text:
The new Su-35 Flanker-E multi-role fighter will be put into service with the Russian Air Force in two-three years, the head of the Sukhoi aircraft manufacturer said on Wednesday.
ZHUKOVSKY (Moscow Region), February 20 (RIA Novosti) - The new Su-35 Flanker-E multi-role fighter will be put into service with the Russian Air Force in two-three years, the head of the Sukhoi aircraft manufacturer said on Wednesday.
The Su-35 is an advanced air superiority fighter powered by two AL-37F engines. It combines high maneuverability and the capacity to intercept air targets with ground and sea attack capability using both unguided and guided, including high precision, weapons.
"I think we will start deliveries of the Su-35 to the Russian Air Force in 2010-2011. We are also planning to promote this fighter on our traditional markets in Southeast Asia, Africa, the Middle East and South America," Mikhail Pogosyan said.
The Sukhoi said the price for the new fighter "will be quite competitive."
"I am certain that we will be able to keep the competitive edge while reducing the price [of the aircraft]," he said.
Pogosyan said the first prototype Su-35 successfully completed flight tests on February 18, and two more aircraft were being prepared for similar tests at an aircraft manufacturing plant in Russia's Far East.
"The tests met our expectations; all systems performed in line with specifications," he said.
According to Pogosyan, the Su-35 is the first step toward the development of the fifth-generation fighter and its electronics allow testing of equipment to be installed on future aircraft.
"The full development cycle for the [fifth-generation] aircraft takes 7-10 years. We have walked a third of the road," Pogosyan said, adding that the first prototype of the fifth-generation fighter would be built in the next few years.
Sukhoi, which is part of Russia's United Aircraft Corporation (UAC), is planning to export over 40 combat aircraft in 2008, the company head said.
In 2007, Sukhoi exported about 50 Su-30MK2, Su-30MKM and Su-30MKI aircraft in addition to spare parts for aircraft sold earlier to Algeria, India, Malaysia, Indonesia and Venezuela.
The company said on January 30 that its overall sales in 2007 exceeded 50 billion rubles (over $2 billion).

industry_corpus2: Aerospace


text:
Learn the definition of concussion, including the warning signs and symptoms. Find out how a concussion is diagnosed and treated.
To learn more about the warning signs and symptoms, as well as how to properly diagnose and treat a concussion, visit our health information page about concussions.

industry_corpus2: Health & Medicine


text:
Tailormade Interiors, Lampshades & Lamp Finials, listed under "Lampshades & Lamp Finials" category, is located at Serving your area Kambah ACT, 2902, Australia and can be reached by 0262315255 phone number. Tailormade Interiors has currently 0 reviews.
Browse all Lampshades & Lamp Finials in Kambah ACT.

industry_corpus2: Manufacturing


text:
By weighing customer satisfaction, popularity, and special offers, we’ve compiled our top recommended TV providers in Oakland. Take advantage of our years of researching and reviewing these companies to see the best one that’s right for you.
We make it easy to browse the highest-rated providers available in Oakland so you can see the channels, packages, and prices that each has to offer. Seeing and comparing features is especially beneficial if watching professional football and basketball games is a priority for you, or if you like to keep up with the hottest new shows and series.
Generally, major networks are available everywhere, but TV packages in Oakland might have a different selection of broadcast channels compared to similar packages in other cities. By comparing prices, packages, and features with CableTV.com, you’ll have no problem selecting the best TV service provider in Oakland, NJ, for your needs and budget.
If you want to know more about TV companies in Oakland, NJ, start your search at CableTV.com. Our TV provider ratings are based on multiple factors, including customer service and reliability. That means our ratings can boost your chance of finding a provider with a channel line-up and customer service record you’ll be happy with.
The highest-ranked company of all Internet Service Providers available in Oakland, NJ, is Verizon.
It’s important to think about speed when looking for the best internet provider in Oakland, NJ. In areas where Verizon Fios Internet is available, you can stream your favorites virtually lag-free on a fast and reliable connection—brought to you on Verizon’s 100% fiber-optic network.
Sorry, no stores were found near zip code 07436 for the provider selected.

industry_corpus2: Film & Entertainment


text: Our Vinyl Siding installations services in Kintyre, ND have been designed to enable you have peace of mind by eliminating your concern about timely and reliable service providers. You will also notice that Vinyl Siding Guys also have very affordable Vinyl Siding rates that won’t cause any financial strain when you are contracting us for the installation. Vinyl Siding is a well-known choice for homeowners who would like to enhance their home's appearances without painting. Considerations when considering Vinyl Siding. - There are many gains to installing Vinyl Siding in your house.

industry_corpus2: Real Estate & Construction


text: American Heroes was Gregg "Viz" Visintainers way to pay tribute to all five branches of the Military. He wanted to capture an image that would make veterans and soldiers proud. This is his way of saying thank you for protecting our freedom. Digital prints are 11" x 14" and printed on 120# silk cover, archival and acid free paper. Print comes with a white backing board and plastic sleeve for protection, which also makes it easy to display.

industry_corpus2: Others


text: New old stock American made JAEGERS doublet achromatic objective 102mm dia X 18mm edge thickness. Uncoated. No cell (Fits perfectly in 4" ID thinwall PVC drainpipe). 900mm focal length (f/9).


text: The Roland SP606 is the last in the series like the 202, 303,404, and 505 but there are some great improvements. First we turn the SP606 around and checkout the back, and see what cables we need to set it up. So get your USB , MIDI, and 1/4 inch audio ready and if you need to keep it low get those headphones out. Next we look at the front, we checkout the D-Beam that's on other Roland machines , like the fantom, it sends a beam of light and when your hand passes over it you can trigger any sound you select. In we explain how each button works and explain how the software works with the buttons this will make it easier for you to understand and use the SP606. Next we make up a beat to show you how easy it is to program a sequence, we use the sounds and built-in loops, to create, and copy, the pattern. When ever you make up a pattern you might want to edit some parts out so we go thru the process to do the edit. Then we go right to sampling we pull out a sample kings CD and sample a beat to edit and loop.

industry_corpus2: Computing & Telecommunications


text:
35W, 35T71/2/CD, 120V, Clear Finish, Tubular Light Bulb, Candelabra Base, 3.625" Maximum Overall Length, 190 Lumens, 1,500 Average Rated Hours, Carded.
20W 12V T3 JC Clear Halogen Xenon Bulb Low Voltage Maximum Overall Length 1-3/16" G4 Base 300 Lumens 10 000 Average Rated Hours Carded.
Sunlite 01326-SU 15CFC/25/CD2 Incandescent 15-Watt, Candelabra Based, Petite Chandelier Bulb, Flame Tip, Clear, Carded 2 Pack.
Westinghouse Lighting Corp 40W, 40T8/IN/MW/CD, 120V, Clear Finish, Microwave Light Bulb, Intermediate Base, 2.625" Maximum Overall Length, 195 Lumens, 1,000 Average Rated Hours, Carded.


text:
Recipe is super simple. I took an “Original” Rotisserie Chickens from HEB (or use any unseasoned rotisserie chicken) If you can’t find unseasoned one just don’t put skin in pan. Pull the chicken and skin off the bones, and then pull it apart with your hands. MAKE SURE TO LEAVE THE SKIN IN THE PAN. Then I add our Adkins Western Style BBQ Rub or Adkins Ranch Style Steak Seasoning or a mix of the 2. I’d say a couple tablespoons. I just do it to taste. After you add the seasoning mix it very well. Then add 1-2 cups of low sodium chicken broth let it warm back up then serve. You can put on tacos, sandwiches, salads, enchiladas, burritos, or just eat it as pulled chicken.
Season chicken set aside. Best if you let seasoning sit over night. Cut potatoes into small pieces let soak in cold water for 10 minutes drain and dry off. Toss potatoes in bowl with oil and Rosemary Seasoning then spread across bottom of pan. Place seasoned chicken on top of potatoes. Cut zucchini & squash into big pieces toss in bowl with Rosemary Seasoning and oil then put around chicken. Bake for 40 minutes.
Dice half onion. Add to preheated 12’ cast iron skillet with two tablespoons Avocado oil cook 5 minutes. Add spinach cook 2 minutes add seasoning and cook until done. Stuff spinach in cooked corn tortillas add cheese if you’d like.
Add ½ Cup Avocado Oil to 8inch Skillet (preferably cast iron) on medium-low. Lightly fry corn tortillas 30 seconds a side. Fill corn tortillas with filling rollup, put in pan top with sauce then bake 15 minutes in a preheated 350 degree oven.
Combine Corn, Mayo, Adkins Chili Seasoning and Lime juice to taste to pan. Cook on Medium heat until warm and well combined.
Combine Corn, Cream Cheese and Seasoning in pan. Cook on medium heat until warm and well combined.

