text:
It’s a long time since I made a contribution to the Regimens post as I believe the only objective way to assess a protocol is to give it time and resist the urge to keep adding modifications to the basic idea. That is what I have been trying to do.
I also believe that it took us a long time to get sick and it does take a long time to get well.
After years of following a basic premise, I admit I have tinkered a little. This has been done as a series of refinements and not by trying to fire random shots at different symptoms. My thinking is spelt out below and I have posted it in this section as it represents my reasoning behind an evolving regimen.
I will try to break this note into several sections and I hope I don’t overcomplicate it. If it is all too hard (or boring) jump to the section called “a quick recap” and go on from there. Hopefully you will see a probable path to MS that at its early stages seems very remote from the commonly held view of an autoimmune disorder.
Firstly, let me say I do have MS and was diagnosed 20 years ago. I know the way you feel when you are diagnosed and how varied the reaction of other people can be. I have known the agony of tight muscles and spasms and what it’s like to read a line of words and not remember what they say when you get to the second line. I know what it’s like to feel devoid of energy as though your body is made of cement and the embarrassment when you are alternately patronised or ignored. I know what it’s like to feel like your neck is made of steel bands but you are being strangled. Above all, I understand what it’s like to feel utterly alone while others discuss you and all you can think is “that’s not me at all”.
I hope I have some good news; despite all that went wrong with me I have recovered. Now, at the age of 56 I was able help a friend close a business recently which required us to count, box and load 40,000 books on to pallets. I worked from 6.30am to 5pm each day for 12 days straight and must have picked up tons of boxes weighing 16 to 17 kilos each. I am an office worker not a labourer. I felt no fatigue or impairment beyond what such a back breaking job creates. If ever there was a test of how well I am this was it. I do not assume my MS is cured, I just believe I have it completely under control.
To avoid repetition I suggest you look at my old post on page 2 of the regimens section called Avonex and Valtrex. It is a story of exploration not one of a conclusion. There are obviously some erroneous ideas included in it but I must have been on the right path. Most of us take a walk into a black hole with no torch to guide us or any sign of a light in the distance. We just stumble along. The note below may help you walk the through the black hole.
Last edited by Scott1 on Thu Jan 23, 2014 11:49 am, edited 2 times in total.
As I said earlier, it took us a long time to get sick. I suspect the first place to start looking for a beginning is the time when we are being nurtured in the womb. At this stage we are clearly not mature and if the mother does not or cannot feed us correctly then certain aspects of growth will be compromised. Do not blame your mother for this, she may have been carrying a susceptibility passed to her by her mother. It is not the cause of MS but it probably plays a role. This may be a genetic issue but, these days, I doubt it.
When we are neonates our adrenal system is not mature. To quote from Pub Med; “The adrenal gland is part of the endocrine system and produces hormones that are essential for survival. The adrenal cortex, the largest part of the adrenal gland, produces three major hormones. Glucocorticoids regulate metabolism of glucose, protein, and fat and allow the body to respond to stress by increasing blood glucose levels and cardiac output. Mineralocorticoids regulate fluid and electrolyte balance and help maintain blood pressure”.
“The human kidney displays a tubular immaturity at birth, with sodium waste, responsible for a negative sodium balance, and an impaired ability to reabsorb water. In the neonatal period, the human kidney is characterized by an impaired ability to regulate water and sodium homeostasis, resembling partial aldosterone resistance”.
This is an excellent summary – ( http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919537/ ).
If the Adrenals are impaired then so will be the production of aldosterone, a mineralocorticoid or steroid hormone, synthesized in the zona glomerulosa of the adrenal gland which regulates sodium conservation, potassium secretion, and water retention.
Importantly, two receptors, Megalin and Cubilin, play a profound role in a healthy renal system. Something we may not have operating correctly at the right time in development.
“Within the last few years, two endocytic receptors, megalin and cubilin, have been shown to be extremely important for this process. The two multi-ligand receptors are strongly expressed in the apical part of epithelial cells in the renal proximal tubule”.
“While megalin is expressed in many epithelial cells, it appears at present that the expression of cubilin is more restricted”.
“It is most likely that megalin can both bind and internalize its ligands, whereas the cubilin–ligand complexes need megalin to be internalized. The ligand binding is Ca2+ (calcium) dependent. The binding affinity varies considerably from one ligand to another and it is likely that the efficiency of the overall process is related to the high expression levels of megalin and cubilin in the proximal tubule, which thus constitutes a high capacity system. Some of the ligands attract special attention such as the vitamin-carrier proteins and transferrin. Thus, it has been demonstrated that the megalin cubilin-mediated reabsorption of vitamin D binding protein is responsible for the renal conversion of 25(OH)D3 to 1,25(OH)2 D3 in the proximal tubule. For transcobalamin (TC) and retinol-binding protein (RBP), the reabsorption appears to preserve vitamin B12 and vitamin A , respectively, for the organism. Likewise, iron is being captured by the cubilin (megalin)-mediated reabsorption of transferrin and haemoglobin, a process which under pathological conditions with increased glomerular filtration may be harmful to the kidney. It has been proposed that megalin, which binds calcium strongly , could act as a calcium sensor in the parathyroids. It may also be involved in the transport processing of thyroid hormones. Cubilin and megalin bind lipoproteins HDL and LDL, respectively but their role in cholesterol metabolism is not firmly established”.
This shows clearly that, from an early phase, the functioning of Vitamin D, Vitamin B12 and Vitamin A are intrinsically bound to renal tubular function as is calcium, iron, the lipids and the clearance of protein.
If all these contributors to normal healthy function are disturbed because Megalin and Cubilin are malfunctioning in the renal system it should be no great surprise that a precondition for poor health exists. It may be that we have a mutant form of Megalin or Cubilin or it could simply be a timing issue in the path to maturity. We do not know. Similarly, we do not know if this is a genetic malfunction or an environmental consequence that may involve introduced pathogens.
The adrenals also play a role in the synthesis of arginine.
Mammals at the newborn stage use their intestines to produce a product called argininosuccinate synthase. This is necessary as the mother’s milk is naturally low in arginine, a non-essential amino acid.
Producing argininosuccinate synthase from the fetal intestine allows the baby to produce arginine.
“At about two to three years of age, the intestine loses the ability to synthesize arginine as a consequence of the loss of argininosuccinate synthase expression. Subsequently, endogenous arginine biosynthesis becomes an inter-organ process, where the net production of citrulline occurs almost exclusively in the enterocytes of the small intestine and absorption of citrulline from circulation takes place essentially in the cortex of the kidney where it is converted to arginine”.
“Arginine is required by all tissues in the human body for protein synthesis, and by some tissues for specialized needs”. “There are five major pathways in which argininosuccinate synthase plays a key role. These are (a) urea synthesis, (b) nitric oxide synthesis, (c) polyamine synthesis, (d) creatine synthesis, and (e) the de novo synthesis of arginine to maintain serum levels”.
“Arginase splits the arginine to ornithine and urea, which ensures that the arginine generated by the actions of argininosuccinate synthase and argininosuccinate lyase is, for the most part, directed to urea production. Urea is excreted and the ornithine is transported back into the mitochondria to complete the cycle”.
Argininosuccinate synthase is also involved in nitric oxide metabolism. “Endothelial nitric oxide synthase (eNOS) utilizes L-arginine as the principal substrate, converting it to L-citrulline and nitric oxide. L-citrulline is recycled to L-arginine by two enzymes, argininosuccinate synthase and argininosuccinate lyase, providing the essential arginine for nitric oxide production in endothelial cells . Together, the three enzymes, eNOS, argininosuccinate synthase and argininosuccinate lyase, make up the citrulline- nitric oxide cycle”.
“In adults, the majority of endogenous arginine synthesis involves the intestinal/renal axis. Citrulline is released by the intestines followed by uptake in the kidney. In the kidneys, expression of argininosuccinate synthase and argininosuccinate lyase then promotes conversion of citrulline to arginine and its subsequent release into plasma “.
Conclusion- As we can see, in a healthy system, which matures, the expression of arginiosuccinate synthase switches from dominance by the intestines to the renal/kidney system. If this latter system fails to operate efficiently the cycle is disrupted and the body will make a compensating response. It is this response that matters. Let us not fret about this but simply accept that the healthy path to maturity is not operating as it should and is awry at an important stage of development.
In a healthy renal system we make symmetric dimethylarginine. When the renal system is faulty we make asymmetric dimethylarginine (ADMA). Asymmetric dimethylarginine (ADMA) is a competitive endogenous inhibitor of all Nitric Oxide Synthase isoforms and has been demonstrated to inhibit Nitric Oxide formation and increase oxidative stress in vascular endothelial and smooth muscle cells.
The body needs Nitric Oxide to function and if certain cells fail to produce Endothelial Nitric Oxide Synthase (eNOS) to synthesise Nitric Oxide the body will behave as if it were wounded and produce inducible Nitric Oxide Synthase (iNOS) as a response. Whilst ADMA will also inhibit the ability of iNOS to make Nitric Oxide it will have a profound impact on eNOS leaving iNOS as the most likely form of Nitric Oxide Synthase to persist.
It is the overexpression of iNOS, most probably caused by a failure of the intestinal/renal axis that presents the first step of our path to MS.
To quote Smith and Lassman 2002 (http://www.thelancet.com/journals/laneu ... S1474-4422(02%2900102-3/abstract (you need to buy it)) “Nitric oxide is a free radical found at higher than normal concentrations within inflammatory multiple sclerosis lesions. These high concentrations are due to the appearance of the inducible form of nitric oxide synthase (iNOS) in cells such as macrophages and astrocytes. Indeed, the concentrations of markers of NO production (eg, nitrate and nitrite) are raised in the CSF, blood, and urine of patients with MS”.
Conclusion - The failure of the renal system leads to the overproduction of iNOS over eNOS and the rise of ADMA. The levels of Nitric Oxide are affected and other radicals such as peroxynitrite can arise. We have seen earlier, a healthy renal system is required to synthesise Megalin and Cubilin and a defect here will lead to the malfunctioning of Vitamin D, Vitamin B12, Vitamin A, calcium transport, iron, the lipids and the clearance of protein.
It has been known for decades that glyconeogenesis was impaired if vitamin A was deficient (see http://ajcn.nutrition.org/content/9/4/36.abstract).
Whilst we may not be premature babies we may have suffered, like a preterm, from incomplete development in the renal/kidney system, as described above, and our retinol stores may be inadequate. This has significant consequences for the health of the gut.
“Vitamin A is especially critical for gut immunity, and its deficiency results in deregulated production of cytokines such as interferon and impaired antibody responses. Because the intestinal mucosa is an enriched source of cytokines that are secreted from various immunological cell types, the role of the immune system is likely to generate an aggressive physiological response to the imbalance induced by the barrier dysfunction because intestinal epithelial cells interface directly with various potentially harmful antigens”.
“It is therefore noteworthy to expect that high Retinoic Acid bioavailability in the intestinal microenvironment preferentially affects gut epithelium, resulting in a reduced incidence of life-threatening epithelial hyperpermeability of the gut”.
“The effects of endogenous Retinoic Acids are achieved primarily by two types of RA isomers (alltrans Retinoic Acid [atRA] and 9-cis Retinoic Acid [9cRA]), which are synthesized from the retinalaldehyde precursor, a derivative of vitamin A, and are mediated by two classes of nuclear receptors, retinoic acid receptors (RARs) and their heterodimeric counterparts, retinoid X receptors (RXRs). RARs are activated both by atRA and 9cRA, but RXRs are selectively activated by 9cRA. Accumulated evidence supports the possibility that atRA is an obligatory component in the differentiation of epithelial cells that leads to the establishment of epithelial integrity”.
Conclusion Without going into any greater detail on the function of retinoids, it is clear that the absence of sufficient Vitamin A, the precursor of retinoids , will have a profound effect on the epithelium of the gut. As we have seen earlier, a malfunctioning renal complex producing an insufficient supply of megalin and cubilin will be compromised in its ability to process Vitamin A. This would imply a renal malfunction exposes the gut to issues arising from permability.
It is also worth noting that 9 cis retinoic acid, which is derived from Vitamin A, is required to activate the master switch of the thyroid like nuclear receptors called the retinoid X receptor. This receptor can hetrodimerise with the other receptors to form complexes. An example of this would be the RXR/VDR complex. If RXR operates sub optimally then the functioning of the Vitamin D receptors will be compromised.
Last edited by Scott1 on Tue Feb 18, 2014 11:29 am, edited 1 time in total.
Remember, as we have seen earlier, our kidneys/renal system may not be functioning correctly.
“Calcidiol is transported to the proximal tubules of the kidneys, where it is hydroxylated at the 1-α position (lower right of the molecule) to form calcitriol (aka 1,25-dihydroxycholecalciferol and abbreviated to 1,25(OH)2D). This product is a potent ligand of the vitamin D receptor (VDR), which mediates most of the physiological actions of the vitamin. The conversion of calcidiol to calcitriol is catalyzed by the enzyme 25-hydroxyvitamin D3 1-alpha-hydroxylase, the levels of which are increased by parathyroid hormone (and additionally by low calcium or phosphate)”.
If we do not address the capacity of the kidney to convert calcidiol to calcitriol then we are wasting our time. If kidney function is impaired then we need to address the issue of Vitamin D with a reference to what has gone wrong in the renal system. This means looking at the parathyroid function and the possible causes of low calcium or low phosphate as well as the role of megalin and cubilin.
