text:
The European Parliament adopted by 520 votes to 68, with 79 abstentions, a resolution on logistics in the EU and multimodal transport in the new TEN-T corridors. Members recalled that modern efficient transport and logistics are essential for the effective functioning of the EUs internal market and important for ensuring competitiveness, creating new business and employment opportunities and achieving the Unions climate goals and the objectives of the COP 21 Paris Agreement. The third goal of the Commissions White Paper on Transport aims to shift 30 % of road freight over 300 km to more sustainable modes such as rail and waterborne transport by 2030, and more than 50 % by 2050, requiring also the development of appropriate infrastructure. The resolution addressed the following key issues: EU freight logistics strategy: Parliament highlighted the need to formulate a renewed EU strategy for freight logistics which should: take account of the new TEN-T infrastructure policy, further reduce regulatory, operational and technical barriers, designed to ensure optimal use of resources, apply and implement new technologies that will strengthen the sectors performance and accelerate the shift towards a secure and low-carbon transport system, increase connectivity and develop infrastructure in areas where it is missing, promote and support the European rail supply industry as well as boosting a European rail reindustrialisation policy, with the win-win perspective of making EU logistics more sustainable and obtaining a better competition position for rail products on the global market, take into account from the outset drones as a future mode of transport, promote continued development of academic research and education in the area transport and logistics, present an independent scientific study detailing: (i) the extent to which road freight could be transferred to rail and inland waterways by 2030 and by 2050, the costs associated with this, and; (ii) the extent to which environmental damage such as noise and air pollution can be avoided. Promoting multimodality: the implementation of the TEN-T network, with particular emphasis on cross-border connections and within the time-frames laid down and completed by 2030, shall reduce bottlenecks, improve interoperability between the various modes of transport. Parliament called for increased involvement of multimodal platforms in Member States planning and in the further development of routes. It also stressed the importance of investments in urban nodes, as well as of the promotion of rail connections with industrial plants and improved interconnectivity of rail with seaports, inland ports and hinterland hubs. The Commission is asked to prioritise these investments in the 2017 review of the Connecting Europe Facility (CEF). Strengthening coordination: regretting that Member States national infrastructure plans are too often decided without reference to the TEN-T objectives, Members stressed the need to increase the coordination between the two levels of planning. The Commission is called upon to strengthen the sphere of action of the TEN-T European coordinators to look beyond the geographical scope of the corridors under their respective responsibility, and to cover horizontal policy issues such as multi-modality and efficient freight logistics Improved simplification and a new framework for digitalisation: the resolution stressed the urgency of greater simplification of documents and administrative and customs procedures across all modes and across the different stages in logistics chains. The Commission is called upon to propose, by the end of 2017, a digital framework for electronic information exchange and transport management in multimodal transport (efreight) with a view to facilitating a simplified, paperless, seamless, transparent, secured and trusted information flow between businesses, customers and authorities, building on established services (such as SafeSeaNet, etc). Investing in the European Transport System with logistics as a focal point: Parliament underlined the need to ensure enough EU funding for the implementation of the TEN-T beyond the present MFF. The Commission is expected to: propose a streamlining of measures and resources for the implementation of the priority projects in good time; urge Member States to make the requisite investments in order to finalise the connections of the EUs core corridors; take fully into consideration automation and its impact in its logistic strategy and devise a new strategy that guarantees that drones can be efficiently integrated into the TEN-T programme. Urgent and more efficient integration of transport modes: Parliament insisted on the need to concentrate major efforts on the revitalisation of railways and on the strengthening of inland waterways (IWW) as a priority for the EUs sustainable transport strategy. It called on the Commission to come forward with specific solutions to ease access to European Fund for Strategic Investments (EFSI) funding for European Rail Traffic Management System (ERTMS) deployment in favour of both infrastructure and locomotive installations. In view of reducing CO2 emissions in general, the Commission is asked to introduce stronger and more effective measures and incentives to encourage rail companies to tackle freight-rail noise, given the adverse health effects of noise pollution. It is also encouraged to: foster the development of electric modes of transport and the necessary infrastructure along the whole TEN-T network, and, especially in town centres; foster the development of innovative transport schemes involving, for example, the use of electric vehicles and renewable energy sources; the development of alternative fuels and the necessary infrastructure. Given the role that the digitalisation of services has to play in encouraging more environmentally friendly transport solutions, Members called on the Commission to facilitate, also through a coherent legislative approach at EU level, the access to and sharing of data concerning traffic flows along the corridors and the use of multimodal transport, especially for SMEs, and to secure greater involvement of local operators and public authorities in this sector. Better training and job conditions to attract new professionals: working and living conditions of the workforce in the logistic chain have deteriorated substantially in the past years, making this sector less attractive for new generations, in particular for mobile workers. The Commission and the Member States are called upon to: identify training and learning needs at EU level and to propose, as a matter of urgency, measures to make it more attractive to young people and to future generations; provide sufficient and safe parking space in the TENT-t corridors to avoid increasing security issues with mobile transport workers; take into consideration Parliaments recent recommendations on social-economic aspects in the transport sector and on combating unfair practices in the labour market. Lastly, the Commission is called upon to work with stakeholders to develop an EU-wide framework for multimodal transport and logistics statistical data, including developing new indicators that better reflect real freight trends.
The Committee on Transport and Tourism adopted an own-initiative report by Inés AYALA SENDER (S&D, ES) on logistics in the EU and multimodal transport in the new TEN-T corridors. This report aims to formulate the European Parliaments position and stimulate initiatives to promote the field of freight transport logistics. Logistics include the services and processes of planning, managing and carrying out the flow of goods and information between the point of origin and the point of destination. The third goal of the Commissions White Paper on Transport aims to shift 30 % of road freight over 300 km to more sustainable modes such as rail and waterborne transport by 2030, and more than 50 % by 2050, requiring also the development of appropriate infrastructure. The report addresses the following key issues: EU freight logistics strategy: given the key role of logistics in relation to efficient and sustainable freight transport operations in the EU, the Commission should put forward a renewed EU strategy to: take account of the new TEN-T infrastructure policy, further reduce regulatory, operational and technical barriers, designed to ensure optimal use of resources, apply and implement new technologies and innovative solutions that will strengthen the sectors performance and accelerate the shift towards a secure and low-carbon transport system, increase connectivity and develop infrastructure in areas where it is missing, promote and support the European rail supply industry as well as boosting a European rail reindustrialisation policy, with the win-win perspective of making EU logistics more sustainable and obtaining a better competition position for rail products on the global market, take into account from the outset drones as a future mode of transport, promote continued development of academic research and education in the area transport and logistics, present an independent scientific study detailing: (i) the extent to which road freight could be transferred to rail and inland waterways by 2030 and by 2050, the costs associated with this, and; (ii) the extent to which environmental damage such as noise and air pollution can be avoided. The report stressed that the implementation of the TEN-T network, with particular emphasis on cross-border connections and within the time-frames laid down and completed by 2030, will reduce bottlenecks, improve interoperability between the various modes of transport and contribute to delivering integrated multimodal freight transport in the EU. It called for increased involvement of multimodal platforms in Member States planning and in the further development of routes. Moreover, Members regretted that Member States national infrastructure plans are too often decided without reference to the TEN-T objectives. They considered that an efficient EU logistics system requires further coordination beyond physical connectivity and an operational TEN-T network. The Commission is called upon to strengthen the sphere of action of the TEN-T European coordinators to look beyond the geographical scope of the corridors under their respective responsibility, and to cover horizontal policy issues such as multi-modality and efficient freight logistics. Improved simplification and a new framework for digitalisation: the report stressed the urgency of greater simplification of documents and administrative and customs procedures across all modes and across the different stages in logistics chains. The Commission is called upon to: analyse redundant EU legislation on transport and mobility, propose, by the end of 2017, a digital framework for electronic information exchange and transport management in multimodal transport (efreight) with a view to facilitating a simplified, paperless, seamless, transparent, secured and trusted information flow between businesses, customers and authorities, building on established services (such as SafeSeaNet, River Information System, intelligent transportation systems, etc). Investing in the European Transport System with logistics as a focal point: Members underlined the need to ensure enough EU funding for the implementation of the TEN-T beyond the present MFF. The Commission is expected to: present the Connecting Europe Facility (CEF) mid-term review in 2017, proposing a streamlining of measures and resources for the implementation of the priority projects in good time; urge Member States to make the requisite investments in order to finalise the connections of the EUs core corridors; take fully into consideration automation and its impact in its logistic strategy, ensuring its smooth and efficient integration into the TEN-T, and to support research on, and investment in, the development of these key technology. Particular focus should be put on TEN-T core network corridors on the coordinated development of projects that promote multi-modality in freight logistics, in particular terminal hubs, logistic platforms and urban nodes. Urgent and more efficient integration of transport modes: the report insisted on the need to concentrate major efforts on the revitalisation of railways and on the strengthening of inland waterways (IWW) as a priority for the EUs sustainable transport strategy. It called on the Commission to come forward with specific funding solutions to ease access to European Fund for Strategic Investments (EFSI) funding for European Rail Traffic Management System (ERTMS) deployment in favour of both infrastructure and locomotive installations. In view of reducing CO2 emissions in general, as well as local pollutant and noise emissions in particular, the Commission is asked to: (i) foster the development of electric modes of transport and the necessary infrastructure along the whole TEN-T network, and, especially in town centres; (ii) foster the development of innovative transport schemes involving, for example, the use of electric vehicles and renewable energy sources, and (iii) the development of alternative fuels and the necessary infrastructure. Members noted that the digitalisation of services has a role to play in encouraging more environmentally friendly transport solutions. They called on the Commission to facilitate, also through a coherent legislative approach at EU level, the access to and sharing of data concerning traffic flows along the corridors and the use of multimodal transport, especially for SMEs, and to secure greater involvement of local operators and public authorities in this sector. Better training and job conditions to attract new professionals: the report noted that the working and living conditions of the workforce in the logistic chain have deteriorated substantially in the past years, making this sector less attractive for new generations, in particular for mobile workers. The Commission and the Member States are called upon to: propose, as a matter of urgency, measures to make the sector more attractive to young people and to future generations; evaluate the possibility of financial investment in dual and vocational training in the transport sector; provide sufficient and safe parking space in the TENT-t corridors to avoid increasing security issues with mobile transport workers; take into consideration Parliaments recent recommendations on social-economic aspects in the transport sector and on combating unfair practices in the labour market. Lastly, the Commission is called upon to work with stakeholders to develop an EU-wide framework for multimodal transport and logistics statistical data, including developing new indicators that better reflect real freight trends.
