hours after ingestion of vardenafil our study design could not deliver data on detecting a more precise point in time for complete recovery.
In conclusion, BAY 38–9456 40 mg (vardenafil hydrochloride) was generally well tolerated. As expected, adverse events were more common in subjects receiving active BAY 38–9456 (vardenafil hydrochloride) compared to those receiving placebo. Our study shows comparable results to studies on sildenafil and confirms a good tolerability of vardenafil in regard to ocular side effects.
Moreland RB, Goldstein I, Traish A. Sildenafil, a novel inhibitor of phosphodiesterase type 5 in human corpus cavernosum smooth muscle cells. Life Sci. 1998;62(20):PL309–PL318.
Boolell M, Allen MJ, Ballard SA, et al. Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. Int J Impot Res. 1996;8(2):47–52.
Ballard SA, Gingell CJ, Tang K, Turner LA, Price ME, Naylor AM. Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. J Urol. 1998;159(6):2164–2171.
Porst H, Rosen R, Padma-Nathan H, et al. The efficacy and tolerability of vardenafil, a new, oral, selective phosphodiesterase type 5 inhibitor, in patients with erectile dysfunction: the first at-home clinical trial. Int J Impot Res. 2001;13(4):192–199.
Stark S, Sachse R, Liedl T, et al. Vardenafil increases penile rigidity and tumescence in men with erectile dysfunction after a single oral dose. Eur Urol. 2001;40(2):181–190.
Klotz T, Sachse R, Heidrich A, et al. Vardenafil increases penile rigidity and tumescence in erectile dysfunction patients: a RigiScan and pharmacokinetic study. World J Urol. 2001;19(1):32–39.
Hellstrom WJ, Gittelman M, Karlin G, et al. Vardenafil for treatment of men with erectile dysfunction: efficacy and safety in a randomized, double-blind, placebo-controlled trial. J Androl. 2002;23(6):763–771.
Keating GM, Scott LJ. Vardenafil: a review of its use in erectile dysfunction. Drugs. 2003;63(23):2673–2703.
Vobig MA, Klotz T, Staak M, Bartz-Schmidt KU, Engelmann U, Walter P. Retinal side-effects of sildenafil. Lancet. 1999;353(9150):375.
Zrenner E. No cause for alarm over retinal side-effects of sildenafil. Lancet. 1999;353(9150):340–341.
Luu JK, Chappelow AV, Mcculley TJ, Marmor MF. Acute effects of sildenafil on the electroretinogram and multifocal electroretinogram. Am J Ophthalmol. 2001;132(3):388–394.
Gabrieli CB, Regine F, Vingolo EM, Rispoli E, Fabbri A, Isidori A. Subjective visual halos after sildenafil (Viagra) administration: Electroretinographic evaluation. Ophthalmology. 2001;108(5):877–881.
Laties A, Zrenner E, Viagra ZE. Viagra (sildenafil citrate) and ophthalmology. Prog Retin Eye Res. 2002;21(5):485–506.
Jägle H, Jägle C, Sérey L, et al. Visual short-term effects of Viagra: double-blind study in healthy young subjects. Am J Ophthalmol. 2004;137(5):842–849.
Beavo JA. Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiol Rev. 1995;75(4):725–748.
Kinnear PR. Proposals for scoring and assessing the 100-hue test. Vision Res. 1970;10(5):423–433.
Brigell M, Bach M, Barber C, Kawasaki K, Kooijman A. Guidelines for calibration of stimulus and recording parameters used in clinical electrophysiology of vision. Calibration Standard Committee of the International Society for Clinical Electrophysiology of Vision (ISCEV). Doc Ophthalmol. 1998;95(1):1–14.
Laties AM, Fraunfelder FT. Ocular safety of Viagra, (sildenafil citrate). Trans Am Ophthalmol Soc. 1999;97:115–125.
Yajima T, Yajima Y, Koppiker N, Grunwald JE, Laties AM. No clinically important effects on intraocular pressure after short-term administration of sildenafil citrate (Viagra). Am J Ophthalmol. 2000;129(5):675–676.
Sponsel WE, Paris G, Sandoval SS, et al. Sildenafil and ocular perfusion. N Engl J Med. 2000;342(22):1680.
Birch DG, Toler SM, Swanson WH, Fish GE, Laties AM. A double-blind placebo-controlled evaluation of the acute effects of sildenafil citrate (Viagra) on visual function in subjects with early-stage age-related macular degeneration. Am J Ophthalmol. 2002;133(5):665–672.
Grunwald JE, Metelitsina T, Grunwald L. Effect of sildenafil citrate (Viagra) on retinal blood vessel diameter. Am J Ophthalmol. 2002;133(6):809–812.
Grunwald JE, Jacob SS, Siu K, Piltz J, Dupont J. Acute effects of sldenafil ctrate (Viagra) on intraocular pressure in open-angle glaucoma. Am J Ophthalmol. 2001;132(6):872–874.
Nivison-Smith L, Zhu Y, Whatham A, et al. Sildenafil alters retinal function in mouse carriers of retinitis pigmentosa. Exp Eye Res. 2014;128:43–56.
Behn D, Potter MJ. Sildenafil-mediated reduction in retinal function in heterozygous mice lacking the gamma-subunit of phosphodiesterase. Invest Ophthalmol Vis Sci. 2001;42(2):523–527.

industry_corpus2: Biopharmaceuticals


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Playground.ph PB400 Powerbank 4400mAh Raffle & Review!
The box contains 1 powerbank, 1 USB cable, 1 User Manual and 1 Playground.ph warranty card.
itself is hidden in the rubber wire on the top side of it.
LED light charging indicator (shown in the red circle).
During the test for two weeks, the powerbank gave the output performance it promises to give. I'm quite a heavy phone user and I charge 1 - 2 times a day as I play music, play some vids, check emails, check social networks apps and turn on the WiFi most of the time. It was able to charge my Nexus 5 up to 2 times throughout the day (well my phone a bit power hungry as it is about 2300mAh in battery size, different phones will have other power capacities that this powerbank can charge up to different times [in some lower capacity phones it may be upto 3 - 4 times] ). The charging output is real good, it's like just using any charger that will charge your phone in the expected time you needed it to, not like other powerbanks that has slow charging speeds.
The Playground.ph PB400 Powerbank 4400mAh is very affordable, good quality build and easy to carry power-station for your gadgets. It let you play much more with your devices without ever needing to find an outlet and save you from much hassle. I think almost anyone with their devices can afford this powerbank as the price tag is only at Php690 each, which makes it a great contender in the powerbank market right now.
Join in the raffle below!
Contestants must be residing in the Philippines.
Only one account per person in any social media (e.g. 1 FB, 1 Twitter, 1 Instagram) is allowed to enter as entry per contestant. No dummy or secondary accounts, any violation to this will lead to automatic disqualification.
Contestants should use their real names (no anonymous names) for verification and security purposes.
The winner should claim the prize within two weeks after the announcement, otherwise, it's forfeited.

industry_corpus2: Computing & Telecommunications


text:
Continuation of clinical internship practice. This course focuses on advanced principles and techniques utilized for specific cancer treatments. Students will demonstrate competence in the deliver and simulation of specific radiation therapy techniques and medical dosimetry. Requires 101 hours/quarter unit and 2 hours of classroom meeting/week.
Demonstrate clinical competence in advanced radiation therapy simulations.
Demonstrate advanced radiation therapy skills in participating fully as a team member.
Demonstrate competence in advanced treatment planning procedures.