Again, we have not yet arrived at a recognised definition of MS but many of the symptoms would be recognisable. It may be reasonable to assume the precondition for a step down in wellbeing exists due to compromised renal function already described.
Superoxide is a radical. It consists of two molecules of oxygen. We need it to maintain health. The primary function is to kill invading microorganisms. It is biologically very toxic. What happens, however, if we produce too much and how might this occur? In simple terms, superoxide will contribute to the aging of cells, the build-up of hydrogen peroxide in the system, neurodegeneration, cardiomyopathy and lactic acidosis. Fortunately, the body produces various forms of superoxide dismutase to manage this but over time this naturally declines and the subsequent rise in superoxide contributes to our decline with age.
If we have an overabundance of superoxide, beyond anything the body’s natural system can cope with then there is an elevated risk that other reactions may occur. A well observed reaction occurs when Nitric Oxide interacts with Superoxide and the product of this reaction is called Peroxynitrite. Of all the radicals that can arise this is the worst.
How might Superoxide arise in abnormal amounts?
The most satisfactory explanation for the elevation of superoxide above the normal levels is the introduction of an infectious agent that promotes its production. A number of differing infections have been suggested over time but the most likely is Epstein Barr Virus (perhaps better understood as the cause of glandular fever, a common infection in the human population). Another agent may play a role but I will limit this discussion to EBV.
“EBV is a B lymphotropic gammaherpes virus that asymptomatically and persistently infects 90% of humans; it occasionally causes infectious mononucleosis in adolescents and in rare instances is associated with the development of several different types of B cell lymphoma and various epithelial tumours”.
It is not a nice infection but is usually well controlled in healthy individuals. As we seen already there are many metabolical malfunctions already in play when the renal system is compromised so we may not be healthy to begin with.
In simple terms; once you are infected by EBV it remains a lifelong infection by binding to the B cells. It is a highly suspicious element as a causative agent in many cancers.
An EBV infected B cell will be a prolific producer of Superoxide. As we make a new B cell we are actually making a new EBV infected B cell adding to the production of Superoxide as the viral load grows.
As superoxide production grows so will the production of Peroxynitrite and, as we will see, this ultimately places ever greater strain on the ability to make ATP to drive the cellular machinery.
Last edited by Scott1 on Wed Jan 08, 2014 2:10 pm, edited 1 time in total.
Szabo( http://www.nature.com/nrd/journal/v6/n8 ... d2222.html ) described a number of biological effects of peroxynitrite; antioxidant enzyme inhibition leading to a diminished ability of the cell to protect oxidant and free radical damage, a shift towards a pro-inflammatory phenotype, membrane channel impairment of the calcium pumps by oxidation and nitration causing impaired cellular calcium handling, inhibition of prostaglandin formation and imbalance of the pro and anti-inflammatory mediator pathways. Importantly, he notes the action of Cytosolic enzyme inhibition resulting in the functional impairment of Glyceraldehyde-3-phosphate, a central step in glycolysis and gluconeogenesis.
In a discussion on MS, perhaps nothing is more important than an understanding of the significance of Glyceraldehyde-3-phosphate.
To keep it simple, when we eat food we expect it to helps us make energy. This process involves a critical step using Glyceraldehyde-3-phosphate. Peroxynitrite disables this step.
As you can see, the phosphate is critical to the proper functioning of the pump. The rate at which the exchange of sodium and potassium into and out of the cell occurs is known as the gradient and rate of flow determines the amount of energy created. If the pump operates sub optimally then less energy is created and you will feel weak and fatigued. Additionally, if the pump does not open often enough the cells will become sodium clogged and the exchange of sodium and potassium in and out of the cell will be compromised. Cells will lose viability as the gradient declines. They become engorged and change shape. Blood cells are a good example to look at.
That was just red blood cells. A similar action would occur in any cell if it is deprived of the energy provided by the normal action of the sodium/potassium pump. If Glyceraldehyde-3-phosphate is disabled by peroxynitrite then we are deprived of energy.
Last edited by Scott1 on Fri May 02, 2014 1:43 am, edited 3 times in total.
Let us recap what is going wrong so far; a malfunction in the renal system means we produce too little megalin and cubilin. As a consequence we are unable to adequately process Vitamin D, Vitamin B12, Vitamin A, calcium transport, iron, the lipids or correctly clear protein. The poor synthesis of Vitamin A into retinoids means little availability of 9–cis retinoic acid to upregulate the retinoid X receptor, the master switch all the thyroid like receptors, including Vitamin D receptors. The lack of megalin and cubilin results in lower conversion of 25(OH)D3 to 1,25(OH)2 D3 in the proximal tubule of the kidney so less Vitamin D is made. Calcium, iron and the management of lipids are also disturbed. The gut wall has become permeable because of the loss of epithelial integrity due to the lack of Vitamin A regulation. The body believes it is damaged and produces iNOS in preference to eNOS negatively impacting on the vasodilating property of the walls of blood vessels. Lastly, the overproduction of Superoxide through the transformation of B cells by EBV infection leads to the production of Peroxynitrite. This potent radical disables a critical step in Glycolysis called Glyceraldehyde-3-phosphate depriving the system of the necessary capacity to produce energy in cells to allow correct respiration and maintain viability. The lack of cell viability impacts on health and particularly impacts on blood cells rendering them disc shaped and gluggy. Little wonder we can become unwell!
This is not yet a definition of MS although so much of what is already going wrong would be recognisable. Ultimately, it is the lesions found scattered throughout the brain and spinal cord, called plaques, where the myelin sheaths that surround and insulate nerve fibres have disintegrated and been replaced by astroglial scar tissue that represents the cardinal pathological feature of the disease.
Moscarello and colleagues ( http://www.ncbi.nlm.nih.gov/pmc/articles/PMC296292/ ) reported that the normal-appearing white matter of multiple sclerosis patients is unlike the myelin of other people.
“... we have determined that myelin obtained from victims of MS is arrested at the level of the first growth spurt (within the first 6 years of life) and is therefore developmentally immature.... We postulate that this developmentally immature myelin is more susceptible to degradation .... The different techniques, isolation of charge isomers, x-ray diffraction, electron microscopy, and mass spectrometry do not agree on the exact developmental age. However, it must be in the first 6 years of life, i.e., one of the two periods of active myelination (the second active period is during adolescence)”.
Behan and colleagues ( http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1168912/ ), noted a reduced anisotropy in multiple sclerosis myelin- ie water will diffuse more freely across MS myelin than normal myelin. Cell membranes and myelin should normally be natural barriers to limit the diffusion of water across white matters.
Essentially, the Myelin of MS patients remains soft like that of a child up to the first 6 years of development. Not only may our renal system be immature, so is the structure of our MS Myelin. The reason behind this remains unknown but our soft myelin does not require an aggressive autoimmune action to disintegrate. It could be a simple metabolic disturbance such as the sum of all the problems described earlier at work.
The greatest initial challenge you will have is finding the right advice. All the references I have noted are from the gold standard literature in medical research. The problem is nobody reads it. In the context of what I have described above most neurologists and doctors would seem manifestly unqualified to treat MS based purely on their own failure to read the available literature. Fear of stepping outside the accepted practice, lack of time and perhaps an element of laziness conspire to leave most practioners parroting the same advice. When a senior, learned figure stands up above the crowd and says “I have a better model” in a language they wish to hear then the bulk of the medical community will suddenly adopt the new approach just to stay with the consensus. It has always been this way but I do not see it happening in MS any time soon.
Step 1 – find a doctor with an open mind. The bed side manner is irrelevant. The only question to ask is “is this person making me better?” If the answer is “no”, then move on. Nice people can still hurt you.
What would I attempt to fix first?
Making the giant leap to agreeing with me means you would look at MS as two distinct issues; 1) a series of metabolical problems stemming from a renal impairment and 2) a dastardly infection giving rise to a collapse in cellular viability due to Peroxynitrite poisoning.
Before you can begin to do anything you need to establish a baseline of health.
As the gut has been compromised by poor Vitamin A processing you may be carrying other infections that will complicate any treatment. Fix this first. It is a matter of knowing what you don’t yet know. Get tested for anything a good doctor suspects you may have; look for chlamydia’s, mycoplasmas, rickettisias, Lyme disease, herpes family virus’s, JCV or any other pathogen your doctor suspects. Treat these first as they get in the way of everything else.
Heal the gut. The inadequate processing of Vitamin A and the consequent lack of retinoic acid has left your gut in a vunerable condition.
1)	Start drinking a large glass each day of fresh carrot juice. This provides a big dose of Vitamin A in a safe form. You will only absorb as much as you need. Vitamin A tablets are no use and you run the risk of a toxic buildup in the liver.
2)	Commence taking the best probiotic you can buy. Ask your pharmacist if there are practioner quality brands behind the counter. The more complex the mix of strains of good bacteria the better. You have to crowd out the pathogens built up over your lifetime. Medications that your doctor prescribes can kill good bacteria in the process so you must supplement with a good probiotic.
If you read my old post (Avonex and Valtrex) you will note I continued to take a standard treatment approach. I don’t for a moment think Avonex really cured me and it was really very difficult to cope with. I did find that in conjunction with another non standard treatment (Valtrex) I got better. All the big name MS treatments have been right through Phase 111 trials and have passed FDA or equivalent approvals. This doesn’t happen unless some benefit was derived. As they are so one dimensional they will not be the answer but persist as best you can as they do something and it is the sum of all treatments that will help. I know how hard this is but do it for now. I have reached the stage where I no longer take Avonex and only rarely use Valtrex for maintenance but it took a decade. A full description is in my old post referred to at the start of this note.
Last edited by Scott1 on Fri Jan 24, 2014 2:39 pm, edited 1 time in total.
Again, this becomes a choice. Do you attack the formation of Superoxide by attacking EBV or do you try to restore cellular respiration? On balance I would choose the latter but as I had to find my own way I did it the other way around. My thinking is a properly respiring cellular system will make general recovery quicker because energy is restored. I may be wrong but I can’t go back to test this. That’s your job if you wish to try.
To restore proper cell function, take Coenzyeme Q10. This wonderful substance lets ADP pick up a circulating phosphate molecule to make ATP.
Start at 150 mg before bed and increase the dose every second night by that amount. You are feeling your way here but what we are looking for is the night you wake up in the dark feeling ready to start getting up. Maybe you won’t feel this without attacking Peroxynitrite first. If there are no adverse effects gradually increase the dose. 600mg is right for me and I doubt you need any more than that. Remember, it is a potent blood thinner as it will allow blood cells to process sodium and cease being engorged. If you are on a blood thinner, such as Warfarin, check with your doctor as you don’t need to make a chemical blood thinner more potent. (Potentially dangerous).
Start taking a teaspoon of L-Arginine in water each evening. This is enough. This will allows the blood vessels to dilate and helps overcome the renal failure which prevents the formation of Vitamin D and creates gut permeability because Vitamin A is compromised. It will help boost the absorption of B12 and process proteins. You could make this step 1 if you wish depending on so many variables.
Commence attacking EBV to lower the viral load. I did this by taking 500mg twice a day of Valacyclovir (Valtrex). I did it every day for 10 years. That is a lot to take but that’s what you need to hit the EBV and keep going. This needs careful monitoring as it is an antiviral and it will attack other similar viruses. The reaction to that can be very difficult to manage. That is why you need a good doctor and the other infections treated first. This could be step 4. I did it as step 2”ish” but some people have an adverse reaction and you may need a doctor’s help.
An alternative to this step is somewhat more risky. As the EBV need the B cell to persist you could use Rituximab (a cancer drug) to blow away the B cells and take Valacyclovir or Gangliovir to finish the job. The risk in taking a monoclonal antibody is it binds to the wrong receptor with deadly consequences (hence get a really good doctor!).
Last edited by Scott1 on Thu Jan 30, 2014 3:47 am, edited 6 times in total.
“Thank God”, they cry, “I thought he’d never shut up!”.
None of this is any more than a rough sketch of what I have done. At the outset I mentioned it would take years to get well. I hope something in these notes is of help to you. As we are all at different stages then it cannot be one size fits all. Above all just look, look and look again for any infections. They can compromise everything I have described. Many of you will say what about X or Y. You didn’t mention it. What I have written is sufficient to start. I could talk about Zinc, Magnesium, Iron or other malfunctions such as the behaviour of Insulin but where do you stop. I think I covered the basics of a metabolic disturbance. If some supplements help then use them as the objective is to recover. If I truly believe I have stumbled on another important step in the story I will add to this note.
Do not ever trust the kindly doctor who says nothing can be done. A cold heartless ba*tard may be your best friend if he knows what he is doing. A good doctor understands infection and contraindications, the rest are rubbish. You deserve the best.
Last edited by Scott1 on Wed Jan 08, 2014 2:41 pm, edited 1 time in total.