8. Calls on the Commission to make available more resources, especially for projects designed to improve interconnectivity with outlying regions and make more effective use of EU funding.
8b. Stresses the need, not least in view of the gradual move towards a circular economy, to integrate outbound and reverse logistics operations with a view to reducing overall vehicle movement volumes.
- strives to continue the development of the academic research and education within the transport and logistics area.
6. Considers that while the comprehensive network is mainly a responsibility of the Member States, both layers are crucial to EU logistics, bringing capillarity to the core network, feeding the corridors with traffic, and performing last- mile distribution; takes the view that secondary networks should not be left outside the European purview, including in terms of financing and regulatory measures, in particular those pertaining to access to the network, slot allocation and charges; urges that missing links in rail infrastructure in cross-border regions should be tackled in order to allow efficient and successful cross-border rail transport.
9. Notes that Member States experiencing economic and budgetary difficultiAdvocates the optimal use of the public and private funding schemes, are unable to co-finance freight projects as a result of a strict interpretation of the Stability and Growth Pact (SGP); advocates a more flexible application of the SGP by excluding genuine European infrastructure projects (i.e. Connecting Europe Facility (CEF) projects) frlso in the light of blending Connecting Europe Facility and Horizon 2020 with the European Fund for Strategic Investments and other financial instruments; welcomes the promotion of more sustainable investments across sectors to further meet COP21-targets and help delivering on the transition to a resource efficient, circular and zero- carbon economy; calls on the Commission to assess the main challenges and to present a road map to overcome the calculation of the public debt;ose, concerning investments in transport and infrastrucure.
10. Considers that an efficient EU logistics system requires further coordination beyond physical connectivity and an operational TEN-T network; calls on the Commission to appoint a TEN-T European logistics coordinator that could effectively complement, coordinate and give coherence to the ongoingmake logistics an integral part of the Core Network Corridors and the work of the cEuropean Coordinators in the area of multimodality;.
10a. Asks the Commission to report back to the European Parliament regularly on the conclusions and measures taken in the Digital Transport and Logistics Forum in order to further supporting digitalisation of freight transport and logistics.
14a. Stresses the potential of automated and autonomous transport and its use for real-time multimodal information services in logistics; Is concerned of the difficulties of ensuring that new automated vehicles and systems interact smoothly with conventional vehicles and vulnerable users . Calls on the automated vehicles and other ITS solutions.
22. Notes with concern that the technologies could undermine the sector’s performance; calls on the Commission to identify training and learning needs at EU level, and working conditions, costs and barriers that discourage the workforce from entering the transport sector, and to propose as a matter of urgency measures to make it more attractive to young people and to future generations; regards this as an opportunity to increase the proportion of women and new entrants on the transport labour market, for example EU migrants;new arrivals; what is more, strategic investment in training and better work conditions should include initiatives for knowledge development within the public sector in order to include freight issues in a better manner in social planning and the development of demonstration and test arenas, where research and innovation related to freight and logistics can be applied and tested under real conditions.
22c. Urges Commission and Member States to provide sufficient and safe parking space in the TENT-t corridors to avoid increasing security issues with mobile transport workers.
The European Parliament adopted by 520 votes to 68, with 79 abstentions, a resolution on logistics in the EU and multimodal transport in the new TEN-T corridors.
Members recalled that modern efficient transport and logistics are essential for the effective functioning of the EUs internal market and important for ensuring competitiveness, creating new business and employment opportunities and achieving the Unions climate goals and the objectives of the COP 21 Paris Agreement.
The third goal of the Commissions White Paper on Transport aims to shift 30 % of road freight over 300 km to more sustainable modes such as rail and waterborne transport by 2030, and more than 50 % by 2050, requiring also the development of appropriate infrastructure.
present an independent scientific study detailing: (i) the extent to which road freight could be transferred to rail and inland waterways by 2030 and by 2050, the costs associated with this, and; (ii) the extent to which environmental damage such as noise and air pollution can be avoided.
Promoting multimodality: the implementation of the TEN-T network, with particular emphasis on cross-border connections and within the time-frames laid down and completed by 2030, shall reduce bottlenecks, improve interoperability between the various modes of transport.
Parliament called for increased involvement of multimodal platforms in Member States planning and in the further development of routes. It also stressed the importance of investments in urban nodes, as well as of the promotion of rail connections with industrial plants and improved interconnectivity of rail with seaports, inland ports and hinterland hubs.
The Commission is asked to prioritise these investments in the 2017 review of the Connecting Europe Facility (CEF).
Improved simplification and a new framework for digitalisation: the resolution stressed the urgency of greater simplification of documents and administrative and customs procedures across all modes and across the different stages in logistics chains. The Commission is called upon to propose, by the end of 2017, a digital framework for electronic information exchange and transport management in multimodal transport (efreight) with a view to facilitating a simplified, paperless, seamless, transparent, secured and trusted information flow between businesses, customers and authorities, building on established services (such as SafeSeaNet, etc).
take fully into consideration automation and its impact in its logistic strategy and devise a new strategy that guarantees that drones can be efficiently integrated into the TEN-T programme.
Traffic Management System (ERTMS) deployment in favour of both infrastructure and locomotive installations.
the development of alternative fuels and the necessary infrastructure.
Given the role that the digitalisation of services has to play in encouraging more environmentally friendly transport solutions, Members called on the Commission to facilitate, also through a coherent legislative approach at EU level, the access to and sharing of data concerning traffic flows along the corridors and the use of multimodal transport, especially for SMEs, and to secure greater involvement of local operators and public authorities in this sector.
Better training and job conditions to attract new professionals: working and living conditions of the workforce in the logistic chain have deteriorated substantially in the past years, making this sector less attractive for new generations, in particular for mobile workers.
take into consideration Parliaments recent recommendations on social-economic aspects in the transport sector and on combating unfair practices in the labour market.
Lastly, the Commission is called upon to work with stakeholders to develop an EU-wide framework for multimodal transport and logistics statistical data, including developing new indicators that better reflect real freight trends.
The Committee on Transport and Tourism adopted an own-initiative report by Inés AYALA SENDER (S&D, ES) on logistics in the EU and multimodal transport in the new TEN-T corridors.
This report aims to formulate the European Parliaments position and stimulate initiatives to promote the field of freight transport logistics.
Logistics include the services and processes of planning, managing and carrying out the flow of goods and information between the point of origin and the point of destination.
The report stressed that the implementation of the TEN-T network, with particular emphasis on cross-border connections and within the time-frames laid down and completed by 2030, will reduce bottlenecks, improve interoperability between the various modes of transport and contribute to delivering integrated multimodal freight transport in the EU. It called for increased involvement of multimodal platforms in Member States planning and in the further development of routes.
Moreover, Members regretted that Member States national infrastructure plans are too often decided without reference to the TEN-T objectives. They considered that an efficient EU logistics system requires further coordination beyond physical connectivity and an operational TEN-T network.
The Commission is called upon to strengthen the sphere of action of the TEN-T European coordinators to look beyond the geographical scope of the corridors under their respective responsibility, and to cover horizontal policy issues such as multi-modality and efficient freight logistics.
propose, by the end of 2017, a digital framework for electronic information exchange and transport management in multimodal transport (efreight) with a view to facilitating a simplified, paperless, seamless, transparent, secured and trusted information flow between businesses, customers and authorities, building on established services (such as SafeSeaNet, River Information System, intelligent transportation systems, etc).
take fully into consideration automation and its impact in its logistic strategy, ensuring its smooth and efficient integration into the TEN-T, and to support research on, and investment in, the development of these key technology.
Particular focus should be put on TEN-T core network corridors on the coordinated development of projects that promote multi-modality in freight logistics, in particular terminal hubs, logistic platforms and urban nodes.
Urgent and more efficient integration of transport modes: the report insisted on the need to concentrate major efforts on the revitalisation of railways and on the strengthening of inland waterways (IWW) as a priority for the EUs sustainable transport strategy. It called on the Commission to come forward with specific funding solutions to ease access to European Fund for Strategic Investments (EFSI) funding for European Rail Traffic Management System (ERTMS) deployment in favour of both infrastructure and locomotive installations.
In view of reducing CO2 emissions in general, as well as local pollutant and noise emissions in particular, the Commission is asked to: (i) foster the development of electric modes of transport and the necessary infrastructure along the whole TEN-T network, and, especially in town centres; (ii) foster the development of innovative transport schemes involving, for example, the use of electric vehicles and renewable energy sources, and (iii) the development of alternative fuels and the necessary infrastructure.
Members noted that the digitalisation of services has a role to play in encouraging more environmentally friendly transport solutions. They called on the Commission to facilitate, also through a coherent legislative approach at EU level, the access to and sharing of data concerning traffic flows along the corridors and the use of multimodal transport, especially for SMEs, and to secure greater involvement of local operators and public authorities in this sector.
Better training and job conditions to attract new professionals: the report noted that the working and living conditions of the workforce in the logistic chain have deteriorated substantially in the past years, making this sector less attractive for new generations, in particular for mobile workers.