industry_corpus2: Hospitality & Catering


text:
During our home selling efforts, Len and I took the opportunity to review our net worth. Anemic by many people’s standards, we’re glad our “portfolio” isn’t made up of finances alone.
We enjoy a different type of wealth — the recession-proof kind that retains its value regardless of the economic climate.
Holy Toledo — we’re not rich, we’re downright wealthy!
One of my friends, Donna Jill Witty, recently returned from North Carolina where part of her time was spent gem mining near Ashville. Much to my surprise and delight, she gifted me with three raw pieces: emerald, sapphire, and citrine. Since green is my favorite color, emerald is the gemstone that I chose to highlight in this post.
But first, please follow this LINK so that I can introduce you to Donna Jill Witty and her amazing artwork. I’m tickled to share that she was featured in the current (summer 2010) edition of the American Artist Watercolor magazine. The article, Mixing Careful Planning with Spontaneity, starts on page 42.
The frequency of Emerald is said to enhance harmony, joy, cleansing, abundance, clairvoyance, memory, and faith. It provides inspiration and helps those in need of balance, healing, and infinite patience. It also benefits intuition, intellect, communication, decision-making, and promotes truthfulness and honesty. It motivates the possessor to give love and wisdom to others. Emerald is used to enhance intuitive awareness and to bring forth manifestation. It’s a stone of protection and is associated with the heart chakra.
Abundance is something that brings a return value to the heart. It benefits your inner self—body, mind, and spirit—with intangible dividends. Examples include love, peace of mind, health, wellness, wisdom, integrity, respect, quality relationships, joy, gratitude, humor, a positive attitude, and contentment—being satisfied. Abundance is inner wealth.
Prosperity is something that brings a return value to the wallet and/or bank account. It is on the outside of self and has tangible dividends. You can touch it, hold it, drive it, live in it, wear it, swim in it, take it to the bank, or deposit it. Examples include money, jewelry, real estate, cars, boats, recreational vehicles, collections, and investments. Prosperity is material wealth.
I am open to receive spiritual abundance.
I am open to receive financial prosperity.
Thank you, and so it is.
Our physical body systems are interdependent with our emotions, thoughts, and spirit. They operate as a whole. What we think, how we feel, our actions, what we ingest, where we work, the people we associate with, and our environment all have an impact—positive or negative—on our inner ecology.
Inner ecology includes the mind (thinking), emotion (feeling), and spirit (essence).
I believe that when we make the time to explore and nurture our inner landscape—cultivate our inner terrain—some of the many dividends include peace of mind, a healthier physical body (the package we currently reside in), and inner wealth.
We may not have large sums of money, but we are rich beyond compare.
Do you nurture your inner ecology?
Yin energy is represented by black.
Its nature is feminine, receptive, calming, cooling, negative and feeling.
Yang energy is represented by white.
Its nature is masculine, projecting, stimulating, heating, positive and thinking.
The idea is that these two energies are what cause everything to happen—ideally in balance. When fit together, the overall shape gives a sense of continual movement.
Out the is used to convey an extreme amount, abundance, or all over the place.
Any time we experience balance, that’s a good thing. Anytime we experience an abundance of balance, that’s a really good thing; it’s out the yin-yang!

industry_corpus2: Finance & Economics


text:
Clarksville, Ark.-The women's swim team was upended by Henderson State University 133-72 Saturday.
Paige Vire won the 100 breaststroke with a time of 1:14.51. While Vire was the only winner of the day, the Eagles had numerous events in which they finished second. Kaitlyn Henrietta was second in the 200 free with a time of 2:14.49. Shalley Coffin was second in the 100 backstroke with a time of 1:15.34. Paige Vire was narrowly edged in the 50 breaststroke with a time of 32.75. Catherine Wellborn was second in the 100 butterfly with a time of 1:11.75. Henrietta was edged out in the 100 free with a time of 59.98. Henrietta placed second in the 50 butterfly with a time of 30.42. In the 50 free, Henrietta was second with a time of 27.60. Coffin was second in the 500 free with a time of 6:08.96.
Seniors Kaitlyn Henrietta, Brenda Sandoval and Jacob Toland were honored as part of Senior Day.
The Eagles will now prepare for the SCAC Championships in San Antonio February 13-16.

industry_corpus2: Sports


text:
Syntax for mixing `use` Closure clause with return type declaration doesn't seem to be documented anywhere.  It's then unclear whether the `use` clause should come before (where PHP7 actually wants it) or after (where HHVM wants it) the return type hint.
As this not only isn't obvious, but also is inconsistent with what HHVM supports for some time, it seems very useful to me to document this clearly.


text:
Successful client advocacy begins with a successful attorney. Attorney Tim W. Avery has nearly 20 years experience handling simple and complex legal problems in the practice areas of criminal law and family law. As a former prosecutor, he is able to evaluate his clients' cases from both sides, anticipating the tactics of the prosecution and developing successful defense strategies to counter their approach. Whether you are facing a sensitive family law problem or need a skilled criminal defense lawyer, you can count on our firm to listen carefully to your concerns and objectives and work diligently in pursuit of your best interests.
Contact the Law Office of Tim W. Avery today for experienced legal advocacy from a trusted family law and criminal defense lawyer. We are available for evening and weekend appointments when needed.

industry_corpus2: Law & Justice


text:
Our largely online programme is designed to allow you to study without the need to take time out of work. However, our blended modules provide short workshop elements for some of the more practical elements. If you intend to work towards a full Masters you will also carry out a research project.
If you are on a low income you may be eligible for help with the cost of travel or dependent care in order to attend workshops.
Which Modules Should I take?
You can start with which ever module most interests you and take as many or as few as you like, either as CPD [link] or to build towards a range of post graduate qualifications [link]. We will be adding new modules every 4 months so there will be plenty to choose from – and if you have an idea about a course you’d like to see provided, just let us know.
Blocks of modules are delivered in a rolling programme, with start dates in January, May and September. The blocks are repeated each year to allow you to cover all your module choices over your years of study: if you are unable to take one in any year you can take it in the next.
Our modules are designed to be flexible so that you can fit studying around your work and other commitments. Our students report spending 10 to 15 hours a week per module studying.
If you are working full-time we strongly advise against taking more than one module at the same time, at least until you have completed one and are aware of the workload entailed.
There are no exams. Each module contains one practice assignment and two assessed assignments. These include tasks such as: completing a report as if for a trade journal, reviewing the latest literature, data analysis, essays, process design, digital stories or online presentations. Each module also hosts a weekly forum and you will be required to submit your best forum posts for assessment.

industry_corpus2: Subject Education


text:
That which can be appraised, assessed, or adjusted through the application of a formula or percentage.
Ratable property is that which is taxable or capable of being appraised or assessed.
adj. taxable according to value, such as an estate or property.
The regulations may provide that income realized before the change date from discrete sales of assets would be excluded from the ratable allocation and could be offset without limit by pre-change losses.
The regulations maintain the general rule of ratable allocation but allow for a closing of the books election made on a timely filed return.
Thus, it makes no sense to attempt to determine the ratable share of E&P in a corporation in which the shareholders do not have any stock ownership.
382 limitation while, under ratable allocation, some portion of the loss would be allocated to the prechange period and subject to limitation.
The notes underlying these securities also now enjoy ratable sharing in the pledge of Meditrust Corp.
736(b) payments to be made to a partner is fixed, however, the partner may determine the amount of gain or loss attributable to each payment by applying a ratable portion of his basis in the partnership interest to each payment.
The agreement expires on June 10, 2002, and is secured by a lien on most of the Company's assets on an equal and ratable basis with the Company's senior notes.
Payment method: The payment method applies to all taxpayers that have not elected the ratable accrual method and that have not elected the recurring item exception.
Pursuant to the US Lines Plan of Reorganization, which became effective in 1990, the former unsecured creditors of US Lines became entitled to receive ratable portions of 5,000,000 shares of the Company's Common Stock.
It will be important to identify at the top of the statement, "REQUEST TO CHANGE TO THE RATABLE ACCRUAL METHOD FOR REAL PROPERTY TAXES UNDER REV.
Clarus anticipates that approximately 90 percent of its license business will be contracted under agreements requiring ratable revenue recognition.
2 million (approximately 80%) of those shares into escrow with the Company's law firm, to be sold in a ratable fashion over the next four years once the various investors' Rule 144 holding periods expire.


text:
Wow. It's been a crazy summer so far. I have tons and lots and gobs of pictures and stories I could share to catch up, but I'm just checking in really quick right now. Maybe I can actually get something more productive than a load of laundry done before the rest of the house wakes up.
All but 3 of the 9 puppies are spoken for. It' s been a crazy couple of days around here with puppy sales and visits. But really fun. I'm watching one play in the early morning light of the kitchen right now (the one I got up with at 6:30 this morning becuase she was weeping and wailing). She's playing a tugging game, playing with a birthday baloon, her tail, chewing Kayla's flip flop- too cute. No idea why she won't sleep. Now she's biting my toes.
Another confirmation email just came in for a puppy that needs shipped (by air) to Pennsylvania. If this one and the one being shipped to California both go through, we've only one puppy to go. But the shipped puppies will hang around here for 2 more weeks because they aren't allowed to fly until they're 8 weeks old. That will help the kids with the transition of seeing so many puppies walk out that door within just a few days.
Corin is due in two weeks. We're anxious and excited, but strangely okay with the fact that he hasn't come yet. It's working out well that the puppy rush came before the baby rush. We're supposed to meet a Michigan buyer north of Chicago to deliver a puppy on Tuesday. Maybe the travel of the day (which happens to be my original due date) will get this show on the road. Well...hopefully not LITERALLY on the road!
In other news: Karissa turned 5 yesterday. We've had 4 out of 6 of our summer birthdays. We're a summer-born family, for sure - see?
We plan summer babies because of David's school schedule and my teaching schedule. And ever since we've been having babies, David's been in school.....hmmm. Maybe I'll leave that one alone without comment this morning.
I had a very short night, so I'm in severe danger of some serious rambling here. I'd better sign off before my fingers get going faster than my brain.
Just wanted to say hello to the great black hole of bloggerdom.
Hello from the great black hole! Hoping your labor is convenient, quick and easy, and that this baby is colic-free ;o) Love you.