text:
Ahead of the festive season, SBI has announced various cashback offers and attractive discounts. If you have downloaded SBI's YONO app, then you would have access to various lucrative deals that have been offered by the bank. Customers who will shop between Oct-16 to Oct-21 via SBI's YOLO app will be eligible for various cashback offers and exclusive deals on the digital platform.
In case you buy petrol or diesel at few selected outlets, and then pay-via Paytm-app, then you become eligible for availing cashbacks upto Rs.7500. These cashbacks would be directly credited to your bank-account. This is a masterstroke from Paytm, as prices of petrol and diesel have been rising consistently in the last-few-months, earlier this week, it breached the crucial Rs.90 mark in Maharashtra.

industry_corpus2: Finance & Economics


text:
The Holland Scholarship is financed by the Dutch Ministry of Education, Culture and Science together with Dutch research universities and universities of applied sciences. This scholarship is meant for international students from outside the EEA who want to do their master’s in the Netherlands.
* € 5,000 for the first year of your studies (No. of scholarships available will be announced soon).
* Have a look at the overview of the estimated costs of living in the Netherlands (excluding tuition fees).
If you applied in round 1, and your application was rejected, an application in round 2 is not considered.
You can only be awarded with one UT scholarship.
In order to be eligible for a Holland Scholarship, you should meet all the requirements below.
* You are an excellent student (i.e. CGPA of 7.5 (out of 10)).
* You have been (provisionally) admitted to one of the qualifying study programmes (Please note: After completion of your application, it may take up to 8 weeks before you receive the results).

industry_corpus2: Subject Education


text:
These Kurdish dvds are Kurdish films - the dvds in Kurdish are region 1, for the U.S. and Canada. If there is demand, we will look for more dvds.
2004 directed by Bahman Ghobadi. Set in Kurdistan, close to the Turkey-Iran border.

industry_corpus2: Film & Entertainment


text:
This is the 101st Fleet Disciplinary Board as it is stated in the regulation and in accordance with Articles 6 and 7 of the Fleet Regulations.
The Officer in question has been found guilty of cyber bullying another member. His sentence is to be demoted to Fleet Ensign and he will remain so for a period of 3 months in disregard of his contribution status. Further more the total of his Lifetime Contribution has been reduced to 0 and all when calculating his new contribution the total of his previous one will be deducted from it for all intents and purposes. He will be able to gain rank in the fleet in 3 months time from this day.
The Officer in Question has been found guilty by senior Fleet Command of multiple charges. Including going AFK during Fleet events in a malicious manner; Abusive behaviour towards other fleets; and bringing the 101st Fleet’s good name into question. The sentence is immediate expulsion from the fleet with no chance of returning.

industry_corpus2: Law & Justice


text:
Get all of the latest technology news and research delivered straight to your inbox the moment it's released.
Wearable medical devices are revolutionizing the healthcare field, with the global wearable medical device market set to reach $27.49 billion by 2026.
Now, Apple might be the face of this industry, but a much smaller company could be the biggest winner.
Historically, some of the biggest gains in the market come from semiconductor stocks after a period of declines.
When business is slow, the door is open for mergers and acquisitions as a remedy to withstand weakness.
After a pause in the markets, semiconductor stocks rocket higher as demand recovers.
There's a lot of volatility during earnings season.
But with 5G on the horizon, we have two 5G penny stocks to watch.
And while it has massive potential, we suggest holding off.

industry_corpus2: Biopharmaceuticals


text:
My response to your response to my response. I will not put a link to your blog. I am too fricken tired to figure out how to do it.
Good morning Jenna. I didn’t see your car in the parking lot. You are probably home sleeping. I am in my trailer eating a bagel smothered with REAL butter and pumping. Right now I am burning more calories eating and pumping than you will at the gym today. Have fun doing those squats.
ps. It is freezing on set today so I turned your heater on at your desk so it would be warm and cozy when you sat down. I mean it needs to be comfy…you might want to nap at your desk while we film.


text: 抄録: Nonwovens are used widely in technical textile applications, but it is necessary to advance apparel industry to get a further growth of Japanese nonwovens industry. In apparel applications, however, various types of characteristics such as clothing comfort, good absorbency, durability, drapeability, shape stability. Strength and elongation etc. are required. In this study, we try to apply nonwovens to apparel uses by using compounding technique for different nonwovens such as spunlace and spunbonded nonwovens. The purpose of this study is to develop the multilayer composite nonwovens which is useful for apparel clothing and medical care sheet by using compounding techniques with high pressure water jet. Especially, we measured effects of secondary water jet pressure on the pore structure and physical properties of composite nonwovens.