industry_corpus2: Health & Medicine


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"Most cancers are caused by random mistakes in the genetic code when cells divide out of the blue, new research shows," the Daily Mail reports.
But this is an oversimplification of research that looked at the role spontaneous random mutations play in the development of certain cancers.
It's well known that environmental and hereditary factors are the cause of many cancers.
This study looked at the influence of a third factor: random genetic mutations that occur by chance as the body's cells repeatedly divide.
Researchers analysed cancer registry data from 69 countries worldwide to estimate the proportion of cancers that could be down to chance. They estimated just over a third of cancers worldwide could be down to chance mutations.
Looking at data for 32 cancers in the Cancer Research UK (CRUK) database, this proportion leapt to two-thirds for reasons that are currently unclear.
But the research has two key limitations, both of which the researchers openly acknowledge. First, these figures are only estimates and may not be accurate.
And second, it would be a mistake to think cancers can only have one cause. A combination of all three factors - environmental, hereditary and luck - could all contribute towards a specific cancer risk.
Making sure you eat healthily, not smoking, exercising regularly, maintaining a healthy weight, moderating how much alcohol you drink, and avoiding too much sun are likely to improve your odds.
The study was carried out by three researchers from the Johns Hopkins University School of Medicine, the Johns Hopkins Bloomberg School of Public Health, and the Johns Hopkins Kimmel Cancer Center in the US.
Funding was provided by the John Templeton Foundation, the Virginia and D. K. Ludwig Fund for Cancer Research, the Lustgarten Foundation for Pancreatic Cancer Research, and the Sol Goldman Center for Pancreatic Cancer Research.
The lead author of the study has worked, or is currently working with, a number of biotech firms with a commercial interest in cancer genetics.
The study was published in the peer-reviewed journal Science on an open access basis, so you can read it online for free.
Both the Mail Online and The Sun failed to make it clear that there's no single risk factor for cancer.
A combination of family history, environmental factors, and just pure bad luck can all contribute towards your risk of developing a certain type of cancer.
This analysis of cancer registry data aimed to look at the relationship between how many divisions stem cells (early-stage cells that can develop into many different types of cell) make and rates of cancer globally.
It's understood cancer is the result of the gradual build-up of gene mutations, resulting in greater numbers of abnormal cells. But the cause of these mutations is often uncertain.
It's thought some could be down to hereditary (genetic) factors and some are environmental, but the researchers explored a third factor: random chance mistakes made during normal DNA replication.
As cells divide, it's always possible that a mistake occurs when the "genetic alphabet" contained inside each cell is copied.
Previous studies suggested the chance of mistakes could come down to the repeated division of stem cells.
The researchers considered that, unlike cancers caused by hereditary or environmental factors, those caused by mistakes in stem cell division should be evenly distributed across human populations.
The researchers analysed 423 cancer registries in 69 countries available through the International Agency for Research on Cancer (IARC). This is said to give coverage of two-thirds of the global population, or 4.8 billion people.
The researchers looked at 17 different types of cancer that have stem cell data recorded in the IARC.
They analysed the relationship between the number of stem cell divisions made in a particular tissue and lifetime risk of cancer in that tissue.
They then estimated what fraction of cancers could be down to hereditary, environmental, and chance division factors.
In all the countries' data the researchers looked at, they found a significant relationship between the number of stem cell divisions in a tissue and cancer rates.
The median correlation figure from birth to age 85+ was 0.80 (95% confidence interval [CI]: 0.67 to 0.84), which indicates a very strong relationship between the two (a figure of 1.0 would be an exact correlation).
The links were generally consistent across countries, though higher in European, North American and Oceania countries (correlation 0.81 to 0.83) than Asian, African and Latin American countries (0.72 to 0.73). The bigger age range covered also gave a stronger correlation.
The researchers estimated that if environmental influences could be theoretically reduced to zero, around 35% (95% CI: 30 to 40%) of the mutations behind cancer would still be down to chance.
They then looked at 32 specific types of cancer reported in the CRUK database and estimated, overall, 29% of cancer mutations were down to environmental exposures, 5% to genetics, and 66% down to chance.
However, the proportions varied considerably by type of cancer. CRUK estimated 42% of these cancers could be preventable.
The researchers say their findings are consistent with previous observational studies, which have indicated the proportion of cancers that may be down to environmental factors.
They say the results "accentuate the importance of early detection and intervention to reduce deaths from the many cancers arising from unavoidable [chance] mutations."
This analysis of global cancer registry data proposes simple chance as the third possible factor behind cancer-causing gene mutations, alongside well-established genetic and environmental factors.
The possibility that random gene mutations can occur when the body's cells repeatedly divide is obviously highly plausible and not really that revolutionary a theory.
However, these researchers have tried to quantify exactly what proportion of cancers could be down to chance. This brings us to the greatest limitation of this research: these are only estimates.
As the researchers themselves point out: "The actual contribution of [chance] mutations to any particular cancer type cannot be reliably estimated from such correlations."
The researchers estimated random chance could be behind just over a third of cancers worldwide. It's not immediately apparent why on the CRUK database this proportion suddenly leaps to two-thirds.
But we don't know that these figures are accurate, and they won't necessarily apply to any individual cancers.
The fact chance may be involved also doesn't take away the importance of modifiable risk factors in cancer development.
Though the CRUK database indicated two-thirds of 32 cancers could be down to chance, CRUK still estimate 42% of these cases could be prevented.
As the study's authors pointed out: "Primary prevention is the best way to reduce cancer deaths. Recognition of a third contributor to cancer - chance mutations - does not diminish the importance of primary prevention."
Making sure you eat healthily, not smoking, exercising regularly, maintaining a healthy weight, moderating how much alcohol you drink, and avoiding too much sun may not be able to completely remove your cancer risk, but does offer the best chance of leading a healthy lifestyle.
"Most cancers are caused by random mistakes in the genetic code when cells divide out of the blue, new research shows," the Daily Mail reports. But this is an oversimplification of research that.


text:
Full version available as INRIA Research Report RR-2986.
This report deals with the formal specification and verification of distributed leader election algorithms for a set of machines connected by a unidirectional ring network. Starting from an algorithm proposed by Le Lann in 1977, and its variant proposed by Chang and Roberts in 1979, we study the robustness of this class of algorithms in presence of unreliable communication medium and/or unreliable machines. We suggest various improvements of these algorithms in order to obtain a fully fault-tolerant protocol. These algorithms are formally described using the ISO specification language LOTOS and verified (for a fixed number of machines) using the CADP (CAESAR/ALDEBARAN) toolbox. Model-checking and bisimulation techniques allow the verification of these non-trivial algorithms to be carried out automatically.

industry_corpus2: Artificial Intelligence


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According to Bungie, Destiny 2's new endgame activity, Lost Forges, won't be as long as a raid.
Bungie has revealed the many quests and loot Guardians will be able to find during the Season of the Forge.
More information about Destiny 2's upcoming seasons and DLC have been revealed.

industry_corpus2: Gaming


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Out Of The Box Technology creates solutions so you can manage your franchise more efficiently. We also develop, train and support franchisees on standardized accounting processes. From simple data entry to full reconciliation and everywhere in between, we will meet the needs of you and your franchisees. Whether you want individual training or our team to do the work for you, we will deliver!
We can recommend the software that will solve your needs and integrate it properly with your data and workflows. If the software doesn't exist, we'll create it for you!
From simple data entry to full reconciliation and everywhere in between, we will meet the needs of you and your franchisees. Whether you want individual training or our team to do the work for you, we will deliver!
We can integrate your website with QuickBooks Software and platform integration solutions to manage your franchise efficiently.
When you order QuickBooks through Out Of The Box Technology, you can get a discount and save up to 20%!
We can help you maximize your profits and achieve long-term success through bookkeeping services and financial services.
We can help with any QuickBooks related problem, including consultation, set up and training.
Provide a Hosted Desktop Environment for QuickBooks and your Integrated Applications.
Recurring Invoicing, Payments, and Collections for QuickBooks Desktop and QuickBooks Online. Recur360 allows you to choose the credit card processor of your choice while still posting all Invoices and Received Payments into QuickBooks as if they had been created there originally.
A Conference App and Event Registration system for Franchisors for their Annual Conferences or for Event Planning Services. OurEventApp is completely customizable so you can import your brand, features, and needs.
"We originally trained our franchisees how to use QuickBooks and found they did not have the time and we did not receive the financial statements. We finally added a requirement in our Franchise Agreement to use Out Of The Box Technology to provide full bookkeeping service to all new franchisees for 1 year. Now the Franchisee and Franchise Business Consultant receive the accurate monthly financials by the 15th of each month. If we could do it all over again, we would have hired Out Of The Box Technology from the beginning."
We focus on the technology so you can focus on growing your franchise. With top certifications in every Intuit platform (Enterprise, Pro, Premier, Online, Point of Sale), we can deliver a solution that's right for your business.

industry_corpus2: Technology & Research


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Bill C-45 has been the most talked about legislation of 2017. As Canadians prepare for the end of prohibition, politicians scramble to create the structure needed. After ridiculous plant height regulations that were repealed, followed by announcements of edibles, it seems like the Liberal’s are getting it figured out. While cannabis pardons going unaddressed, it’s hard to say what else will be done with with past cannabis convictions. There are a few parliamentary paragons that deserve to be recognized for their voice within cannabis. Leader of the Green Party of Canada Elizabeth May proved to be one of these paragons.
May was one of the few MPs to submit amendments to Bill C-45, demonstrating a true desire to put people first.
“We must ensure that Bill C-45 will not further stigmatize vulnerable populations and that those with criminal records due to cannabis prohibition are pardoned. Cannabis must be fully legalized, and the tax rate must keep costs in line with current dispensary sales if the government wants to get rid of the illicit drug market.” - Elizabeth May, Leader of the Green Party of Canada.
We applaud May's effort to reduce the ridiculous amount spent on cannabis enforcement and heartache of those previously convicted. She submitted a total of 18 amendments to Bill C-45, which went through clause-by-clause consideration at the Standing Committee on Health. What makes these amendments unique is the clear understanding of constituents, unlike so many of the proposals that came from the Liberal government.
The most noticeable amendments were not new ones, but ones which aimed to remove additional criminalization. One major amendment was aimed to remove aspects of the bill that criminalized youth. This effort to reduce the stigma attached with cannabis consumption and protect youth is one that should not be overlooked. It is well known that involvement in the justice system as a youth is associated with repeat offending. By not labelling youth consumers as criminals in the first place, they are less likely to offend in the future.
Decriminalizing youth cannabis youth will also save enforcement costs, and be used to educate at risk youth. This kind of social policy surrounding cannabis is exactly what the community was looking for upon legalization. Along with protecting youth, May also proposed to reduce overly high criminal sanctions and remove provisions that would allow the government to reject anyone with a criminal record from obtaining a permit to grow. Every provision was essentially addressing the hypocrisy of prohibition in the first place.
The tragic part about all these amendments? Not a single one was adopted.

industry_corpus2: Law & Justice


text:
Your suitable date is 9,18,27 and days are Tuesday,Friday. Colour is Red and Ratna is Moonga.
The south facing shop is suitable for you. you should try to sit east direction for success in business.
Articles which are red in colour you should begin the business.
In your shop/mall you should sit in south west corner facing east.
For improve your business you should pray/worship God Hanuman and a kuber yantra keep in your cash box.
In general we can't tell you anything. Detailed study to be made. Accordingly the decision to be made.