text:
Having endured a poor start to the County Championship season following promotion, the hosts may well be pleased to get away from it all.
Surrey are a side full of promise – both in young exciting players and experienced names – but are yet to enjoy themselves this season. Despite their status, Division One has proved very difficult so far, with three draws and three defeats leaving them rock-bottom of the league.
The latest defeat – a three-day thrashing by Lancashire – underlined the weakness of Michael Di Venuto’s side as they picked up just three points against a side who have taken to the league much better.
But as we well know, T20 cricket is a different kettle of fish and Surrey will take confidence from their opening Blast fixture in which they held off Essex to win by eight runs. Veteran Azhar Mahmood was the star, taking 4-38 with the ball to go alongside his 42 runs with the bat.
They will take on a Glamorgan side who have yet to play in the shortest format this season and are experiencing a similarly dire start to the four-day campaign. Like their opponents, Glamorgan are bottom of their division, with three draws and three losses in the County Championship.
However, the Welsh side opened their 2015 T20 Blast season with the same fixture and will take confidence from that game, in which they posted a truly ridiculous, club-record total of 240-3 in a 25-run win.
Neither side made it out of the group stages last season and will obviously be looking to get off to a quick start this season in front of the Sky cameras.
On his day no-one is more effective – and better to watch – than Surrey’s Jason Roy. The England opener made a brisk 25 against Essex, including a trade mark glorious straight drive, before the all-too-often mode of dismissal struck as he spooned into the offside. Despite his inconsistencies, memories of his 122* from 65 balls against Somerset at the Oval last season, and his 141 career T20 strike-rate, remains a source of optimism for the home fans.
The away side’s batting line-up will rely heavily upon the fortunes of Jacques Rudolph. The experienced South African scored 461 runs in last season’s competition – the seventh-most of any batsman – and, at 35, is still a quality player at the top of the order. Rudolph, like the rest of his team mates, will have fond memories of the Oval where he smashed 62 to get the team off to a flying start last season.
Zafar Ansari returns to the Surrey squad after a thumb injury, but Rory Burns in unavailable after receiving a blow to the head while fielding at short leg against Lancashire in the County Championship. Overseas signing Dwayne Bravo is still away on IPL duty.
Glamorgan have completed the signing of Dale Steyn, but unfortunately won’t be able to call upon him for their opening game of the season, as he’s still in India with the Gujarat Lions. However, Colin Ingram, who wacked 91 in last season’s fixture, is fit and raring to go.
The forecast, thankfully, is for dry and even sunny weather in south London, meaning the game underneath the flood lights should not be hampered by late spring rain.
The pitch meanwhile has always presented an opportunity for the batsmen with the aforementioned 465-run fest of last season testament to the road-like wicket. In fact, two of the three highest scores from last season were scored by away sides at the Oval.
However, there has been wet weather around recently and early-ish season conditions aren’t always conducive to batsmen launching the ball into the night sky at ease.


text:
On this page you will find a list of online shoe retailers where you can buy size 19 boots for men. If you fit size 19 boots then the number of options available to you are less than those with size 15, size 14 and size 13 boots but there are still a small number of retailers out there that cater for you. The types of boots that you can find include Chelsea, leather, chukka, suede and many others.
Do you stock size 19 boots for men for people to buy online and want to be listed below? Contact us.


text:
Intellectual property (IP) enjoys specific legal protections. The University of Stuttgart has made protecting the rights of all parties to the research process a strategic goal.
Scientists at the University of Stuttgart year in year out produce groundbreaking research results. Their discoveries, especially inventions, patents, and trademarks, can often be put to a variety of commercial uses. The University prefers to license them rather than sell them outright. We stand ready support your commercialization efforts by collaboratively developing technologies that we license to you into market-ready products.
Research findings are intellectual property; fundamentally, they belong to those who produce them. The University of Stuttgart has set down in an IP strategy (german) how to manage this intellectual property.
The IP strategy is designed to safeguard the interest of all parties involved: researchers, the University itself and its cooperation partners. It makes knowledge and technology transfer possible without putting limits on academic freedom.
Goals of the IP StrategyIn principle, research findings will be disseminated in a timely manner, especially in relevant professional journals or by registration of IP rights, so that the discoveries achieved are widely disseminated.
Utilization of research results as the basis for further research and in teaching will be ensured.
Research results that can be commercialized are to be protected by patent or trademark filings, for example, before being publicized. Until then, they are to be kept under wraps by internal nondisclosure.
The economic value of research results is to be safeguarded by direct or indirect, self- or third-party commercialization at market rates.
TTI Technology Transfer Initiative GmbH supports the spinning off of University-spawned startups that develop goods and services based on discoveries made at the University.
Upgrades of existing cooperative arrangements between individual institutes and companies to long-term partnerships and alliances at the university level will be monitored continuously to reinforce existing research emphases and identify new research priorities.
Internal regulations apply for the realization of the IP Strategy. The regulations can be found in the additional elucidatons Realization of the IP Strategy (german).
Classifying research findings as intellectual property preserves the owner’s rights in intangible goods – for example, research outputs such as inventions, processes, copyrights (e.g. for computer programs), designs and the know-how related to them – whether or not they can be patented or trademarked. Fundamentally, the rights to intellectual property are vested in whoever produces it. If required legally or contractually, these rights may be conveyed to an employer or client on a case by case basis.
This is the preferred model, since it lets the University of Stuttgart retain ownership of the intellectual property. This makes it easier to accommodate the differing needs of individual cooperation partners.
This model may be used only in exceptional cases (e.g., with contract research) if justified by circumstances. To be kept in mind here is that it very much complicates continued research activities with third parties in a particular field.
These options are considered when entrepreneurs want to turn concepts spawned in the University of Stuttgart into products or services.


text:
(3/14/19) Simek will undergo knee surgery to repair damage to both his ACL and MCL and has no timetable to return.
Simek's leg injury comes at a terrible time for the Sharks, as he'll undoubtedly miss extended action because of the issue. With the playoffs about a month away, there's a good chance Simek will be sidelined for the remainder of the regular season and at least part of the postseason. The team should provide a better timetable for his recovery once he's on the recovery path.
(3/12/19) Simek left Tuesday's game versus the Jets with a leg injury, Kevin Kurz of The Athletic reports.
Simek's leg bent in an awkward way as he went to the ice, and he's not expected to return to the contest. The 26-year-old was working on a defensive pairing with Brent Burns, although he wasn't producing much with just nine points in 40 games. Expect Joakim Ryan to enter the lineup for Thursday's meeting with the Panthers if Simek can't shake the injury.
(2/8/19) Simek notched an assist while logging 18:22 of ice time during Thursday's 5-2 win over the Flames.
Simek hadn't registered a point since Jan. 19 prior to Thursday's contest, so it was nice to see him snap his four-game scoreless streak. However, the rookie blueliner has only totaled eight points in 26 appearances this season, so he doesn't warrant consideration in most fantasy formats.
(1/8/19) Simek returned from a concussion and recorded two shots on goal, a hit and a blocked shot during 18:09 in Monday's win over the Kings.
Simek returned to the Sharks' bottom pairing and clocked a season high in ice time. He hasn't been much of a scorer this season with five points in 15 games, but he has a solid two-way, physical game to add plenty of value on the team's blue line.
(1/7/19) Simek (concussion) will suit up for Monday's home contest against Los Angeles, Jon Rosen of Fox Sports West reports.
Simek was injured late in a loss to Calgary on New Year's Eve and has missed two games since then. The Czech rookie has a goal and five points in his first 14 NHL games, all coming during the month of December.


text:
As a condition of function hire, all hirers are required to use only approved surf club caterers. We have selected a range of local caterers and function management companies with a wide range of offerings. Feel free to take a look through our list of caterers/function managers.
Head Chef Kate Hoskins, Event Coordinator Scott Foster and the eQuality Catering team deliver their service with warmth and professionalism, to make your day a truly memorable experience.
At eQuality we prefer to design a menu with you to suit your style, flavour and budget. We only take on one event per day. This essentially means that you will always get our best team catering and staffing your event.
Byron Bay Weddings is a collective of Byron’s most experienced, creative and innovative wedding coordinators, stylists (The Wedding Shed) and caterers (Fig Tree & Feast Events).
Our team of experts combines all the elements needed to seamlessly bring together an epic, unforgettable wedding. With a wealth of local and international experience, we ensure the process of having a wedding in Byron Bay is easy, enjoyable, stylish, tasty and above all fun.
Seaweed cuisine is a fully licensed wedding + event catering company based in beautiful Byron Bay. Seaweed cuisine has earned the reputation for excellence in catering since 2001, with fresh, personalised menus and the very highest level of customer service.
We bring you our own distinct style, balancing international flavours with hand-picked seasonal produce direct from our local farmers, with a fantastic range of fresh seafood caught daily from the clean waters of Byron Bay and the option of matched wines and beverages.
Eat Drink’s philosophy is affordable abundance, best of season, prepared with love. We create catering solutions unique to your event, from shared feasting tables to you & the chef food stations.
Every element of your day is taken into consideration & our many years of experience guarantee you seamless service throughout.
The Larder Team are proud to consistently lead in this game, monitoring present food trends and offering top notch culinary services. We guarantee to make others envious of your event!
As caterers who are a favourite to numerous exceptional event areas, we can make your planning even more easier. Whether it involves fresh and fast company catering drop offs, conference and boardroom support or cocktail parties that are tailored and more official functions, The Larder Catering promises high quality seasonal and locally sourced produce, unique food ideas and expert service.
100 Mile Table is a Byron Bay based catering company creating unique feasts and celebrations. We utilise the abundance of great local produce in the Northern Rivers region of NSW or any region of Australia we are cooking.
Creating beautiful weddings, unique celebrations and unforgettable events is what we truly love to do. We have hand picked Byron’s finest staff and will work closely with you to create the perfect experience for you and your guests.
Your day – your way! The Frank & Joy team specialise in styling and coordination and have an extensive furniture and decor hire range. Our many years of experience enable us to listen to your dreams and ideas, combine them with your inspiration images and formulate a creative brief that reflects who you really are, compliments your venue and fits your budget.
We work with the best suppliers in the industry to breathe life into your event and clear communication throughout ensures you have full confidence in the process. With creativity, practicality and the ability to think outside the box we not only deliver incredible events, we will save you time and money plus ensure the whole experience is stress free and FUN!
Let’s talk about how we can best help you!
We are here to help you plan and deliver your next corporate event every step of the way. With our wealth of experience we offer expert advice and support, industry connections, and extensive local knowledge.
Host a destination corporate event in Byron Bay, a place where business innovation and creative thinking comes to thrive. Allow us to take care of everything – from concept to styling, all the while working alongside the region’s most talented suppliers.