industry_corpus2: Manufacturing


text:
Anne's Food: HP-sauce - win a dinner!
HP-sauce - win a dinner!
Do you know HP-sauce? It's pretty popular as a condiment in Sweden (and I'd imagine, in England and other parts of the world). I usually have a bottle in my fridge, and when HP-sauce asked me to be one of the ambassadors for "HP-week" - which is next week, I gladly accepted.
And, it also means that if you live in Sweden, you can win all the ingredients used to create my recipe! I won't be able to come and cook for you, but think of it as the next best thing..? I assure you it's something really tasty, and pretty unusual!
I have never, in my entire life, tried HP sauce. A giant gap in my general knowledge.
The sauce of Houses of Parliament - haha I thought you left policits outside of your cooking Anne ;-) Even though it was called "Wilson's Gravy" after the labour prime minister Harold Wilson due to his whife Mary Wilson´s statement in a Sunday Times interview: "If Harold has a fault, it is that he will drown everything with HP Sauce" - I still like it a lot. To spice up BBQ sauces for the wonderful BBQ evenings or to give that hickory flavour to my favorite lunch baguette; smoked turkey/tomatoe/lettuce/red onion/sprouts .... Or do I even need to mention a really nice home cooked "pytt i panna" with eggyolk and HP sauce????
We use it for the pyttipanna. Even the kids like it, even though it's not ketchup!
Whenever you're frying potatoes you should have a bottle of HP Sauce on the kitchen table; whether it's French fries, pyttipanna or just good ol'fashioned råstekt potatis - HP sauce will lift it. Yum.
I usually use HP-sauce with homemade hamburgers - it is so good with the smoky-grilled meat, just a little dollop goes a long way. Also, I've learned that pyttipanna does not taste as good without the HP-sauce, it somehow brings the basic taste of the potato-meat mixture to a higher level.
In my family we use HP-sauce more than (and usually instead of) ketchup. With pyttipanna, burgers, steaks and sausage. It´s also great in marinades and dressings!
I think I have missed out on something cause I haven't tried HP sauce at all. But now I'm getting curious. I cross my fingers and hopefully I will win so I can try it.
I don't think I have had HP sauce more than just a few times. I am typically an A1 kind of girl, a similar condiment. It has recently made an appearance at ICA Maxi in Nacka. ;) Anyway, I prefer to put it on burgers with french fried onions and pepperjack cheese. Mmmm!

industry_corpus2: Hospitality & Catering


text:
In 2012, the number 343 bus caught fire outside my bedroom window in southeast London. Caught fire might be misleading. Rather, it exploded, rattling my windows, waking me up, and drawing most of the neighbours – or at least those who did not have to go off to work at 8 AM – out into the street to look. I knew the 343 bus well – it was my route to the supermarket, to my girlfriend’s house, to the cinema, the pub, the park. I, along with my fellow neighbours, rode it almost every day. It was, I thought, ‘my’ bus. So it was strange to walk outside in my pyjamas and slippers that early March morning and join the gaping sodality as the big red bus burned before our eyes.
No one was injured – that much we could tell. The ambulance was off to the side, the paramedics idle. Nor were the fire brigade in any big hurry to do much about it. ‘Best to let it burn itself out,’ one of them told me as his colleagues languidly sprayed the flames. Slowly, the big red vehicle disintegrated in front of my eyes.
I’m not sure what was more bizarre: the burning bus itself of the pictures of the burning bus – my burning bus – on news sites, in the paper, on TV. The police were not treating the incident as suspicious, which struck me as odd. Not that I suspected terrorism – not at all. But still, a burning bus, or rather an exploding bus, struck me as incredibly suspicious. A robbery of sorts. That was our local bus, I felt like shouting. And now it’s gone, without so much as a police investigation.
I’ve since moved out of that house, but I still live in the same area, and I still ride the 343 every now and then. Recently, after visiting a friend near London Bridge I decided to ride it home – something that I hadn’t done in some time. It was a rainy afternoon. Blustery. The bus was nearly full. The windows had fogged up. It would be a long journey, but I didn’t mind. The 343 is one of those circuitous buses. It traverses few main thoroughfares, choosing to snake down the suburban roads, the backstreets, all the way from City Hall to New Cross Gate. This can be explained by the fact that the 343 wasn’t always the 343. Before the route was sold to Abellio – a Dutch transport company, one of the handful of private corporations in charge of London’s various bus routes – it was known as the P3, one of those single-deckers meant to shuttle pensioners and schoolchildren from door, to shop, to door. When Abellio bought the line, they expanded the service. Now it’s one of the least efficient bus routes in all of London,among the ten worst performing in the whole city.
The bus halted in traffic at Elephant and Castle. I rubbed the fog off the front window to see the large construction site just beyond the old shopping center. This used to be home to the Heygate Estate, which was demolished last year. A few cranes swayed in the wind. A man sipped a cappuccino outside one of the refurbished shipping containers at the new Boxpark. I had no right to get romantic about the Heygate – it was a hellish, rusk-hulk of a ruin. But this too felt bleak. Just beside the Boxpark was a large digital picture of the world to come: the new development was to be called Elephant Park, and flats were officially for sale. Old London burnt up, purified by fire, making way for the boxy corporate design of condos and flats, soon to be home to white-collar workers, low-level execs, those trying to get a rung on the property ladder. A bastion of healthy living: a gym, rooftop gardens, a children’s play area – residents’ access only.
Eventually the Walworth Road unjammed, and the bus turned on to one of the small roads heading south. Ads for Elephant Park continued for another half-mile or so: large, digital illustrations of the bright, white redevelopment scheme. But the advertisements disappeared as soon as we reached the Aylesbury Estate, where a good portion of passengers alighted. I was always fascinated by the Aylesbury when I passed it on this bus: I knew it as one of the most ‘notorious’ estates, not to mention the largest social housing project in Europe, a great grey city unto itself, where Tony Blair made his first speech as Prime Minister, promising to bring prosperity to Britain’s ‘forgotten people’. But I recognized it from somewhere else, too. Television. That old Channel 4 ident, in which a camera pans slowly out onto one of the balconies, surveying the bleak ruin as a large number 4 arranges itself in the center of the screen. The estate doesn’t really look like this, of course. The Channel 4 film crew brought along a few props when they filmed this little clip: plastic bags, wet washing lines and empty lager cans were placed in the shot for effect. The satellite dishes dotting the windows were added later, in post-production.
The bus carried on past Burgess Park, through the strange residential area between the Walworth Road and the Old Kent Road. We passed rows of old Victorian terraces, a few smaller estates and a handful of new Elephant Park-style condominiums. But as we rode, I noticed something strange. Something was missing from my journey. The announcements – that was it: the bland, computerized female voice that announced each stop had ceased. The journey felt somehow empty without her.

industry_corpus2: Transportation


text:
With a Final 3 deal in place with Dan Gheesling and Shane Meaney, Danielle Murphree used the Power of Veto to save Dan from eviction. That also gave Dan the only vote to evict. He then betrayed Danielle by eliminating Shane.
If her reaction is any indication, Danielle might still be picking her jaw up off the floor.


text:
We are a team of passionate marketers and designers. Our mission is to help businesses run more successful display campaigns and to make the internet a little better for the end user.
We achieve that by doing our best to design ads and banners that are aesthetically pleasing, engaging, informative, unintrusive, providing value to both the advertiser and the viewer.

industry_corpus2: Computing & Telecommunications


text:
食物アレルギーに関する臨床医学論文リスト » アナフィラキシーにおける専門医診療とアドレナリン自己注射の系統的レビューと費用対効果の解析/A systematic review and cost-effectiveness analysis of specialist services and adrenaline auto-injectors in anaphylaxis.
食物アレルギーに関する臨床医学論文リスト > 急性期治療／Acute treatment > アナフィラキシーにおける専門医診療とアドレナリン自己注射の系統的レビューと費用対効果の解析/A systematic review and cost-effectiveness analysis of specialist services and adrenaline auto-injectors in anaphylaxis.
アナフィラキシーにおける専門医診療とアドレナリン自己注射の系統的レビューと費用対効果の解析/A systematic review and cost-effectiveness analysis of specialist services and adrenaline auto-injectors in anaphylaxis.
Armstrong N, Wolff R, van Mastrigt G, Martinez N, Hernandez AV, Misso K, Kleijnen J.
Title: A systematic review and cost-effectiveness analysis of specialist services and adrenaline auto-injectors in anaphylaxis.
Citation: Health Technol Assess. 2013 Apr;17(17):1-117, v-vi. doi: 10.3310/hta17170.
Abstract: BACKGROUND:Anaphylaxis is a severe, life-threatening generalised or systemic hypersensitivity reaction with high mortality. Specialist services (SSs) are believed to reduce anaphylaxis recurrence and improve use of adrenaline injectors (AIs), which can reduce mortality if used correctly and in time.
OBJECTIVES:To review the evidence on which persons are at high risk of anaphylactic episodes, the effects of history-taking (including signs, symptoms and physical examination) for anaphylaxis, and when (suspected) patients should be referred. To assess the cost-effectiveness of SS compared with standard care (SC) with or without prescription of AIs.
DATA SOURCES:In order to assess the clinical effectiveness, 10 databases [Cochrane Database of Systematic Reviews (CDSR), Cochrane Central Register of Controlled Trials (CENTRAL), Database of Abstracts of Reviews of Effects (DARE), Health Technology Assessment (HTA), NHS Economic Evaluation Database (NHS EED), Science Citation Index (SCI), Cumulative Index to Nursing and Allied Health Literature (CINAHL), EMBASE, MEDLINE, MEDLINE In-Process & Other Non-Indexed Citations, from inception up to March 2011] were searched without data restriction in order to identify relevant studies [randomised controlled trials (RCTs), controlled clinical trials, observational studies, prognostic studies using a multivariate model] written in English.
REVIEW METHODS:Standard review methods were applied for the assessment of clinical effectiveness. A Markov model, validated by clinical experts, was constructed, which modelled anaphylaxis according to trigger: either food, drug, insect or idiopathic. Anaphylaxis mortality was modelled as a function of time to die and time for emergency response. Probabilistic sensitivity analysis on key parameters was performed.
RESULTS:From the systematic review, 11,058 references were identified by the searches for studies assessing the clinical effectiveness. In total, 107 papers were obtained, and five prospective observational studies, including 1725 patients, were included. These studies estimated the risk of recurrence to be between 30% and 42.8%. In children (< 12 years), an overall recurrence of 27% was reported, with food being the most frequent allergen (71%). From the cost-effectiveness analysis (CEA), SC with injectors was dominated by SS with or without injectors. SS with no injectors would be cost-effective if the threshold for a quality-adjusted life-year (QALY) was greater than about £ 740 and with injectors would be cost-effective if the threshold was > £ 1800. These results were robust to all sensitivity analyses except at relatively extreme values of a small number of parameters.
LIMITATIONS:Limitations of the study include the low yield from the systematic review; in particular there were no good-quality studies of either SSs or AI effectiveness. This implied a great reliance on expert opinion in the CEA. However, this was appropriately addressed using sensitivity analysis.
CONCLUSIONS:Only five observational studies assessing clinical effectiveness were identified. Owing to the lack of good data to inform the effectiveness of anaphylaxis intervention, we recommend considerations of RCTs or at least well-designed observational studies of the components of care in SSs. The results of the CEA showed that SS with AIs was cost-effective at a threshold of £ 20,000 per QALY. More well-designed prospective studies on the effectiveness of SSs are needed to confirm these findings.

