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Recently, I had the privilege of speaking at the Bethany Presbyterian Church’s Women’s Retreat on spiritual practices, the brain, and living in the unforced rhythms of grace.
One of the main practices I encouraged was breathing deeply.
Little did I know that my own practice would get a serious testing just a few days later.
Recent advances in neuroscience and brain imaging has radically expanded our understanding of how the brain works.
God has fashioned our brain with two important systems, the one we are most familiar with, fight or flight, and the second lesser known companion, pause and plan.
We know what fight or flight feels like. Historically, the saber-toothed tiger would give chase and the much slower human would call upon an instinctive burst of energy to run like hell or stand her ground and fight.
The brain in fight or flight mode suspends all future considerations in favor of immediate escape from death. No planning is necessary unless it’s the instantaneous calculations for running to a safe tree or cave, or taking good aim on the attacker. Immediate gratification options that would dispel the threat and fear are valued, as well as risk-taking behavior that might increase chances of escape.
Fight or flight narrows the world to a pin-point of focus: survival.
The problem is that the brain cannot tell the difference between a physical life or death threat from a hungry tiger, or a metaphorical threat in a stressful work situation, family conflict, gridlock traffic, overwhelming to-do lists, or worries about finances, health, or family members.
And even more challenging: these stresses are not dependent on the hungry tiger losing the scent or getting tired of the chase. The human brain was built to jump into fight or flight mode for brief periods. Now, we are a nation constantly running or fighting.
A person under constant stress finds it incredibly difficult to plan for the future, because the brain is focused on the present perceived danger. Instant gratification–choosing anything that promises to dissipate the stress– will win out over choices toward long term goals. Willpower becomes non-existent. Risky behavior becomes the norm.
The other, lessor known system, pause and plan, is the brain’s long-range vision. It encourages and supports choices toward future goals. It says no to instant gratification and strengthens willpower.
How can we move from fight or flight into pause and plan?
It may seem simple but breathing deeply and slowly for a few minutes will shift the brain into the pause and plan system. The stressor will still be there, but the brain will be able to move from a focus on surviving a predator’s attack to figuring out longer term strategies for dealing with the situation.
A few months ago, I realized I needed to move from my lovely apartment into a less expensive living situation. Jobs are scarce these days and I decided I’d rather start living creatively now, than get into a difficult position down the road. I’ve been incredibly blessed to find a room with a family from my church.
Leaving the Contemplative Cottage (at least, this incarnation of it) has been painful. Just after the women’s retreat and a few days before a wonderful bunch of friends came to help me move, I paced my half-packed apartment fearfully and couldn’t decide what to do next. My brain had taken off-line any ability to plan or make long-range decisions, and all I wanted to do was hide under the covers. The moving tiger was in full chase.
Once I became aware of what was happening, I sat down and spent ten minutes just breathing, slowly and deeply. The shift was striking. Suddenly, I could plan again. The future didn’t seem like a black hole. My heart rate slowed. My anxiety lifted. There was still sadness that I needed to move and concern over not having a job, but it was coupled with a feeling of confidence that I could face it and whatever comes next.
I was also able to feel connected to my community and to God’s presence. In fight or flight mode, I often find the world becomes very lonely, narrow, and small. Whatever is chasing me seems bigger than God. Shifting into pause and plan opens up the world, reminds me I’m a friend, well-loved daughter, and member of the Body of Christ, and helps me trust God’s provision and redemption of my circumstances.
The next time you find yourself chased by a metaphorical tiger, stop and breathe deeply and slowly for ten minutes. At first, you will probably think it will do no good, but that is just the fight or flight system at work, negating long-term strategies. Give it time, and the tiger will slowly fade back into the jungle.
For more about the brain, willpower, and the challenges of living under constant stress, read The Willpower Instinct: How Self-Control Works, Why It Matters, and What You Can Do To Get More of It, by Kelly McGonigal.
Do not be discouraged at your faults; bear with yourself in correcting them, as you would with your neighbor. Lay aside this ardor of mind, which exhausts your body, and leads you to commit errors. Accustom yourself gradually to carry prayer into all your daily occupations. Speak, move, work, in peace, as if you were in prayer, as indeed you ought to be. Do everything without excitement, by the spirit of grace. As soon as you perceive your natural impetuosity gliding in, retire quietly within, where is the kingdom of God. Listen to the leadings of grace, then say and do nothing but what the Holy Spirit shall put in your heart. You will find that you will become more tranquil, that your words will be fewer and more effectual, and that, with less effort, you will accomplish more good.–FRANÇOIS DE LA MOTHE FÉNELON.
God has brought us into this time; He, and not ourselves or some dark demon. If we are not fit to cope with that which He has prepared for us, we should have been utterly unfit for any condition that we imagine for ourselves. In this time we are to live and wrestle, and in no other. Let us humbly, tremblingly, courageously look at it, and we shall not wish that the sun could go back its ten degrees, or that we could go back with it. If easy times are departed, it is that the difficult times may make us more in earnest; that they may teach us not to depend upon ourselves. If easy belief is impossible, it is that we may learn what belief is, and in whom it is to be placed.–F. D. MAURICE.
I won’t mince any words. The past six weeks have run the gamut from delightful to downright awful.
In early December, I woke up with heart-pounding, stomach-clenching anxiety like I haven’t had since comp exams.
And it continued. And continued. I finally called my dear friend Kimberlee and she packed me up to her house, put me on the couch, and fed me dinner. Jack and Jane drew me pictures, which I have taped above my sink. A few days before all hell broke loose, I had waxed poetic to Jack about the Book of Kells and showed him pictures of the illuminated manuscript on-line. He drew me an illuminated picture of my name. I could not see it for the tears.
Later, Kimberlee and I sat by candle-light late into the evening and talked about dreams and regrets and hopes. A healing, holy moment. For awhile the panic abated.
Yet over the next weeks, I continued to lose sleep, have migraines, and stomach aches. The fear and trembling would strike at the oddest times, then disappear.
Pit or door. Idol or icon.
Suffering can become an idol. We flee from it in terror or sacrifice to it in hopes of relief. We don’t want to ever go through it again, so we build the walls to keep it out. We move away, or hide away. We offer it tokens to buy an uneasy peace. It can become a petty god, demanding our lives in submission. Idols stop our gaze at themselves–there seems to be nothing more to life.
Or, suffering can be an icon. Never as an end in itself, never to be sought, but when experienced, walked through as a door into a wider reality, a reality where hearts of stone can break and reveal the flesh of Christ’s own love.
A heart that feels grief can also find love painfully present. When I focused on the love, the door opened wide.
I stopped at the exact spot on the carpet where, the night before, grief had filled me, a beige shag abyss of panic, and realized that I never need flee or appease the suffering again. I could simply step into it…and through. I continued to feel the panic in my very marrow and cry out of the depths with the psalmist, but I did not fear it. God could and would redeem the experience. Every experience. No matter what. And not for me alone, but for others, too. The icon beckoned me beyond.


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With the economic uncertainty looming, a lot of retail industry is forced into reducing their workforce and involved in hiring temporary staff to fill in for their seasonal spurts. The challenges are humongous and their staffing needs are complex. Providing for different industries and meeting their specific demands is what a complete and robust HCM suite must do. Having said that, the retail industry has a unique set of requirements when it comes to HR. All the way from hiring in spurts due to seasonal changes and peaks in the business to the on-boarding of different types of employees, to their extensive paper work, to extensive filing and storing of the documents, it all involves meticulous screening processes . Time is ripe for the retail industry to tackle this problem with better, more technologically advanced software, that not just meets their demands but assists them in doing everything swiftly. The time between recruiting , then training and then finally putting an employee to work is very limited when it comes to the retail sector, as they directly deal with customers.
With a booming employee turnover, the teams keep changing and to build customer loyalty begins to become more of a challenge for these businesses, that is where it is best to go an extra mile to break the habit of hiring more often and try to retain the best recruits for longer gains. A large number of employees usually comprise of young generation, still pursuing their studies, using job as their financial support mechanism, tells us just one thing, that they don’t tend to stick to their jobs for a long time, creating a constant gap in the workplace. This incessant change can be tiring and effects the customers of that particular business, as they get used to deal with familiar faces. This in-turn effects the business and to tackle this problem, better hires and a better recruitment process needs to be in place. Fortunately these days there are software around that make it easier to go through this process. Not just these software take a convenient path to hiring, they enable the managers to be able to select better candidates, using a detailed scoring ritual assisting them, to make informed decisions.
In this new age where there is a constant battle of online retailers versus brick & mortar stores, there is also an evident war between managing people the old way and adopting newer platforms to do just that. The future of the workplace looks at the modern workforce differently, demanding a system in place that can meet challenges of the modern day. Companies like “WebHR” truly believe, that a company or a business only thrives when its employees thrive and they are a fundamental part of their success. Such companies tend to look after the most important asset of any business involved, “its people” in the best way possible.
WebHR brings forth a cutting edge automation and ease of dealing with these major issues, by conducting extensive market research and formulating a solution that is no longer a “forte” for large enterprises. They present a universal solution that is expendable and adaptive to any company whether small or large, like big “retail chains”. It has successfully served in different sectors including the retail sector.They believe employee retention can remove the unnecessary costs of hiring but if it is imperative for a business to hire, then WebHR helps in reducing those costs to minimum and financially strengthen a business, making it easier for them to spend money where it is most needed.
The expenditures for retail businesses is far more than online ones and hence, the need for physical tools to help with the business should not become a cumbersome liability, so cutting down on budgets allocated for managing people should be amongst the top priority. That is where WebHR comes in, it presents an affordable and complete mechanism, that not just saves those extra expenditures but also puts management and the top executives at ease, as a culture of engaged more shining employees create a sense of well-being for the business as a whole.
Retail industry already has a lot on its plate to deal with , so when it comes to regular appraisals, it is no less than a war at hands. Cloud based applications can be a savior as they already have easier ways to approach this issue, creating a transparent tool to do that for them. A tool specifically designed to work with different levels in an hierarchy at any particular business. Its rewards and badges, make employees believe in a community system. That sense of belonging, a tribe or a clan brings about a cohesive work pattern and builds team work. Even the youngest or the newest employee instantly feels at ease, as WebHR helps them embark a socially connected network of employees with a transparent means of communication.
The retail industry understands the imminent need to replace the outdated HR systems with modern day cloud technologies like “WebHR” to better initiate a process of innovation at work. As the cloud technology helps retail industry climb the ladders towards better management, more engagement amongst employees, it also allows executives a liberty to work more on strategy and development, rather than being bothered about menial tasks.