industry_corpus2: Others


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Do you know about trampoline workouts? If no, then we are sure that you have missed one of the best health devices. Trampoline workouts are common in many parts of the world. The workouts performed using trampoline is also referred as rebounding. The trampoline can also be used as a recreational activity.
A research by NASA has found that the trampoline exercise offers 70 percent fitness when compared to jogging for the same time. The trampoline workout has many benefits like burning calories, improving heart and lung fitness etc. There are many types of trampoline workouts in the world, some of the best trampoline workouts are listed below.
The best and the simple workout is the straight jump.
Stand straight in the trampoline.
Keep the arms raised above the head.
Jump up in the straight position.
Repeat this for about 30 seconds. Then minimize the speed and relax. The higher you jump, the higher will be the number of calories burned. This is because of the anti-gravity action offered by the trampoline.
The vertical elevation dance is also an easy workout.
Add simple dance steps like turning your arms, hips etc.
This method has, jump up and down along with the dance moves; which offers the user to burn more amount of calories. The calories will burn in accordance with movement.
The seat drop is a common exercise especially done in the trampoline.
Lift the limb in a seating position in the midway.
Land back with the legs.
This will constitute the seat jump. The seat jump will be useful to burn the calories along the ribs, limbs and offer complete fitness.
This is also an important exercise that can be used to combine the activities of both jogging and trampling. It is well suited for the daily joggers.
Increase the height of the warm up jump.
After you reach a perfect height, land with the other foot.
Repeat this with alternate foot.
By doing this, you can combine both jogging and jumping. It will help to maintain the health of the body and also helps the limb muscles to work well.
This is the best trampoline workout that is used to increase the heart function. This exercise can be performed easily.
Stand on the trampoline with feet 6 – 8 inches apart.
Start jumping on the trampoline, with your arms on your hip.
In the midway raise one limp to the hip level.
Do this alternatively with both left and right limb.
Repeat this for about 60 times. This will help to increase the blood flowing capacity in the body.
The core rotation is an important exercise that will help you to support your hips.
Keep your limbs and hips wide apart and the arms held near the chest.
While jumping rotate the body below the arms.
Keep focusing on rotating your toes for stability. Perform this daily for about 30 seconds for better results.
So purchase the best trampoline and perform these workouts and safeguard your health. If you have any queries with this, comment us in the box.

industry_corpus2: Sports


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Renovated! Custom Home on .43 Acre: NEW Kitchen, 3/4 Bedrooms, 3 Full Baths, Central Air, Ducting, FHA heating system, Plumbing, Hot water heater, Electrical 150 AMP, Direct generator hook-up. High ceilings, New Roof, Windows, & Siding. All Bedrooms have Walk-In Closets. NEW hardwood floors & carpeting. Newly painted interior, crown molding, new interior & exterior doors, recess lighting, designer kitchen cabinets w/ soft close drawers & granite counter tops with large breakfast bar, S/S appliances, Open concept living space. Bathrooms have upscale tile and fixtures. Laundry on 1st Floor. A partial basement for extra storage. Patio & large flat yard. Parking 3+ Vehicles Brand New Septic. A Short distance to Lake Lliff. Lake privileges available - Optional..This property is not a DRIVE-BY, IT IS TOTALLY MOVE-IN ready!
his Equestrain property features a 4BR 2.5 bath Center Hall Colonial on 4+ acres! 6 stall horse barn w/ tack room and fenced in pasture/paddocks. Two story entry foyer, Formal DR, LR w/ fireplace, cozy family room and kitchen w/ breakfast bar & nook! Kitchen features stainless steel appliances, granite countertops, recessed lighting and sliders to the pool area. All Lg bedrooms on second floor with laundry room. MBR suite w/ walk in closet and full bathroom w/ soaking tub and stall shower. Outdoors features a Lg lemonade porch, heated in ground pool and paver patio in addition to the pastures, barn and riding arena. Three car detached garage w/ loft storage. Country living at it's finest yet close to route 23 & 287. Bring the horses and lifestock and enjoy tranquility on this farm!
MLS: 3390216 | CITY: Jefferson Twp.
One Marina 2 waterfront locations on Lk Hopatcong. 2 residences, plus 1 commercial bldg. 74 wet slips 80+ dry dock, 100+ indoor racks, new boat sales, #1 restorer and retailer of antique wood boats, Located on NJ's largest lake only 45 min from NYC excellent business opportunity w/ 2 locations on the water, one in Lake Hopatcong (Morris Cty) in Great Cove, with a total of 1.34 acres are 3 buildings totaling 15,500sq ft with a showroom, service bays, and 2 bdrm 1 bath residence and one in Hopatcong (Sussex Cty) in Henderson Cove, on 3+ waterfront acres sit 4 buildings approx. 14,100sq ft consisting of showroom/office, work/wood shops, storage warehouse and a 4 bdrm col with 2 car garage. Both have hoist systems and ramps. Wood boat location has sterile finish room. Current 75 wet slips w/room for expansion.
Stunning 3story colonial w 3rd flr office, updated kitchen, HW flrs. French doors to large LR w crown moldings & wood burning FP. Large Formal DR & Attached Fam Room. Updated EIK w/ Granite counters, 6 burner Stove, warmer, island & copper sink. Large 1/2 Bath off Kitchen, 4 BRs on 2nd Flr, 3 w/Ceiling Fans, Full Bath. 5th BR on 3rd floor. Full Basement, Partially Finished w/ Full bath, storage room, Dry Bar, Rec Room, Workshop, Newer Furnace. Timberline Roof less than 10 yrs. 1 yr old cooling system. Newly built 1 car Garage. Near all Major Highways, Shopping Malls, Bustling Downtown Area, & Public Transportation to NYC. A must see!
CHARMING 3 BEDROOM CAPE COD HOME IN THE VILLAGE OF GOSHEN!
GREAT CONDO IN DESIRABLE EDISON AREA!
reat property w/ 2 bedrooms, 2.5baths, EIK, spacious living area & more! Large Bedrooms and baths, with a lot of closet space. PowderRoom on the 1st floor. The living room has sliding doors to the deck, living/dining combo. Property has carpet and laminate flooring, and bathrooms with ceramic tiles. Siding is 2 years old (John Hardey Cement Siding), the roof is Owen Corning 100% (50-year warranty with ridge vents/attic fan).Ample basement with laundry facilities and tons of possibilities. Excellent location w/ close proximity to major highways, shopping, Metuchen train station & Roosevelt Park. Great opportunity!
Perfect Starter Home describes this adorable Ranch Style home! Remodeled in 2007 & 2018. Kitchen with Cherry Cabinets, Granite Counters, Stainless Steel Appliances, and so much more! Full bath with ceramic tile. Wood Floors throughout. Walk-in closet. Entire home interior just painted. Crown Molding in Living Room. Hot water baseboard heat. Above ground oil tank. A 1 car detached garage. A Brand new roof!
Elegant brick front Toll Brothers award winning model - 5 bedrooms with sweeping two story foyer; spacious & sunny gourmet kitchen with upgraded cabinetry; dynamite sunroom with walls of windows; huge family room; a convenient first floor office; expansive master suite with sitting room and sumptuous master bath with whirlpool; a princess suite with full bath plus 2 additional bedrooms with a Jack & Jill bath - - - A fabulous home on a gorgeous lot in a sensational neighborhood! Backyard was further cleared by the current owner to further enhance the beauty of this large flat level lot.
New construction 3 br, 3 full ba, kitchen features granite counters, ss appliances, center island, living room with free standing fireplace, hardwood floors on main and upper level, efficient gas heat & central air, finished walkout basement, wrap around deck, with fantastic lake views. enjoy swimming, boating, fishing and dining minutes away at nj largest lake and morris county largest park.

industry_corpus2: Real Estate & Construction


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SXSW accepts registrations and hotel reservations between August 2019 and March 2020. When hotels go on sale, all SXSW hotel blocks are made available to registrants at our low conference rates.
Attendees who purchased SXSW 2020 limited badge presale registrations will be sent registration confirmations in late July, with more information about when and how to book their hotel reservations.
Be sure to join our mailing list and follow us on Twitter for the most up-to-date information about booking your hotel for SXSW 2020.

industry_corpus2: Film & Entertainment


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The Pastry Room with OGURA COFFEE Has Been Offering Exclusive Freshly Baked and Roasted Goods.
Copyright © 2015 The Pastry Room with OGURA COFFEE. All rights reserved.