industry_corpus2: Health & Medicine


text: WARM, super-soft Gildan Heavy Blend Hoodie Sweatshirt. Relaxation done right! These cozy sweats are made from Heavy Blend, a fabric that's as soft and comfy as it is durable and good-looking. Made from Heavy Blend, a 7.75-oz. 50/50 cotton polyester blend for comfort you have to feel to believe. Double-needle stitching for added durability without sacrificing comfort. Comfortable set-in sleeves. Athletic rib-knit cuffs and waistband with spandex for a snug fit. Machine wash / dry.


text:
Good news is that if me and my wife only needed insurance it would only cost 88.00 per month for 3 cars. The ridiculous part is that just because our soon is a new driver we are being charged 100 per month for his LIABILITY insurance policy.
These insurance people at company level are a serious joke. 1200.00 per year for a ticket and accident free teen that has nver been in any trouble ever.


text:
Earphone with Remote & Mic for any Apple products with lightning connection in White. This is a Hands-free headset for your iPhone and iPod, with great sound quality and bass response. Built-in remote that lets you adjust the volume. Fits all MP3 players with lightning connection.
Astonishingly small, extraordinarily light and conveniently fits into your pocket - but don't let the small size fool you, these earphones have fiery bass and explosive sound.


text: Here we offer you a great opportunity to invest close to Pomorie, Sunny beach, Bulgaria. A plot of land suitable for building a complex from villas, located just 10 minutes away from the biggest sea resort in Bulgaria - Sunny beach resort, Pomorie and Burgas Airport. The land is situated in the village of Medovo , The site has Natural Spring Water. The site is also bordered by the Achaloy river which runs to Pomorie , Burgas district. The Plot has Spring Water on site. The plot size is 11,484 , Ideal For Spa Hotel Or Holiday Villas with swimming pools, cafe, bar, shop, car-parking. Fish filled achaloy river runs just meters away from the plot.

industry_corpus2: Real Estate & Construction


text:
2011 TRANSATLANTIC RACE FINISHES IN FORCE 10 WINDS!
Sasha in friendlier conditions! Photo by Amory Ross.
The 2011 Transatlantic Race from Newport, Rhode Island, USA to Lizard Point in Cornwall, UK, saw the final yacht finish the race in no Force 10 winds. Sasha, a 42-foot Sparkman & Steven-designed wooden yacht, experienced up to 55 knots of wind and 40-foot breaking waves in a storm that came up while on its final approach to The Lizard. The husband and wife crew of Munich, Germany had difficulty slowing the boat down, even with three reefs in the main and a storm jib. They were also taking on water and simple survival was the name of the game for them in the storm. Sasha did finally finish the race at 20:10 UTC on July 17, the last yacht over the finish line to take 5th place in IRC4 class.
Rambler 100 after finishing the Race. Photo by Mark Lloyd - lloydimages.com.
In the early hours of July 15 no less than 16 yachts finished the 2,975 mile race. Of those 16 yachts, 10 started in the second of three starts designed to see all yachts finish at The Lizard as close together as possible. Ambersail started the procession at 02:58 UTC and the Race Committee was kept busy for a further four hours while the next 15 yachts finished. Beau Geste finished 19 minutes behind Ambersail, followed by Vanquish, Sojana and Varuna, all a few minutes behind each other. The last four boats to finish the day were Snow Lion, Nordwind, British Soldier and Carina, all across the line by 06:44. After 17 days of racing, Carina and British Soldier finished less than one minute apart!
The two Class 40s, Concise 2 and Dragon, battled it out until the end with Concise 2 beating Dragon to the finish line by only 29 minutes. The two skippers agreed that it had been close racing all the way across the Atlantic, making it an exceptionally memorable event for both of them and their crews.
ICAP Leopard finished the race on the 12th of July, having broken its bow sprit only 36 hours into the race. The breakage wasn’t even report until several days after it happened but the skipper and crew kept their spirits up, thinking on their feet and improvising where necessary while enjoying the race to the best of their ability in the circumstances. Although they had no chance of winning their class as a result, they still had an excellent performance picking up the 3rd place trophy in the IRC1 Class.
Soon after Leopard, Maltese Falcon finished the race. Also not in contention to win her class, she put on an incredible performance considering she is a large super sailing yacht and not a racing machine. First place in the Open Class in which Maltese Falcon was one of only two boats went to the bright orange Gunboat Phaedo which finished the race in just under 12 days, 15 hours and 43 minutes.
Line honours went to Rambler 100 on July 10, finishing the 2,975 nautical mile race in 6 days, 22 hours, 8 minutes and 2 seconds, a new record for the race from Newport, RI to Lizard Point, Cornwall, UK. Rambler 100 did not manage to take home the top prize however. That went to Puma’s Mar Mostro, the second boat over the finish line finishing in 7 days, 11 hours and 40 minutes. Puma won IRC1 Class and IRC Overall on corrected time after all results had been tabulated.
Gunboat Phaedo finishes 1st in the Open Class. Photo by Richard Langdon/Ocean Images www.oceanimages.co.uk.
The 2011 Transatlantic Race was an exciting event enjoyed by all the skippers and crews which saw, for the most part, excellent conditions and fantastic racing with few breakages. Congratulations to all 26 yachts and crew who participated in this exciting event.
For complete results see: http://www.antiguanice.com/v2/documents/results.pdf.

industry_corpus2: Sports


text: Dogs can be miracle workers in our lives and are angels that do not judge or condemn us. They are there for us in the best and worst of times. If your heart has been broken and you feel like you cannot trust again, seek comfort from your furry, faithful best friend. With a dog at your side you can get through anything life throws your way.

industry_corpus2: Others


text: The Havamal in a pocket-sized format. Few collections in the world’s literary history present sounder wisdom than the Havamal. These Words of The High One (Othin), occasionally rise to lofty heights of poetry. It shows noble ideals of loyalty, truth, and unfaltering courage. This text (by HENRY ADAMS BELLOWS) is in the public domain because it was not renewed in a timely fashion as required at the time by copyright law. 1936 (U.S. Copyright Office online records). The footnotes, which contained attempted explanations, have been eliminated by the designer of this booklet; encouraging the reader to form their own opinions and meanings behind the verse, for each of us has his/her own truth within.

industry_corpus2: Literature & Emotions


text:
**This ebook contains a bonus vignette!
I love this series. I missed book 2 but there was no spoilers or feeling like I missed something. I do want to go back and read the second book just because the books are so great. The characters are well developed with plenty of growth in each book. The writing keeps your interest. There was more than one thing to figure out and both kept me guessing. One I had guessed right fairly early but the other I was completely off base with. The world building is fantastic and the glimpse we get in the next book shows that we will become more familiar with the "other life" that Bailey left for her new one. There's a big difference to me between moving on and actually getting closure. I'm glad that we got to see Bailey get the closure that was needed. Yeah, she had moved on from her previous romance but now, even the reader feels ready for that next step. I am also glad we saw some character development in Eric too. I'm not sure what his future is or if we will see more of him in the future, but I enjoyed how things played out there. Overall, this continues to be a fantastic series and I recommend them in any order. Recipe Included: Bailey's Peppermint Bark Thank you to Amanda Flower, Kensington Books, and NetGalley for allowing me the opportunity to read this wonderful story and share my thoughts and opinions with others.
I really enjoyed this book. I feel like this series has hit its stride and is moving along well. Is it moving in the right direction? I have some doubts. The next book will hopefully tell us yes. I received a copy of this book from the publisher in exchange for an honest review. I was not paid for this review.
It’s Bailey King’s first Christmas in the Amish town of Harvest, Ohio . After leaving New York City and her ex behind to help her Grandmother run the family candy shop, Bailey has settled into her new life and has plans for both the family business and her love life. Then her ex shows up on her doorstep with a filming crew with plans of his own. While blindsided by Eric’s arrival and his expectation for her to participate in the filming of his show, Bailey can’t let him take the rap when his producer is found murdered. The story is well written and moves at a good pace. The characters are well developed and clues are left along the way for you to guess at who the murderer is, but you really don’t truly know who and why until closer to the end. I look forward to reading the new books in this series and Amanda Flower does not disappoint. I’m looking forward to the next book in the series!
Premeditated Peppermint by Amanda Flower is the third tale in An Amish Candy Shop Mystery series. Bailey King is looking forward to a peaceful Christmas in Harvest, Ohio with her grandmother, Clara and cousin, Charlotte. They have been busy preparing a variety of peppermint candies for their Swissmen Sweets table at the Harvest Christmas Market. Then a grinch arrives in the form of Bailey’s ex-boyfriend and baker, Eric Sharp along with a camera crew. He wants to film the Christmas special of his show in Harvest with Bailey. Bailey agrees to meet the producer, Rocky Rivers the next morning to discuss the proposal. On her way to the meeting, Bailey notices a set of lights out on the gazebo. When she enters the gazebo, Bailey finds Rocky dead with the lights wrapped around her neck and Eric standing over her body. Deputy Aiden Brody quickly arrives on the scene and targets Eric as his prime suspect. Eric asks Bailey to prove his innocence before he ends up as head baker at the local prison. Linc Baggins (not a hobbit) arrives to take over production of the show and he has a surprising business proposition for Bailey. Then Juliet Brody approaches Bailey with a special request for her almost daughter-in-law (Aiden and Bailey have yet to have a first date). Juliet feels that Jethro has the face for television, and she wants Bailey’s help jumpstarting the pig’s career. Then Margot needs Bailey’s help with the live nativity. Bailey’s Christmas is quickly spiraling out of control. Premeditated Peppermint is an entertaining cozy mystery as you can tell from my summary. You will be hooked from the very first page. While Premeditated Peppermint can be read alone, I suggest reading the series in order. It will provide you a better understanding of Bailey and how she came to live in Harvest. I thought Premeditated Peppermint was well-written with a good pace. It is just the right length at 306 pages. I had been reading a different book that was dragging along (I fell asleep), so I switched to Premeditated Peppermint and quickly devoured it. Harvest is a quaint small town that has a mixture of Amish and English citizens. There are charming shops and events that attract tourists such as the Harvest Christmas Market. Bailey is a smart and talented main character. I was happy to see Bailey’s best friend, Cass pop up in Harvest to help Bailey. Juliet Brody is quite a character. She goes around town with her pig, Jethro on a leash. I can see Jethro acting as the ring bearer if Aiden and Bailey ever marry (picture Jethro wearing a cute little tux). There are many laugh out loud moments in Premeditated Peppermint courtesy of Juliet, Jethro, Eric, Margot Rawlings, and the camel, Melchior. I enjoyed the descriptions of the delectable candies being prepared at Swissmen Sweets. The mystery was interesting with a handful of suspects and misdirection. The method of murder fit in with the book and the author provided good clues to aid the reader in solving the crime. There are recipes at the end of book and a preview of Toxic Toffee. My rating for Premeditated Peppermint is 4 out of 5 stars.