industry_corpus2: Computing & Telecommunications


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“The Tea House" - an architectural treasure, this waterfront design features an open pavilion, guest house, greenhouse, and two-car garage, located at the end of a private drive.
The footprint offers 2,695 square feet of potential living space. The incredible design incorporates unique materials in both the structures and landscaping. And, facing west, you can be assured of spectacular sunsets.
Plus, with membership in the Highlands Association, you have access to the dock, beach, tennis court, and club house.

industry_corpus2: Real Estate & Construction


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from Real Housewives of Atlanta, her co-stars are proving that they have her back.
According to TMZ, the Real Housewives of Atlanta castmembers — except Stewart's nemesis Kenya Moore — presented a united front to the show's producers after Kandi Burruss's wedding (which was filmed for an upcoming special), saying that if Stewart is fired, they would all walk. What's more, RHOA heavyweights Phaedra Parks and NeNe Leakes are maneuvering to have Moore, who most of the cast has accused this season of stirring up drama, fired from the show instead.
Things came to a head between Stewart and Moore during the show's reunion special, during which they castmates got into a heated brawl. According to sources, executives were looking to use the debacle as an excuse to fire Stewart, but the stand-off with the rest of the cast may make that impossible.
Whoever thought we would see such a display of unity among our favorite backstabbing bunch?

industry_corpus2: Film & Entertainment


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Kemmerer is the largest city in and the county seat of Lincoln County, Wyoming, United States. The population was 2,656 at the 2010 census. As the county seat of Lincoln County, Kemmerer is the location of the Lincoln County Courthouse.HistoryExplorer John C. Frémont discovered coal in the area during his second expedition in 1843. The Union Pacific Coal Company opened the first underground mine in 1881 after construction of the Oregon Short Line Railroad from Granger to Oregon.Patrick J. Quealy (1857–1930) founded Kemmerer as an "independent town" in 1897 when he was vice-president of the Kemmerer Coal Company, located 6mi south of the original townsite. He named the company and town after his financial backer, Pennsylvania coal magnate Mahlon S. Kemmerer (1843–1925). In 1950, the operation converted to strip mining and became the world's largest open pit coal mine. In 1980 the Kemmerer Coal Co. was sold to the Pittsburg & Midway Coal Company, now a subsidiary of the Chevron Corporation. The pit remains in operation with an annual output of about 5 million tons.Quealy sold lots in the townsite rather than lease them, which permitted the establishment of independent businesses. The company's subsidiary, Frontier Supply Company, provided electricity by utilizing a used $1,150 generator acquired in Utah. Quealy immigrated from Ireland. In Wyoming, he and his wife became active in Democratic Party politics and in St. Patrick's Church, for which the company donated land.
Kemmerer is in Wyoming (WY). Take a look at our United States online road trip planner to refine the details of your trip to Kemmerer.

industry_corpus2: Mining


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98 pages with 34 colour and 32 black-and-white illustrations.
This publication acquainted the Swedish public with the Russian period of the famous artist Marc Chagall. The illustrated catalogue is accompanied by annotations and a shot chronicle og Chagall's Russian period.

industry_corpus2: Literature & Emotions


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Horizontal pneumatic press with side membrane.
High draining surface thanks to a high slots number placed along the surface.
Machine equipped with automatic axial feed valve complete with pressure switch and safety rupture disc against over-pressures.
Frame entirely made of AISI 304 stainless steel with large juice collecting pan. Frame for models TECNOVA 115 and TECNOVA 150 is entirely made of painted steel, stainless steel frame is an option.
Simple and user-friendly operator interface with “Touch-Screen” to easily access to programming pages.
The touch screen control panel is mounted on a stainless steel support which allows adjustment in inclination to give the best visibility all of the time. The panel can be easily dismantled from the press in order to protect it during periods of prolonged inactivity.

industry_corpus2: Manufacturing


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Mylan Q3 Earnings Beat (NASDAQ: MYL) - 24/7 Wall St.
When Mylan N.V. (NASDAQ: MYL) reported its most recent quarterly results after the markets closed on Monday, the company said that it had $1.25 in earnings per share (EPS) and $2.86 billion in revenue. The consensus estimates had called for $1.17 in EPS and $2.87 billion in revenue. In the third quarter of last year, it said it had EPS of $1.10 on revenue of $2.99 billion.
During the most recent quarter, the decrease in total revenues included lower net sales in the North America segment of 14%. This decrease was partially offset by increased net sales in the Rest of World segment of 4%. Net sales in the Europe segment were essentially flat. The overall decrease in total revenues was primarily driven by a decrease in net sales from existing products.
Net sales in the North America segment totaled $1.01 billion in the current quarter, a decrease of $159.9 million or 14% when compared to the prior year period.
Net sales in the Europe segment totaled $1.04 billion in the current quarter, an increase of $0.5 million, when compared to the prior year period.
Net sales in the Rest of World segment totaled $773.7 million in the current quarter, an increase of $30.4 million, or 4% when compared to the prior year period.
Looking ahead to the fourth quarter, consensus estimates call for $1.42 in EPS and $3.14 billion in revenue.
Mylan’s third quarter performance was in line with our expectations and we delivered solid year-over-year growth. Our confidence in the company’s bright future extends well beyond any single factor or particular quarter, including the current, short-term macro market turbulence our industry is experiencing. Year-to-date, we have launched nearly 475 new products across our segments, including a record number of complex generics and biosimilars for Mylan. These medicines represent many different therapeutic categories, channels and dosage forms.
Shares of Mylan closed Monday at $31.37, with a consensus analyst price target of $44.75. The stock has a 52-week trading range of $30.33 to $47.82. Following the announcement, the stock was up over 8% at $34.05 in early trading indications Tuesday.

industry_corpus2: Biopharmaceuticals


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Suitable for all hair length. This ultra hold hair spray contains an environmental friendly formula (V.O.C) ≤55% Even under humidity, it can still provide long-lasting and firm hold results.
Shake well before use. Spray directly onto the desired hair at a distance of 20cm.

industry_corpus2: Others


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A Deck Profile for the Archetype “Magical Musket”.
In depth look into the Salamangreat deck. This deck utilizes the swarming capabilities of archetype quite well.
Orcust deck with the new support. In depth guild on new cards and plays to make.
A different form of Gem-Knight “FTK”.

industry_corpus2: Gaming


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One can spend only so much time surfing in 30C+ weather ;). So while my body was recovering from too much sunshine I decided to play with Hadoop to learn first hand what it actually is.
The easiest way to start is to download a preconfigured VMware image from Cloudera. This is what I did and it worked but it did not work well. The highest resolution I could set was 1024x768. I installed the VMware client tools but they did not seem to work with the Linux distribution picked by Cloudera. I managed to figure out how to use vim to edit text files but a tiny window with flaky UI (you can see what is happening inside Hadoop using a web browser) was more that I could handle. Then I thought about getting it working on Mac OS X which is a very close cousin of Linux. The installation process is simple but the configuration process is not.
As far as I know Microsoft is going to to contribute their changes back to the Hadoop project so at some stage we might get Hadoop running natively on Windows in the same way nodejs is.


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To apply for admission to the French Academy of Arizona, begin by completing an application. For questions regarding the application process please see our Application FAQs .
You've read about our educational philosophy - come see our programs for yourself. The best way to know if FrenchAm Academy is the right fit for your child's education is to visit us.
Want to receive updates about the Academy, including notices of upcoming open enrollment? Join our Interest List.
Here are answers to some frequently asked questions about the application process and open enrollment.

industry_corpus2: Subject Education


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Whatever you’re expecting to find in Moscow, trust us: there will be a pleasant surprise or two. The intellectualism of the the University of Idaho mixes with the individualism of people from all walks of life…and it comes together in a medley of unexpected goodness.
Moscow has plenty of parks to please everyone. From hikers to bikers to canines. Whether you want a quiet sanctuary to take a break, a playground area for kids to romp, a rousing game of horseshoes, the perfect spot for a picnic with friends and family, or a safe space to let your dog run free, we've got it all!
Bring the whole family! There are plenty of activities for kids and parents to keep you active and having a great time, indoors and out. Moscow is the perfect place for family bonding and building memories.
Sure, you can expect to find major retailers and brands you love. But on top of that, you'll also find unique outlets, boutiques, and shops with plenty of local flavor. Co-ops. Vintage shops. Outdoor retailers. Arts and crafts stores. It won't take long to find that perfect keepsake.
As home to the University of Idaho Vandals, Moscow offers sporting events year-around: football, basketball, tennis, swimming, and much more. Plus with plenty of parks, fields, stadiums, and sports complexes, recreational sports are just a way of life here.
We make the great outdoors just a little bit greater. The Latah Trail offers 13 miles for biking, hiking, and sightseeing...and miles of trails connect our neighborhoods and greenways. Enjoy nearby national forests, wildlife areas, and other public lands.
Go for a scenic drive. We are surrounded by rolling green fields of the world-famous Palouse...which also make spectacular rolling green fields for golf. Make a tee time on a local course, and get into the swing of a sunny Moscow afternoon.
In most places, a farmers market fills a block or two for a few hours. In Moscow, it fills the entire downtown with music, vendors, artists, performers, and of course, farm-fresh produce. It's just one way Moscow takes an expected idea and gives it an unexpected twist.
We have performing arts theaters in historic venues. We have dozens of museums and galleries filled with original ideas. We have one of the most-beloved jazz festivals in the nation. It's part and parcel for a city that attracts people who naturally think outside the box.

industry_corpus2: Travel & Geography


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Q: The Jacob/Esau birthright deal seems to be superstitious nonsense.
God is not obligated to honor contract deals by liars and schemers. Also, I don’t believe there was a mystical birthright Isaac could give to whomever he wanted, like he could give a piece of property.
A: Well Edward, I’m a little surprised by your question because this is not superstition.
It’s there in the Bible, as you correctly noted, and Isaac had the right to give a birthright—normally it was given to the oldest son, who, in this case, would have been Esau instead of Jacob. But you know the whole story. It’s not a superstitious story, nor was this a superstitious ritual.
The firstborn was recognized as having special privileges, so when Isaac gave the birthright to Jacob, this had significance among the family and among the whole matter of inheritance issues. No, it wasn’t like a piece of property—this was a special blessing and responsibility instituted by God.
Yes, it’s true that Jacob was a schemer and yet he received the blessing. You called him a liar. I’m not sure if that’s exactly right, but at any rate, sometimes God uses crooked sticks to make straight lines.
If you look at the life of Isaac and Jacob, and even Rebecca, who was in on the scheme, you see that God is greater than the failures of human beings. He had chosen this family, and He continued to use this family for His honor and glory. And by the way, Edward, aren’t you glad He is a God of grace?
It wasn’t until my marriage failed totally that I found freedom from sexual sin.