text:
You can trust in Home Inspection Crew to deliver the most impressive professional services regarding Home Inspection in Willow Springs, MO. Our team of well trained contractors will offer the support you need with the most innovative technologies around. Our materials are of the best quality and we have learned to save you costs. We intend to provide help to put together decisions for your own work, reply to your questions, and arrange a meeting with our workers once you give us a call at 888-358-0442.
You have a budget to stick to, and you intend to save money. You'll still need to get superior services with Home Inspection in Willow Springs, MO, and you can have faith in our business to save you money while continuing with supplying the very best quality results. Our attempts to save a little money are not going to compromise the superior quality of our work. We work with the finest solutions and supplies to be certain that your job will withstand the test of time, and conserve your funds with strategies that don't affect the excellence for your mission. We will accomplish this by providing you with the top discounts available and eliminating expensive blunders. To be able to lower your expenses, Home Inspection Crew is the company to connect with. You are able to connect with us at 888-358-0442 to start.
If you're considering Home Inspection in Willow Springs, MO, you should be knowledgeable to make the most effective judgments. We ensure you know exactly what can be expected. We will take the unexpected situations from the equation by providing adequate and detailed information. You can start by talking about your job with our customer support reps when you call 888-358-0442. We will talk about your questions and concerns once you contact us and get you organized with a scheduled appointment. We consistently appear at the appointed time, all set to work with you.
If you find yourself organizing a job regarding Home Inspection in Willow Springs, MO, there are lots of reasons to work with Home Inspection Crew. We've got the greatest customer satisfaction ratings, the best resources, and the most helpful and reliable cash saving practices. Our company has the expertise you need to fulfill your goals and objectives. Dial 888-358-0442 to reach Home Inspection Crew and discuss your expectations regarding Home Inspection in Willow Springs.


text:
The serene setting of Durango, Colorado will make this your best vacation yet, regardless of the time of year.
Picture a secluded log cabin, soaking under the stars in the hot tub near a beautiful mountain lake. Or experience a winter wonderland from the cabin which is only 6 miles south of Purgatory Ski/Summer Resort.

industry_corpus2: Travel & Geography


text:
4941 4102 campuses need to be covered in prayer. Together we can make a difference.
Prayer walk a campus and see how God moves.
Use my location Finding your location... Sorry, your browser won't let us use your location. Try searching manually.
Be the first to Prayer Walk!
Is there an active campus ministry on this campus that isn't represented here? Let us know!
Standard text rates may apply.
Can't find the campus you're interested in?
We believe that prayer changes students, campuses, and cultures.
EveryCampus is a collaborative venture of multiple ministries to mobilize prayer and gospel movements to reach every campus in the country.
None of us can do this alone. Would you share this movement with friends that could help make this a reality?
Sign up for ongoing updates as we see campuses across the country be covered with prayer.


text:
And why we shouldn’t always treat E. coli as the enemy.
This week, we’re going back in time.
Precisely 100 years back in time, as a matter of fact, to bring you the fascinating story of a remarkable strain of bacteria that was first isolated on a World War I battlefield in the Balkans, back in 1917.
At that time, the Romanian and Russian armies were fighting the forces of the Central Powers (Germany, Austria-Hungary, the Ottoman Empire, and Bulgaria) in a Balkan region called Dobrudja, which lies between the lower reaches of the Danube and the Black Sea.
Dobrudja now straddles Romania and Bulgaria.
Much of the fighting was taking place in what sounds like thoroughly unpleasant marshland, heavily contaminated with enteric pathogens: the types of bacteria that can make people very sick, and not exactly a great environment for soldiers whose officers expected them to be fighting fit.
The German army had been particularly affected by intestinal infections, and thus welcomed a visit from a physician and bacteriologist from Freiburg, named Alfred Nissle (later, Professor Nissle) who examined patients in field hospitals, and also collected stool samples from soldiers who had been unaffected by intestinal infections.
A hundred years ago, there were no antibiotics, so Nissle rather liked the idea of using harmless strains of bacteria as a kind of living drug, which could inhibit the growth of bacterial species responsible for intestine-based diseases. Salmonella, for example.
In particular he was interested in E. coli.
Now, E. coli, or Escherichia coli, to give it its full name, is something of a Jekyll and Hyde microorganism.
Some strains of E. coli can make people extremely sick, while others promise great therapeutic potential.
The E. coli species as a whole was first identified in 1885 by another German, Professor Theodor Escherich.
Possibly a modest man, he originally called it Bacterium coli commune, but eight years after his death, others decided it should be renamed Escherichia coli, in honor of the man who discovered it.
Anyway, back to Nissle in 1917, who was busy collecting stool samples from German soldiers in Dobrudja (well, someone had to do it).
He became intrigued by one man in particular, a non-commissioned officer, who had remained stubbornly healthy, while most of the other men in his unit had fallen sick.
On examining the stool specimen collected from this (sadly unidentified) officer, Nissle found a particular strain of E. coli that appeared to behave in similar ways to what we would now term a probiotic.
Perhaps lacking the modesty of Escherich, he immediately labelled this strain E. coli strain Nissle 1917, since abbreviated to EcN.
In his laboratory, Nissle tested different bacterial strains for their abilities to suppress the growth of typhoid bacteria, and it was EcN that he found most effective in its antagonistic actions.
Clearly certain he was onto something, Nissle grew the strain on agar plates, then packed it into small gelatin capsules, sealed with wax.
Next, knowing full well of course that the bacteria had originated from the bottom of a German soldier, he bravely popped a capsule or two into his mouth and knocked them back with a glass of water. Fortunately there were no ill effects.
These days of course, it can take many years for a drug to progress from discovery to prescription, but there was clearly less red tape a hundred years ago.
That very same year – 1917 – Nissle began manufacturing his capsules under the trade name Mutaflor (meaning flora-changing).
It’s a medication that has stood the test of time.
We know, for example, that Adolf Hitler’s physician, Theodor Morell, prescribed Mutaflor to his patient in 1936 – apparently for flatulence.
Doesn’t it make you think that Robert Harris’s book about Hitler, Fatherland, could just so easily have been called Farterland?
In fact, Mutaflor is still manufactured today, and prized for its probiotic qualities, although it isn’t legally available in the USA.
Studies have suggested that EcN may help with ulcerative colitis and Crohn’s.
Its commercial value is highlighted by its deposit as an industrially-used strain under “patent deposit” rules at the German Collection of Microorganisms and Cell Cultures – which sounds like a fun place for a day trip.
As far as we’ve been able to assert, the Collection’s deposit, as well as the entire output of Mutaflor manufactured since 1917, all started life in a culture grown from that stool sample collected from a single German soldier in the First World War Balkan trenches.
Demonstrating, perhaps, that not all crap business ideas are bad ones.
Salmon Sperm and Bee Venom in Your Eye?

industry_corpus2: Biopharmaceuticals


text:
The Audi A3 is one the most popular cars on British roads, and with good reason. It’s a handsomely-styled, practical family hatchback that’s fun to drive and far from a binger when it comes to fuel consumption.
It sounds like the perfect mix but, if you’re seriously looking at trading your banger for a brand new A3 (and who could blame you?), steel yourself for some serious head-scratching. The list of options is long enough to see you through a week of bedtime reading.
That’s why we’ve read it for you, and picked out the add-ons that deserve a closer look and the ones you should probably avoid.
There’s no worse sound than the crunch of your car reversing into something else. A wall, a post, another car… Whatever you’ve hit, it always means one thing: repairs and bills are heading your way.
Avoid denting your brand new A3 (not to mention your pride and your wallet), by adding a reversing camera. Unfortunately, this isn’t quite as simple – or as cheap – as it should be, because you’ll also need to opt for the Audi Parking System, which adds front and rear selective display and sets you back a further £595.
Nobody likes getting lost, and it’s no less embarrassing doing so in a brand-new A3 than it is in a clapped out rust-bucket. The solution is simple: unless you’ve chosen the SE Technik trim, on which sat-nav is standard, opt for the Audi satellite navigation system.
When the time comes to sell up, the fact your A3 has sat-nav built-in could help you to squeeze a little bit extra out of your buyer – and that’s never a bad thing.
Tired legs? Weak arms? Or are you just bored of using conventional handbrakes and pedals to hold you in place on a hill? If you find yourself sheepishly nodding, the hold assist feature might just be the option for you.
This handy device holds the vehicle stationary with just the press of a button and, when the traffic starts moving, lets you drive away with zero fuss by putting your foot on the gas.
Modern cars are safer than ever, largely thanks to government interference. Rules and regulations are forcing manufacturers to think about how the cabin protects us – but you can go further by adding rear side airbags.
Just note: this option is only available on the A3 Sportback (that’s the five-door variant). At £300, though, we think it’s a small price to pay for what could save your passenger’s life in a crash.
Unless you’re a professional skier, you probably don’t have much need for an Audi ski/snowboard bag on your new A3. You’ll probably have even less of a need when you discover that this option is only available if you’ve already chosen the optional ‘through-load facility’, which sets you back another £150.
To be fair, the through-load facility probably is a worthwhile option even if you’re not a skier, as it means you can transport long items safely by folding down the centre armrest in the back seats.
There is no denying that Bang & Olufsen produces some epic high-fidelity sound systems. In fact, we’re pretty certain the optional B&O kit you can specify here would also be rather epic.
In the real world, the amount of time that you’ll spend in the car in such surroundings will be minimal – which we think makes the Bang & Olufsen sound system rather pointless. As a result, we advise you to stick with the perfectly capable stereo that comes as standard.
If you like the look of the Audi A3, check it out in our car configurator to see how much you could save on your ideal model. Or, for more options, head over to our deals page to see our latest discounts.