text:
Walk through of a typical case with a thyroid cyst.
After several minutes the ethanol is removed.
Post PEI ablation of the cyst.
Patient leaves my center in 30 minutes and can go back to work.
Can’t same the same for surgery!
PEI done in my office for over 12 years without a single serious complication.
Call Alicia at 310-393-8860 or thyroid.manager@protonmail.com for evaluation for ethanol ablation of your symptomatic or cosmetically challenged cystic complex thyroid nodule, parathyroid cyst or thyroglossal duct.


text:
LendingUSA helps you get easy and affordable financing – so you can buy more of the goods and services you want, when you want them. All loans include zero interest rate on principal option promotion if paid in full in six months and checking your payment won't hurt your credit score!
The range of monthly payment amounts for the terms discussed above are based on aprs, which range from 16.39% to 29.99% apr. the apr offered to you will depend on such factors as your credit score, application information, loan amount, and credit history. the zero interest rate on principal option promotion includes a non-refundable origination fee of 8% that results in an apr up to 29.99%. the non-refundable origination fee will be included in the principal loan amount and withheld from the loan proceeds.
Apply at the provider's office, on your computer, or on your mobile device.
Med Loan Finance specializes in helping people with their financing needs for their Medical and Dental Procedures. With their dedicated network of partners of both secured and unsecured options, and their experienced agents, they are dedicated to finding you the best option available with some of the most competitive rates.
Apply online, by fax or phone, or at the provider's office.
Fill out Loan Search Form (This enables you to obtain the best offers including Minimum Payments of 1% of Balance).
Check loan status (Look for email notification or check status on-line at www.MedLoanFinance.com or Call 1-800-504-4053).


text:
Bill de Blasio may have just reached the magic 40 percent threshold. He also may have just missed it. With 97 percent of precincts reporting, his numbers sit at 40.21 percent. But it’s close enough that the Board of Elections will conduct a recount, one that won’t be resolved until next week.
“The voting machines are going to be opened up on Friday. The tally is going to recounted then. And the paper ballots won’t be opened until next Monday,” NY1 reported. Absentee ballots and overseas ballots also need to be tallied before De Blasio’s precise share of the vote can be finalized. Until then, the race will be in a sort of limbo, with De Blasio the presumed nominee but Bill Thompson just barely hanging on, the political version of a patient on life support.

industry_corpus2: Politics & Administration


text:
Donegal native Daniel O’Donnell has made a pledge to help the people on the Inishowen peninsula whose lives have been devastated by the torrential rain of last week which has displaced many locals from their homes and livelihood.
During his current sold-out Irish tour Daniel saw the turmoil in Donegal unfold on TV news and immediately responded to a call from local woman Deirdre Grant who was putting together a fundraising event.
A few phone calls later and the true spirit of country music was revealed as a line-up of stars emerged for “Flood Aid for Inishowen”. Daniel will be joined on stage by Declan Nearney, Johnny Brady, Dominic and Barry Kirwan, and Nathan Carter with the house band.
The highly anticipated event takes place in the Aura Centre in Letterkenny next Sunday, September 3rd at3pm.
Well known Donegal personality Noel Cunningham will host the show ably assisted by Phil Mack from the Keep it Country Music Channel. Phil has family in Inishowen so decided to fly over to give any help he can.
Daniel says that Donegal people are generous and kind, and they will come out in force to support their own. “I’m sure like myself you are all shocked and horrified but thank God nobody lost their lives” he said, “As well as the money raised we hope that the people of Inishowen will derive some sort of comfort from this show of support and that their plight is being heard”.
The organisers have been overwhelmed by the generosity of the many people who have already contacted them offering help.
Tickets cost €30 and go on Sale on Monday through local outlets and at the Aura Centre. They are also available through ticketmaster midweek and will be subject to an added service charge. All proceeds, after costs, going to the Red Cross. All artists have offered their services free of charge.


text:
Speed traps are becoming more frequent in Spain with both fixed speed cameras and mobile radars in use.
Fixed speed controls are often placed in locations of particular risk in an effort to prevent future accidents.
Please check back on a regular basis for our latest updates.
* Information is supplied to the best of our knowledge however we cannot be held responsible for errors or omissions.
* Blue Sky Super Cars recommends that you stay within the speed limits in Spain at all times.

industry_corpus2: Automobiles


text:
The circa 1771 Old Exchange and Provost Dungeon is known for being haunted, but it’s not the dead who are the scariest inhabitants of the building. The Provost Dungeon part of the museum is peopled with the creepiest mannequins around. And the creepiest of the creepy is dead-eyed Zombie Ben Franklin.
He’s actually not Ben Franklin, but I can’t remember who the guide said he was supposed to represent. Looks like Ben, though, doesn’t he.
We were up and out early on our first full day in Charleston. There are only a few museums open earlier than 10 am, and we chose to start at one of them: the Old Exchange and Provost Dungeon (they open at 9). The Exchange building has been a commercial exchange, a custom house, a post office, and a military post. It’s now a museum, owned by the Daughters of the American Revolution and run by the city. Exhibits include the prison that existed in the basement during the colonial era, when the British owned the town and the building, and elegant rooms on the upper floors, featuring exhibits on antibellum Charleston history.
It’s where George Washington danced, dined or attended a concert almost every day of his Charleston stay. “[I]n the evening went to a very elegant dancing Assembly at the Exchange,” he wrote in his diary, “at which were 256 elegantly dressed & handsome ladies.” Yes, GW had an eye.
We went from the dungeon to the top floor, where the South Carolina delegation had signed the Constitution. What I thought was another creepy mannequin sat at a desk in the corner. Then he moved.
I screamed. Then laughed, embarrassed. “Sorry,” I said to him. “I thought you were a mannequin.” He wasn’t amused. He just stared at me with zombie eyes for a few seconds before saying, “We have a copy of the Constitution you can sign if you want.” Then he looked down at his desk and resumed his mannequin pose. So maybe ….
I won’t go into detail about the Exchange, because I’ve written about it before. But I do want to mention that they’ve expanded their exhibits about enslaved Africans, focusing on the slave markets that surrounded the Exchange.
They also had some very cool items in their gift shop, specifically, Revolutionary and Civil War artifacts that they’ve dug up around town. I think the smaller of these sold for about $120.
George watched a parade from the steps of the Exchange, then walked down Broad Street to the town house of Thomas Heyward Jr., where he would stay for his week in Charleston. Heyward, a wealthy planter, was at one of his country plantations at the time and the city fathers had rented his town house for Washington.
Kathie and I followed GW’s path down Broad Street to the Heyward House, now the Heyward Washington House museum. I’ve written about it, too. But what’s new at Heyward Washington since my last visit: information about Sarah and Angelina Grimke during the tour. Sarah and Angelina were sisters from a wealthy, slave-owning Charleston family who became active abolitionists. They were raised in the Heyward house after their father brought it from Thomas Heyward in 1794.
Their story was popularized in a 2014 book, The Invention of Wings by Sue Monk Kidd., which tells of Sarah and of Hannah, a Grimke slave. I recommend the book highly though *warning* its depiction of the brutality of slavery is a difficult read. It’s a good reminder, though, in the clear light of a 21st century spring day, in a beautiful garden behind a beautiful house, of the human cost for that all that beauty.
Gallery | This entry was posted in South Carolina and tagged George Washington, Grimke, Heyward-Washington House, Old Exchange, Provost Dungeon, Southern Tour 1791. Bookmark the permalink.