industry_corpus2: Hospitality & Catering


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The Nobel Prize in Economic Sciences is a dubious thing at best.
First, it's not a "real" Nobel Prize in the sense the Nobel Foundation neither chooses nor pays the recipient(s). Technically, it's the "Bank of Sweden Prize in Economic Sciences in Memory of Alfred Nobel." The award itself is of checkered provenance, created by Swedish central bankers hoping to bolster the scientific image of economics. It's chosen by committee members who purposely apply the same principles used to determine winners in medicine, physics, and chemistry, thereby hoping the public won't much notice its lack of connection to the late Alfred Nobel (or his surviving family, one of whom blasted the prize as a PR effort designed to improve the bad reputation of economists).
More importantly, though, the "Nobel Prize confers on an individual an authority which in economics no man ought to possess," as none other than Friedrich Hayek exclaimed in his own remarkable acceptance speech upon receiving the award in 1974.
In Hayek's view, the Prize threatened to create an aura of hard science certainty around the decidedly social science of economics. This veneer, he worried, would influence both government officials and the public to view economic theory more like laws of physics or properties of molecules.
This was dangerous, in the view of a man who had seen Europe and Russia collapse under "scientific" socialism and written extensively about political economy in The Road to Serfdom and The Constitution of Liberty. He understood the deadly combination of hubris and certainty, and hoped to impress upon the audience that economics remained a discipline that studied humans, with all their irrationalities and frailties. In this sense he demonstrated the degree of respect he still had for the praxeological foundation of his then recently-departed old mentor Ludwig von Mises.
The Nobel award comes as a surprise on two counts. Not only because all the previous Nobel Prizes in economics have gone to left-liberals and opponents of the free market, but also because they have gone uniformly to economists who have transformed the discipline into a supposed "science" filled with mathematical jargon and unrealistic "models" which are then used to criticize the free-enterprise system and to attempt to plan the economy by the central government.
F.A. Hayek is not only the leading free-market economist; he has also led the way in attacking the mathematical models and the planning pretensions of the would-be "scientists," and in integrating economics into a wider libertarian social philosophy. Both concepts have so far been anathema to the Nobel establishment.
The political prescription that flows from the Hayekian theory is, of course, the diametric opposite of the Keynesian: stop the artificial inflationary boom, and allow the recession to proceed as fast as possible with its work of readjustment. Postponement and government attempts to stop or interfere with the recession process will only drag out and intensify the agony and lead to our current and probably future turmoil of inflation combined with lengthy recession and depression. The Mises-Hayek analysis is not only the only cogent theory of the business cycle; it is the only comprehensive free-market answer to the Keynesian morass of government planning and "fine tuning" that we are suffering from today.
But F.A. Hayek did not stop with this monumental contribution to economics. In the 1940s he widened his approach to the entire area of political economy. In his best-selling Road to Serfdom (1944) he challenged the prosocialist and pro-Communist intellectual climate of the day, showing how socialist planning must inevitably lead to totalitarianism, and demonstrating examples in the way in which the socialistic Weimar Republic paved the way for Hitler. He also showed how the "worst always get to the top" in a statist society.

industry_corpus2: Finance & Economics


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Best Haircut I ever had!
Amazing! Best hair cut I have ever had! Listens to what I want!
Crystal is a master of hair - Truly Gifted! After every appointment I always leave feeling AMAZING!!!
Crystal is the Real Deal!
Tried and true! I have never been more happy with a stylist! Crystal is the real deal!


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The Space Rift universe has been expanded with another game! The spin-off Space Rift Rogue A.I. is being released for the Samsung Gear VR in the Oculus Store, today. The arcade-heavy VR space adventure mesmerizes with a thrilling story of an out-of-control artificial intelligence.
The thrilling story is driven by the dialogue that takes place between an A.I. and its supervisor. The A.I. operates an automated transported, but spirals out of control after a large amount of quantum rift is salvaged. The supervisor then decides to shoot down the ship. The player has to defeat the attacking drones while evading asteroids, all the while trying to find out where the A.I. is headed and why.
Space Rift Rogue A.I. - Power-ups!
The credits generated through mining and shooting down enemies can be used in between levels to improve the ship's stats. This includes, for example, the damage dealt by the primary and secondary weapons, shield strength and regeneration, as well as movement speed. Additionally, useful power-ups will keep appearing in the game, like a temporary shield or high score multipliers. There's also a special power-up that destroys all opponents in the vicinity. During the run, the players collect points towards their high score. Depending on the selected level of difficulty (easy, medium or hard), they'll get more points for each successful action.
Space Rift Rogue A.I. is available in the Oculus Store for 4.99 USD/EUR.
The Space Rift universe is expanded by another gripping gameplay experience with Space Rift Rogue A.I. to date, the VR space adventure Space Rift - Episode 1 has also been released. It is available for PC and all major VR headsets at a price of 19.99 USD/EUR (14.99 GBP) both on Steam and in the Humble Store. The PlayStation VR version is available for 19.99 USD/EUR (15.99 GBP).


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Quality lenses from top brands at unbeatable prices.
A diverse selection of quality frames at great value.
A variety of quality sunglasses at unbeatable prices.
A collection of fashionable styles at great prices.
Pick your perfect pair from our on-trend collection.


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We give an algorithm and source code for a cryptoasset statistical arbitrage alpha based on a mean-reversion effect driven by the leading momentum factor in cryptoasset returns discussed in https://ssrn.com/abstract=3245641. Using empirical data, we identify the cross-section of cryptoassets for which this altcoin-Bitcoin arbitrage alpha is significant and discuss it in the context of liquidity considerations as well as its implications for cryptoasset trading.
Alessandretti, L., ElBahrawy, A., Aiello, L.M. and Baronchelli, A. (2018) Machine Learning the Cryptocurrency Market. Working Paper. Available online: https://arxiv.org/pdf/1805.08550.pdf.
Amjad, M.J. and Shah, D. (2017) Trading Bitcoin and Online Time Series Prediction. Working Paper. Available online: http://proceedings.mlr.press/v55/amjad16.pdf.
Baek, C. and Elbeck, M. (2014) Bitcoins as an Investment or Speculative Vehicle? A First Look. Applied Economics Letters 22(1): 30-34.
Bariviera, A.F., Basgall, M.J., Hasperué, W. and Naiouf, M. (2017) Some stylized facts of the Bitcoin market. Physica A: Statistical Mechanics and its Applications 484: 82-90.
Bouoiyour, J., Selmi, R., Tiwari, A.K. and Olayeni, O.R. (2016) What drives Bitcoin price? Economics Bulletin 36(2): 843-850.
Bouri, E., Molnár, P., Azzi, G., Roubaud, D. and Hagfors, L.I. (2017) On the hedge and safe haven properties of Bitcoin: Is it really more than a diversifier? Finance Research Letters 20: 192-198.
Brandvold, M., Molnár, P., Vagstad, K. and Valstad, O.C.A. (2015) Price discovery on Bitcoin exchanges. Journal of International Financial Markets, Institutions and Money 36: 18-35.
Briere, M., Oosterlinck, K. and Szafarz, A. (2015) Virtual currency, tangible return: Portfolio diversification with bitcoin. Journal of Asset Management 16(6): 365-373.
Cheah, E.T. and Fry, J. (2015) Speculative Bubbles in Bitcoin markets? An Empirical Investigation into the Fundamental Value of Bitcoin. Economics Letters 130: 32-36.
Cheung, A., Roca, E. and Su, J.-J. (2015) Crypto-currency Bubbles: an Application of the Phillips-Shi-Yu (2013) Methodology on Mt. Gox Bitcoin Prices. Applied Economics 47(23): 2348-2358.
Ciaian, P., Rajcaniova, M. and Kancs, D. (2015) The economics of BitCoin price formation. Applied Economics 48(19): 1799-1815.
Colianni, S., Rosales, S. and Signorotti, M. (2015) Algorithmic Trading of Cryptocurrency Based on Twitter Sentiment Analysis. Working Paper. Available online: http://cs229.stanford.edu/proj2015/029_report.pdf.
Donier, J. and Bouchaud, J.-P. (2015) Why Do Markets Crash? Bitcoin Data Offers Unprecedented Insights. PLoS ONE 10(10): e0139356.
Dyhrberg, A.H. (2015) Bitcoin, gold and the dollar – a GARCH volatility analysis. Finance Research Letters 16: 85-92.
Eisl, A., Gasser, S. and Weinmayer, K. (2015) Caveat Emptor: Does Bitcoin Improve Portfolio Diversification? Working Paper. Available online: https://ssrn.com/abstract=2408997.
ElBahrawy, A., Alessandretti, L., Kandler, A., Pastor-Satorras, R. and Baronchelli, A. (2017) Evolutionary dynamics of the cryptocurrency market. Royal Society Open Science 4(11): 170623.
Gajardo, G., Kristjanpoller, W.D. and Minutolo, M. (2018) Does Bitcoin exhibit the same asymmetric multifractal cross-correlations with crude oil, gold and DJIA as the Euro, Great British Pound and Yen? Chaos, Solitons & Fractals 109: 195-205.
Garcia, D. and Schweitzer, F. (2015) Social signals and algorithmic trading of Bitcoin. Royal Society Open Science 2(9): 150288.
Georgoula, I., Pournarakis, D., Bilanakos, C., Sotiropoulos, D. and Giaglis, G.M. (2015) Using Time-Series and Sentiment Analysis to Detect the Determinants of Bitcoin Prices. Working Paper. Available online: https://ssrn.com/abstract=2607167.
Hale, G., Krishnamurthy, A., Kudlyak, M. and Shultz, P. (2018) How Futures Trading Changed Bitcoin Prices. Federal Reserve Bank of San Francisco, Economic Letter, No. 2018-12. Available online: https://www.frbsf.org/economic-research/files/el2018-12.pdf.
Harvey, C.R. (2016) Cryptofinance. Working Paper. Available online: https://ssrn.com/abstract=2438299.
Jiang, Z. and Liang, J. (2017) Cryptocurrency Portfolio Management with Deep Reinforcement Learning. Working Paper. Available online: https://arxiv.org/pdf/1612.01277.pdf.
Kakushadze, Z. (2015) 4-Factor Model for Overnight Returns. Wilmott Magazine 2015(79): 56-62. Available online: https://ssrn.com/abstract=2511874.
Kakushadze, Z. (2018) Cryptoasset Factor Models. Algorithmic Finance (forthcoming). Available online: https://ssrn.com/abstract=3245641.
Kelleher, K. (2018) Bitcoin Futures Killed the Bitcoin Rally (and Will Keep It from Returning), Economists Say. Fortune (July 2, 2018). Available online: http://fortune.com/2018/07/02/bitcoin-futures-killed-bitcoin-rally-will-keep-coming-back-economists/.
Kim, Y.B., Kim, J.G., Kim, W., Im, J.H., Kim, T.H., Kang, S.J. and Kim, C.H. (2016) Predicting Fluctuations in Cryptocurrency Transactions Based on User Comments and Replies. PLoS ONE 11(8): e0161197.
Kristoufek, L. (2015) What Are the Main Drivers of the Bitcoin Price? Evidence from Wavelet Coherence Analysis. PLoS ONE 10(4): e0123923.
Lee, D.K.C., Guo, L. and Wang, Y. (2018) Cryptocurrency: A New Investment Opportunity? Journal of Alternative Investments 20(3): 16-40.
Li, T.R., Chamrajnagar, A.S., Fong, X.R., Rizik, N.R. and Fu, F. (2018) Sentiment-Based Prediction of Alternative Cryptocurrency Price Fluctuations Using Gradient Boosting Tree Model. Working Paper. Available online: https://arxiv.org/pdf/1805.00558.pdf.
Liew, J.K.-S. and Hewlett, L. (2018) The Case for Bitcoin for Institutional Investors: Bubble Investing or Fundamentally Sound? Working Paper. Available online: https://ssrn.com/abstract=3082808.
Liew, J.K.-S., Li, R.Z. and Budavári, T. (2018) Crypto-Currency Investing Examined. Working Paper. Available online: https://ssrn.com/abstract=3157926.
Nakano, M., Takahashi, A. and Takahashi, S. (2018) Bitcoin Technical Trading With Artificial Neural Network. Working Paper. Available online: https://ssrn.com/abstract=3128726.
Ortisi, M. (2016) Bitcoin Market Volatility Analysis Using Grand Canonical Minority Game. Ledger 1: 111-118.
Shah, D. and Zhang, K. (2014) Bayesian regression and Bitcoin. Working Paper. Available online: https://arxiv.org/pdf/1410.1231.pdf.
Sharpe, W.F. (1994) The Sharpe Ratio. Journal of Portfolio Management 21(1): 49-58.
Van Alstyne, M. (2014) Why Bitcoin has value. Communications of the ACM 57(5): 30-32.
Vo, A. and Yost-Bremm, C. (2018) A High-Frequency Algorithmic Trading Strategy for Cryptocurrency. Journal of Computer Information Systems (forthcoming). DOI: https://doi.org/10.1080/08874417.2018.1552090.