industry_corpus2: Automobiles


text:
Being a journalist is a great privilege for a citizen. One of the many privileges is meeting people and be fortunate enough to get to know them. Jack Layton was one of them. The following is some of my recollections of meeting him first as a citizen and then as a journalist.
My inbox brought the sad news from the NDP: Jack Layton died this morning.
I was at a lost for words. I sat staring at my screen and hoping that this was a sick joke by some hacker group. I checked the header and confirmed the email originated from the NDP server. Then, confirmation from CBC News.
Mr. Layton knew how to connect with people. He made people feel that they were the centre of the universe when he was with them. Despite a grueling schedule, he somehow found a way to not be in a hurry.
What follows are my personal experiences and reflections.
I first met Jack Layton as a second year university student. I was a student politician at the time and Mr. Layton was visiting my university as part of a cross-country town hall tour.
I had the pleasure of asking him a question in this public forum. It was many years ago and I don’t exactly remember my question. I do clearly remember how Jack took my question and the fun we had with it.
My question was about tuition fees. I used the phrase “they keep ‘Jacking up’ tuition fees.” Mr. Layton with great humour spoke up the second time I used the phrase “Jacking up” to say “I’m not sure if I’m a fan of that term, let’s try something else.” He didn’t suggest changing the phrase to the name of one of his opponents, instead he was just humourously pointing out that I was using his name. He joked that he probably used the same phrase if his parents gave him a different name.
I finished my question and Mr. Layton answered it by actually responding to the question. Too many politicians only listen to a question to decide the closest speaking point to respond with. Mr. Layton actually listened to the question to answer the question.
During the event, he honestly answered dozens of questions and remained past the scheduled end time to take a few more.
Mr. Layton not only knew how to connect with citizens, he knew how to lead a team. He wasn’t just the leader of the NDP caucus, he was a member. What I mean is that he did not have an overbearing leadership style and did not dictate policy to his caucus, he decided with them.
I cover higher education. In the 40th Parliament, I often reached out to the NDP for comment on post-secondary issues. Denise Savoie served as the post-secondary education critic for the third-party and she was the chief spokesperson for the party about higher education affairs.
Whenever I spoke to Mr. Layton or Ms. Savoie, it was clear they were communicating with each other as equals.
There are a couple of instances I remember well. In late 2007, Ms. Savoie was on a flight and I was writing a story on a tight deadline. The NDP communications team put me in touch with Mr. Layton. While I was interviewing Mr. Layton, an email arrived to his staff that Ms. Savoie’s flight had landed. Mr. Layton offered to put me in touch with Ms. Savoie immediately or finish the interview as I was on deadline.
This was indicative of Mr. Layton’s style – he wanted his caucus to get media attention as much as possible. It indicates the confidence he held them in. His answers were just as informed as Ms. Savoie – he seemed to read more briefing papers than I thought humanly possible. Ms. Savoie and I spoke while she was awaiting her luggage in the airport.
This conversation with Ms. Savoie began with small talk about a recent in-person interview I conducted with Mr. Layton over lunch in a campus pub. This reflected the strong communication between Mr. Layton and Ms. Savoie. The conversation also revealed the great joy that Ms. Savoie and Mr. Layton enjoyed in working together.
Mr. Layton and I sat down over lunch at the graduate pub The Phoenix. The McMaster NDP club joined us at the table. This was a bit unique and reflected the comfortable relationship I had with all the campus political party clubs. I conducted my interview at the table with some tough questions in there. I included the ‘isn’t it discouraging being the third-party’ question.
The Silhouette‘s photography team took dozens of photos of the interview. One of the photos showed Mr. Layton pouring a cup from a full pitcher of beer at a moment that his facial muscles are completely relaxed and his eyes partly closed. It’s one of those photos that do not reflect the moment and disposed of.
The Silhouette runs a joke front page on our back cover called *The Speculator *in honour of The Hamilton Spectator. We decided to run this photo on the joke page shortly after the 2007 provincial election with a caption that Mr. Layton was drowning his sorrows on election night.
A few months later, I bumped into Mr. Layton on Parliament Hill. He smiled about the joke and said he rather enjoyed it. We had an enjoyable chat and he offered the advice that I should enjoy every moment of student journalism I had – cherish the freedom of student life.

industry_corpus2: Media & Journalism


text:
Just as hydration is critical in any athletic sports, so is the container that holds the water. Filthy water bottles can be incubators of bacteria, mold, and mildew. It is even more dangerous when the bottle is kept with leftover sports drink mix. The longer you keep them untouched, the greater the danger they pose to your health. It is essential that you keep them fresh and clean more often than you think you should so you can enjoy your water bottle for more years of use.
Here are some helpful tips you need to consider to keep the grime and the germs off your water holder and the liquids that you drink while on the go.
Wash them after every use. Just as you would want your drinking cup or glass thoroughly cleaned before and after using them, you would never want to drink from a water bottle that you have missed to clean. You can’t be sure what you leave on its lid every time you open the bottle as you ride and drink. If you don’t have soap and water at the moment, even just rinsing the bottle will do.
Wash the bottle with your hands. The easiest way to clean your water bottle is to use your hands to rinse or wash it with soap and water.
Use a bottle brush. It is easier to clean hard to reach parts of the bottle with a long-handled bottle brush. This can remove the sticky residue better and easier than just rinsing the water.
Clean the water bottle cap. You may have cleaned the water bottle for cycling thoroughly, but did you remember the bottle cap? Note that as your bicycle moves, the fluid inside your water bottle also touches the cap. The same thing happens when you drink from the bottle. Make sure to clean the bottle cap as well. You can squeeze into the bottle cap some soap and water or use a brush to remove the sticking grimes and other residue clinging to it.
Avoid the dishwasher. The dishwasher, although an easier option may melt the plastic material that the bottle is made of or affect the material composition of the water container. Some of the chemical compounds in the bottle may leach when they are subjected to heat.
Avoid harsh cleansers. Bleach, in particular, may not be easy to remove even if you think you have washed the water bottle thoroughly. If you have to use any harsh chemical to clean your water bottle, it may be time to throw it away. Note that these chemicals may contaminate any liquid that you will fill the bottle the next time you use it.
Allow the bottle to dry completely. You can leave it open or upside down in a drainer until it is totally dry. This will make sure that no cleaning compound or water that you used while cleaning the bottle will remain in the bottle that would eventually mix with the drinks that you will fill it with.
Use baking soda and vinegar. If you think that washing the bottle with soap and water is not enough or that the smell of its previous content still lingers, use some baking soda (a tablespoon or two will do) and half a cup of vinegar. Leave the mixture in the bottle for about 60 seconds before cleaning the insides of the bottle and the cap with a brush.
If your water bottle sits long enough with liquid in it, it may grow different types of unhealthy organisms. Make sure you keep it away from heat and do not drink the content of any water bottle that has been exposed to heat or kept in a closed container where there is very high temperature. Consider the tips that we have provided above to make sure that you are always drinking fresh and clean water or liquid from your water bottle.
Be safe on the road and while on the go. Bring clean water to hydrate while cycling. You can be more and do more when you keep these things in mind.
Hi All, Thanks for visiting my site. You can follow my career, checkout race, training and free time images and videos as well as getting the inside word from the races that I compete in through out the year. Enjoy the ride….


text:
If you are struggling to get rid of ants in your home, it is important to not only think of new ways to eliminate ants, but you must also think about the mistakes that you might be making that are causing your home to become infested with ants in the first place.
Do not simply try to kill the ants. You must understand why the ants are entering your home in the first place. In fact, killing individual ants can sometimes cause the ant infestation to become worse as other ants come to retrieve the dead bodies to dispose of them. Relying too much on chemical pesticides can cause ants to bud up into multiple colonies. When you do apply the recommended treatment option, do not expect the ants to be killed off immediately. For example, there are some treatment options that require that the poison builds up over time in order to kill off the ant infestation.
Do not continue to use the same bait stations. Instead, use many bait stations and use different types of bait. Bait tends to dry out and will no longer attract ants. Also, ant preferences for food change regularly and ants may lose interest in one brand. However, if you continue to use bait, you will eventually allow for the poison to build up within the ant colony and you will likely kill the queens, which can lead to the death of the colony.
Do not assume that you will need to use the same treatment approach for every ant species. You will need to identify the type of ants you are suffering from in order to determine which treatment option will be effective. For example, if you need to use bait to kill ants, you must use a bait that will be attractive to the particular ant species. Some ants prefer greasy bait, while other ants prefer sugary bait.
Do not combine dry with wet baits in the same station. The humidity that is caused by the wet bait will cause the dry bait to mold, which can cause a separate set of issues and may reduce the effectiveness of the bait. The good news is that you can save money on bait stations by reusing them and simply filling them with new bait.
For more information, talk to a professional like Environmental Services Pest Control.

industry_corpus2: Agriculture & Fisheries


text:
Well, we can’t take you through the whole list, but let’s throw out a couple new things on the Blues side that we are digging.
Have you listened to the new James House and The Blues Cowboys James is old friend, and yep, writer of many country hit records. He is also a killer performer and has a cool blues feel about his new tunes. Hit the link and head to his FB page to learn about him if you don’t know. Well worth checking out James. And, he is one of the nicest fella’s you could ever meet, so go see him live and say hi.
I guess since we mentioned James, we should also send you over to check out the new Joe Bonamassa, since James co-wrote a bunch of the songs. Great guitar playing and real cool record, give it a chance and check it out.


text:
Mountain View, CA (December 2, 2009)--Post house Berwyn Audio, a division of New York's Berwyn Editorial, has installed a Euphonix S5 Fusion digital audio mixing system as well as two MC Pro DAW controllers in its Soho-based facility.
Mountain View, CA (December 2, 2009)--Post house Berwyn Audio, a division of New York's Berwyn Editorial, has installed a Euphonix S5 Fusion digital audio mixing system as well as two MC Pro DAW controllers in its Soho-based facility.
A Euphonix S5 Fusion digital audio mixing system fitted with an MC Pro media controller was installed in Studio A, the main audio suite, while a single MC Pro was installed in Studio B, a smaller audio project suite. For Berwyn, the MC Pro workstation control surfaces as well as the S5 Fusion will integrate and control Pro Tools, Logic 8 and Nuendo due to EuCon, Euphonix' proprietary high-speed Ethernet control protocol.
"Although primarily working in Pro Tools, we did not want to be forced into only working within one platform - the S5 Fusion and MC Pro's ability to control any media application is a big plus for us. With Euphonix' proven technology, we knew we would have the ability to handle whatever type of business comes to us" explained Eric Thompson, mixer and sound designer at Berwyn. "That advantage, coupled with the expandability of the S5 Fusion, made the console the perfect solution for us, now and into the future."
"With an MC Pro in each of our audio suites, we can easily bounce projects from room to room without interrupting our workflow. No matter what application we are working with that particular day, we can count on Euphonix to get the job done," continued Thompson.
Berwyn has various high-profile clients such as Dos Equis, Jaguar, and Marriott. The first project for the newly equipped Euphonix audio suite was a campaign for Jaguar mixed in 5.1.