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KIH #64 – Get real!
Real people fi. Oops. Cursed by dualistic language, once we write that, we’ve turned ourselves into despicable judgmental dunces. What does that term make the rest? Hifi for faux people? Let’s try again.
I just want to document what ‘real’ people apart from diehard audiophiles might/should do with small speakers like these Amphion Argon3s. For evidence, your prosecutor of the cause presents exhibit A. That’s my wife’s room. It’s how she has always set up her bedside system around her MacBook with external DVD drive. The usual equally white Amphion Helium 510 in residence here simply made room for their bigger brethren. An Aura Note Premier 2 from Simon Lee’s old brand April Music is her designated driver all in one box. The laptop quickly disconnects from the USB cable should she do some writing work in bed.
And yes, this puts speakers within inches from the front wall. But guess what? With the rear-aiming auxiliary bass radiators of the Finns, there’s no issue. It just increases their radiance resistance for even snappier loading and was clearly superior to the Heliums’ rear ports. Of course, that wasn’t the only thing to improve. With its larger mid/woofer and opposing radiator, Argon3s was fleshier and denser in the all-important midband. This gave voices proper chest cavity over lesser toothiness. That low-end reach would reach lower than the smaller speaker was perfectly predictable even if in this anti-bombastic context, its primary contribution was really to jack up the black levels of the tonal palette for enhanced colour saturation. Your takeaway should be that a speaker like the Argon3s is right at home in such setups. It’s not an eco-warrior tree but wall hugger. Front ports or passive radiators preferred.
… our audiophile had a road to Damascus moment. What the heck is that? A rare sighting of the only Republic of Ireland hifi brand I’m aware of. Say hello to Ardán Audio‘s unique desktop speaker stand.
“Yeah okay” you allow. “But what the funk, it sits on the bleeding floor”. Now the defense protests in combined ire. And it sure does. It mimics Pierre Sprey’s of Mapleshade Records favourite setup for Anthony Gallo’s Strada 2 of yesteryear.
Far from rug-rat audio and little green men and women—green is the national Irish colour after all and St. Patrick’s Day just happened last Sunday—it precisely aims up and toes in your tweeters to hit your ears like a contractor’s twin laser. What’s more, it deliberately exploits boundary reinforcement from the floor which is always present so might as well become useful for a change. This simultaneously minimizes the usual time-delayed but otherwise unavoidable floor bounce.
The big difference of the Irish hardware to Pierre’s Quaker-sourced solid maple affair is that simple rotator knobs quickly adjust the rake angle and rotate the assembly above the decoupled plinth. The farther you sit away, the less lean-back you need. Which begs the question: would you want to sit closer – like a lot closer?
Get ready to inspect exhibit C.
a quasi-surround very immersive sonic bubble effect like giant headphones.
Now the defense is finally speechless. Hurray.
Real if not so common sense. Such a near-field setup has a 4th benefit. It works close to a wall if the speakers comply. With their passive radiators, the Amphions do. Being time-aligned compact two-ways, there’s no widely-spaced vertical driver array to enforce greater distance before it integrates. Argon3s is a quasi-point source. All of this means that the usual transgressions against living-room integration, interior real-estate disputes and decor complaints can be easily mitigated with a Pierre Sprey layout. Now there’s fewer sore eyes to appease.
Wall art isn’t partially or wholly obscured by tower speakers (or monitors on stands). Gone is the common psych issue of big loudspeakers standing in the way of lateral phantom performers which, as our brains know, can’t occupy the same space at the same time. Remove the speakers from the visual equation and suddenly your grey matter has a lot less denial to process. With properly aligned tweeter axes, the sound will focus at or above sitting height so there are no bottle-sized performers to crawl around your carpet. If you prefer the more conventional audiophile aesthetic, get a compact speaker on stilts like this Polish Fram Midi 150. That also sports passive radiators but goes even further than the Amphion by containing its own DSP, DAC and power amp. Just add a coaxial or analog input signal.
Back to loss over distance. With bass-capable speakers listened to from 3 meters or more which are set up in audiophile-typical free space, the finest treble tends to get drowned out by big long bass waves which boom back out of the front corners’ compression zones to have your ears count them twice or thrice as late reflections.
Sitting very close invokes the proximity effect to prevent that. Plainly put, it increases resolution and linearity from fewer losses and room issues. Which means that you can listen at very low SPL to hear everything there is to hear and can open up music ops which respect for co-dwellers and neighbors would otherwise shut down.
The floor-based near-field solution really is a win/win/win all around. And because it relies on compact speakers, you needn’t pay for big cabinets and mega woofers. Small and easy does win for a change. You don’t even need that fancy Irish stand. Just tilt back your boxes with ordinary household items like doorstops or wedges. Case closed!
Srajan is the owner and publisher of 6moons. He used to play clarinet at the conservatory. Later he worked in audio retail, then marketing for three different hifi manufacturers. Writing about hifi and music came next, then launching his own mag. Today he lives with his wife Ivette and Nori and Chai the Bengal cats in a very small village on Ireland’s west coast, between the holy mountain Croagh Patrick and the Atlantic ocean of Clew Bay in County Mayo’s Westport area. Srajan derives his income from the ad revenues of 6moons but contributes to Darko.Audio pro bono.


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As a Top 100 Lawyer (according to the American Society of Legal Advocates), a Top 10 Attorney in 2013 (according to the National Academy of Criminal Defense Attorneys), and a 2014 Top 100 Trial Lawyer (according to the National Trial Lawyers), Daniel Hilf solidified his reputation and the acknowledgment of his exceptional ability within the legal community.
Avvo currently lists Daniel Hilf as a superb lawyer, and has given him their highest rating of 10.0 in the areas of experience, industry recognition, and professional conduct. Oakland County Circuit Court ascribes Daniel Hilf’s criminal defense credentials as a level 1 capital offense attorney, and he is selected to serve as a mentor to new criminal defense lawyers. He has lectured other criminal lawyers on multiple occasions before the Oakland County Bar Association as a guest speaker. In 2013 Aspatore Books approached Daniel Hilf to contribute to their Inside the Minds series (“featuring partners from some of the nation’s leading law firms”), which resulted in the publication of a book chapter entitled “Best Practices for Jury Selection: Connecting with Jurors in Criminal Cases”. Attorney Daniel Hilf and his wife, Attorney Sufen Hilf, appeared together on the “Street Beat” television program offering their perspective concerning Immigration and Naturalization law issues for the CW50 network in Detroit.
2013 Aspatore Books Inside the Minds publication “Best Practices for Jury Selection: Connecting with Jurors in Criminal Cases”.
The cases Daniel Hilf handles range in severity from misdemeanor offenses (such as traffic offenses, retail fraud, domestic violence, etc.) to life maximum felony offenses (such as armed robbery, criminal sexual conduct, major controlled substance violations, etc.) and everything in between. Daniel Hilf has appeared on numerous occasions before District, Circuit, Juvenile, Family, and Appellate Court Judges throughout the State of Michigan, and as a skilled criminal defense attorney he has fought and obtained not guilty verdicts, dismissals of charges, and charge reductions on many occasions. He has represented people from all walks of life including: professional athletes, alleged organized crime figures, business leaders, police officers, politicians, laborers, housewives, students, etc. His legal career is distinguished by an ability to think on his feet, effectively analyze issues in both conventional and unconventional ways, and to persuasively react against the arguments and challenges presented by prosecutors, police, witnesses, and alleged victims.
Since 1996 Daniel Hilf became licensed as an attorney and has consistently remained a lawyer in good standing with the Michigan Bar Association. He is also admitted to and does practice before the United States District Court for the Eastern District of Michigan concerning federal criminal law matters. In 1996 Daniel Hilf received his Juris Doctorate from the Detroit College of Law (now Michigan State University), and completed his Bachelor’s degree in 1991 from the University of Michigan, Ann Arbor. While in law school, Daniel Hilf served with distinction as the chief judicial law clerk for the Honorable Steven N. Andrews of the 6th Circuit Court of Michigan.
“There is no greater hardship than to be deprived of your family and your freedom. The quality of lawyer that stands beside you often makes all the difference. When the government – the prosecutors and the police with all of their power and resources – chooses to act against you, you need the help of an experienced criminal defense lawyer. I have the experience, talent, and confidence to fight for you to obtain the right result. I will make a difference”.

industry_corpus2: Law & Justice


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I decided to participate in a September, Lingerie challenge. There were different themes for each week.
These were done on 5x7 cards of watercolor paper, predominately with micron pens, watercolor pencils and a palate of mixed watercolors.


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Participates must be at least 10 years of age. Field day classes only are taught at the BPAR office. Registration for the online course and field day class can be done through the Louisiana Wildlife and Fisheries website, class capacity is 30.
Can you tell me who my child's coach is?
What time does Mike Wood Park close?
Do you have the number to the North Bossier Tennis Center?
Do you have the number to Bossier Little League?

industry_corpus2: Agriculture & Fisheries


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A controversial planning application for the creation of a so-called “super cemetery” near the site of the Ulster Grand Prix circuit in Co Antrim has been turned down.
Members of Lisburn and Castlereagh City Council’s Planning Committee yesterday decided to refuse planning permission for Loughview Park Cemetery at Dundrod – a decision that will come as a relief to the thousands of people who objected to the application.
The Loughview Park Cemetery masterplan.
Committee members ruled that there was no need for the cemetery, which would have had an estimated lifespan of 75 years, in the Lisburn and Castlereagh area.
The 96-acre development was to involve an initial £10 million investment and include funeral facilities, catering, parking, woodland walkways and a memorial garden.
Carston, the company behind a proposal, said it was “dismayed” by the committee’s refusal decision.
However, it has been welcomed by local residents and supporters of the Ulster Grand Prix, who feared the new cemetery’s proximity to the race circuit could spell the end for the annual motorcycle road racing event.
UGP organisers, the Dundrod and District Motorcycle Club, welcomed the Planning Committee’s “unanimous rejection” of the application.
“Race fans far and wide felt so strongly about the impact these plans could have on this international event that they launched a ‘Don’t Bury the UGP’ petition, which has been supported by motorcycle fans around the world,” Des Stewart, chairman of the Ulster Grand Prix Supporters Club, commented.
Noel Johnston, UGP Clerk of the Course added: “We are pleased with the unanimous decision taken by the council Planning Committee to reject the cemetery in favour of the planning officers’ recommendation for refusal.
DUP Alderman James Tinsley, who has opposed the application from the outset, welcomed the committee’s ruling, saying it came as “a huge relief” to those fighting the controversial plan.
“In the end it all came down to need and it is clear that there is absolutely no need for this cemetery in this area,” he said.
A statement issued by Carston claimed that while there may not be any need for additional cemetery space within Lisburn and Castlereagh at present, there is a need for new burial space in the neighbouring Belfast City Council (BCC) area.
The company said it had spent “a huge amount of money in trying to secure planning permission” for the project.
“The Loughview Park site would become to north and west Belfast what Roselawn is to the south and east of the city. It would also become a vital piece of civic infrastructure for the entire Greater Belfast, Lisburn and South Antrim catchment area. If Belfast City Council and others want it to become a reality, they need to get involved in this planning debate now,” the statement added.