industry_corpus2: Travel & Geography


text:
They only won 1-0 away to Gibraltar which sounds like an evern squeaker bum game that ours yesterday.
We put 6 past them twice btw.
Well, they have just beaten Georgia which we couldn't do, so no. We are the only team out of the 4 home nations and RoI to fail to win both opening games. We all select players from basically the same leagues so our players must be considerably worse than those available to the others.
ROI been poor for about 8-9 years now....in that time they've played at Euro 2012 and 16 and made play offs for last WC!
Coleman- Used to be their Robbo but not the same since he broke his leg. At least he has great experience to organise the back 4.
Shane Duffy- Good CB for Brighton.
Richard Keogh- Everytime I watch Derby he's awful.
Jeff hendrick- O.k Burnley CM.
Glen Whelan- Actually played o.k for us this season.
Hourihane- Great FK which he does for us on occasions. McGinn is far and away main man in Villa CM though.
Robbie Brady- Another Burnley player. Injured for most of the season.
McGoldrick- Sheff United. Think McBurnie has scored more than him this season.
I would say their best player is Matt Doherty who has been brilliant for Wolves as a right wing back. He was only on the bench last night so guess they're having the same issues in that their best two players play in same positions.
So from that plenty of championship and lower end prem players like Scotland. Difference as I've said is they can go away and grind out results. Last time out they were in a much harder group than Scotland imo and they went to Austria, Serbia and Wales and took 5 points so no 3-0 type horror shows in Slovakia.
Think aswell because they have been to tournaments in recent memory there's the mentality that no matter how bad things get they'll still be in shake up to qualify whereas with Scotland it's complete opposite.
Man for man we probably have slightly better players but they as you say are able to grind out results. Also half our best players seem to miss games or drop out for certain reasons. If we could get management right then we should be able to match their achievements. Same goes for ni and Iceland, overall inferior squad to us but able to grind out results.
We beat Georgia twice at home as well.
At the moment I'd fancy ROI to beat us.
Big Mick McCarthy knows to build teams that may not play the most exciting football but can grind out good results.
In fact NI would fancy their chances against us too.
Wait till you play them away like we did. last twice we beat them by 1 goal at home but went on to lose away both times.
ROI drew 1-1 in Tiblisi in the World cup groups...Wales snuck a 1 nil win.
Generally I’ve always thought we were mentally weaker than Ireland.
Were any of your players excused from playing on the plastic?
As a country they're much more united. The RoI isn't divided over their sense of identity.
Their state broadcaster isn't fighting a rearguard action against Irish self-confidence and political aspiration.
The fans of Ireland's biggest clubs don't hold disdain for the national team or sing "if you hate the Green Army clap your hands" etc.
Playing for Ireland really is the pinnacle of an Irish player's career. The last Irish player to have his loyalty questioned because of dodgy call-offs was, funnily enough, a Scot (James McCarthy).
While i'm at it, i should add my pet theory on why Ireland are much better at being a 'hard to beat' side than us.
It's because....wait for it.... they have better defenders!
But seriously, my theory on why they've produced better centre halfs than us is because of the GAA. All Irish footballers will have played GAA as kids (apart from the granny-rule imports maybe). It has remained a physical game (unlike fitba). It's also a game (both football and hurling) where the ball is constantly in the air. Reading a high ball is natural to Irish players.
Not sure better defenders, although our two now need way more experience. But better at setting up defensively.
Our best campaigns over the barren years were the back end of 06 and the 08 campaign. When Walter set us up quite defensively and using ferguson and faddys skill to create a little bit with the poacher miller at top. But overall we mostly defended in those games and we had our best results.
All for Scotland playing attacking football, but maybe we should wait for this team to get older and for more players to be at our top two and abroad. So for me maybe we should go back to being solid at back. Chrippers back 3/5?
or get Paul Dickof in cause he was a striker.
Well it's the difference between a 2-page thread and a 22-page one.
I assume if we play anybody ranked above us we would get humped.
Along with dozens of teams below us in the ranking, see the Kazakhstan result.
I honestly don't feel confident of us beating anyone at the moment.


text:
and all the the praise.
and the truth of the empty grave.
This is preaching the gospel to yourself.
Mark 12:42 And a poor widow came and put in two small copper coins, which make a penny.
A penny in Greek was two lepta, which make a kodrantes; a kodrantes (Latin quadrans) was a Roman copper coin worth about 1/64 of a denarius (which was a day's wage for a laborer).
Luke 21:2 and he saw a poor widow put in two small copper coins.
Greek two lepta; a lepton was a Jewish bronze or copper coin worth about 1/128 of a denarius (which was a day's wage for a laborer).
Imagine, for a second, that you are the widow. The POOR widow.
You have faith in God. He has always provided everything you need, according to His riches.
You put your trust in the Living God.
He has always been faithful.
He has always provided EVERYTHING you need.
So you trust Him, and you GIVE those last two coins. Each of them are worth about an eighth of a cent... together, they amount to a full quarter of a penny.
Not out of your abundance, for you have very little.
You give it out of faith.
Faith in the God Who Sees.
Faith in the God Who Knows.
Faith in the God Who provides everything we need, according to His riches in Christ Jesus, Our Lord.
When you find yourself in dire circumstances, do you question the Lord of All? Or do you remind yourself that He has a purpose and a plan for everything that happens to you?
Yes, God could have blessed that widow with riches.
Instead, He blessed her with poverty. He blessed her with two small coins, copper coins, worth 1/8th of a cent each.
Jesus pointed her out. Jesus taught a lesson, using the faith and generosity of that widow. He compared her sacrifice to the offering of the rich, and He told the truth: SHE gave SO MUCH MORE, for she gave out of her poverty, while the rich gave a small portion of their abundance.
Are you poor? Are you struggling?
Don't think for a minute that God has abandoned you, that He is unaware of your circumstances.
He could be using your two tiny coins to teach timeless principles of sacrifice.
I finally am writing my last post on this wonderful little book, Abiding in Christ, by Andrew Murray. You can find the original online here. I can tell you that reading and pondering this book and its principles has helped me to remember that I am IN CHRIST, that I am kept there by His power, and that I can live continually with a sense of His presence. He promised never to leave or forsake those who have been called out of darkness. Not even for a millisecond.
Abundant life belongs to those who Abide in Christ.
Jesus is seated in the heavenly places, in perfect victory and rest. He triumphed over evil, and lives in the unclouded light of His Father's presence. Everything is holy there. Everything is in perfect harmony.
As we abide in Christ, we get a taste of this glory. As we die to self and surrender to the will of God, Jesus' glorious life streams through us in works of love and goodness. Christ, seated on His throne, lovingly dispenses His gifts and watches and works for His people.
Just as a fruit tree bears fruit, and a branch in the vine produces grapes, so a Christian abiding in Christ cannot do so without feeling himself stirred and strengthened to work.
Jesus waits in expectation until that Great and Terrible day, when all of His enemies are crushed, His glory revealed to all, and His beloved people with Him forever in glory. He looks forward to that day as a Bridegroom longing for His bride. The believer who abides in Christ will share in that spirit of expectation. He will continually hope for the coming of our Lord and Saviour, Jesus Christ. Do you long to see Him?
Can a frail child of dust really dwell in fellowship with the King of Glory?
Just as it is Christ's work to save, it is His work to keep. All the believer has to do is to trust, to rest, to yield, to surrender. In faith, the soul must abandon itself entirely to the keeping of Christ's almighty power and the merits of His eternal life.
The Christian life is not a list of rules to keep or things to do. It is not a burden or an effort, but rather it is the increasing abandonment of self to the Lord, and the increasing faith that God is working, in all circumstances, to conform us to the image of His Son, and to glorify His name.
This is a quote from John Piper's Book, Exposing the Dark Work of Abortion. Click on the link and download it.
All of that happens to you when you become a Christian by putting your trust in Jesus as Savior and Lord of your life.
The rest of the story is: become what you are!
Love—out of your being loved.
Shine—with the light that Christ is in you.
So the call to Christian pro-life action is first a call to conversion—to new birth—to repentance and faith in Jesus.
Then it is a call to let your light shine in the darkness—to walk as children of the light. This is why in verse 9 Paul says, “For the fruit of light is found in all that is good and right and true.” Paul calls goodness and justice and truth the fruit of light because it grows naturally out of light. Fruit comes out of a tree because of what the tree is. That is the Christian life: becoming what you are—bearing fruit.
And the point is the same: true Christian living is essentially fruit-bearing, not essentially working. It is essentially letting the fruit show what the tree is like. It is not working to become a tree. We become a tree and stay a sound tree by trusting in the free mercy of God and all that he is for us in Jesus. The Christian life—with all its pro-life action and everything else that is good—is being what we are, God-forgiven, God-adopted, Christ-loved, fruit-bearing trees.
We are children of the light. Abortion is a work of darkness. The apostle Paul said, “Take no part in the unfruitful works of darkness, but instead expose them” (Ephesians 5:11).
God is calling passive, inactive Christians today to engage our minds and hearts and hands in exposing the barren works of darkness. To be the conscience of our culture. To be the light of the world. To live in the great reality of being loved by God and adopted by God and forgiven by Christ (yes—for all the abortions that dozens of you have had), and be made children of the light.
The Old Covenant did not secure its objective - to unite Israel and God. The New Covenant would need to secure God's faithfulness to His people, and His people's faithfulness to God.
"He likewise became the guarantee that man would faithfully fulfill his part, so that God would bestow on him the blessing of the covenant."
Jeremiah 32:40 I will make an everlasting covenant with them, that I will not turn away from doing them good; but I will put My fear in their hearts so that they will not depart from Me.
It is God Who keeps the covenant! God stands for Good for both parts!
Jesus is our Melchizedek (He ever lives to make intercession for His people)! He takes no breaks. There is never a moment's interruption. Jesus lives to pray for us and to bless us. He cannot be unfaithful!
To abide moment by moment is easy, even simple.
"Each moment of CONSCIOUS COMMUNION with Him let us say, "Jesus, our guarantor, keeper, ever-living Saviour, in whose life I live, I abide in You."
"Each moment of need, darkness, or fear, we still say, Great High Priest, in the power of an endless, unchangeable life, I abide in You.
mumble and grumble we are lazy and apathetic we are self-indulgent and greedy and we want our own way.
that You are the Covenant Keeper - that You never fail.
for praying for me for blessing me with good things for blessing me with trials.
Thank You for ordering my steps and giving me work to do that matters, in time and for eternity.
Keep me safe and pure and holy.
I am Yours, and I am grateful.
And Linda knows I'll answer her. But DO NOT think I want to do this again. Harrumph.
Passionate, articulate, redeemed, poetic, creative, wretched, contented.
Rick the night owl. And pain.
Elisabeth Elliot. Or Joni Eareckson Tada. A Woman of Faith and Wisdom.
My comfy pajama bottoms and one of Rick's T-shirts that fits over the cast easily.
Loss - of loved ones, pets, home, etc. But I remind myself of God's Sovereignty and no longer fear. I am more afraid of not finishing well.
Best things: Sharing what I have learned with others who might benefit; expressing myself in writing. I love to get feedback but don't often get it.
Worst thing: Insignificance. That what I write may not matter in the scheme of things.
I'd like to be slower to speak.
http://www.theslanket.com/ Can you say 'claustrophobic'? Ewwww… NO!
Linda I love. She is my muse.
Heather, Rachel, Elena and Rick.
It is hard for us humans to really get that. To really understand that in us, there is nothing good.
We like to think of ourselves as accomplished, talented, brilliant, capable, organized, lovely and loving people. We like to think of ourselves as spiritually-minded, moral, and good.
There is nothing farther from the truth.
The truth is that everything we do, everything we say, and everything we think is TAINTED. We do a lot of bad things, and it's fairly easy for us to acknowledge that. We think bad thoughts. We are selfish (did you ever try to beat someone to the empty checkout line at the grocery store?), proud (did you ever think you are better, more talented, more accomplished at _____________ than someone else?). We do not honour our parents or anyone above us in rank or position. We do bad things, we think bad things, every single day.
But here's the rub: EVEN OUR GOOD THINGS are tainted.
Even our prayers are not as fervent or God-centered as they should be. Even our service to others is not as pure and other-centered as it ought to be. Even our worship and praise to God fails to measure up to His holiness. ALL OF OUR RIGHTEOUSNESSES ARE AS FILTHY RAGS.
So how do sinful, God-loving, elect human beings ever hope to Abide in Christ, and to do so continually?
The only path to true life is to follow the path our Lord took before us: DEATH.
Do you long to abide in Christ? To be kept from sinning? To be in the closest possible fellowship with the Beautiful One?
Then know this: Your greatest enemy is SELF. Your greatest enemy is self-will, doing it in your own power, living the Christian life by your own flesh.
Am I prepared to say that my old self will no longer have a word to say; that it will not be allowed to have a single thought, however natural, not a single feeling, however gratifying, not a single wish or work, however right?
I can hear you asking, "What about our natural talents? Can't I use my God-given talents for the glory of God?"
Our natural powers, our God-given abilities, our talents and accomplishments CAN be sanctified and used of God, but only if they are taken out from under the power of self and brought under the power of the life of Christ.
Yield your talents, your gifts, your possessions.
Through complete surrender, offer EVERYTHING to be used by Him.
HE IS READY TO TAKE CHARGE!
Realize - you are dead to self, but alive to Christ.
Self is still strong and alive, but it has no power over you. The only time it has any power at all is when you carelessly or faithlessly consent to yield to self's usurped authority.
Realize: you were ransomed from a tyrant and made a conqueror. Self was nailed to the cross, but struggles to be free. It seeks to allure you into giving it some little liberty, or to deceive you by professing to do some service for Christ. It is a dangerous, defeated enemy. It seeks to 'serve' and look 'good' and BE SOMEONE, but nothing good dwells in it. Do not give self any quarter.