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These filters fit our 4 qt. strainers. Box contains 200 disks. Discount for 3 or more boxes.
Fresh milk should always be strained through a new filter disk before cooling. Never reuse filters. High-quality non-gauze filter disks allow faster milk flow, remove more fine sediment, and give more uniform filtering than gauze-faced disks. These filters fit our 4 qt. strainers. Actually "in-line" filters for a pipeline setup, they're slightly thicker than other filters; they work well. Box contains 200 disks. Discount for 3 or more boxes.

industry_corpus2: Agriculture & Fisheries


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You may notice that our edit of this film is even more cinematic than usual. All the different aspects of this wedding allowed us to put together something really stunning and dramatic, which we love getting to do once in a while. Filming alongside Jeremy from Studio This Is Photography gave us plenty of opportunities to create editorial-style shots like the ones that we use to open the film.
The wedding lasted several days and guests were treated to one luxurious event after another. The team at Events by Nisar orchestrated everything beautifully and the use of color and light in the event design was gorgeous and exciting to film.
Our whole team loved getting to be a part of this celebration. Chicago is our city, but we love the chance to occasionally travel for events farther from home!


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We have the kadachakka tree in our house and we make different dishes with this.This kadachakka is round in shape and not big like jack fruit. Next time when I go to Kerala or Mumbai take a snap and add to my recipe.When it is cooked very soft and tender. I searched in Google and got the English name for kadachakka is breadfruit.We can make kadachakka thovaran, koottu, eriseri and use even in sambar and thenga aracha kozhambu.My favorites are Kadachakka koottu and eriseri.
Remove the skin and middle part of the kadachakka and cut into small pieces.
Cook with water salt and turmeric powder.
Grind the coconut with chili and cumin seeds.
When the kadachakka is cooked, add the ground coconut and dhal. Mix well.
Heat a pan with oil, add mustard seeds, urad dhal, curry leaves and two tsp coconut.
When the mustard crackles, add to the koottu.
This is very tasty kadachakka koottu.
Soak the dhal for two hours.
Grind with chili, asafoetida and salt coarsely.
Heat a pan with oil add mustard seeds and urad dhal.
When the mustard crackles add the ground dhal.
Mix well continuously till the water evaporates.
Wash the gawar(Clustered beans) into small pieces.
Boil water, cook the beans with turmeric and salt.
Drain all the water and keep.
Add this beans to the dhal and mix.
It goes with sambar./ rasam rice.
For this potato fry I use all small potatoes.Very tasty and it is a side dish for sambar /rasam rice.
Boil the water with potatoes for 15 minutes.
Peel the skin and keep.
When the mustard seeds splutter add potatoes, salt,turmeric powder, chili powder, asafoetida and curry leaves.
Fry for five minutes and the tasty potato fry is ready .
Transfer the dish into a serving bowl.
This curry I learn t from my mother in law. It is very easy to prepare.
Wash and remove of the skin and cut into small cube.
In this recipe I used frozen chenai or Yam.
Boil water and add chana dhal, chenai pieces and turmeric powder.
When the chenai is cooked add salt,the coconut, chili and ginger.
Mix well add curry leaves and lemon juice.
lemon juice, salt and pepper and olive oil.


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Materials: 6 aluminum round parts screwed together. Taupe (purple/brownish) painted on the inside. Black aluminium tube on top. Bakelite socket.
Period: 1960s – Mid-Century Modern – Scandinavian Modern.
Designers: Sigurd Lindkvist alias Carl Thore (1916-1999).
Manufacturer: Granhaga Metallindustri AB, Töreboda, Sweden.
Other versions: Made in many versions.
Carl Thore was born in 1916 in Amal (Sweden’s Dalsland). After working for a lighting firm called Luko, in 1961 he joined Granhaga Metallindustri, for whom he designed lights and was also head of sales, and where he remained working until his retirement around 1981. The real name of the designer known as Carl Thore was Sigurd Lindkvist. He passed away in 1999.
Lindkvist adopted the pseudonym Carl Thore for his Granhaga light designs on the spur of the moment when he was presenting the lights to a client who asked the identity of the designer. “Carl Thore,” Lindkvist blurted out, these being his two middle names. After that Granhaga lights were embellished with a small label on which the words “Design Carl Thore” were printed in a handwritten-style font.
Granhaga Metallindustri AB was founded after World War II in 1947 and was managed by Sven Persson. The company was located in Töreboda, Sweden, a locality with some 4700 inhabitants (2017). Töreboda is the hometown of the famous punkband Asta Kask.
Granhaga Metallindustri merged in 1979 with Hermanders Metallindustri AB and renamed in Nordsales Granhaga AB.
Folke Hermansson and Hugo Andersson started Hermanders Metallindustri AB in 1951.
Nordsales Granhaga AB filed bankruptcy in 1989.
In 1989 Hermanders AB was purchased by Töreboda Skrotaffär. Hermanders AB filed for bankruptcy in 1991. Nya Hermanders AB starts with new owners Jan Engström and Göran Johansson. In the next years the company expanded to what it is today.

industry_corpus2: Manufacturing


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Is dental anxiety holding you back from scheduling an appointment at the dentist? While many times fear of the dentist can be justified, not receiving the proper professional dental care can harm your oral health long-term. We can help you conquer your dental anxiety with our calming sedation dentistry options! Sedation dentistry is a safe and relaxing solution for our fearful patients, and allows us to provide the care you need while you remain calm and oblivious to the sights, sounds, and smells of the dental office. We are certified in IV sedation and also offer oral sedation in addition to local anesthesia. We are trained to administer sedation safely and effectively for adolescent and adult patients. Have you been putting off your visit? Our skilled team is here to keep your smile in great health by providing sedation dentistry to help you feel relaxed during your appointment!
To ensure that our patients experience the most relaxed and painless care, we give you the option to receive IV sedation dentistry. Unlike other sedation options, IV sedation can be administered at a higher level, helping patients with severe dental anxiety relax comfortably during their procedure. We are able to adjust the dosage and strength, which lets us provide more predictable and customized level of sedation right from the beginning and throughout your whole treatment. IV sedation will not “wear off” at any point during your procedure and will only be halted once treatment is complete. For many of our fearful patients, IV sedation dentistry gives them then confidence they need to attend their dental appointments in the future!
Local anesthesia is used to numb the area in need of treatment, and is often combined with stronger forms of sedation for virtually painless dental care.
Oral sedation is taken in pill form before the appointment, leaving patients with mild-to-moderate dental anxiety in a calmed state throughout treatment.
IV sedation is administered through the veins, putting patients with severe dental anxiety or in need of extensive treatment into a conscious “sleep” state.
Overcoming dental anxiety with the help of sedation dentistry has profound psychological and health effects on our patients. Without a fear of the dentist, many patients feel empowered in their experiences with us, and are capable of maintaining routine appointments and undergoing treatment that was out of the question before. Similarly, the care they receive from us benefits their oral health, improves the function of their teeth, and restores aesthetics to their smile! We never want dental anxiety to be the reason you do not receive necessary dental care. If you are fearful of the dentist, turn to us!
ready to conquer your fears?