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MidCity is growing and has an opportunity for a creative, analytical, and self-disciplined full-time Interior Designer to work in their fast-paced environment.
Draw upon many disciplines to enhance the function, safety, and aesthetics of interior spaces. Focus on how different colors, textures, furniture, lighting, and space work together to meet the needs of a company’s workforce.
• Collaborate with Sales Associates to confer with client regarding factors affecting planning work environments, such as budget, architectural preferences, and purpose and function.
• Work closely with Sales Associates to advise client on interior design factors, such as space planning, layout and utilization of furnishings and equipment, and color coordination.
• Formulate environmental plan to be practical, esthetic, and conducive to intended purposes, such as encouraging innovation, raising productivity, etc.
• Create two- and three-dimensional renderings using AutoCAD and other industry software.
• Estimate material requirements and costs, and present design to client for approval.
• Proven experience in interior design with an emphasis on office projects a plus.
• Bachelor’s Degree in Interior Design or Architecture from an accredited school.
• Working knowledge of CAD, drawing, perspective, spatial planning, color and fabrics, furniture design, architecture, and ergonomics.
If you're interested, respond to this posting with cover letter and resume including salary requirement.
FYI – $40k for the right candidate with a minimum of 2 years experience.
Send your resume and cover letter electronically to Kurt Amico, President of MidCity Office Furniture at kurt@midcityoffice.com, or to Sara Evans, Lead Designer at MidCity Office Furniture at sara@midcityoffice.com.
MidCity is also committed to supporting today's college students through the introduction of real work experiences.
MidCity offers Interior Design and Business students the opportunity to gain experience in a commercial furniture dealership. Interns will be exposed to daily business operations of a small firm, learning the structure and hierarchy of a company. During the internship you will work under the direct supervision of a single manager but will have the opportunity to interact with each member of our staff.
If you would like to be "green" conscious you can also send your information electronically to sara@midcityoffice.com.


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Double Gold Medals for the Best Sparkling Wines!
We are honored to announce the San Francisco International Wine Competition has recognized Rack & Riddle as producing some of the very best sparkling wine available on the market by awarding top medals and rankings to our bubbly!
The Rack & Riddle Blanc de Blancs was awarded 94 points and the Double Gold Medal, while the Blanc de Noirs won a Gold Medal and received 93 points! Congratulations to our incredibly talented sparkling winemaker, Penny Gadd-Coster and the rest of our winemaking crew!
Visit our online store to purchase or read more about our award-winning sparkling wines! Take advantage of our new low shipping rates, and for a limited time, shipping is included when purchasing a four-pack of bubbly.


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STAN WIEST Concert Pianist Band Leader is opening a Piano Performance Studio for students of all ages, music majors and those who simply want to increase their proficiency for their own enjoyment.
Stan’s Internationally acclaimed Solo Piano CD is being played on major radio stations in the United States, Europe, Asia and Australia as well as on download sites such as iTunes, Spotify, Google Play etc.
This entry was posted on Wednesday, May 23rd, 2018 at 11:04 pm	and is filed under News. You can follow any responses to this entry through the RSS 2.0 feed. Responses are currently closed, but you can trackback from your own site.


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Canada’s Husky power Inc has found out a considerable deepwater fuel reserve with its chinese language partner, China nationwide Offshore essential oil Corp (CNOOC), inside the South China Sea close to Hong Kong.
Based on preliminary evaluation of drilling results, the discovery could include a possible recoverable source of 4 to 6 trillion cubic ft (120 billion to 180 billion cubic meters) of organic gas, the power organization mentioned in the assertion noticed Friday.
“We are extremely pleased with our exploration final results and also this discovery confirms our self confidence inside the considerable undiscovered hydrocarbon possible inside the South China Sea,” John Lau, Husky CEO and president said.
The discovery was created inside the mouth in the Pearl River about 250 kilometers (150 miles) south of Hong Kong, it added.
The properly would be sidetracked for even more evaluation in the spend zone, Husky said, adding there have been programs for any three-dimensional seismic questionnaire to assess numerous comparable structures which have been completely identified from other seismic data.
Earlier this month, CNOOC signed two manufacturing sharing contracts with Britain’s BG party PLC covering two deep drinking water blocks inside the South China Sea.
To date, CNOOC has signed 4 deep drinking water manufacturing contracts with overseas partners.
© Copyright 2009-2012, Shanghai Shibang Machinery Co., Ltd.

industry_corpus2: Power & Energy


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Welcome to Let’s All Laugh At, the new name for the Extra Time Talk podcast. It’s the same podcast you know and love just with a new name and a new feature. Each week, we pick something from the footballing world that has tickled us and, owing much to the popular football chant, we award the story with the ‘Let’s All Laugh At’ trophy (Disclaimer: trophy is metaphorical and not physical. Sorry).
Numbers were back up compared to last week, so George Pavlou was joined by George Priestman and the returning Andrew Aziz.
This week, the group discussed the Champions League draw and the chances that the English teams had against the mostly-German opposition and they also looked back on the Premier League results from the weekend.
To view more of George’s (the host) work, visit the Extra Time Talk website or you can go straight to his page.
To view more of George’s (on the panel) work, visit the Last Word on Football website or you can go straight to his page.

industry_corpus2: Sports


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Short Sale. SHORT SALE. BEAUTIFUL HOME IN A GREAT COMMUNITY CLOSE TO EVERYTHING ALL MAYOR MALLS. PRICE JUST REDUCED. GOOD SIZE FOR FAMILY AND VERY SPACIOUS FOR ENTERTAINING. MOTIVATED SELLER BRING YOUR BUYERS THEY WILL LOVE IT. TOP RATED SCHOOL DISTRICT. ACCESS TO BATHROOM FROM OUTDOORS. MATURE LANDSCAPING AND GREAT COMMUNITY PARK BEHIND THE HOME.
Amenities Additional Fees Amenities include Hunter's Creek Recreational Facilities. Golf Course is Not included it Can Be Paid Separately.
Listing provided courtesy of Suarez Realty Inc..


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Intractable seizures and metabolic bone disease secondary to celiac disease.
Department of Medicine, Lokmanya Tilak Muncipal Medical College and General Hospital, Sion, Mumbai.
Celiac disease (CD) is Gluten sensitive enteropathy with a wide spectrum of severity and protean clinical manifestations. Patients with atypical (non-diarrhoeal) presentations are missed as the diagnosis of Celiac Disease is not considered. We present three young girls (ages 18, 19, 23 at presentation) who were admitted to our hospital as intractable seizures. All had low serum calcium, features of rickets/osteomalacia and anaemia. This prompted us to consider malabsorption due to CD. The diagnosis of CD was confirmed by serologic tests (IgA transglutaminase and IgG antigliadin antibodies) and biopsy of the duodenum. In all patients gluten free diet not only provided drug free control of seizures but also helped correct other features of malabsorption like hypocalcaemia and anaemia as the primary pathology behind these symptoms was corrected. We wish to highlight that hypocalcaemia of CD which may present as intractable seizures can be treated only by treating CD with gluten free diet and not by oral vitamin D and Calcium alone.

industry_corpus2: Health & Medicine


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Hi! My zipper bags are usually 15$ by themselves, but if you'd like two of them you can get a discount! c: You get 5$ off! Shipping doesn't increase for getting two. So maybe ... get one for your friend too?
1. https://www.etsy.com/shop/storyofthedoor?section_id=14165784 Go check my zipper bag selection and see if there are two you want.
2. There are two you want! YAAAAAAY!!!
3. Add this Pick Two listing to your cart.
4. Buy this Pick Two listing and during check out, tell me in your purchaser notes which two zipper bags you want. If you don't tell me which two bags you want, I will note you after I've received your purchase.
5. I'll ship you two bags! 8D Thanks very much!
The prints are very sharp and the bag is well made. Great design!
Super fast shipping and adorable freebies!


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- circle, square, teardrop and pod shaped - in graduated sized sets.
In Europe they can be purchased at ChezUnChef.com and at Clayaround in the UK.
2. A new option of seamless cutters is now on the market manufactured by Ateco. They exactly match the sizes and number of cutters in each set as the Fat Daddios. They have all the same excellent features as the Fat Daddios except you cannot put them in the oven. They are made from polycarbonate.
They are currently available at Shades of Clay.
Once you have a new set of Fat Daddio's or Ateco plastic cutters, run your finger along the inside bottom edge of a cutter. Due to the manufacturing process, you will feel a small ridge. This will negatively affect the sharpness of your cut. There is an easy fix.
Use an 800 or 1000 grit sandpaper (purchased at an automotive/hardware store) to smooth away the ridge. It just takes a minute or two and the results will be well worth your time. The thinner the cutting edge, the sharper the cut, but you have to be careful that the edge is not so thin that it becomes fragile. Note that only the inside edge needs sanding. Sanding your cutters will give you superior results.