industry_corpus2: Transportation


text:
Save 10% off your order with Coupon Code GREEN at check out!
Recycled and eco friendly textiles with the best stories and adventures created into one of a kind pieces just for YOU!
Trying to preserve all of your memories that are in favorite wears and finds by storing them in boxes and plastic containers? Let us help you eliminate the clutter while still holding those items close to your heart in a much smaller eco friendly piece of our art you can revisit daily.
Ickebadika...what? Exactly what I said when my two year old daughter discovered this eco friendly critter outside our picture window. After several sightings and numerous stories we brought Ickebadika to life. Ickebadika is available for you to own. Customize as a memoriy keeper or add love to one of our handmade creations. You can find Ickebadika in three sizes as well as on pursues, shirts, yard art, pins, magnets, and more! Story book coming soon!
Copyright © 2018 Claudia's Creation - All Rights Reserved.

industry_corpus2: Others


text:
Feel free to update or provide your own, there are still some holes that will likely be filled during the season.
OL - No goddamn clue.
i think i saw mcwilliams with an interception during the spring game so he might see some playing time.
Throwing an interception to him is like losing a duel against a toddler.
We're going RBless? Bold move.
Anyone know why Langham is gone? Was really looking forward to watching him.
The kid from Louisville will start on the other side of Zuniga I think. He is a game one ready player.
Not sure at all on secondary. Stew and Dean could make an interesting combo back there. I couldn't tell what Dean played in the spring game watching it live(one contact) but heard his name a few times.
I'd like to see Wilson/Henderson/Steele(star)/Dean/Stew on the field at the same time.
Also think Pierce moves ahead of Davis to become the number 2 back.
Someone said that he was upset about playing time and wanted to be closer to home.
This is fair assessment, but Gouraige has impressed everyone during r/s frosh last year that he is capable and I think he will either start at RT at Orlando or take over mid year. He has the footwork you like to see. The Ol will be ok.
Would be awesome if Gouraige was ready, I just don’t want to count on it until I see it. He had some work to do physically.
Weight gain and more training of course...but he is my homey and I know a few people who have been around him. I also stated he might be ready to start til mid season, and maybe not til next year? Dunno. I also think Moon will get a lot of snaps and a few sacks.
I had hoped Moon could be a stronger version of Alex McCallister. Both pretty rangy and mccallister was very good at getting to the QB. Obviously still time for Moon to get a lot of snaps to do just that.