text:
Hunter’s can choose from several forms of hunting including, spot and stalk, bow hunting, rifle hunting, pistol hunting, or hunting from a blind.
Our Trophy Wildebeest Hunt offers a great opportunity for you to hunt Wildebeest at this legendary ranch.
Wildebeest are also known as gnus.
Their are two kinds of Wildebeest, black wildebeest and a blue wildebeest.
Wildebeest travel with Zebra, to help their survival chances.
Call today to make your reservations for your next Wildebeest Hunt!


text:
Hi, hello there, did you know that the rejected Bruce Springsteen song that he wrote for Harry Potter is finally seeing the light of day, just 16 short years after he first copyrighted it? Oh, I'm sorry, let me backtrack: Did you know that Springsteen wrote a song for Harry Potter that was ultimately rejected? A lot of information to absorb here, but I believe in you, and I'll wait patiently until you've taken it all in, because there's more of this journey still to come.
Ready? The song is called "I'll Stand By You Always," and Springsteen had revealed back in October 2016 that he wrote it for his son, after the two read Harry Potter and the Sorcerer's Stone together, and had hoped to see it included in one of the Harry Potter films — he doesn't specify which. However, The Boss filed a copyright for the track in 2001, suggesting he'd hoped to sneak it into the first movie, which came out in November of that year, and for some reason, Warner Bros. hadn't snapped it up.
Annnnnd not to sound like a sassy old Slytherin or anything, but now that I've heard "I'll Stand By You Always," after its Friday release on the torrent site Jungleland (along with 12 other Springsteen songs), I have a pretty good idea of why it never made it to the soundtrack. It's a fine song, it just doesn't scream "Harry Potter" to me at all; to be frank, it doesn't even whisper it. I'm almost certainly biased by the actual soundtrack, which was all magic and mystery and swelling majesty, created by the incomparable John Williams, but this song feels like it should accompany an animated feature.
Listening to it, I feel like I should be watching two lions fall in love; or Moana shoving off in a raft, set for adventure; or Andy's childhood toys getting bundled away, now that he's gotten too old for them. Take a listen for yourself, and just try to tell me I'm wrong.
Like, it's a very sweet message of friendship and support, and I love what it's bringing across, but for me, it really didn't capture any of the relationships at the forefront of the Harry Potter series. But hey, don't get me wrong: As a lover of both the movies and the books myself, I really appreciate the intent, and the thought behind the writing of this song.
I can't imagine Springsteen is in desperate need of more success in his life, but if this is a passion project that means a lot to him, may I recommend the Fantastic Beasts series? The Potter-spinoff is set to be a trilogy, so he'd still have two more chances to worm his way onto the soundtrack — hop to it!


text:
Democratic gubernatorial candidate Jack Conway is concerned about the influence that a conservative 501(c)(4) group could have on Kentucky’s fall elections and beyond.
Americans for Prosperity was founded in 2004, and was led by David Koch of the billionaire, right-wing Koch brothers fame. The group and its network of undisclosed donors spent $40 million in 2010 to wrest control of the U.S. House from Democrats.
And with the recent announcement that the group has hired a director for its Kentucky chapter, Attorney General Conway says he’s concerned that the network of “dark” campaign money will warp Kentucky politics.
So far, Conway is the lone Democratic candidate running for governor in 2015, and says he plans to use his own PAC to combat the tide of money that is sure to pour into Kentucky this fall and the next.
Conway announced Tuesday his campaign has raised $750,000 dollars since it began in early May. Hal Heiner is the GOP's only declared candidate so far, attempting to replace the term-limited Gov. Steve Beshear.
Kentucky Attorney General Jack Conway officially announced in a video press release on Tuesday his candidacy for governor, adding that he has tapped House Democratic Caucus Chair Rep. Sannie Overly, D-Paris, as his running mate.
Conway has served as the state’s Attorney General since 2008. Overly, a Democrat from Paris, was first elected to the Kentucky House of Representatives in 2008, and in 2013 became the first woman in state history to be elected Caucus Chair by House Democrats.
Conway is the first Democrat to announce his candidacy in the 2015 gubernatorial election; former Louisville Metro Councilman Hal Heiner, a Republican, threw his hat into the ring earlier this year. Former Lexington urban-county council member K.C. Crosbie is Heiner's running mate.
Citing a need to be with his family, Democratic Kentucky State Auditor Adam Edelen has declared he won't run for governor next year.
Speculation was rampant that Edelen would enter the contest, but he quelled it with an announcement Wednesday.
Attorney General Jack Conway is currently the only Democrat seeking the governor's office.
Edelen says he is withholding any endorsements until more candidates enter the race.
But he thinks Conway will benefit from greater name recognition among voters. Republican Hal Heiner of Louisville is the only Republican to announce a gubernatorial candidacy so far.
Edelen says he is “absolutely” considering running for governor in the future.
A prominent Republican says former Louisville councilman Hal Heiner will kick off his campaign for Governor Tuesday in Lexington, joining with another urban Republican for his running mate.
Former state GOP chairman Bob Gable says Heiner will introduce former Lexington-Fayette County Councilwoman KC Crosbie as his running mate. Crosbie ran for state treasurer in 2011, narrowly losing to Democratic incumbent Todd Hollenbach. Gable said Crosbie is an excellent campaigner and said Heiner's selection of her for the ticket is "ingenious."
Gable says he believes Heiner will be the Republican nominee for Governor and that he showed his vote-getting ability in the 2010 mayoral race in Louisville. Heiner lost a hard fought campaign in that 2010 race and also served two terms on the Louisville Metro Council.


text:
After having to settle for silver in the last two Olympic Games, USA athlete Allyson Felix finally got her hands on a gold medal with a brilliant run in the 200m final.
Felix, runner-up in Athens and Beijing to Jamaica's Veronica Campbell-Brown, overcame a sluggish start to lead coming off the bend and was never going to be caught, the 26-year-old clocking a time of 21.88 to finish 0.21 ahead of 100m champion Shelly-Ann Fraser-Pryce.
USA's Carmelita Jeter - silver medallist over 100m - took bronze, with Campbell-Brown fourth.
The USA then enjoyed a one-two in the 110m Hurdles as Aries Merritt stormed to victory in 12.92, the fastest time in the world this year and just 0.01 off the Olympic record set by Liu Xiang in Athens in 2004.
Team-mate Jason Richardson took silver in 13.04, with Jamaica's Hansle Parchment claiming bronze in a new national record of 13.12. World record holder Dayron Robles of Cuba pulled up injured midway through the race.
And a glorious night for the USA was completed when Brittney Reese won gold in the women's Long Jump.
Russia's Natalya Antyukh won the 400m Hurdles, the 31-year-old just holding off USA's Lashinda Demus at the finish.
Antyukh recorded a personal best of 52.70 to finish just 0.06 outside the Olympic record held by 2008 champion Melaine Walker, with Demus setting a season's best of 52.77.
Czech Zuzana Hejnova claimed the bronze medal just ahead of Jamaica's Kaliese Spencer.
Usain Bolt also eased into the 200m final. The 25-year-old looked impressive, effectively winning his semi-final before halfway and almost jogging down the home straight to win in 20.18.
Jamaican team-mate Yohan Blake was the fastest qualifier after also slowing down markedly in winning the opening semi-final in 20.01.
World record-holder Ashton Eaton enjoys a 220-point lead over team-mate Trey Hardee after the first day of the gruelling Decathlon.