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Services — T.B. HARSKI & ASSOCIATES, L.L.C.
Our Business Enterprise Valuation, Property, Plant and Machinery & Equipment Appraisal, Forensic, and Risk Management services focus across a range of purposes in accounting, tax, litigation, finance, insurance, operations, and transaction equity investment.

industry_corpus2: Finance & Economics


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Michelle’s lab develops innovative approaches to screen for chemical tools and drug leads, using biophysical approaches like fragment-based drug discovery and biological approaches including high-content imaging with primary cells and organisms. Our goal is to demonstrate ‘druggability’ of new target classes and to use our compounds to discover new targets for drug discovery. Areas of interest include protein-protein interactions, allosteric and scaffolding sites in enzymes, and orphan and neglected diseases. Michelle is Associate Director of the Small Molecule Discovery Center, a collaborative research and core lab that includes a high-throughput screening facility (smdc.ucsf.edu).
Sijbesma E, Hallenbeck KK, Leysen S, de Vink P, Skora L, Jahnke W, Brunsveld L, Arkin MR, Ottmann C. Site-Directed Fragment-based Screening for the Discovery of Protein-Protein Interaction Stabilizers. J Am Chem Soc. 2019 Feb 01.
Klein HL, Ang KKH, Arkin MR, Beckwitt EC, Chang YH, Fan J, Kwon Y, Morten MJ, Mukherjee S, Pambos OJ, El Sayyed H, Thrall ES, Vieira-da-Rocha JP, Wang Q, Wang S, Yeh HY, Biteen JS, Chi P, Heyer WD, Kapanidis AN, Loparo JJ, Strick TR, Sung P, Van Houten B, Niu H, Rothenberg E. Guidelines for DNA recombination and repair studies: Mechanistic assays of DNA repair processes. Microb Cell. 2019 Jan 07; 6(1):65-101.
Laurie MT, White CV, Retallack H, Wu W, Moser MS, Sakanari JA, Ang K, Wilson C, Arkin MR, DeRisi JL. Functional Assessment of 2,177 U.S. and International Drugs Identifies the Quinoline Nitroxoline as a Potent Amoebicidal Agent against the Pathogen Balamuthia mandrillaris. MBio. 2018 Oct 30; 9(5).
Ryu JK, Rafalski VA, Meyer-Franke A, Adams RA, Poda SB, Rios Coronado PE, Pedersen LØ, Menon V, Baeten KM, Sikorski SL, Bedard C, Hanspers K, Bardehle S, Mendiola AS, Davalos D, Machado MR, Chan JP, Plastira I, Petersen MA, Pfaff SJ, Ang KK, Hallenbeck KK, Syme C, Hakozaki H, Ellisman MH, Swanson RA, Zamvil SS, Arkin MR, Zorn SH, Pico AR, Mucke L, Freedman SB, Stavenhagen JB, Nelson RB, Akassoglou K. Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration. Nat Immunol. 2018 Nov; 19(11):1212-1223.
LaPorte MG, Burnett JC, Colombo R, Bulfer SL, Alverez C, Chou TF, Neitz RJ, Green N, Moore WJ, Yue Z, Li S, Arkin MR, Wipf P, Huryn DM. Optimization of Phenyl Indole Inhibitors of the AAA+ ATPase p97. ACS Med Chem Lett. 2018 Nov 08; 9(11):1075-1081.
Lee J, Pappalardo Z, Chopra DG, Hennings TG, Vaughn I, Lan C, Choe JJ, Ang K, Chen S, Arkin M, McManus MT, German MS, Ku GM. A Genetic Interaction Map of Insulin Production Identifies Mfi as an Inhibitor of Mitochondrial Fission. Endocrinology. 2018 Sep 01; 159(9):3321-3330.
El-Sakkary N, Chen S, Arkin MR, Caffrey CR, Ribeiro P. Octopamine signaling in the metazoan pathogen Schistosoma mansoni: localization, small-molecule screening and opportunities for drug development. Dis Model Mech. 2018 07 30; 11(7).
Coussens NP, Sittampalam GS, Guha R, Brimacombe K, Grossman A, Chung TDY, Weidner JR, Riss T, Trask OJ, Auld D, Dahlin JL, Devanaryan V, Foley TL, McGee J, Kahl SD, Kales SC, Arkin M, Baell J, Bejcek B, Gal-Edd N, Glicksman M, Haas JV, Iversen PW, Hoeppner M, Lathrop S, Sayers E, Liu H, Trawick B, McVey J, Lemmon VP, Li Z, McManus O, Minor L, Napper A, Wildey MJ, Pacifici R, Chin WW, Xia M, Xu X, Lal-Nag M, Hall MD, Michael S, Inglese J, Simeonov A, Austin CP. Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery. Clin Transl Sci. 2018 Sep; 11(5):461-470.
Markossian S, Ang KK, Wilson CG, Arkin MR. Small-Molecule Screening for Genetic Diseases. Annu Rev Genomics Hum Genet. 2018 Aug 31; 19:263-288.
Kostic M, Arkin M. Chemical Biology as a Driver of Innovation in Cancer Research and Drug Discovery. Cell Chem Biol. 2017 09 21; 24(9):1057.
Theofilas P, Ehrenberg AJ, Nguy A, Thackrey JM, Dunlop S, Mejia MB, Alho AT, Paraizo Leite RE, Rodriguez RD, Suemoto CK, Nascimento CF, Chin M, Medina-Cleghorn D, Cuervo AM, Arkin M, Seeley WW, Miller BL, Nitrini R, Pasqualucci CA, Filho WJ, Rueb U, Neuhaus J, Heinsen H, Grinberg LT. Probing the correlation of neuronal loss, neurofibrillary tangles, and cell death markers across the Alzheimer's disease Braak stages: a quantitative study in humans. Neurobiol Aging. 2018 01; 61:1-12.
Plowright AT, Ottmann C, Arkin M, Auberson YP, Timmerman H, Waldmann H. Joining Forces: The Chemical Biology-Medicinal Chemistry Continuum. Cell Chem Biol. 2017 Sep 21; 24(9):1058-1065.
Carlson HK, Mullan MR, Mosqueda LA, Chen S, Arkin MR, Coates JD. High-Throughput Screening To Identify Potent and Specific Inhibitors of Microbial Sulfate Reduction. Environ Sci Technol. 2017 Jun 20; 51(12):7278-7285.
Burnett JC, Lim C, Peyser BD, Samankumara LP, Kovaliov M, Colombo R, Bulfer SL, LaPorte MG, Hermone AR, McGrath CF, Arkin MR, Gussio R, Huryn DM, Wipf P. A threonine turnstile defines a dynamic amphiphilic binding motif in the AAA ATPase p97 allosteric binding site. Org Biomol Chem. 2017 May 16; 15(19):4096-4114.
Pappalardo Z, Gambhir Chopra D, Hennings TG, Richards H, Choe J, Yang K, Baeyens L, Ang K, Chen S, Arkin M, German MS, McManus MT, Ku GM. A Whole-Genome RNA Interference Screen Reveals a Role for Spry2 in Insulin Transcription and the Unfolded Protein Response. Diabetes. 2017 06; 66(6):1703-1712.
Visperas PR, Wilson CG, Winger JA, Yan Q, Lin K, Arkin MR, Weiss A, Kuriyan J. Identification of Inhibitors of the Association of ZAP-70 with the T Cell Receptor by High-Throughput Screen. SLAS Discov. 2017 03; 22(3):324-331.
Bulfer SL, Chou TF, Arkin MR. p97 Disease Mutations Modulate Nucleotide-Induced Conformation to Alter Protein-Protein Interactions. ACS Chem Biol. 2016 08 19; 11(8):2112-6.
Banerjee S, Bartesaghi A, Merk A, Rao P, Bulfer SL, Yan Y, Green N, Mroczkowski B, Neitz RJ, Wipf P, Falconieri V, Deshaies RJ, Milne JL, Huryn D, Arkin M, Subramaniam S. 2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition. Science. 2016 Feb 19; 351(6275):871-5.
Alverez C, Bulfer SL, Chakrasali R, Chimenti MS, Deshaies RJ, Green N, Kelly M, LaPorte MG, Lewis TS, Liang M, Moore WJ, Neitz RJ, Peshkov VA, Walters MA, Zhang F, Arkin MR, Wipf P, Huryn DM. Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway. ACS Med Chem Lett. 2016 Feb 11; 7(2):182-7.
Suzawa M, Miranda DA, Ramos KA, Ang KK, Faivre EJ, Wilson CG, Caboni L, Arkin MR, Kim YS, Fletterick RJ, Diaz A, Schneekloth JS, Ingraham HA. A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver. Elife. 2015 Dec 11; 4.
Visscher M, Arkin MR, Dansen TB. Covalent targeting of acquired cysteines in cancer. Curr Opin Chem Biol. 2016 Feb; 30:61-67.
Alverez C, Arkin MR, Bulfer SL, Colombo R, Kovaliov M, LaPorte MG, Lim C, Liang M, Moore WJ, Neitz RJ, Yan Y, Yue Z, Huryn DM, Wipf P. Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97. ACS Med Chem Lett. 2015 Dec 10; 6(12):1225-30.
Frye SV, Arkin MR, Arrowsmith CH, Conn PJ, Glicksman MA, Hull-Ryde EA, Slusher BS. Tackling reproducibility in academic preclinical drug discovery. Nat Rev Drug Discov. 2015 11; 14(11):733-4.
Khare S, Roach SL, Barnes SW, Hoepfner D, Walker JR, Chatterjee AK, Neitz RJ, Arkin MR, McNamara CW, Ballard J, Lai Y, Fu Y, Molteni V, Yeh V, McKerrow JH, Glynne RJ, Supek F. Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease. PLoS Pathog. 2015 Jul; 11(7):e1005058.
Ekins S, de Siqueira-Neto JL, McCall LI, Sarker M, Yadav M, Ponder EL, Kallel EA, Kellar D, Chen S, Arkin M, Bunin BA, McKerrow JH, Talcott C. Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery. PLoS Negl Trop Dis. 2015; 9(6):e0003878.
Neitz RJ, Bryant C, Chen S, Gut J, Hugo Caselli E, Ponce S, Chowdhury S, Xu H, Arkin MR, Ellman JA, Renslo AR. Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas' disease. Bioorg Med Chem Lett. 2015 Nov 01; 25(21):4834-4837.
Zhang X, Gui L, Zhang X, Bulfer SL, Sanghez V, Wong DE, Lee Y, Lehmann L, Lee JS, Shih PY, Lin HJ, Iacovino M, Weihl CC, Arkin MR, Wang Y, Chou TF. Altered cofactor regulation with disease-associated p97/VCP mutations. Proc Natl Acad Sci U S A. 2015 Apr 07; 112(14):E1705-14.
Tran K, Arkin MR, Beal PA. Tethering in RNA: an RNA-binding fragment discovery tool. Molecules. 2015 Mar 04; 20(3):4148-61.
Bulman CA, Bidlow CM, Lustigman S, Cho-Ngwa F, Williams D, Rascón AA, Tricoche N, Samje M, Bell A, Suzuki B, Lim KC, Supakorndej N, Supakorndej P, Wolfe AR, Knudsen GM, Chen S, Wilson C, Ang KH, Arkin M, Gut J, Franklin C, Marcellino C, McKerrow JH, Debnath A, Sakanari JA. Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis. PLoS Negl Trop Dis. 2015 Feb; 9(2):e0003534.