industry_corpus2: Sports


text:
In his highly anticipated testimony before the Senate Intelligence Committee on Thursday, Comey discussed the bureau's investigation into Clinton's use of a private email server, noting that he thought it was odd of Lynch asking him to call it a "matter".
Following the hearing, McCain acknowledged that his questions "went over people's heads", joking that the inquiry was affected by an evening spent watching the Arizona Diamondbacks. He seemed to be arguing that Comey exonerated Clinton, in a sense, but left an investigation looming over President Trump, setting a double standard.
"Because I have been very loyal to you, very loyal; we had that thing you know", Comey quotes Trump as saying, as part of a request that Comey state publicly that Trump himself was not under investigation.
The email controversy dogged Mrs Clinton's presidential campaign.
Back when the server story was still unfolding, Cornyn called for Comey to launch a full investigation with its own special counsel, similar to the role that Robert Mueller is playing in the FBI's Russian Federation probe.
Senator John McCain (R-AZ) asked about the treatment of Hillary Clinton's email probe and the Russian investigation.
"At least in the minds [sic] of this [committee] member there's a whole lot of questions remaining about what went on, particularly considering the fact as you mentioned it's a quote big deal, as to what went on during the campaign. In other words, we're complete in the investigation and anything that former Secretary Clinton had to do with the campaign is over and we don't have to worry about it anymore?"
The Republican National Committee and GOP lawmakers highlighted Comey's revelation about Lynch after the hearing, but Kaine said they should focus on the ongoing investigations into Russia's role in the 2016 election.
He confirmed Loretta Lynch wanted him to call the Clinton investigation a "matter" to downplay it.
One of the oddest moments of the day came from Arizona Senator John McCain.
McCain said he "missed an opportunity" to ask a pointed question in today's hearing but would clarify his question and submit it to Comey in writing.
McCain said he was trying to see if Comey would apply the same approach in the case of his conversations with President Trump, and make a public determination into whether President Trump's conversations with Comey constituted obstruction of justice.
Ireland's manufacturing sector posted its fastest growth in nearly two years in May, according to a survey published on Thursday. The official non-manufacturing PMI , a gauge for the service sector, rose to 54.5 percent from 54 percent in April.
By necessity, any scenario for global improvement in digital ad experiences has to include the biggest ad seller in the world. Surprisingly, Google is one of the largest ad distribution platform for website owners and customers around the globe.

industry_corpus2: Politics & Administration


text:
It’s All About Loving Your Parents!
Bollywood filmmaker Karan Johar has become the single parent of twins — a girl and a boy— born through surrogacy last month. The civic officials said the births were registered with its public health department on Friday.
“The birth registrations were done on Friday,” BMC executive health officer Dr Padmaja Keskar said. TOI confirmed this from the central government website for birth and death registrations. The twins were born at Masrani Hospital in Andheri (West) on February 7. However, Johar hasn’t yet informed the BMC about the names of his children. A high-ranking BMC official said the children were registered in their birth record as a “baby girl” and “baby boy”. Johar’s close friend actor Shah Rukh Khan ‘s third baby, AbRam, too, was born in the same hospital to a surrogate mother.
Civic officials said the birth registration details listed Johar as the children’s father, but there is no mention of the mother’s name. The BMC has taken the declaration of Dr Masrani and his infertility clinic about the birth.
So he named his babies after his parents. Yash for the boy after his father and Roohi, as an anagram of his mother’s name Hiroo.
Congratulations Karan! You have made the famous tagline of one of your productions ‘It’s all about loving your parents’ come true through Yash and Roohi.
Fed Up Of Diet Food? Try These 'Healthy' Chaats!

industry_corpus2: Film & Entertainment


text:
Want your tickets now? Visit TicketsWest to buy early.
Exhibitors can purchase Parking Passes for $8 per space, per event day. Exhibitor passes are sold as run-of-show passes only.


text:
Relationship Science aggregates deep and verified information on over 9 million influential decision makers and the over 1.7 million organizations with which they are associated. From this data, we create a "business social graph" that highlights who knows whom. Here are Dina Dublon's strongest connections.
This web site is not endorsed by, directly affiliated with, maintained, authorized, or sponsored by Dina Dublon. The use of any trade name or trademark is for identification and reference purposes only and does not imply any association with the trademark holder. The Presence of Dina Dublon's profile does not indicate a business or promotional relationship of any kind between RelSci and Dina Dublon.


text:
Enter into an exploration of C.G. Jungâ€™s personal transformation as recorded in the Red Book and viewed from Buddhist perspectives.
To learn what the Red Book may mean to us know, the C.G. Jung Institute of San Francisco, together with the Institute of Buddhist Studies in Berkeley, hosted a series of â€œRed Book Dialogueâ€ between Jungian Analysts and leading teachers, writers, and artists. These conversations, brought together people who have challenged themselves to engage with their own depths, are designed to appeal to people both in and out of the psychological professions. In this way, the meaning of Jungâ€™s journey can come to life in each of us.
Our second dialogue, between Jack Kornfield of Spirit Rock Meditation Center and Dyane Sherwood, analyst member of the C.G. Jung Institute of San Francisco, was held at the Hotel Kabuki in San Francisco on November 12, 2010.
Originally recorded November 12, 2010 at the Hotel Kabuki in San Francisco, Ca.

industry_corpus2: Subject Education


text: I bring to Century 21 Cedarcrest Realty, exceptional customer service skills. I have over six years experience in customer service working at Valley National Bank, where i was promoted to a supervisory role within my first year. I have lived in West Caldwell over 17 years. I graduated from James Caldwell HS, where I played soccer and ran track. I also graduated from Essex County College with an Associates Degree in Business Management. My skills are transferable to multiple industries and have been put to the test with success. I not only embrace change, I have proven I can lead it effectively. Real estate provides me the opportunity in helping others pursue their dreams of owning their own home.

industry_corpus2: Real Estate & Construction


text:
Entrusting the electrical wiring of your home or business to a low voltage contractor is not a decision made lightly. Rely on Kumar Electrical Inc. to assess, diagnose and repair all your electrical needs, provide maintenance to any electrical system, conduct inspections and provide documentation to ensure your home or business is in compliance with regulatory codes for Austin, TX.
Fully insured and bonded, Kumar Electrical Inc. electricians are available on call, 24/7, for emergency repairs when prompt response to any electrical emergency is crucial. Call (512) 614-0278 for immediate assistance in the case of any suspected power problems.