text:
Compound , through the series of amides , was discovered to have ADME properties considered enough to allow it for being applied like a proof of principle compound in xenograft models of cancer and was for that reason characterised more entirely. Compound was discovered to block proliferation of 3 distinctive cancer cells lines with related IC values of nM, inhibit Auroras A, B, and C with Ki values of , and nM, respectively, and present fold selectivity over kinases as well as Src and GSKb. In addition, it had been implemented to present that blocking of mitosis by an Aurora inhibitor success in cell death . The cell death was thanks to apoptosis as proven by annexin V binding, DNA fragmentation ELISA and TUNEL staining. In the two week xenograft experiment, the compound inhibited the growth with the MCF tumour by when administered at its highest tolerated dose .
Animal physique weights were largely unaffected, even though, as expected, total white blood cell counts had been decreased. Taken with each other, these final results improved our belief in Aurora kinase inhibition being a target for cancer treatment. While quinazoline compounds this kind of as had properties ample for demonstrating pharmacological exercise, selleck chemicals purchase IWP-2 far better potency and enhanced physical properties, specifically solubility, were necessary for clinical advancement. Examination of co complicated crystal structures led towards the hypothesis that the lipophilic binding supplied from the fused benzene portion on the quinazoline could be replaced by appropriate substitution on the position of a pyrimidine ring. The method of utilizing a pyrimidine rather then a quinazoline being a core scaffold was notably captivating in that it was anticipated to supply the scope for getting ready a lot more soluble molecules.
More lipophilic binding could be obtained by building more effective interactions during the pocket utilised through the i thought about this methyl group within the pyrazole of compound or by raising the size or nature from the amide group. A series of compounds built to optimise the substitution with the position of your pyrazole as well as size in the amide over the thiophenyl ether group showed that while gains in potency might possibly be accomplished, a comparison between compounds , illustrates this stage, it was in most cases on the cost of basic kinase selectivity . Being a consequence, optimisation of pyrimidine based Aurora inhibitors was focussed on methylpyrazoles and amides of compact aliphatic acids since the thiophenyl substituent.
Lipophilic substitution with the position from the new pyrimidine scaffold, as illustrated from the sequence of inhibitors in Table , led to compounds that were equal in potency against Aurora A to quinazoline but without having gains in cellular potency.
From the docking experiments by Autodock , it had been located the interaction of pyrazolo pyridine derivatives with Aurora A kinase is equivalent to that of PHA . The aminopyrazole group would type three hydrogen bonds with GlU and AlA residues. So the pyrazolo pyridine derivatives need to bear the equivalent anti proliferative exercise to PHA. Therefore, a series of its derivatives had been synthesized . As for tolyl group, the exercise of methyl in meta place is larger than para and ortho in HCT cell line. When it comes to chlorine atom, the spot and quantity have little result to the actions . As for that electron withdrawing groups CF and F, para place showed very good routines. With regard to your electron donating groups this kind of as methoxy, ortho place k is superior to para position j, nonetheless k was invalid on the cell line. Furthermore, compound l getting two methoxy groups substituted over the meta position was synthesized and it had been discovered that l showed fantastic inhibitory pursuits in 3 sorts of cell lines.
Furthermore, furan, pyridine, and heterocyclic derivatives have been also examined, and their activities have been also well. Among them substituted pyridyl derivative p had the best activity, which could possibly be ascribed on the formation of an extra hydrogen bond between the pyridine nitrogen and also the PF-2545920 molecular weight phenol hydroxyl moiety of TYR aside from the widespread 3 hydrogen bonds using the GlU and AlA residues reported by Fancelli et al. and Talele and McLaughlin. In conclusion, a series of new compounds bearing pyrazolo pyridine scaffold, represented being a novel class of compounds to inhibit the Aurora A?s activity, had been synthesized and evaluated. They really should interact using the Aurora A kinases during the very similar mode to PHA.
The ongoing deliver the results aimed to examine the efficacy Compound Libraries of compounds p, s, and p in the variety of in vivo designs, are going to be the subjects of potential reports. Cancer cells often consist of mutations in the variety of genes, which ultimately lead to uncontrolled cell growth and tumor metastasis. As enzymes specific for and very important to cell development and division, Aurora kinases hold the potential to get necessary control points for slowing the development and spread of tumors. Aurora relatives kinases regulate vital events while in mitosis which includes centrosome maturation and separation, mitotic spindle assembly, and chromosome segregation. Misregulation of Aurora kinases resulting from genetic amplification and protein overexpression success in aneuploidy and may well contribute to tumorigenesis.
3 Aurora kinase isoforms A, B and C really are a household of serine threonine kinases that are believed to perform a variety of roles from the development and progression of cancer, by acting as regulators of cell proliferation, by transforming normal cells into cancer cells and by down regulating the tumor suppressor p. The Aurora enzymes are expressed in mammals, each and every of and that is believed to play critical roles in regulating mitosis.
This could be achieved by not allowing Smac to inhibit other IAP members, this kind of as XIAP . An additional fascinating example of a bi directional effect is present in the intimate association of IAPs with caspases. IAPs inhibit caspases, yet this interaction comprises an intrinsic regulatory mechanism, as the caspases can cleave the IAPs. So far XIAP, cIAP , and most recently Livin are already proven to undergo exact and functional cleavage by caspases. While in the situation of XIAP, cleavage success in two sub units: one that encompasses BIR and , and the 2nd, BIR RING. The N terminal BIR fragment exhibits a lowered capability to inhibit caspases and , whilst the BIR RING fragment retains its capability to inhibit caspase . The cleavage of cIAP takes place right away following the BIR domain and generates a pro apoptotic C terminal fragment, which the RING domain is preceded by a spacer sequence of amino acids .
The going here pro apoptotic exercise of c IAP fragment, which does not have BIR, will not be surprising since RING domains of other baculoviral and mammalian IAPs are able to induce apoptosis when expressed devoid of their BIR domains . We recently described a novel regulatory mechanism by which Livin is particularly cleaved by effector caspases at Asp to produce a big C terminal sub unit containing the two the BIR and RING domains . In contrast to XIAP and c IAP, our final results pertaining to Livin, showed the first illustration of an IAP cleavage item that acts being a pro apoptotic factor even though it includes a BIR domain. A achievable explanation for this exceptional habits is that an additional, as but undetermined, motif while in the primary amino acids of Livin can modulate the anti apoptotic result on the BIR domain.
The absence of this motif may possibly enhance the E ubiquitin ligase activity with the RING domain that in flip targets other anti apoptotic proteins to proteasome mediated degradation. Interestingly, effector caspases read this article , and and never upstream initiator caspases and are responsible for the specific proteolytic cleavage from the numerous IAP proteins. This is often despite the fact that these anti apoptotic things can interact with both types of caspases. This might allow the cell to type a gradient of inhibition along the apoptotic cascade. At the upstream degree, IAPs inhibit caspase , which can not cleave any IAP. However, the moment the cells are committed to apoptosis and downstream caspases are energetic, they are able to overcome IAP inhibition by a specific cleavage.
Phosphorylation has also been shown to be involved in the regulation of sure IAPs. Most a short while ago, Akt using a professional survival result, was shown to interact with and phosphorylate XIAP. Phosphorylation of XIAP decreased its ubiquitination, which resulted in better stability of XIAP .
We utilized placental microvascular density to characterize the angiogenic environment inside of the placental bed and we give proof to recommend that these alterations in our examine are certainly not related with elevated VEGF expression. Rather, we demonstrated that PEDF, an endogenous inhibitor of angiogenesis, is expressed in ordinary placentas and its loss is associated with stillbirth and heightened angiogenesis. Subsequent research which investigate the interactions amongst angiogenic inhibitor PEDF and inducer VEGF beneath altered environmental situations similar to intrauterine hypoxia could further elucidate probable mechanisms associated with perinatal condition processes similar to intrauterine fetal demise. Partial ureteral obstruction is among the most typical concerns in urological practice. It’s been demonstrated that urinary tract obstruction induces progressive apoptosis of each renal tubular and interstitial cells . Tubular cell apoptosis is called a significant factor to the progressive renal tissue loss in obstructive uropathy.
Nitric oxide is shown for being created in acute unilateral ureter obstruction and it is recognized to modify renal selleck chemicals signaling inhibitor hemodynamics inside the early phase within the obstruction . This substance functions as an antifibrotic element while in the persistent phase of UUO . NO synthase , the enzyme accountable for that production of NO, has 3 significant isoforms, namely, neuronal, endothelial, and inducible NOS. Whilst endothelial NOS is Cat dependent and it is expressed in many tissues, like testes, inducible NOS is Cat independent and it is induced in tissues after publicity to inflammatory cytokines or ischemia . Sildenafil citrate, vardenafil HCl, and tadalafil are widely applied as major treatment methods of erectile dysfunction .
They’re phosphodiesterase purchase GW9662 inhibitors and enhance cyclic guanosine monophosphate and NO mediated vasodilatation with resulting improvement of ED . Even though these drugs had been developed for ED, they grew to become one particular within the most regularly prescribed pharmaceuticals. The romance among PDE inhibitors and apoptosis was also reported. Sildenafil is not long ago shown to possess a powerful protective result towards apoptosis as a result of a NO signaling pathway . The aim of your present examine was to evaluate the effects of sildenafil citrate, vardenafil HCl, and tadalafil on renal tubular apoptosis and in addition on expressions of eNOS and iNOS in rat PUUO model. Sufferers and techniques The experimental review was carried out just after obtaining the approval of the community Ethics Committee. Forty Wistar albino rats have been enrolled.
All surgical interventions had been performed underneath sterile conditions from the similar surgical group with the exact same time period and atmosphere. The rats have been randomly assigned into 5 experimental groups. The groups have been classified as followsdGroup : PUUO; Group : PUUO t sildenafil inhibitorst ; Group : PUUO t vardenafil inhibitorst ; Group : PUUO t tadalafil inhibitorst ; and Group : sham.
In human, BAFF mRNA was abundant from the spleen and B lymphocytes . Thymus, heart, placenta, small intestine, and lung showed weak expression. Thus, lymphoid cells would be the key supply of BAFF in human. Our data produce new locating that BAFF is additionally expressed in mammary epithelial cells along with myeloid cells and T cells, and associated with the Expi induced apoptosis of mammary epithelial cells . It’s been regarded the BAFF functions by way of three BAFF receptors: BAFF receptor, TNF receptor homologue TACI , and BCMA . The RT PCR and Northern analyses showed that only expression from the BAFF receptor was detected and induced within the Expi transfected cells , although the TACI and the BCMA expressions weren’t detected in mammary epithelial cells . High degree of BAFF R expression was detected in numerous B cell lines, but cell lines of T cell, fibroblastic, epithelial , and enothelial origin have been all negative for BAFF R expression . In other experiments with human tissues, high levels of BAFF R mRNA were detected while in the spleen and lymph nodes .
Similarly, murine BAFF R was expressed at high amounts inside the spleen and at reduced levels while in the lung and thymus. Our research shows that BAFF R gene can also be expressed in mammary selleckchem kinase inhibitor epithelial cells as well as B cells. The data demonstrate that the Expi induced mammary apoptosis is linked with BAFF molecules and mediated by way of BAFF receptor. Presently, how Expi is linked with BAFF molecule is not recognized. Even further research is needed to identify interacting mechanisms amongst Expi and BAFF molecules. Within the present studies, the induction of Bax, cytochrome c, caspase , caspase , and caspase was observed while in the Expi transfected cells. Hence, the Expi induced apoptotic pathway would seem to adhere to activation of professional apoptotic Bax, release of cytochrome c through the mitochondria to your cytosol, and serial activation of caspases . In this study, we observed DNA fragmentation and induction of CIDE A gene expression inside the Expi transfected cells. CIDEs perform as signaling parts that regulate the ability of a caspase activated deoxyribonuclease to mediate DNA fragmentation .
Thus, the general information in the existing study show that Expi induces apoptosis of mammary epithelial cells. Seeing that BAFF and BAFF receptor are primarily expressed in lymphocytes, the raise in Expi, BAFF, and BAFF receptor could have some relation while in the communication of epithelial cells with lymphocytes to induce apoptosis in mammary Scriptaid epithelial cells for the duration of in vivo mammary gland regression. The Expi may perhaps have an essential function in extracellular matrix remodeling throughout the operation of mammary apoptosis. These ought to be tested in vivo technique.