Pfaff SJ, Chimenti MS, Kelly MJ, Arkin MR. Biophysical methods for identifying fragment-based inhibitors of protein-protein interactions. Methods Mol Biol. 2015; 1278:587-613.
Visperas PR, Winger JA, Horton TM, Shah NH, Aum DJ, Tao A, Barros T, Yan Q, Wilson CG, Arkin MR, Weiss A, Kuriyan J. Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding. Biochem J. 2015 Jan 01; 465(1):149-61.
Neitz RJ, Chen S, Supek F, Yeh V, Kellar D, Gut J, Bryant C, Gallardo-Godoy A, Molteni V, Roach SL, Khare S, Stinson M, Chatterjee AK, Robertson S, Renslo AR, Arkin M, Glynne R, McKerrow J, Siqueira-Neto JL. Lead identification to clinical candidate selection: drugs for Chagas disease. J Biomol Screen. 2015 Jan; 20(1):101-11.
Dar RD, Hosmane NN, Arkin MR, Siliciano RF, Weinberger LS. Screening for noise in gene expression identifies drug synergies. Science. 2014 Jun 20; 344(6190):1392-6.
Chou TF, Bulfer SL, Weihl CC, Li K, Lis LG, Walters MA, Schoenen FJ, Lin HJ, Deshaies RJ, Arkin MR. Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains. J Mol Biol. 2014 Jul 29; 426(15):2886-99.
Arkin MR, Ang KK, Chen S, Davies J, Merron C, Tang Y, Wilson CG, Renslo AR. UCSF Small Molecule Discovery Center: innovation, collaboration and chemical biology in the Bay Area. Comb Chem High Throughput Screen. 2014 May; 17(4):333-42.
Flygare JA, Arkin MR. Inhibiting caspase-6 activation and catalytic activity for neurodegenerative diseases. Curr Top Med Chem. 2014; 14(3):319-25.
Wilson CG, Arkin MR. Probing structural adaptivity at PPI interfaces with small molecules. Drug Discov Today Technol. 2013 Dec; 10(4):e501-8.
Murray J, Giannetti AM, Steffek M, Gibbons P, Hearn BR, Cohen F, Tam C, Pozniak C, Bravo B, Lewcock J, Jaishankar P, Ly CQ, Zhao X, Tang Y, Chugha P, Arkin MR, Flygare J, Renslo AR. Tailoring small molecules for an allosteric site on procaspase-6. ChemMedChem. 2014 Jan; 9(1):73-7, 2.
Slusher BS, Conn PJ, Frye S, Glicksman M, Arkin M. Bringing together the academic drug discovery community. Nat Rev Drug Discov. 2013 Nov; 12(11):811-2.
Bagriantsev SN, Ang KH, Gallardo-Godoy A, Clark KA, Arkin MR, Renslo AR, Minor DL. A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels. ACS Chem Biol. 2013 Aug 16; 8(8):1841-51.
Heise CE, Murray J, Augustyn KE, Bravo B, Chugha P, Cohen F, Giannetti AM, Gibbons P, Hannoush RN, Hearn BR, Jaishankar P, Ly CQ, Shah K, Stanger K, Steffek M, Tang Y, Zhao X, Lewcock JW, Renslo AR, Flygare J, Arkin MR. Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6. PLoS One. 2012; 7(12):e50864.
Wu VM, Chen SC, Arkin MR, Reiter JF. Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13644-9.
Gunatilleke SS, Calvet CM, Johnston JB, Chen CK, Erenburg G, Gut J, Engel JC, Ang KK, Mulvaney J, Chen S, Arkin MR, McKerrow JH, Podust LM. Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51. PLoS Negl Trop Dis. 2012; 6(7):e1736.
Pu M, Hayashi T, Cottam H, Mulvaney J, Arkin M, Corr M, Carson D, Messer K. Analysis of high-throughput screening assays using cluster enrichment. Stat Med. 2012 Dec 30; 31(30):4175-89.
Rogers KE, Keränen H, Durrant JD, Ratnam J, Doak A, Arkin MR, McCammon JA. Novel cruzain inhibitors for the treatment of Chagas' disease. Chem Biol Drug Des. 2012 Sep; 80(3):398-405.
Debnath A, Parsonage D, Andrade RM, He C, Cobo ER, Hirata K, Chen S, García-Rivera G, Orozco E, Martínez MB, Gunatilleke SS, Barrios AM, Arkin MR, Poole LB, McKerrow JH, Reed SL. A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target. Nat Med. 2012 Jun; 18(6):956-60.
Zhong M, Gadek TR, Bui M, Shen W, Burnier J, Barr KJ, Hanan EJ, Oslob JD, Yu CH, Zhu J, Arkin MR, Evanchik MJ, Flanagan WM, Hoch U, Hyde J, Prabhu S, Silverman JA, Wright J. Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye. ACS Med Chem Lett. 2012 Mar 08; 3(3):203-6.
Lee H, Moody-Davis A, Saha U, Suzuki BM, Asarnow D, Chen S, Arkin M, Caffrey CR, Singh R. Quantification and clustering of phenotypic screening data using time-series analysis for chemotherapy of schistosomiasis. BMC Genomics. 2012; 13 Suppl 1:S4.
De Muylder G, Ang KK, Chen S, Arkin MR, Engel JC, McKerrow JH. A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit. PLoS Negl Trop Dis. 2011 Jul; 5(7):e1253.
Ang KK, Ratnam J, Gut J, Legac J, Hansell E, Mackey ZB, Skrzypczynska KM, Debnath A, Engel JC, Rosenthal PJ, McKerrow JH, Arkin MR, Renslo AR. Mining a cathepsin inhibitor library for new antiparasitic drug leads. PLoS Negl Trop Dis. 2011 May 03; 5(5):e1023.
Ben Khalaf N, De Muylder G, Ratnam J, Kean-Hooi Ang K, Arkin M, McKerrow J, Chenik M. A high-throughput turbidometric assay for screening inhibitors of Leishmania major protein disulfide isomerase. J Biomol Screen. 2011 Jun; 16(5):545-51.
Gut J, Ang KK, Legac J, Arkin MR, Rosenthal PJ, McKerrow JH. An image-based assay for high throughput screening of Giardia lamblia. J Microbiol Methods. 2011 Mar; 84(3):398-405.
Zhong M, Hanan EJ, Shen W, Bui M, Arkin MR, Barr KJ, Evanchik MJ, Hoch U, Hyde J, Martell JR, Oslob JD, Paulvannan K, Prabhu S, Silverman JA, Wright J, Yu CH, Zhu J, Flanagan WM. Structure-activity relationship (SAR) of the a-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists. Bioorg Med Chem Lett. 2011 Jan 01; 21(1):307-10.
Zhong M, Shen W, Barr KJ, Arbitrario JP, Arkin MR, Bui M, Chen T, Cunningham BC, Evanchik MJ, Hanan EJ, Hoch U, Huen K, Hyde J, Kumer JL, Lac T, Lawrence CE, Martell JR, Oslob JD, Paulvannan K, Prabhu S, Silverman JA, Wright J, Yu CH, Zhu J, Flanagan WM. Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists. Bioorg Med Chem Lett. 2010 Sep 01; 20(17):5269-73.
Engel JC, Ang KK, Chen S, Arkin MR, McKerrow JH, Doyle PS. Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease. Antimicrob Agents Chemother. 2010 Aug; 54(8):3326-34.
Hawtin RE, Stockett DE, Byl JA, McDowell RS, Nguyen T, Arkin MR, Conroy A, Yang W, Osheroff N, Fox JA. Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II. PLoS One. 2010 Apr 15; 5(4):e10186.
Bryant C, Kerr ID, Debnath M, Ang KK, Ratnam J, Ferreira RS, Jaishankar P, Zhao D, Arkin MR, McKerrow JH, Brinen LS, Renslo AR. Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases. Bioorg Med Chem Lett. 2009 Nov 01; 19(21):6218-21.
Arkin MR, Whitty A. The road less traveled: modulating signal transduction enzymes by inhibiting their protein-protein interactions. Curr Opin Chem Biol. 2009 Jun; 13(3):284-90.
Rubio BK, Tenney K, Ang KH, Abdulla M, Arkin M, McKerrow JH, Crews P. The marine sponge Diacarnus bismarckensis as a source of peroxiterpene inhibitors of Trypanosoma brucei, the causative agent of sleeping sickness. J Nat Prod. 2009 Feb 27; 72(2):218-22.
Conroy A, Stockett DE, Walker D, Arkin MR, Hoch U, Fox JA, Hawtin RE. SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples. Cancer Chemother Pharmacol. 2009 Sep; 64(4):723-32.
Arkin M, Moasser MM. HER-2-directed, small-molecule antagonists. Curr Opin Investig Drugs. 2008 Dec; 9(12):1264-76.
Choong IC, Serafimova I, Fan J, Stockett D, Chan E, Cheeti S, Lu Y, Fahr B, Pham P, Arkin MR, Walker DH, Hoch U. A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties. Bioorg Med Chem Lett. 2008 Nov 01; 18(21):5763-5.
Arkin M. Protein-protein interactions and cancer: small molecules going in for the kill. Curr Opin Chem Biol. 2005 Jun; 9(3):317-24.
Waal ND, Yang W, Oslob JD, Arkin MR, Hyde J, Lu W, McDowell RS, Yu CH, Raimundo BC. Identification of nonpeptidic small-molecule inhibitors of interleukin-2. Bioorg Med Chem Lett. 2005 Feb 15; 15(4):983-7.
Raimundo BC, Oslob JD, Braisted AC, Hyde J, McDowell RS, Randal M, Waal ND, Wilkinson J, Yu CH, Arkin MR. Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions. J Med Chem. 2004 Jun 03; 47(12):3111-30.
Hyde J, Braisted AC, Randal M, Arkin MR. Discovery and characterization of cooperative ligand binding in the adaptive region of interleukin-2. Biochemistry. 2003 Jun 03; 42(21):6475-83.
Braisted AC, Oslob JD, Delano WL, Hyde J, McDowell RS, Waal N, Yu C, Arkin MR, Raimundo BC. Discovery of a potent small molecule IL-2 inhibitor through fragment assembly. J Am Chem Soc. 2003 Apr 02; 125(13):3714-5.
Arkin MR, Stemp ED, Holmlin RE, Barton JK, Hörmann A, Olson EJ, Barbara PF. Rates of DNA-mediated electron transfer between metallointercalators. Science. 1996 Jul 26; 273(5274):475-80.
Murphy CJ, Arkin MR, Ghatlia ND, Bossmann S, Turro NJ, Barton JK. Fast photoinduced electron transfer through DNA intercalation. Proc Natl Acad Sci U S A. 1994 Jun 07; 91(12):5315-9.
Murphy CJ, Arkin MR, Jenkins Y, Ghatlia ND, Bossmann SH, Turro NJ, Barton JK. Long-range photoinduced electron transfer through a DNA helix. Science. 1993 Nov 12; 262(5136):1025-9.