industry_corpus2: Power & Energy


text:
Riches don’t just happen to most people. Some, to be sure, get lucky and win a lottery, or are born into a wealthy family. Others happen to pursue a career or business that ends up raining riches on them.
Most of us, however, have to really work at it to become financially independent. We have to choose wealth.
What keeps you from choosing wealth?
Our upbringing, attitudes, beliefs, environment and the company we keep all influence our ability to become wealthy.
If you grew up in a poor household and were not ever exposed to the possibility that you could become financially independent, you are not likely to do so.
If you believe that riches are not worth pursuing, you are not likely to become rich.
If your neighborhood draws you into bad habits, causes you to overspend or become a criminal, you are not likely to choose wealth.
If you surround yourself with nay-sayers who don’t believe that you can change your financial circumstances, you are unlikely to do so.
How can you choose wealth?
Make sure that is what you want.
You have but one life. Before you start down the path to financial independence (which admittedly can be a long one), figure out if you want it badly enough. Figure out what wealth means to you. Is it really money or is it something else? What is your life’s dream?
Know that it is possible – for you.
Consciously take a look around – getting outside of your normal domain to see what there is to see. Figure out what your current environment is, what expectations of you there are, what influences you in your surroundings. Find and study other ways of living, earning, learning and dreaming. Travel, find a mentor, volunteer in another area. Seek out stories of people just like you who succeeded in gaining the wealth they sought.
Surround yourself with cheerleaders who encourage you to follow your dream.
What do you enjoy? What skills do you have? What innate abilities can be put to use to help you start the path to wealth? If you are good at something, typically you will enjoy doing it. If you enjoy doing it, you will persist. Persistence is of prime importance in choosing wealth.
Choose the a career that pays.
You know your talents, but perhaps some additional training will sharpen the saw. If you take post secondary education, consider not only what you enjoy studying, but also what you can do with the education or training you receive from the studies. Consciously determine if your choice of trade or major will allow you to become financially independent.
If you are married, make sure you talk the money talk, frequently, with your spouse. Set your financial goals together and you both will be more likely to stick to them.
Weigh each decision against your financial goals.
Should you spend the money on that new flat screen and sound bar, or save it for the emergency fund? Consider not only the financial aspects, but the life enjoyment aspects as well. Life really is a journey that you only travel once. Too great a focus on money may well hinder your ability to gain true wealth (as opposed to monetary riches).
Educate yourself and your family in personal finance concepts.
Once you have that dream career, paying enough to allow you to start to accumulate, you don’t want to loose your nest egg on an unwise investment. Take a class, read some books, visit websites like this one to learn all you can about things like borrowing money, paying off credit and loans, ways to save, how to invest and more.
Choosing wealth isn’t a one time activity. You will need to keep at it for awhile to gain headway. Persistence is a key to your success in becoming financially independent. Use every tool at your disposal to aid your persistence. Automatic payroll deductions and investments, scheduled money discussions with your spouse, budget reviews, measurements toward your financial goals and net worth tracking are just a few of these.
I chose wealth, so can you. Read more about it in my book: Choose Wealth! Be a millionaire by midlife.
Are you financially independent? How did you get there?

industry_corpus2: Finance & Economics


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An iPod works by playing tracks in mp3 format. A mp3 is computer file that is music in nature as data, not a file made up of pictures or letters. A mp3 file is formed when it is converted into digital form from analog signals. The only thing worrisome for the iPod is that mp3 files must be compressed in order to fit into the iPod properly. Mp3 files are huge space takers on the memory of the iPod or any digital music player there is. But Apple have solved it by creating iPods with different amount of hard drive memory.
The bigger the memory,the more songs can be put in the iPod. One thing the iPod is known for is the sound quality of the player. It is as clear and not more than CD quality clear but much better than that. The iPod up to know still offer the best quality sound among digital music players today. And this is where Apple would not reveal its secrets about the iPod and how it actually works. There are many positive and negative effects of the iPod in society and in pop culture today.
One effect is that at first the iPod is a fad, a must have thing or the “in” accessory of the season. What stated out as a “want” turned into a “need”. iPods became part of our lives. It has become a convenient and important accessory in life in general today. It is an essential accessory like your wallet and cellphones. iPods also have defined on who a person is based on what he has playing on his iPod. It also gets the people to show who they are thru the iPod.
It also made interaction with other people much more better especially when downloading music or getting insights on what to download on the iPod. The bad thing about the iPod is that it does make someone isolated in society in the real world. He or she is more engrossed on their own digital world, the iPod. The lack of personal interaction is a thing to be worry about. And it also opened the doors on medical problems like ear injuries and causing to be deaf because you are listening to the iPod too loud.
And that it has become the same as cash or jewelry, it is a magnet for thieves. And it may caused a few industries to go down particularly those in record stores and somewhat the music industry wherein artists get to put their albums on record bars. They lose money because people now prefer to download music for a cheaper price or illegally than buy at a record store. No matter what it no denying that the iPod has changed the way people go in their everyday life. It has become more interesting, colorful and convenient. If you need a music fix anytime, anywhere you just plug in your iPod and go. Life has definitely changed since the invention of the iPod.

industry_corpus2: Computing & Telecommunications


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A simple and elegant pair of cufflinks that will stand the test of time. Their minimal, classic design means they can be easily paired with any shirt you like, giving you ultimate versatility.
They've been crafted from one piece of solid brass, so there are no hinges or screws to come loose or break. The rigid design also means you can wear the cuff links with either end facing out.
Each piece is individually finished by hand, so you can be assured the cufflinks you wear have a character of their own. The cuff links are presented in a complimentary timber gift box, exclusive to Burton Metal Depository.
For an extra special touch, the cuff links can also be custom engraved with a symbol or initial/monogram. Leave us a message and we'll get in touch to discuss this.
This is a collection piece and will ship from our studio in 1-3 business days.

industry_corpus2: Manufacturing


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Stop bad dreams from occurring with the help of our subliminal mp3s and get a peaceful night sleep.
Do you hate going to sleep at night because you're afraid of having a bad dream?
Do you tend to have bad dreams that occur over and over again...night after night?
Do you go to bed hoping you won't have yet another nightmare?
Do you end up feeling stressed during the day due to lack of sleep because bad dreams keep waking you up in the middle of the night?
All dreams originate from your subconscious mind and are typically a combination of whatever happened during your day, worries over things in your life or even events from your past. When you go to sleep with all of this stuff on your mind, your subconscious tries to sort everything out.
The problem is the same thoughts and worries are still active and can turn into disturbing images or bad dreams, and if you don’t take any action to clear out your subconscious mind, and change the way your dreaming mind deciphers information then you will continue to suffer from nightmares.
Because everything originates in your subconscious mind, subliminal messages can be a great tool for reprogramming your dreams. They will send positive information into your subconscious mind so that you are flooded with happy thoughts, positive feelings and good emotions - making you much less likely to have a nightmare, or a bad dream. On a deep level they will change the way your subconscious mind decodes information from your day and will stop you from having recurring bad dreams and nightmares.
You will actually be able to look forward to sleeping at night and not be afraid of having bad dreams.
This isn’t just a fantasy. If you can change on a deeper subconscious level then you really can stop your nightmares at the source and change your dreams forever!
Listen every night as you fall asleep and soon you will leave those bad dreams behind!
Download this mp3 today to stop bad dreams at the source and claim your life back from night terrors!
As your dreams start to improve then our remember your dreams subliminal can be a great album to help you remember all of those new positive dreams!

industry_corpus2: Health & Medicine


text: Larks in Transit is a compendium of travelers' tales and the general shenanigans of 20 years as a travelling comedian. With musical virtuosity, surreal tangents and trademark intelligence, Bill Bailey tackles politics, philosophy and the pursuit of happiness. Plus, he fashions a symphony from a ringtone, tells the real story of Old McDonald and a re-imagines the Stars and Stripes. Two decades of touring larks from a comic described by the Daily Telegraph as "the brainiest comic of his generation".