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Is it fair to say that Riccardo Tisci has revolutionised the Burberry brand? We certainly think so!
Riccardo Tisci is a renowned Italian designer who decided to move on from Givenchy in order to become the creative director of Burberry. In fact, he was the protagonist of the London Spring/Summer 2019 Fashion Week.
Tisci chose to pay tribute to the Burberry of the past by creating a collection which incorporates the beige colour – the Burberry colour of excellence – but he made a lot of changes too.
He decided to invest in the trench coat, this item of clothing became the emblem of womanhood.
Even if he decided to use the typical colour of the brand, he shocked the fashion week audience with a throwback to the past – the dark shades. He took a chance on 90s nostalgia by using the typical colour used in this decade.
It’s not all about the beige and black, the animalier style is back and for Tisci this pattern is going to stay for a bit. Burberry has shown even the basics essentials during this fashion week too. In fact, there were a lot of black dresses that were included in the catwalk.
The catwalk was graced by the most famous models of the moment, such as Kendall Jenner, Cat McNeil, Riley Montana and Mariacarla Boscono who has painted her hair for the occasion.
I am Jessica Maglione, a twenty-two years old girl from a small town near Florence (Italy).
I graduated at tourism high school, so I have knowledge of English, French, Spanish and economics. I did a few English courses in England during summer. I am a passionate about music, books and art. I am studying at the University of Pisa communication because I am interested in culture and music. My big dream is to work in the music industry and writing for www.conversationabouther.net is a great first step to be a part of this industry.


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Back in the Spring this year we teamed up with some of the East Midland’s finest Wedding suppliers to produce a beautiful Springtime styled Tipi Wedding shoot. During the ideas stage for the photo shoot, it was really important for us to use local, East Midland based suppliers who we knew would deliver a fabulous end result in their respective field …..and deliver they certainly did!
The shoot took place at The Izaak Walton Hotel, in the heart of the picturesque Peak District which was the perfect setting for the Tipis and provided the perfect playground and setting for the shoot itself. The shots took place predominantly in and around the Tipis, capturing the styling, beautiful blooms, cake and eclectic mix of perfect props, but we also ventured to the iconic stepping stones in the Peak District’s Dovedale valley to capture the models against some scenic, landscape backdrops.
We took inspiration from the beautiful surroundings of Thorpe Cloud and Dove Dale, along with the natural, rustic presence of the Tipis to create a relaxed, whimsical and fun theme. The rationale behind the shoot (conceptually developed by the National award winning Wedding stylist, Mad Philomena) involved tapping into the emerging trend for paint splashes and abstract art and combining this with the concept of re-cycling – re purposing of everyday items to give them a newfound use and beauty.
The palette was fun, springtime, candy sweet, to contrast with the upcycled elements, whilst also keeping a romantic, feminine theme. An outdoor, summer feeling is delivered through both colour and the use of icons such as bicycles and kites. Neon signage was also incorporated as a vibrant ‘statement’.
The beautiful shots were captured by the delightful duo, Hannah and Toby of Red on Blonde Photography, who’s creative, fun and artistic style was exactly what we were looking for. We also captured the essence of the shoot in motion on video by the fabulously talented Adam Galwas, which gave the shoot an entire different and unique dimension.
Our Bride and Groom were styled with both hair and makeup by Claire Lowe Hair and Makeup with a view to represent a relaxed style with a slight nod towards Boho-chic. Our bride wore a pre-loved, true vintage wedding dress from Abigails vintage bridal , high street pretty pastel jewellery along with custom, bespoke footwear by MadP.
Fabric Theatre created a show-stopping, vibrant peak filled with ribbons to make a real focal point above the dance floor and lead into the glittering disco ball.
A colourful and welcoming entrance way was created with lashings of beautiful bunting from Tickety Boo Bunting.
A stunning collection of pretty pastel and gorgeous textured floral’s were lovingly set by Nadia Di Tullio within upcycled giant tin can centerpieces, as well as signature single stems in an eclectic collection of mini glass bottles.
A vibrant array of cake and treats were baked and displayed by Yummy Little Cakes, including the show-stopping piñata rainbow sprinkle cake.
Like the look and vibe of our atmospheric Tipis and are planning your own special day or event? Well why not get in touch and let us help create a memorable and unique day that you and your guests will never forget. Drop us a email on info@peaktipis.mmandb-staging.co.uk, or call us on 0344 411 3460 and let’s talk Tipis!

industry_corpus2: Travel & Geography


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How do I deal with dark circles?
Many people visit the clinic for treatment of dark circles. Before we can embark on how you can deal with dark circles, lets spend some time figuring out what causes the dark circles.
Anemia, thyroid disorders, ageing, UV induced damage, raised blood insulin levels, diabetes, excessive use of skin cosmetics may all contribute to darkness around the eyes. Many people are also genetically prone to develop dark circles around the eyes.
A very common cause for dark circles (particularly in Indians) is a tear trough. This is like a guttering under the skin of the eyes. People usually complain of puffy eyes and dark circles. Under the skin, there are pockets of fat. With age, these pockets sometimes melt away. The protuberance of the cheeks is reduced and a hollow appears below the eyes. This makes one look tired and like they haven’t slept well whereas they may be very well rested.
Should I get some tests done for the dark circles?
We often recommend a full blood count along with iron studies to rule out anemia. We also suggest checking your thyroid functions and a fasting glucose test. The fasting glucose is generally recommended if one is over 40 years and has not had a test in the past 6 months. Some other skin signs like skin tags or darkening of the underarms or side of the necks also suggest that one is at a slightly higher risk of developing diabetes and we recommend a fasting blood glucose test in these circumstances.
What Can I do at home to manage the Dark circles?
We would advise you to use a sunscreen regularly. You need a sunscreen with spf 30 or more and PA++ or more. Apply the sunscreen 15 minutes before you step out of the house. Re-apply the sunscreen once every 2 hours when you are outdoors. I would also recommend that you use goggles with UV protective filters for added protection.
At night, you can use some skin lightening creams along with some anti-ageing creams around the eyes. These will help slow down further deterioration and may also help improve the tone and texture of the skin. A dermatologist will be able to help you with a prescription of the appropriate creams.
If you have an underlying medical issue like anemia, thyroid imbalance or high glucose levels, you must get them treated.
Chemical peels may help in treating dark circles. Repeat treatments are required every 3-4 weeks to maintain the improvement.
Hyaluronic acid fillers may be very useful in treating tear troughs. In India, the majority of dark circles and tired looking eyes tend to be due to tear trough due to ageing of the skin. This problem can be easily corrected using some hyaluronic acid fillers.


text: There is a widespread concern today about the “radicalization” of young Muslim men, and the deprived areas of Western cities are believed to have become breeding grounds of home-grown extremism. But how do young Muslims growing up in the cities of the West really live? Fabien Truong uncovers a network of competing loyalties and maps the road these youths take to resolve the conflicts they face: becoming Muslim. For these young men, Islam stands, often alone, as a resource, a gateway – as if it were the last route to “escape” without betrayal and to “fight” in a meaningful and noble way. During the lecture, Fabien Truong will talk about his book.