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The work Barney, Tee-rific bugs & animals represents a distinct intellectual or artistic creation found in Old Colony Library Network. This resource is a combination of several types including: Work, Moving Image, Visual Materials.
Barney & friends (Television program)., Selections.


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The placement of an Automated External Defibrillator (AED) in your dental practice can increase the chances of survival by up to 70% and make the difference between saving a life and having a victim die.
The importance of having AEDs readily available at your dental practice, Medi Aid (UK) Ltd have created a special offer package for dental surgeries. We are offering HeartSine Samaritan PAD 300P or PAD500 AED + AED training for a group of 12 delegates at your surgery/venue. Special offer price below.
You can buy your Dental Practice Package online by credit card or request a pro forma invoice to pay by bank transfer. Simply add the item to your basket and follow the instructions for your required method of payment.


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The band has two albums in its catalog, a self-titled full-length released in June 2015 and its latest, “How Will You Know If You Never Try,” released in April. That worthwhile aphorism was displayed prominently onstage, emblazoned on what was a screen that broadcast graphic images throughout the nearly 70-minute show.
Most of the crowd of 400 or so seemed to know the lyrics to all 15 songs on the set list, starting with the opener, “Feeling,” which, like everything that followed, was a brash blend of groovy and melodic indie-pop/rock and synth-pop with an occasional dash of emo.
There is some sophistication in their songcraft: pre-choruses and bridges are common, as are clever chord progressions. Imagine a blend of the Killers and the Bravery and you’ll have an idea of Coin’s relentlessly catchy sound.
Occasionally, they swerve into Coldplay territory, as in “It’s a Trap.” Other times, they flirt with pop-metal, as in “Run,” a galloping dance-rock number with gang vocals that prompted one of many boisterous singalongs.
“Miranda Beach,” another highlight, flashed a hint of glam-rock. They can slow it down, too, as they did during “Malibu 1992,” which started as an ethereal ballad before climaxing with a frenzied finish.
Coin is led by singer Chase Lawrence, whose impressive mane of curly hair resembles that of Mick Hucknall of Simply Red. When he wasn’t fortifying songs via a synth, Lawrence was flouncing and bouncing and head-banging about the stage, keeping the energy needle in the red all night.
Before they ended with “Fingers Crossed,” Lawrence, sounding genuinely impressed with the crowd’s size and enthusiasm, thanked everyone for the rousing welcome. It was Coin’s first performance in Kansas City, he said, then promised it wouldn’t be its last. It’s likely, however, that its next performance will be in a much larger venue before a much bigger crowd.
Feeling; Atlas; Holy Ghost; I Don’t Wanna Dance; Time Machine; Are We Alone?; Don’t Cry, 2020; I Would; It’s a Trap; Run; Boyfriend; Miranda Beach; Malibu 1992; Talk Too Much; Fingers Crossed.


text: Skydiving school located at Skydive The Point. Operating weekends and holidays. Weekdays by appointment. Convenient to Richmond, Northern Virginia and the Tidewater area.


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The days of repairing tooth decay with fillings made from metal amalgam, or composites of powdered glass and ceramic could be over sooner than what we thought.
Researchers at King’s College London have found that a drug named Tideglusib could encourage cells in the dental pulp to heal small holes by generating new dentine. Teeth can currently produce a very thin band of dentine if the inner dental pulp becomes exposed, however this cannot repair deep cavities of tooth decay.
The team at King’s College London showed this was possible by soaking a biodegradable sponge in the drug, inserting it into a cavity and then applying a protective layer over the top of it. Over time the sponge broke down and left just the dentine, which healed the tooth. The team are now investigating whether this method could repair larger holes.
Currently with fillings patients may have to return multiple times during a lifetime to get them replaced. However the complete, effective and natural repair of this new process leaves the space occupied by the sponge full of minerals as the dentine regenerates, meaning it shouldn’t fail in the future. This process of repairing teeth could be available within 3-5 years from now.
With the potential of no longer needing an unattractive, sometimes painful filling to be inserted into damaged teeth, will this mean people may take less notice of their oral care regime? Let us know what you think on this.


text: Citation: Gabriel, N.,Chua, F.K. (2006). Capturing focused attention. Perception and Psychophysics 68 (8) : 1286-1296. ScholarBank@NUS Repository.


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Thirunallar consists of a good blend of hotels and tourist locations, making it an ideal place to visit. Travellers may visit Thirunallar all around the year and experience the diversity of the place. Thirunallar is speckled with varied social amenities and has a smooth dispense of services.
Buses in Thirunallar can be booked easily by travellers. Online bus reservation is available in Thirunallar and tickets can be booked at redbus.in.
Are you looking for more hotel options in Thirunallar?


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Come and join James Wilton and company dancers for a fast paced and fun three-day workshop, exploring the companies highly physical style fusing floor work with martial arts, acrobatics, and contact work.
Unfortunately accommodation is not provided, however the company can assist with accommodation searches where necessary. Please note that the nearest train station is Eastbourne, and the nearest airport is London Gatwick ( 1 hour train away).


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Romanesque Ornament by Granger - 5.125" x 8.000"
Romanesque Ornament art print by Granger. Our prints are produced on acid-free papers using archival inks to guarantee that they last a lifetime without fading or loss of color. All art prints include a 1" white border around the image to allow for future framing and matting, if desired.


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It was an amazing evening. For me, it was the very first performance God is an Astronaut that I visited. And I was stunned. It’s a magical music, that engaged you from the first notes of the first song. Awesome light on the stage, beautiful music and spellbound atmosphere.
I hope that isn’t my last visit to the GiiA show. I’ll wait for the next show and next album.
Thank you guys, it was great.


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The Elizabeth R Media Fund’s Commonwealth Digital Challenge for 2019 is now open. Application form available here.
We hope the competition will inspire, and help, young innovators and entrepreneurs to find new ways of improving media through the use of technology.
It was originally established as The Elizabeth R Broadcasting Fund in 1995 to assist the development of broadcasting skills in the Commonwealth with a donation from Buckingham Palace. The donation came from royalties from “Elizabeth R”, the 1992 BBC documentary which marked the 40th anniversary of the reign of Queen Elizabeth II.
The Fund has fulfilled an important role for more than 20 years, bringing together Commonwealth broadcasters via a programme of travel bursaries and training opportunities.
However, the media landscape has changed greatly since that ground-breaking Elizabeth R documentary and the Fund is now developing to meet the challenges of the media’s digital age.
Thomson Foundation has been charged with re-branding and re-launching the Fund.
It is a fitting choice as the foundation has, for over 55 years, helped raise standards of journalism and communications across the world and has trained journalists and media managers from every Commonwealth country.
For any queries on the Commonwealth Digital Challenge, please email: inquiries@thomsonfoundation.org. For an update on the progress of last year's winner, John Otunga, click here.
Sign up to our newsletter for notification of Thomson Foundation journalism competitions and courses.

industry_corpus2: Media & Journalism


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The 2013 Science of Benefits series is kicking off with a special presentation by Terry Burnham, author of Mean Markets and Lizard Brains. He'll discuss how irrationality can actually help predict market direction. Dr. Benjamin Gillen, Assistant Professor in Economics at Caltech, will provide his unique perspective based on his research in financial econometrics. Whether you're just starting to save for retirement or you're a seasoned investor, you'll enjoy this lively discussion. Attend and you'll have a chance to win a Kindle Fire HD or a signed copy of Terry Burnham's book.
No reservations are required. For details, visit www.tiaa-cref.org/caltech.


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Protect the rights, property or personal safety of Complaints DB, its users or the general public.


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High quality cartridge needles allow you to work faster: Transparent disposable medical plastic cartridges, with color and blood reflux blocking membrane system, are easily interchangeable and available in a wide range of configurations.
The Kwadron Cartridges are available as Round Liner, Round Shader, Magnum, Soft Edge Magnum and Flat Shader. These Kwadron Long Taper Modules are available in three needle sizes: 0.25 0.30 0.35 mm.


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Hello all, I just bought the goty edition of this game after completing the majority of the content. I would like to play the two bonus episodes LANDSLIDE and HOUSE OF SAND but even with the GOTY i cant access them…and when I try to download them it says content not available on PSN. Did I just get screwed out of 20 dollars for content that doesn’t exist anymore for whatever reason? Thanks in advance.
@Travis_IOI, I tried searching Hitmanforum and Google to no avail… Maybe you can help him?
But otherwise I really advise you to message the most constant developer on this website called @Travis_IOI who is available anytime just Email him to fix the problem for the PS4 store.
Also i am sorry I didnt mean to say steam I meant to say PS4 store which you did - I advise you to check it once more for any disturbance in the mechanism or if they are simply not downloaded.
You maybe aren’t playing in online mode since you have to be online for playing bonus episodes.
Can you tell me what country you are in and also what you’ve purchased? Please be exact and specify whether it’s the digital or disc versions?
If you own the disc version, then it will came come with a voucher/code in the box that you can redeem. That’s how to get the Bonus Episode.
He is not a developer, tho.
If it’s a used copy, you would need to find a code separately. If you were to buy the GOTY Edition separately from what you own now, you would get access to the Bonus Episode, yes.
I got Hitman from PSN Plus (containing the ICA Missions only) and upgraded to GOTY. But I can’t find the Bonus Episodes in PSN (Germany) in the USA PSN I see it. Are those not available in Germany?
I have what sounds like the same problem. Purchased Hitman preplayed so the code didn’t work obviously. eB Games said if we bought game of the year edition it would unlock. So we have original version disc and bought GOTY upgrade from the PSStore. The bonus episodes are visible in the game but inaccessible, and there is no add-on content to download.
Is it only available for physically purchased GOTY editions?
here it 2019 and still no bonus episodes for those of us that bought the game used, then added goty thru psn. Fix this why don’t you???