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EUROPEAN ENCOUNTER - Smartway Travel and Tours, Inc.
15 nights: For 15 nights, you’ll be treated to the luxury of hotels in the best bits of its destination we visit. Sleep twin or triple share, or upgrade to single share for a little bit extra.
21 Meals: We’ll be dinning over European on this trip, sampling moreish local cousin and saucy pasta. 15 continental breakfast will be included, as will 6 delicious dinner. The rest of the time is there for you foodies to roam free and discovery just what all the fuss is about around this continent of delectable tastes.
Tick even more off your bucket list with our optional Me Time activities. From cruising the Blissful Lake Lucerne, an evening of feasting in the hillsides of Tuscany kicking your hills up the world- famous Moulin Rouge cabaret show, there’s Something to satiate everyone’s crazy urges.
Ferry across the English Channel & head to the free-wheeling, vibrant city of Amsterdam via Belgium.
Motor down the autobahn & get ready for a dose of uber-cool in Berlin. Tonight enjoy this cutting-edge city’s exploding arts, bar & club scene.
Savour the mix of old and new in this ever changing city. You’ll find historical significance in everything from the streets to the grand monuments.
Bite into some local fare, like bratwurst, in Dresden on your way south to Prague, an ever modernising hub of Eastern European revival.
* See the rebuilt Baroque architecture of the Royal Residence, Zwinger Palace, Opera House & Frauenkirche in Dresden.
Snake trough this medieval city’s maze of cobblestone streets & discover Gothic architecture, bargain-priced beer & Bohemian crystal beads.
Head sout to picture – perfect Salzburg, home to Mozart & the Sound of Music.
Wind through both the Austrian & Italian Alps into Italy. Meander through the “floating city” & find grand squares, art-filled palazzos & interesting little shops.
Tap into ‘La Dolce Vita’ of the ‘Eternal city’ & explore this living museum of the history. Later , there’s a chance to delve into history with a tour of the Vatican museum including the Sistine Chapel.
Pass through rural Umbria’s rolling hills & vineyards to Renaissance Florence. A local guide gives you the inside track on the city’s striking buildings and sacred art.
This morning after a visit to the iconic Leaning Tower of Pisa, we arrive the Italian Riviera where you will be provided with a day pass to explore the stunning five lands of the Cinque Terre at your leisure.
Cathch a glimpse of Lake Combo before arriving in Lucerne, nestled in the Swiss Alps.
Breathe in the alpine beauty of this lakeside town as you spend the day exploring. Wander the cobbled streets of this gorgeous mountain setting & shop for goods that Switzerland is known for- watches, chocolates & Swiss Army Knives.
Indulge in sophisticated Paris where you’ll find magic, romance & history amongst he city’s legendary icon.
Morning transfer to Paris CDG Airport (est arr. 10:00 am) or choose to take a complimentary transfer to Central London & extend your stay.

industry_corpus2: Travel & Geography


text: The Fuji Xerox Docuprint M455DF mono laser copier is fast, efficient and feature rich to increase your office productivity. Print, copy, scan and fax capabilities mean you've got all your document management needs in one compact copier. Print securely at speeds of 45ppm, with a 60-sheet Automatic document feeder you can copy and scan easily as well. Automatic duplex, secure network connectivity & a touch panel control add to its ease of operation. With its first page out in less than 5 minutes, long life drums & high yield toner cartridges you're sure to get increased office productivity from this small footprint. Customisable with optional paper trays, cabinet & wireless connectivity means you can tailor this machine to suit your office needs.


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A simple word as it may sound, Recall simply keeps happening in my mind. Not sure, if its the same for everyone my age and kind, but thought its okay to share anyways.
I looked at a sketch that my daughter made and recall how some of our precious books back home had similar scribbles - those of mine, my mother told me later.
I heard two college students talk about Voltage, Shunt and Series and Parallel Controller and some such highly "Electrical Engineering" like words this morning. Could not help recall how I was in a similar position fifteen years ago discussing and studying same subject.
I bought coconut cookies yesterday for my children and recalled how I used to be crazy about them back in childhood.
I got dressed in a saree the other day and my daughter asked if I would buy her the same color saree some day. Recalled how I had asked similar questions to my mother when I was of my daughter's age.
I take the children out today and they hail an auto immediately. I recall how I loved auto travels too back in childhood, and even today.
Recalls are good if they make you smile. Recalls make you connect with the past and the people of the past. Recalls ascertain that nothing of the basics change over the generations or decades. The stage that you are in makes the decision and not YOU really. And its good if a child behaves like one, a teen ager behaves like one, a college student behaves like one and a working professional behaves like one..
After this stage is when the RECALLS really happen more often... When we realize that the wheels keep moving just the same way always . Today or Yesterday or Tomorrow.
Life is a Wheel. The Tyre on it may change over times but the concept of the Wheel is quite old and stands tall.


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Private investigators and private detectives also need personal protection; this really is due to the fact that the field of private investigation can be a risky company. Nonetheless, the desire to help other individuals know the truth about a case or an problem is paramount that's why plenty of private investigators and private detectives demand extensive training also as use of private investigation gadgets and equipment. It is imperative to create survival skills for a private investigator or a private detective due to the fact in order to survive or counter any ordeal or challenges that could be faced by the private investigators and private detectives. Nonetheless, coaching sometimes is not sufficient for survival; in a technology driven society a private investigator and private detective must also be equipped with all the understanding on how you can use the most recent equipment and gadget. One of the gadgets that are crucial to the job of a private investigator and private detective is illumination. Most of the time, private investigators and private detectives are conducting their investigation throughout the night and therefore illumination is important. Night time surveillance is crucial in some situations on account of the reality that some unscrupulous transactions are happening during the evening and a private investigator or private detective must be well equipped throughout the investigation.
1 of the very best illuminators that a private investigator or private detective could have will be the PD20D Efficiency LED Flashlight. It really is regarded as to be a torch light that's equipped with six settings where four of them are settings for output levels. The general mode of the illuminator PD20D is 12 lumens which can withstand 30 hours of operation. The turbo mode setting provides you 180 lumens of light intensity that could last for an hour. Furthermore this device comes using a flashing strobe light mode which could assist private investigators and private detectives in giving signal for assist or backup.