industry_corpus2: Subject Education


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Volunteering – could your spare time help animals in need?
Without the help of volunteers, we wouldn’t be able to do half of what we do here at Leicester Animal Aid. However much time you have to spare, and whatever your interests are, there’s a way you could get involved and help.
Volunteering is also a great way to try new activities, meet new people and to gain experience in new roles.
For some volunteer roles we have a limited number of positions available at any one time, so if the role you are interested in is currently filled we can keep your details on file.
You will need to be aged 18 or over to volunteer at LAA, due to insurance reasons.
Gardening - we are very lucky to have lots of green space and planting on site but keeping everything tidy can be a challenge! If you are green fingered and like working outdoors, we would love to hear from you. No vacancies currently available.
Dog Walking – dog walkers typically arrive on site around 8.30am and help staff to walk the 40+ dogs we have on You will need to be able to commit to attending on a regular day(s) as we need to be able to make sure all dogs get out for a good walk every morning. Our Kennel Manager will provide an induction to how we do things at LAA to keep everyone safe, and you will probably be ‘buddied up’ with a more experienced dog walker for your first few visits. Vacancies available on Monday, Wednesday and Saturday mornings. Please complete the volunteer application form to apply.
Pet Sitting - volunteers spend quiet quality time with dogs and cats to help build their confidence. You need to be able to commit to attending on a regular day(s). For dogs pet sitting takes place between 12:30pm and 2:30pm and for cats from 11:00am to 2:30pm. Vacancies available for dogs on a Saturday afternoon.
Cattery Cleaning– cattery cleaning volunteers usually arrive from 8am and are allocated to a section of the Cattery to clean down and make ready for the cats. Hygiene and infection control are especially important in the cattery environment as cat flu and other viruses can easily be transmitted if due care is not taken. You will need to be able to commit to attending on a regular day(s) as we rely heavily on volunteers to support our staff in keeping the Cattery clean and safe for our residents. Vacancies available on Monday, Thursday and Friday mornings. Please complete the volunteer application form to apply.
Cat Grooming & Socialisation– grooming is an important bonding activity we do with all cats in the Cattery. Some cats may become withdrawn in the cattery environment or they may have been stray for a long time and need a bit more coaxing to interact with people again. Some 1 to 1 time with a volunteer can help the cats start to enjoy socialisation Ideally, volunteers would need to be confident with cats and to give a regular commitment of time. Grooming and socialisation typically happens between 11am and 2pm, once the cattery has been cleaned. Sorry - no vacancies for volunteers currently - please check back soon!
Dog fostering - some of our dogs find living in rescue difficult or may need extra attention if they are very young, very old, have long-term health problems or perhaps need a little more help with socialising or learning how to be a dog from a more experienced, confident friend. We are always looking for people that are able to commit to fostering dogs who need that little bit extra. If you are interested, please complete the volunteering form.
Charity Shop Volunteers– our onsite Charity Shop is open 7 days a week between 10am and 2.30pm and is manned by volunteers. You would need to be numerate and enjoy speaking with the customers. Sorry - no vacancies for charity shop volunteers currently - please check back soon!
Donated Goods Sorter –sorting the donated goods takes place on Tuesday and Wednesday mornings at the Centre. The sorters empty the donated goods sheds, decide on the best place to sell an item for maximum profit (we use eBay and auctions for some items for example) and price them for sale. Sorry - no vacancies for donated goods sorters currently - please check back soon!
Coffee Shop & Mini Market volunteers– our Coffee Shop opens on the first Saturday of each month and is run by volunteers who prepare the food and drinks for customers. Six times a year we hold a Mini Market which is a large outdoor sale of donated goods. Goods are divided into sections around site and volunteers man the sections and are responsible for taking the sales of donated goods. Both Coffee Shop and Mini Market are usually very well attended so you would need to be used to working cleanly in a kitchen and not be phased by being busy! Sorry - no vacancies for coffee shop & mini market volunteers currently - please check back soon!
Event Support - to help support the wide range of events hosted by the Charity, full training provided. No regular commitment required. Please complete the volunteer form.
Local Food Collector -LAA is very lucky to be supported by many local supermarkets and businesses who have food collection points to help to provide food and toys for the dogs and cats at the Centre. We rely entirely on volunteers to help pick up and deliver this the Centre. Regular commitment is required and food bins are usually emptied weekly, although some are shared between a number of volunteers. Sorry, no vacancies at the moment.
As part of Corporate Social Responsibility Strategies, many companies are now offering their employees the opportunity to spend one or two working days per year helping at a charity.
Corporate Volunteers (Practical Projects)– Team volunteering days typically involve the renovation of an onsite area, making use of your team’s skills set whether that is painting, gardening or something more technical such as refitting a kitchen or storage space. Due to incredible support this year, we are unable to cater for any further Corporate Volunteering Days this year. Please do get in touch regarding 2019 opportunities.
Skills Sharing– we are a small team and always appreciate support from businesses who are happy and able to share some of their skills, knowledge, expertise and time with us to help support the Charity's work. This could be in areas such as marketing, retail or online. If you think you can help, please do get in touch.
Please email Izzy Tutcher, our Fundraising Manager at izzy.tutcher@leicesteranimalaid.org.uk or call 01455 888257.


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Age 86, passed away on Friday, March 30, 2018, in Caro, Michigan. In accordance with Alice’s wishes, cremation has taken place. A Celebration of her Life will be held on April 15, 2018, at the Bavarian Inn Lodge and Conference Center in the River Room from noon until 4:00 pm.
Alice was born on September 2, 1931, in Fairgrove, Michigan, to Mr. and Mrs. Richardson and Mary (Hickey) Gage. She went on to marry the love her life Rudolph “Rudy” Kosik; sadly he preceded her death in 2012. In her free time, she enjoyed baking, painting, sewing, puzzles, going dancing and swimming. She was a very caring person who loved spending time with her family.
Alice is survived by her 3 children: Dan and wife, Harumi Kosik, Cindy and husband, Micheal Enos, and Dale and wife, Jodi Kosik; 8 grandchildren; 14 great-grandchildren; sister, Betty and many other family members and friends.
Alice was preceded in death by her parents, loving husband, Rudy, son, Glen, brother, Junior, and sisters, Phyllis and Jean.


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You can sign-up for the UPLIFT TV by visiting the site and submitting your email in the form provided. Once you have signed up you will receive a regular emails highlighting all the latest releases on UPLIFT TV.
UPLIFT takes your privacy seriously, and as such will never sell your details or use them other than for the purposes outlined above. You can unsubscribe at any time by tapping the "Unsubscribe" link at the bottom of every email.

industry_corpus2: Media & Journalism


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Ray Jones, a retired Baltimore City police officer, joined the Sykesville Police Department last week. His appointment brings the town force to seven officers.
"He comes to us very qualified for the job," said Matthew H. Candland, town manager.
A 20-year veteran of police work, Mr. Jones, 42, has a bachelor's degree in criminology from Indiana University of Pennsylvania.
He has worked as a member of the Quick Response Team and is trained in counter-sniper tactics and radar detection.
Sykesville: Sykesville and Gamber units responded to a call about a carbon monoxide leak in the 400 block of Obrecht Road at 10:58 a.m. Thursday. They were out 45 minutes.


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Ideal for serving either cake or pavlova.
A sleek serving utensil that is a must for any event where food is being served. Ideal for vegetables.
A sleek serving utensil that is a must for any event where food is being served.


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Kenneth Mahood was born in Belfast in 1930. He started painting in 1950 and had his first one-man exhibition in 1955. He is well known as a cartoonist for Punch, The New Yorker, The Times and the Financial Times. Since the late 1980s, he has concentrated on collage works which have been shown in New York and, in London, at the Royal Academy and England & Co.
Contact the gallery for full details of works currently available.


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Bike accidents are some of the worst kinds of crashes that you can be involved in, especially if you are cycling and get hit by a motor vehicle in Philadelphia. These types of accidents frequently end with serious, life-altering, or even fatal injuries for bikers in the region. The treatment for these bike injuries is often expensive enough to also put your financial well-being into doubt.
Having a personal injury attorney to help you get the compensation you need from the person who deserves to pay it for their role in causing the bike crash can be the best way to protect your future. Reach out to the lawyers at the Philadelphia law office of Gilman & Bedigian.
Chronologically, the first type of treatment that you are likely to need after a bike crash in Philadelphia is emergency care. While this type of medical attention comes in a variety of forms, all of these have one element in common: They are needed immediately, with no time to spare.
The timely need for these types of treatment, unfortunately, also makes them much more expensive than they would have been, otherwise. The high price tag that comes with emergency care can be enough to threaten your financial well-being, so pursuing compensation from the person who caused the crash – and created the need for those services – is essential.
Many of the worst bike accidents that happen in Philadelphia require invasive medical procedures like surgeries to correct the injuries and complications that result from the crash. Unfortunately, depending on the severity of the crash and your injuries, these surgeries can be very complicated or can be necessary in the immediate aftermath of the crash.
Even minor bike accidents can require surgery for an injured biker. Frequently, these surgeries are required to fix wrist, hand, or arm injuries that the cyclist sustains when he or she is thrown from their bike. The natural instinct in these circumstances is to put your hand out to brace your fall. However, the force of your fall is often enough to severely damage the muscles, tendons, and bones in your hands or wrists. This can require one or more surgeries to completely fix.
For bikers, surgeries and their attendant complexities and recovery times are even more significant than for other people because bikers are known to live an active lifestyle. When they are going through the road to recovery after a bike accident and have to undergo one or more surgical procedures to heal, being sidelined from their outdoor activities can be even more difficult to cope with.
One of the types of surgery that an injured cyclist might need after a bike crash is a plastic surgery. These are non-emergency procedures that aim to correct a superficial condition.
While plastic surgeries have a reputation as being only for the vain, this is far from the case when it comes to bike accident victims. The injuries that you commonly suffer in a bike accident – like road rash – often come with long-lasting disfigurements that can serve as a continual reminder of the horrors of the crash. This can weigh heavily on your mind as you try to overcome the memory of the accident, causing significant amounts of emotional distress. Getting plastic surgery done to remove some of the outward signs of the accident can be a huge part of your recovery process.
Similarly, seeing a therapist can also help you deal with the memory or the pain and the terror of the bike accident you have been put through. Many bikers report seeing their life flash before their eyes in the instant before getting hit by a car in Philadelphia. Seeing a psychotherapist can help you deal with the emotional trauma that comes with such an experience and overcome the hardship.
Therapy is not just for the mind, though. Your body can also use occupational and physical therapy to overcome the difficulties you will face on your road to recovery from a severe bike accident in Philadelphia.
Occupational therapy is often reserved for victims of the most severe bike crashes in the region, as it is used to help accident victims recover basic motor skills and mobility in their injured extremities. Typically necessary to overcome head, neck, or spinal injuries after a bike crash that cause nerve damage or severe muscular problems, occupational therapy focuses on rebuilding the basic levels of dexterity that you need to perform the basic tasks necessary to live a normal life, like cleaning yourself, cooking, and tying your shoes.
Physical therapy, on the other hand, helps all kinds of bike accident victims rebuild their strength and mobility back to their normal levels. Often a part of the recovery process after a surgical procedure, physical therapy focuses on getting the strength and mobility of any affected body parts back to where they were, before the crash. For bikers who live an athletic lifestyle, physical therapy can be one of the most important aspects of the recovery process.
Each and every one of these types of treatment can be expensive. None of them would have been necessary, though, were it not for the negligence or poor conduct of the person who ultimately caused your bike accident. Having them pay for the costs of your treatment and recovery, therefore, would only be fair.
That is where the personal injury attorneys at Gilman & Bedigian can help. By representing your interests in and out of the courtroom, we can fight for the compensation you deserve. Contact our Philadelphia law office online.