A variety of agents are already reported to induce overreplication. In particular, ? radiation induces above replication in p? ? and p? ? cells through cytokinesis failure . In this case, cells enter mitosis and progress into G phase without the need of completion of cytokinesis. Considering that mitotic entry in more than replicating cells depends upon the degree of CDK action , doses of ? radiation capable of inducing in excess of replication may perhaps only partially inhibit CDK exercise. Doses of ? radiation that thoroughly inhibit CDK exercise might induce cytotoxicity. About the other hand, our final results showed that mitotic entry is inhibited while in bleomycin induced in excess of replication. Even at low cytotoxic concentrations, bleomycin is very likely to inhibit CDK activity, main to over replication as a consequence of inhibition of mitotic entry. Bleomycin brings about times fewer DNA cleavages in S phase cells than in G or G M phase cells . Inhibition of cell cycle progression is probably to depend over the extent of DNA cleavage induced by bleomycin .
These benefits propose that bleomycin at lowconcentrations with lowcytotoxicity looks to inhibit mitotic entry rather then DNA replication, thereby resulting in the induction of more than replication. We found that inhibition on the ATM ATR pathway suppressed bleomycin induced more than replication. As described over, decreased ranges of cyclin B by degradation may perhaps be accountable for G arrest and subsequent over replication while in the selleckchem discover this late phase of treatment. This raises the probability the ATM ATR pathway is associated with regulation of cyclin B degradation. Time lapse recording and movement cytometry examination showed that cyclin B degraded progressively through the early phase in response to bleomycin treatment, suggesting the ATM ATR pathway activated by bleomycin induced DNA injury may possibly stimulate the degradation pathway of cyclin B from the early phase . Quite a few reports described crosstalk among the DNA injury checkpoint and also the proteolysis pathway .
Nonperiodic pop over to this site activation of APC induced polyploidization . In some kinds of cells, like human megakaryocytes, Drosophila follicle cells, and yeast, activation of APC mediated proteolysis contributes to polyploidization . Activation of the degradation pathway in response to DNA injury is probable to contribute for the induction of in excess of replication. As an illustration, the degradation of geminin, an APC substrate and potent inhibitor in the initiation of DNA replication , could possibly be related to more than replication aswell as the degradation of cyclin B. ATM is required to the good function from the DNA restore pathway in response to bleomycin induced DNA harm in mammalian cells .
Our final results are comparable to these in cells with impaired AK activity that failed to pass the spindle assembly checkpoint and arrested prior to cytokinesis, resulting in polyploidy . Other groups also discovered that failure of the spindle assembly checkpoint because of AK inhibition decreased cell viability . Considering the fact that AK inhibition was not lethal, Giardia might possibly not possess a spindle assembly checkpoint. It has been proposed that protozoa could lack or have divergent cell cycle checkpoints. We utilised the anti phosphorylated AK A antibody to specifically localise the presumably lively giardial pAK. This has proven to get a worthwhile tool to identify and examine Giardia cells in mitosis. Inhibition of AK activity also decreases pAK, suggesting that like Ipl and human AK A, gAK is most likely for being autophosphorylated . AK inhibitor ZM inhibits phosphorylation of Thr in AK A in Xenopus eggs . Even more studies are required to elucidate the pathway and consequences of phosphorylation of gAK. Extra conserved eukaryotic mitotic aspects are vital to AK perform .
gCenH, a homologue of metazoan CENP A, localised to centromeres . CENP A is known as a histone H variant that is phosphorylated by AK A during prophase and assists to recruit AK B to assist in correct spindle microtubule attachment on the kinetochore . Nevertheless, a lot of proteins that associate and interact with aurora in other organisms appear for being missing in Giardia , much like T. brucei . Specifically, GiardiaDB searches did not reveal orthologues of TXP, Ajuba, SB590885 p, INCENP, Survivin and Tousled. Whilst gAK plainly localised to microtubular structures, the proteins that ordinarily mediate these interactions are missing or also divergent to be confidently recognized. Other proteins which have been apparently missing from your Giardia genome are p, vimentin and desmin. p is important towards the spindle assembly checkpoint in metazoan cells . Vimentin and desmin are phosphorylated and destabilised by AK B at cytokinesis and localise near the centrosomes in other protozoa .
The absence of your leading identified AK substrates and effector proteins suggests that Giardia utilises proteins and pathways numerous selleckchem TAK-438 from most metazoan cells to finish mitosis. Based on each the localisation and inhibitor results, we propose that gAK is involved with the regulation of microtubule disassembly in Giardia mitosis by way of: direct phosphorylation and destabilisation of still unidentified cytoskeletal proteins or recruitment of microtubule destabilising proteins or complexes towards the web sites of cytoskeletal disassembly. In long term studies, we will attempt to elucidate giardial mitotic checkpoints and also to recognize substrates of gAK. As a consequence of its part in Giardia growth and its apparently divergent substrate specificity compared with human AKs, gAK might be an outstanding target for selective anti giardial remedy.
Following quick centrifugation, supernatants have been assayed for protein concentration by using the Dc Assay kit and boiled for min with sodium dodecyl sulfate sample buffer . Samples of prostate homogenates have been subjected to SDS polyacrylamide gel electrophoresis, and proteins were blotted on Protran nitrocellulose membranes . Membranes have been blocked above evening, and subsequently incubated with rabbit anti phospho Akt antibody, mouse anti phospho Akt antibody, or mouse anti Akt antibody . Subsequently, membranes were washed with phosphate buffered saline containing . Tween , and incubated with secondary peroxidase coupled goat anti mouse or anti rabbit antibody . Blots had been produced with enhanced chemiluminescence implementing ECL Hyperfilm . Intensities within the resulting bands have been quantified implementing Image J . In every single experiment, samples with no noradrenaline or phenylephrine were set to , and information of stimulated samples have been expressed as of these unstimulated samples.
Immunohistochemistry Sections from frozen tissues have been stained by an indirect immunoperoxidase process. Sections were fixed with acetone, and endogenous peroxidase action was blocked by . HO. Thereafter, sections have been blocked with horse serum diluted : in PBS and incubated with mouse anti Akt antibody . Primary antibodies have been diluted : in PBS at space PP242 temperature and incubated with the sections more than night. Just after washing fold in PBS, biotinylated secondary horse anti mouse antibody and avidin biotin peroxidase complicated have been sequentially utilized for min every single. Staining was performed together with the AEC peroxidase substrate kit . Eventually, all sections have been counterstained with hemalaun. Control stainings with out major antibodies did not yield any immunoreactivity. Tension measurements Prostate strips had been mounted in ml aerated tissue baths , containing Krebs Henseleit answer . Preparations had been stretched to . g and left to equilibrate for min to achieve a sInhibitors resting tone.
After the equilibration time period, optimum contraction induced by mM KCl was assessed. Subsequently, chambers had been washed selleck chemicals PHT-427 3 times with Krebs Henseleit alternative to get a total of min. Cumulative concentration response curves for noradrenaline were developed just before and immediately after addition of Akt inhibitors , or on the solvent dimethylsulfoxide . Cumulative concentration response curves for the adrenergic agonist phenylephrine were produced following addition of Akt inhibitors or DMSO. Frequency response curves induced by electric discipline stimulation have been created ahead of and just after addition of Akt inhibitors or DMSO. ELISA Enzyme linked immunosorbent assay for phospho Akt was carried out utilizing PathScan Sandwich ELISA kits . Frozen prostate tissues were homogenized within the Cell Lysis Buffer, which was included while in the kits, and by using the FastPrep procedure with matrix A .
Earlier, Epand et al reported that the negative curvature in membranes which is necessary for OMM permeabilization was promoted by tBID . Correspondingly, in our experiments the lack of significant OMM permeabilization by BAX alone might be explained by the lack of alterations within the membrane curvature. In our experiments, tBID and Ca augmented BAX insertion oligomerization from the OMM and strongly amplified membranepermeabilizing exercise of BAX. The Ca dependent amplification of BAX activity is of individual interest. Bearing in thoughts that BAX could cause Ca efflux in the endoplasmic reticulum and, hence, increase the likelihood on the Ca induced mPT , the Ca induced stimulation of BAX insertion oligomerization inside the OMM resulting in enhanced OMM permeabilization may well signify a feed forward amplification loop guaranteeing prosperous, irreversible progression of your apoptotic program. Previously, it was proven that Ca stimulated BAX mediated Cyt c release from isolated liver mitochondria . On the other hand, the mechanism of this stimulation was not investigated even more.
In our study with isolated brain mitochondria, we demonstrated that the Ca induced amplification with the BAX mediated Cyt c release occurred parallel to augmented alkali resistant BAX insertion oligomerization while in the OMM, and that both BAX insertion oligomerization in theOMM and BAX mediated Cyt c release had been facilitated by mPT induction. Consequently, our success propose augmented BAX insertion oligomerization a mechanistic link amongst the Ca induced mPT and purchase SCH 900776 improved BAXmediated Cyt c release. In contrast to Ca , tBID stimulated BAX insertion, oligomerization, and Cyt c release appeared to become mPTindependent, but in this instance augmented BAX insertion oligomerization also correlated with the increased Cyt c release. Anti apoptotic Bcl , a close relative of Bcl xL , can inhibit professional apoptotic BAX activity by heterodimerizing with BAX or by binding tBID and hence precluding tBID dependent activation of BAX . No matter whether Bcl xL BAX heterodimerization affected BAX insertion oligomerization while in the OMM or inhibited currently inserted and oligomerized BAX remained unclear.
In our experiments, recombinant anti apoptotic protein Bcl xL failed to avoid BAX insertion and oligomerization selleck chemicals oral MEK inhibitor in the OMM. However, Bcl xL strongly inhibited Cyt c release induced by a blend of BAX and Ca . Earlier,we showed that recombinant Bcl xL inhibited Cyt c release induced by a mixture of tBID and monomeric BAX . Hence, our effects assistance a scenario during which Bcl xL inhibits inserted oligomerized BAX and emphasize the truth that BAX insertion oligomerization within the OMM may be dissociated fromOMMpermeabilization. How Bcl xL restrains the inserted oligomerized BAXfrompermeabilizing theOMMhas yet to be established.
As a result, we performed the membrane insertion and pore formation assay of Bcl xL with folds of lipids. To map the binding interface of Bcl xL subunits in LUV, cysteinedirected cross linking was utilized to explore Bcl xL residues at the interface. Cysteine directed cross linking is successfully utilized to research the molecular architecture of membrane protein complex. For example, SecYEG is really a protein complicated that mediates the translocation and membrane integration of proteins in Escherichia coli. To probe the interaction web sites concerning the subunits of SecYEG complicated about the membrane, cysteines were launched into transmembrane segments of SecY and SecE . In the event the C atoms in the cysteines of two subunits are while in the selection of , they’re able to type a disulfide bond at oxidizing circumstances of CuP . By this technique, distinct residues with the interface between SecY and SecE had been identified.
Similarly, cysteine directed PIK-75 cross linking was employed in our present study to map the binding interface of Bcl xL subunits in lipids. Especially, Bcl xL was incubated with folds of LUV followed by reaction with membrane permeant oxidative, CuP. As shown in Inhibitors A , two main bands close to kDa and kDa, corresponding to two isoforms of BclxL disulfide bond dimers , seem after incubation in the liposomebound Bcl xL with CuP. This consequence is consistent which has a previous report that Bcl forms SDS resistant dimer soon after incubation with liposomes at pH Because the protein was incubated with folds of LUV in advance of the oxidization, the disulfide bond should be formed within the liposomes. Actually, only negligible disulfide bond dimer was detected from the absence of LUV , confirming that the disulfide bond dimer is formed in liposomes. As Bcl xL has only one cysteine residue and found within the helix , it must be with the binding interface of Bcl xL subunits in membranes. To more map the residues on the binding interface, we substituted Cys with alanine and modified other probable residues of Bcl xL to cysteine.
From these mutants, we uncovered that Bcl xL could selleckchem order Omecamtiv mecarbil type disulfide bound dimer within the presence of LUV and CuP . In contrast, the incubation with LUV and CuP will not induce the disulfide bond dimer formation of Bcl xL , which excludes the possibility that the disulfide bond dimer formation of Bcl xL and Bcl xL is due to non precise cross linking of cysteine residues arising from a basic unfolding of Bcl xL in liposomes. Hence, the disulfide bond formation of Bcl xL and Bcl xL in LUV signifies that Cys on helix and Asn on helix are at the binding interface of two neighboring Bcl xL subunits. Meanwhile, it was reported that the domain swapped dimer of BclxL could insert to the synthetic membranes and type pores as Bcl xL monomer .