industry_corpus2: Law & Justice


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Staying healthy is something we start thinking about early on in life. As you get older, your body experiences some changes that require you to incorporate different habits to keep going at top speed. Here’s what you need to know about healthy aging as you achieve landmark ages in your 60’s, 70’s, 80’s, and beyond. We’ll give you six tips to stay active, lean, and make the most of your retirement years.
Eating a nutrient-dense diet is important at every age, but later in life, it can reduce your risk for developing some of the scarier chronic diseases. Focus on healthy foods like lean proteins, fruits, vegetables, and whole grains to ward off osteoporosis, high blood pressure, heart disease, and cancer.
Try to avoid junk food like soda, chips, cookies, and alcohol as they are loaded with calories and preservatives. They can cause inflammation in your joints, and eating too many of these treats will also make you gain weight.
Finally, stay away from trans fats and saturated fats that you find in highly processed foods, margarine, and fatty red meats. Studies show they can increase your cholesterol levels and contribute to health issues, especially in adults over 60.
Being socially active with friends, neighbors, or in your community, nourishes your brain in your golden years. Those connections not only give you something to look forward to, and they also provide a purpose that will keep you plugged into the outside world and allow you to enjoy each day fully.
If you’re looking for a way to get more involved, check out local senior centers for daily and weekly activities. You’ll find things like card tournaments, movie nights, potlucks, day trips, and other social events where you can connect with other retirees in your area.
Whether you’re eight or 80, chances are good you don’t particularly like going to the doctor. However, as you age, it becomes more important than ever to go to your check-up appointments and keep an eye on your physical health.
Be sure to do all of your recommended health screenings, and take your medications as they are prescribed to keep in tip top shape.
There are dozens of proven health benefits of exercise, and some studies suggest that no one will benefit more from regular movement than active older adults.
Not only will regular exercise help you maintain your independence and keep your body strong enough to live on your own without the risk of falling and breaking something, but it also reduces the risk of many chronic diseases. Conditions like coronary heart disease, high blood pressure, colon cancer, and diabetes can be kept at bay with regular exercise.
The movement will maintain healthy bones, muscles, and joints, and can even control the swelling and pain that occurs if you develop arthritis.
The best news? If you’re not already active, it’s not too late to start. As little as five to ten minutes a day of gentle movement that raises your heart rate and gets you a little sweaty will have positive health benefits.
You can go for a walk around your neighborhood, play with your grandkids, or look for an exercise class near you. Senior centers, YMCA’s, and other fitness facilities often offer group classes specific to retirees that include movements that are both safe and effective.
Your sleep needs may change as you age, but it’s still important to get enough rest. Poor sleep quality or not getting enough shut-eye can lead to depression, and even worse, it affects your coordination and may make you more likely to have a fall.
If you’re having issues sleeping at night, talk with your doctor as many treatments and remedies can help.
Keeping your body active as you age is important, as is regularly exercising your brain. Studies show that seniors who did 12 one-hour sessions of cognitive training stayed sharper over a period of ten years. What does this mean for an average Joe or Jane like you? If you incorporate brain training into your daily lifestyle, you’ll keep your mind in top shape as you age.
It’s easy to add activities that will boost your memory to the day. Try doing a crossword puzzle, to remember your grocery list without writing it down, or to learn a new activity or sport. By introducing new material to your mind on a regular basis, like the rules of golf, for example, you’ll keep your brain tissue healthy for years to come.


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This course has been designed specifically for CIFs and will focus on the actions that these firms must take in order to comply with their AML and KYC obligations.
In today’s demanding environment, CIFs are required to exercise due diligence and perform specific controls on their clientele in order to comply with AML / KYC requirements. Furthermore, CIFS are obligated to collect specific documents from clients.
CySEC has issued specific guidelines for the controls and reports that regulated firms need to perform in order to comply with their obligations.
The programme will take for form of presentations, case studies and extensive discussion, as well as real life examples, all of which will assist with the better understanding of the content and thus assist participants to apply what they learn to their own job functions upon their return to the workplace.


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See our full program of events. Please use Firefox or Chrome to view the program.
Peter Bartlett is a professor in the Computer Science Division and Department of Statistics at the University of California at Berkeley, and professor in Mathematical Sciences at the Queensland University of Technology. He was awarded the Malcolm McIntosh Prize for Physical Scientist of the Year in Australia in 2001, and was chosen as an IMS Medallion Lecturer in 2008, and an IMS Fellow and Australian Laureate Fellow in 2011. His current research interests include machine learning, statistical learning theory, and adaptive control. Terry Speed received a BSc at the University of Melbourne (1965) majoring in mathematics and statistics, and PhD in mathematics and a Dip Ed at Monash University (1969). He has held appointments at universities in Australia, the U.K. and the USA, and also at the CSIRO. He is currently head of the Bioinformatics Division at the Walter and Eliza Hall Institute of Medical Research. His research interests are broad, but with a current focus on cancer genomics.

industry_corpus2: Math & Statistics


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Lolium perenne var. aristatum Coss. & Germ.
Lolium perenne var. aristatum Coss. & Germ. is a synonym of Lolium multiflorum Lam.
The record derives from Tropicos which reports it as a synonym (record 50094723) with original publication details: Fl. Descript. Analytique Paris 2: 656 656 1845 .

industry_corpus2: Agriculture & Fisheries


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We are a non-profit cooperative, founded in 1923. Our main purpose is providing affordable living in the area of Hausruckviertel. We provide flats mainly in Attnang-Puchheim, but we also do in: Neukirchen an der Vöckla (Zipf), Neukirchen bei Lambach, Oberndorf bei Schwanenstadt, Ohlsdorf, Ungenach, Frankenmarkt and Vöcklamarkt.
So, please feel free to contact us during our business hours. If you want to meet us in person please regard our opening hours.
By personal appointment by phone or email with one of our staff!


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The Young Vic Theatre in Waterloo invites Gender Identity Clinic service users who live in Lambeth or Southwark to join us for shows, workshops and events!
You don’t need any previous experience of theatre to take part in any of our workshops or events. All you need to do is be curious, call us, email us, pop by, and sign up to whatever takes your fancy.
Two Boroughs is open to all residents of Lambeth or Southwark, and aims to build a local community around our theatre. Our friends and neighbours are really important to us. They are our beating heart, and we believe that if you live in one of our two boroughs, you should visit us at least once. If you don’t like it, you never need to come back, but there’s a chance that this will be the start of a lifelong relationship.
Once registered you’ll have the chance to come and see a show for free at the Young Vic as well as a range of free workshops, theatre club, projects and events throughout the year.
Upcoming shows include ‘How to Win Against History’, and an associated two-week project around Queer performance and musical theatre.
Our ticket scheme also provides free and discounted tickets for Lambeth and Southwark residents.
Individuals can usually book 2 tickets. This may vary depending on the availability of tickets, and the people you choose to bring with you must be residents of Lambeth or Southwark too.
To register for a workshop or sign up for tickets, please give us a call on 0207 922 2846, or email twoboroughs@youngvic.org.