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Cash is king in any industry, but in the restaurant business it is particularly vital to carefully balance cash in and cash out. This blog examines the most common challenges faced by business owners and offers practical advice and solutions to help restaurants with their cash flow.
Fluctuating payroll – more so than in a lot of businesses, restaurant payroll can fluctuate up and down and this can be a nightmare for restaurant owners. The reasons for this are plentiful – seasonality, high staff turnover and varying hourly rates dependant on experience. It requires careful scrutiny and management to ensure that costs are affordable and that the business remains profitable. Restaurant staff usually expect to be paid weekly, so paying them on time presents an ongoing pressure on cash flow and is a non-negotiable cost. Without a team the restaurant cannot remain open. It is a good idea to set a budget, either weekly or monthly and make it is adhered to. Forecasting can help to set the appropriate budget, taking in to account seasonality.
Not having time to forecast – Knowing your numbers is paramount for business owners, but often finance slips down the priority list and becomes an after-thought. The benefits of forecasting and planning are enormous. Not only can you minimise surprises by planning ahead, you are also far less likely to be de-railed by an unexpected bill or the heightened cash flow pressures of peak season.
Seasonality – understanding the flow of money throughout the year means that you can plan ways to manage it in advance, rather than reacting in a panic when it is too late. Particularly in hospitality, depending where you are in the world, there will be times of year that are much slower than others and in those times you need to ensure you can keep your doors open. Unless you are very lucky, fixed costs like rent will remain the same all year round, so this usually requires that you scale back on flexible overheads like staff costs and readjust ordering according to customer demand. On the other hand, during peak season you will most likely need to accommodate paying temporary staff and allocate money for how payroll will change as a result.
Lack of contingency cash – like owning a car or a house, owning a restaurant comes with the risk of unexpected expenses. Whether that is a bill, a faulty appliance or another cost, it can have a big impact on your cash flow. Operating hand-to-mouth, without a cash buffer means that you run the risk of any such unexpected cost derailing your business completely. Keeping a contingency fund, as well as taking out insurance means that you safeguard the future of the business.
Relying on credit – if you want to stay on top of the numbers make sure you have an efficient way to manage your outstanding invoices. Cloud accounting software is great for providing an up-to-the-minute cash flow picture but use whatever suits you. If it worries you, where possible, try to pay for deliveries on arrival. There might be discounts available for paying immediately or within a week of delivery and so this method has multiple cash flow benefits.
Scrutinise your menu - Your menu can have a massive impact on your cash flow. Make sure you do not stock a lot of high price/low margin items – keep your menu concise – customers are usually overwhelmed by too many choices and you can concentrate on delivering fewer dishes to a high quality. Remove slower moving dishes from the menu altogether and keep inventory as low as possible to minimise waste. Make sure someone is in charge of monitoring stock - you are far less likely to have surplus stock to throw away or find your self out of pocket if you keep careful tabs on it all. Keep a close eye on how much your inventory costs – if your suppliers put their prices up then you need to consider doing that as well. Make sure that your menu looks great and is easy to understand and put high margin dishes in plain sight or on a ‘specials’ areas of the menu.
Shop around – use different suppliers and negotiate discounts wherever you can. Over reliance on a singular supplier may sometimes give you bulk discounts but one supplier is rarely the cheapest for everything and knowing that you are sourcing your ingredients elsewhere may make them more competitive. Bear in mind that if a delivery is late and you have to take popular dishes off the menu, it is your cash flow that suffers, so it is prudent to ensure that you have multiple people to call on for last minute requirements if you are suddenly let down.
Planning and forecasting – track your cash flow weekly to spot trends and fluctuations. Your future-self will thank you as you can use history to predict and forecast for the coming years. Ideally you would plan your budget at least six months ahead. If you are able to, look back over several years to avoid being driven off course by one off spikes or troughs caused by external factors.
Seasonality planning – Yearly budgeting does not always work with a restaurant due to the seasonal nature of sales so individual monthly or quarterly plans might suit you better. Remember to factor in changes to pay roll as your team size expands or reduces. If you are not confident planning and forecasting, ask an expert. There are now a wide range of companies offering part-time Financial Directors or you can ask you accountant. This type of support is exactly what they are there for and a good one will take an active role in advising you on all financial matters to do with your business. In addition to forecasting budgets and planning for payroll, seasonality may demand some attention on marketing. Online discount voucher sites or offers and promotions in local media will help you to fill tables during quieter months.
Business Cash Advance – Even with the right planning and management, cash flow is always a challenge. If you want to reinvest in your business, refurbish or take on a new premises for example, or if seasonality puts on too much pressure you could consider partnering with an external finance provider. If your restaurant business takes card payments and needs a cash flow boost then a Business Cash Advance (BCA) is the perfect solution. It works like a business loan but with flexible, instead of fixed, monthly repayments. You can borrow up to 125% of your monthly card takings, from £5,000 to £150,000+, and only pay back what you can afford.

industry_corpus2: Hospitality & Catering


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Sails Eatery is the best value dining option on the lake!
Serving all your bistro favourites including schnitzels, salads, roasts and regular specials all in the comfort of the best seats in the house. Boasting sweeping views and alfresco dining on The Deck, Sails Eatery is the prime location to enjoy a value meal – whether it be breakfast, lunch or dinner – with the family.


text: How exciting!!! My husband and I were just in Mason looking at the Park Inn. I am amazed it is the only hotel by frank loyd wright left standing!!!!!


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ForeScout Technologies, Inc. announced a significant increase in its European presence with the additions of key personnel to bolster customer development and support in EMEA and the DACH sub-region (Germany, Austria and Switzerland). Beyond personnel, the company has further tiered services and benefits for Gold and Silver authorised resellers to fortify sales efforts. The expansion is in direct response to increased customer demand throughout the region to enhance network security, enable BYOD and advance continuous monitoring and mitigation capabilities.
Jon Martin, UK channel account manager: Martin will fortify channel sales engagement in the UK region.
• Gael Barrez, regional sales manager, France: Barrez will lead the sales and channel development efforts in France.
• Markus Auer, regional sales manager, DACH: Auer will lead the development and implementation of new sales strategies in the corporate environment.
• Marion Feitsma, channel account manager, DACH: Feitsma is responsible for the entire channel program and distribution in the DACH region.
• Jürgen Bemmerl, global account manager, DACH: Bemmerl is responsible for the management of key accounts and directs the strategic development of global accounts in the DACH region.
• Falk Schwendike, system engineer, DACH: Schwendike is responsible for implementing and managing all technically-related customer requirements from support and product demonstration to assistance at test environments in the DACH region.
• Richard Adams, global account manager, UK: Adams is responsible for the management of key accounts and directs the strategic development of global accounts in the UK region.
• Rachel Place, regional sales manager, UK: Place will lead the development and implementation of new sales strategies in the corporate environment.
• Jolanta Popiel, Account Manager: Popiel will focus on renewal business across Europe.
• Bruce Fowlie, system engineer Global Accounts UK team: Fowlie is responsible for implementing and managing all technically-related customer requirements from support and product demonstration to assistance at test environments for Global Accounts in the UK region.
• Andrew Noonan, system engineer UK: Noonan is responsible for implementing and managing all technically related customer requirements from support and product demonstration to assistance at test environments in the UK region.
• Tim Wallen, regional sales manager, UK: Wallen will lead the development and implementation of new sales strategies in the corporate environment focusing on the finance vertical.
• Jan Hof, director of international marketing: Hof is responsible for expanding corporate and channel marketing programs, communications and alliance development across UK, France and DACH regions.
ForeScout CounterACT™ is a pervasive network security platform that enables IT organisations to efficiently address network visibility, access control, endpoint compliance, mobile security and threat management challenges within today’s complex enterprise networks. In addition, the company’s ControlFabric architecture enables CounterACT to interoperate with other leading network, security and management systems to address a wide variety of operational issues and cyber threats. The extensibility of the platform provides significant professional service opportunity for system integrators to enhance implementation value and application as well as to enable their customers to better optimise security resource and infrastructure investments.
ForeScout also recently enhanced its two-tier channel program to further align services, support and sales advantages for its network of certified Gold and Silver reseller partners across Europe. The program is designed to ensure that partners are better equipped to support enterprise and government customers in terms of sales, technical sales resources, support and professional services and will be supported by recently added personnel. A newly launched partner portal expedites partner field communications and sales support, lead distribution and deal registration, and application for marketing funds. The two-tier program, which has revenue target and personnel certification requirements, offers broader tiered benefits which include: margins, allocation of evaluation units, dedicated ForeScout regional sales and technical support, lead generation and deal protection, training and Market Development Funds (MDF).

industry_corpus2: Technology & Research


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In a food processor, combine the almonds and the confectioners sugar and pulse on and off for 40 seconds, or until powdery. Add the cocoa powder and pulse very briefly just to mix.
In a large mixing bowl, beat the egg whites to very soft peaks and beat in the granulated sugar until the mixture is glossy, 1 minute, more. Sieve the almond-cocoa mixture over the egg whites and gently fold it in, being careful not to crush too much air out of the egg whites. Using a piping bag fitted with a 1/2-inch plain tip, pipe 1 1/2-inch circles of the mixture onto the parchment-lined baking sheets. Very gently poke a whole almond into the top of each one. Bake in the oven for 25 to 30 minutes, or until firm, turning the pans around halfway through the cooking time to cook them evenly. Transfer the sheets of paper onto damp tea towels and let stand for 5 minutes, then peel the macaroons off and finish cooling them on a rack. Serve at room temperature or store in an airtight tin, layered with sheets of waxed paper, for up to 2 weeks.


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I know this feeling so well...I am not as bad as I once was. Maybe I am just older but I do get a little more proactive these days. Still, Bill is not always one who plans and does what i wish. It is tough but it is OKAY for you to say something!! 10 is a BIG anniversary!
Your trip sounds like it was such fun. And you won awards too! Congratulations! But I already knew you were amazing!
I am so thrilled about Peasnap Catering and will keep you all in my prayers and thoughts. This is a big deal!
Please give my love and hugs to AM and have her give you some back from me as well!
I am going to go work on making more money. It's the thing I have been putting off.
I am also going to make a menu for the week and COOK WHAT I SAY I'LL COOK.
And I am going to review my room cleaning plan, which isn't quite working, and see how I can alter it to make it more applicable.
P.s. I weigh 172 today! I am almost to the 160's. Woo hoooo!
Aww, gosh, you guys are too nice.
And congratulations, Wendy. I hope I have a good weigh-in tomorrow - at least our low-key celebration kept me from doing something unwise in the eating department!
Some people think I'm aggressive. I'm just really pro-active!


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At Gamut, we value each and every employee and this is the feeling you would experience from day one. We assure growth opportunities and achievement of career goals of a hardworking employee. We operate with more than 60 manned locations across India and over 200 skilled employees.
Human Resources remain our greatest asset. We identify the industry's best potential talent and carefully nurture them into well-rounded professionals. We allow their individuality to blossom and provide the right motivation along with a stimulating, cordial and challenging work environment.


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Hotel Suarel Center is located in Duitama, just 7 miles from Paipa. Guests can enjoy the on-site restaurant. Free WiFi is featured throughout the property and free private parking is available on site.
Every room is equipped with a TV. Every room is fitted with a private bathroom.
There is a 24-hour front desk, an ATM, a hairdresser's, and a gift shop at the property.