text:
Made with durable LDPE plastic, these cylinder bottles include a fine mist sprayer cap. Dip tube will need to be cut to fit. When cutting the dip tube, make sure to cut at a 45 degree angle.
Is LDPE right for me?
LDPE containers are durable, flexible, squeezable, chemical resistant, lightweight, and provide moisture barrier properties. This well-rounded material is suitable for foods, beverages, personal care, chemicals and many other applications.


text:
JOLIET – A Plainfield man was arrested after he allegedly hit his girlfriend and her mother and then tried to prevent them from contacting the police, authorities said.
On Thursday morning, Willie J. Akins Jr., 21, of the 1900 block of Cumberland Court in Plainfield got into an argument with his 24-year-old girlfriend, who is pregnant with his child, Joliet Deputy Police Chief Ed Gregory said.
The argument then turned physical, Gregory said.
The girlfriend alleged to police that Akins struck her in the face, slapped her and pushed her off the bed in their home at Cumberland Court, Gregory said. The girlfriend’s mother tried to intervene, but Akins allegedly slapped and pushed her as well, he said.
When the girlfriend tried contacting the police, Akins reportedly pulled the phone cord out of the wall, Gregory said. That is when the mother hit the panic alarm in the house and Joliet police responded, he said.
Officers arrived and arrested Akins on charges of aggravated domestic battery, interfering with the report of domestic violence and domestic battery.
Akins was booked into the Will County jail. He was scheduled to appear in court Friday afternoon.


text:
Andrea Schroeder is the 33rd President of the Clarkston Optimist Club. It has been a busy year for Andrea, as she was also elected to the Michigan House of Representatives serving Clarkston and Waterford. Andrea has been an Optimist for over ten years and has supported many club projects.
She and her husband Mark, a former president of the club are very active in the community. Andrea was active in the Parent Teacher groups in the Clarkston Schools as a supportive mom to her three children.
CLARKSTON OPTIMIST ORATORICAL CONTEST - Tuesday, April 9, Clarkston United Methodist Church, 6600 Waldon Rd., 6:00 p.m.
The Clarkston Optimists offer up to four scholarships for high school seniors who live in the Clarkston Community School attendance area no matter the school that you attend. The Optimists work with the Clarkston Chamber of Commerce to offer the scholarships through the joint community scholarship. The scholarship is available at the live link on this posting and the Clarkston Chamber of Commerce website. Scholarship applications are due Friday, March 22, 2019 at the Chamber of Commerce office by 4:00 p.m. For questions, contact info@clarkstonoptimists.org or 248 514 1729.
The Clarkston Area Optimists Club is accepting grant applications for the 2019 grants focusing on projects and activities for children and youth in the Clarkston Community Schools attendance area. Grants will awarded in May to individuals, organizations, and clubs that support the development of youth and children of the community. Grant applications are due Friday, April 8, 2019. A paper application should be mailed to Clarkston Optimists, P.O. Box 891, Clarkston 48347. For information, contact info@clarkstonoptimists.org or call 248 514 1729.
Service for the Community is a monthly Community television show, with volunteer leaders of the community sharing what is happening in the community with their organization.
All people are welcome to attend any Optimist meeting starting at 7:30 a.m. at the Clarkston United Methodist Church, 6600 Waldon Rd., Fellowship Hall. Each Wednesday, the programs listed below will be at least 30 minutes.


text: General Information: This strain was isolated from a 58-year old man with sepsis and has been shown to be resistant to ciprofloxacin and ceftriaxone. This organism also causes severe disease (swine paratyphoid) in pigs. Causes enteric infections. This group of Enterobactericiae have pathogenic characteristics and are one of the most common causes of enteric infections (food poisoning) worldwide. They were named after the scientist Dr. Daniel Salmon who isolated the first organism, Salmonella choleraesuis, from the intestine of a pig. The presence of several pathogenicity islands (PAIs) that encode various virulence factors allows Salmonella spp. to colonize and infect host organisms. There are two important PAIs, Salmonella pathogenicity island 1 and 2 (SPI-1 and SPI-2) that encode two different type III secretion systems for the delivery of effector molecules into the host cell that result in internalization of the bacteria which then leads to systemic spread.


text:
Deciding on the right curtains and blinds for your home or business can be confusing. With nearly thirty years specialist experience in the design and fitting of curtains and blinds in Joondalup, we can help. The team at Abbey blinds make it easy for you. We achieve the exact blend of light, security, functionality, insulation and style to meet your needs. You don’t have to take our word for it, our testimonials speak for us.
We provide competitive pricing for high-quality curtains and blinds in Joondalup. We have sourced and built relationships with suppliers that give both quality and value. Our mobile showroom offers flexibility that our customers love, as we show you the full range at the comfort of your home or business.
Curtains: Curtains are both functional and decorative. They’re incredibly versatile, transforming a room with a feel of elegance and style while also managing temperatures and blocking out the light. For added precision or specific requests, custom curtains can be made specifically for you, to match your interior and any additional requirements you have. Abbey Blinds offer standard curtains, blackout curtains, sheer curtains and pelmets and curtain accessories.
Why use Abbey Blinds for your curtains and blinds in Joondalup?
We listen, we take an honest approach and above all else, we value our customers.


text:
Worcester v Maidenhead Utd postponed.
Quarter-final: Chelmsford City v Aveley postponed.
Central Division: Thetford Town v Ipswich Wanderers postponed.
North Division: Downham Town v Wisbech St Mary, Wisbech Town v Mildenhall Town both postponed.


text:
In the coming months, we will be selling the large animal portion of our practice to Dr. KC Fagan, our current large animal veterinarian. Dr. Fagan will be operating her own separate practice, and all large animal care will go directly through her.
We are so excited for her on this new journey. She is an excellent veterinarian, and we know your horses, llamas, alpacas, sheep, goats and pigs will remain in great hands with her.
We will keep you updated on this transition as it takes effect this spring and how to contact Dr. Fagan directly; for now, you can continue to call us to schedule appointments just as you always have.