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Total abdominal colectomy is the removal of the entire colon. This may be necessary due to ulcerative colitis, Crohn's colitis or familial polyposis. In many patients, this procedure can be performed using laparoscopic technology.
The laparoscope is a fiberoptic telescope that is connected to a high-resolution video camera. Four or five small incisions (1/4 inch to 1/2 inch) are made in the abdominal wall, one of which is usually just below the umbilicus (belly button). The images from the laparoscope are projected onto a television monitor to be viewed by the surgeon in the operating room. Small specialized surgical instruments are inserted into the abdomen to perform the surgery. The abdomen is inflated with carbon dioxide gas in order to allow your surgeon to see the abdominal structures. The gas is removed from the abdomen before you wake from anesthesia (you will be asleep for the entire procedure).
What is the Postoperative Course Following Laparoscopic Total Colectomy?
After a two-hour stay in the recovery room, the patient is transferred to a surgical floor. Most patients are out of bed the evening of surgery. Injectable pain medication is given the first night and oral pain medication the day after. A tube in the nose (nasogastric tube) is not required. Clear fluids are given the day after surgery, and solid food when the patient passes gas. Discharge from the hospital is usually 4 or 5 days following surgery, and return to normal activities is around two weeks after the operation.
What are the Benefits of Laparoscopic Total Colectomy?
Four or five small incisions, avoiding a large scar.
Shorter recovery time, and quicker return to daily activities.
Am I a Candidate for Laparoscopic Total Colectomy?
Many patients are candidates for this procedure, but not all. Patients should discuss this surgical option with their physician. Extensive training in laparoscopic techniques is required in order to complete this procedure laparoscopically. If performed by a qualified laparoscopic surgeon, it is as safe as traditional surgery.


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I'm not gonna lie. It's hard for me to write about it. I love me some Bloodline. Like...LOVE.
Those Rayburns just can't seem to stay out of trouble. Season 2 picks up right where Season 1 left off. I don't want to spoil anything, and if you haven't watched Season 1, GO, binge watch it NOW. It is so painful to watch the bad decision making spiral out of control for these characters. But it is SO good.
John Leguizamo is so bad...and creepy...and BRILLIANT. The dread just seeps into every episode. There are times when you just want to tap them on the shoulder and say "Stop. Just STOP."
These characters are flawed. You want to root for them...but they've done terrible things. There's no way there can EVER be a happy ending for any of them. I don't know if there's a Season 3 in the works, and I'll be sure to let you know if I hear anything. Season 2's finale...just left me staring at the screen. I. Did. Not. See. That. COMING!
Who are my Bloodline fans? Have you binged the second season? I need someone to commiserate with!


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Our family favorite campground. The only area that could use improvement is the dusty roads. The pool is very clean and well maintained. The showers and restrooms are modern and clean. This campground is highly recommended, you won't be sorry. We camped at Milton KOA in a Tent Trailer.
Our family stayed for 4 nights and thoroughly appreciated the quietness of this campground, the paved roads and extremely clean showers and restrooms. The management staff was not rude to us, not the most talkative bunch, but remained polite and professional. If we are ever back in the area we would definitely pick Stand Rock again. We camped at Stand Rock Campground in a Tent Trailer.
We decided to camp here over Memorial Day weekend 2007 and we will never return. We knew that with over 1000 sites there would be some noise, however, we never expected the volume to reach the degree that it did. We were unable to fall asleep until 3am on Friday night due to the loud radios and people partying in the area. We contacted security both Friday and Saturday night, with one person finally being arrested well after midnight by the sheriff dept. The showers are clean, but they are the push-type that turn off the second you release your hand. The one pro to the weekend was the free tram that takes you over to the boardwalk for a few hours of entertainment. We camped at Indiana Beach / Monticello KOA in a Tent Trailer.


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Even after the hardest day take the time to cleanse your face and thus create a little spiritual hygiene.
Gift collection includes 6 products for facial care.
Every evening, massage our fragrant Rosemary Butter Cleanser over your face and neck and gently remove with a warm dampened washcloth. Use our Rose Conditioning Mist to refine and hydrate your skin. For a deeper treatment, blend Calendula Face Mask with Rose Conditioning Mist and apply. Then rinse off the mask and reapply Rose Conditioning Mist. For everyday care, gently massage your skin with rejuvenating Rose Facial Serum and apply Sea Buckthorn Eye Balm in the sensitive eye area. To finish off, apply our tasty Honey Lip Balm.


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Determined loner Katri Kling lives in a tiny attic flat in a remote Nordic hamlet with Mats, her simple-minded younger brother. Mostly because of her unfriendly nature, the locals don’t want much to do with Katri but they do go to her when they have financial problems they need advice on. With her uncompromising attitude and her head for figures, Katri knows just how to advise people on getting the best deal. One day Katri makes a decision: she and Mats are going to live in “the rabbit house”, a striking property a short distance from the hamlet. There is one stumbling block, however: the house is occupied by Anna, a successful middle-aged illustrator of children’s books. Like Katri Anna is something of a loner but she is sociable when she wants or needs to be; whereas Katri is cold and hard, Anna is warm and sentimental.
Katri sets of on a path of deceit in order to get herself and Mats into the rabbit house. Once there, she finds unanswered correspondence relating to Anna’s financial affairs that show that publishers and merchandisers having been cheating Anna for a long time. Katri persuades Anna to let her take charge of her affairs and get more money for her. As the pair embark on a battle of wills – sentiment against ambition – they each learn that they other is not what they initially thought. Who is the “True Deceiver” of the book’s title?
“True Deceiver” is not, strictly speaking, a thriller but it does have a strong element of suspense and mystery. The scope of the action is limited and really very little happens but I found myself drawn in right from the beginning and I read the book (which admittedly is fairly short) in almost one sitting. I had my own thoughts about the characters and the situation and the characters’ mutual mistrust of each other only serves to increase the tension.
The real beauty of “True Deceiver” is in the sparse, economic style of writing which manages to convey a multi-layered story along with painting a vibrant portrait of each of the main characters so that within just a few pages you know the characters well and your mind is teeming with ideas as to what might happen. The writing style is cleverly (and inextricably) linked with other aspects of the novel such as the setting – not just the location but the time of year – and the whole cast of characters.
The events of the story take place in the depths of winter as the hamlet is almost entirely cut off. One villager skis to the nearest town to pick up supplies which are distributed through the village shop. There is, however, a sense that even when spring comes, this tiny collection of houses will be no less isolated. The people who live there know each other but there is no feeling of community that one might expect from a rural village. It isn’t specified where exactly the setting is, it could be any tiny place in Nordic Europe, but there is generally a strong feeling of Scandinavia arising from the simple lifestyles of the characters and the interiors of the houses, and the quiet nature of the characters. It reminded me a lot of the film “Kitchen Stories” set in 1950s rural Norway.
The fact that the story takes place in winter only reinforces the stark atmosphere that is created by the sparse style of writing and seems to add another layer of crisp white. There are few incidental details, mostly the reader only learns what is essential to the story though that is not to say that writing is not evocative; I felt completely carried away to a tiny community in a chilly Scandinavian winter. What is really very striking is that the author uses the same skill of economy to convey both a sense of almost nothing – such as the snowy landscape – and to paint colourful portraits of complex characters.
The additional characters reinforce the idea of isolation and mystery. They are all single people a fact which adds to the idea of a fragmented little society in which nobody really trusts anyone and any relationships are really just for material benefit. People are outwardly polite and co-operative but you get the feeling that they are happiest doing their own thing. Only Liljeberg the local boat-builder shows any compassion, allowing Mats to help out with odd jobs in the boatyard but the arrangement is very casual with Mats often turning up when the yard is closed and quietly getting on with jobs through the cold night.
The author of “True Deceiver” is Tove Jansson. Best known for creating the much loved characters for children, the Moomins, Jansson did not begin writing fiction for adults until she was in her sixties. If you choose to, you can find parallels between Anna and Tove, who herself sometimes found the balance between her artistic integrity and business difficult to manage. Her writing here is wonderful but we shouldn’t forget that this is a translated work. The translator, Thomas Teal, deserves special praise for his work; the words run beautifully and capture the essence of backwater Scandinavia, the frosted window panes and the cold, crisp air of wintry meadows.
“True Deceiver” is an engrossing and utterly charming read. I have not experienced such a rewarding read for some considerable time.
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industry_corpus2: Literature & Emotions


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OSWEGO, N.Y. – The State University of New York Oswego has awarded Tanner Shore of Murrieta, who is majoring in business administration, a Destination Oswego scholarship, which goes to high-achieving students from outside New York state.
linkDestination Oswego awards are worth from $20,000 to $36,000 over four years. The university honored more than 850 incoming students with merit scholarships. Outstanding first-year students are offered presidential scholarships of $20,000 or $5,000 a year for up to four years, $6,000 deans’ awards or $1,500 a year for up to four years, $3,000 merit awards or $750 a year for up to four years and, for outstanding students from outside New York state, Destination Oswego scholarships of $5,000 to $9,000 a year.
The awards are part of about $6 million in merit scholarship money offered at SUNY Oswego. These funds are in addition to approximately $90 million in need-based grants, loans, work-study and scholarship awards that SUNY Oswego students receive annually.
A 156-year-old comprehensive college in the State University of New York system, Oswego enrolls about 8,000 students in its College of Liberal Arts and Sciences; School of Business; School of Communication, Media and the Arts and School of Education.