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The liver contains several different laminin (LN) isoforms that play important roles for development, liver tissue homeostasis, organization and regeneration. Hepatic progenitor cells (HPCs) and are always closely associated with a laminin-rich basement membrane. After injury, laminin accumulate around the progenitors and the laminin-liver progenitor cell interactions are a critical for hepatic progenitor cell (HPC) mediated regeneration (Carvalho, 2008; Lorenzini, 2010). Murine regeneration models show that the alpha-1, alpha-2, alpha-4 and alpha-5 laminin chains increase in association with HPC activation and that laminin alpha-5 containing matrix (laminin 511 and laminin 521) is deposited around HPCs during regeneration. Moreover, alpha-5 laminin matrix promotes HPC attachment, migration and maintenance (Kallis, 2012; Klaas, 2016).
Hepatic stellate cells (HSCs) are liver-resident mesenchymal stem cells which are critical for liver regeneration and can contribute to fibrosis in chronic liver diseases. The HSCs reside in a quiescent state in the space of Dissé on a basement membrane-like structure that contains a5 laminins. The fact that a5-laminins are important elements of the HSC niche was show in an article by German researches where they show that culture on Biolaminin 521 supports the quiescent state of the HSCs. Biolaminin 521 improved HSC adhesion and better preserved their retinoid stores as well as quiescence- and stem cell-associated phenotype, whereas HSC cultured on uncoated polystyrene plates or plates coated with non-relevant laminin isoforms developed into myofibroblasts-like cells. In addition, laminin-functionalized, gold-nanostructured glass surfaces further enhanced the expression of quiescence-associated genes in the HSCs (Rohn, 2018).
In a publication by Cameron et al., the authors show that culture of human ES cells (hESC) on human recombinant Biolaminin 521 and Biolaminin 111 substrates significantly improved hepatocyte differentiation, maturation, function and stabilization of phenotype compared to Matrigel cultured cells (Cameron, 2015). In addition, the authors recently published a JoVE protocol that describes the scalable and GMP-ready differentiation process (Wang, 2017). The laminin differentiation protocol generates high ratio of hepatocyte-like cells positively stained for ALB, CYP2D6 and CYP3A and the cells exhibit significantly increase in P450 metabolic enzyme functions relative to cells on Matrigel or human primary hepatocytes. The Biolaminin cultured hESC-derived hepatocyte-like cells display a more primary hepatocyte-like appearance and are often bi-nucleate with very pronounced nuclei. Moreover, the hepatocyte-like cells arranged themselves in lobule-like structures within the laminin coated culture dish, reminiscent of regenerating liver. hESC differentiated on Biolaminin 521 and 111 exhibit vast networks of highly organized hepatocytes which express multidrug resistance-associated protein 1 (MRP1) and 2 (MRP2) and are capable of biliary efflux. The results presented in the paper represents a significant advance compared to any previous published data, especially regarding metabolic activity and functional cell organization.
hepatocytes which express MRP1 (green) are capable of biliary efflux.
Courtesy of Dr. Kate Cameron, University of Edinburgh.
The positive effect of laminin 521 on hepatic differentiation is supported by a recent publication by Kanninen et al. that show that human recombinant Biolaminin 521 can be used as stage specific matrix to guide the hepatic specification of pluripotent stem cells (Kanninen, 2016). Moreover, the expression of laminin 521-specific integrins increase during definitive endoderm and hepatic specification. hPSC-derived hepatic cells differentiated on these laminin matrices show up-regulation of liver-specific protein markers, secreted human albumin, stored glycogen, and exhibited cytochrome P450 enzyme activity and inducibility. Contrary, the authors show that fibronectin is not a vital matrix protein for generation of definitive endoderm cells. A screening of the acellular matrix produced by the popular hepatic tumor cell line HepaRG show that laminin isoforms 521 and 511 and fibronectin are highly expressed.
The importance of extracellular niche factors for bridging the gap in functional differences between hepatocytes derived from human induced pluripotent stem cells (i-Heps) and primary cells is further discussed in an recent article from a research group in UK. They applied a Hepatocyte Likeness Index platform to screen hepatocyte extracellular factors for their ability to drive i-Heps closer to the standard. In their study, laminin 411 was identified as a key niche protein, advancing i-Heps toward functional significance and prolonging survival of hepatic progenitor cells (Ong, 2018).
The research results presented above are in accordance with studies from Japanese researchers showing that isolated and hESC-derived hepatic progenitor cells effectively can be expanded with maintained phenotype on Biolaminin 111. The group of Mizuguchi show that human recombinant Biolaminin 111 is optimal for maintenance and clonal expansion of homogenous populations of hESC and hiPSC derived hepatoblasts (Takayama, 2013). The hepatoblasts were efficiently expanded on Biolaminin 111 for more than 15 passages with maintained phenotype and could thereafter be further differentiated into both hepatic and biliary lineages. Moreover, since pluripotent stem cells cannot survive and self-renew on Biolaminin 111, residual, undifferentiated cells are effectively eliminated from the differentiated hepatoblast population by the matrix itself, an important mechanism from a therapeutic aspect. When transplanted in CCl4-treated immunodeficient mice, the laminin-cultured hepatoblasts successfully engrafted and albumin-positive cells were observed in the liver of the transplanted mice.
In a recent article, the authors searched for a suitable extracellular matrix to promote cholangiocyte differentiation from human iPS cells and found that both laminin 411 and laminin 511 were suitable for this purpose. Hepatoblast-like cells were mixed in a collagen gel and plated and for cholangiocyte differentiation, laminin was added to the medium. The gene expression levels of cholangiocyte markers were increased by the addition of laminin 411 or laminin 511. In addition, the percentage of AQP1-positive cells was increased from 61.8% to 92.5% (Takayama, 2016).
In a publication by Watanabe et al., Biolaminin have also been shown to promote attachment of human primary hepatocytes and can effectively be used as culture substrate for these cells (Watanabe, 2016).


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She lived a colorful life, according to my great great great aunt Arlene she was the wild one out of her and her sister. She was too smart for her own good and when she went to college at age 50, she had a 4.0 and accepted nothing less. That's how she was with me, a B was considered average and she expected above average out of me.
There are so many memories it was really just her and I since I was 7. She was a work-aholic, who loved animals, was beautiful and loved to get dressed up but would change a tire or fix anything that was broken. She needed no one to help her! She did everything it seemed. She told me hard work and volunteering is what I should do and needed to do to be a valuable part of my community.
She ran a place called HHP, Help for Homeless Pets in Billings and cared so much for the animals it hurt her all the time to see sick or injured animals. She did so much for so many dogs though. She liked maroon, pink and teal like color scheme. She had lots of these fancy egg like decorations and lots of Waterford crystal.
We would watch lots of law shows, Golden Girls, Fast Times at Ridgemont High... to name a few. Her dad, my great grandpa, loved "Grumpy Old Men" so we had those movies. She loved computers but we couldn't afford one. She hated photos and talking on the phone but would always try to make time for me when I called. She was busy all the time and never stopped moving.
Just a few quick memories and thoughts about my Grandma Dee. I can still hear her telling me to moisturize my neck as well as my face so I don't get wrinkles. I try to do something in her memory and I know this sounds funny but she was the ultimate clean freak and she would be very mad at me with how messy my house is so I think her honor I will clean. She would not mind me doing that thinking of her. She was just one of those classy, independent women.


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Book a Video consultation with Vijay Jalvadi and get best legal advice of your legal problems.
Book a Message consultation with Vijay Jalvadi and get legal opinion without any delay.
Have a Meeting Vijay Jalvadi across your locality and clear your legal doubts easily.


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Vecoplan has continued a positive growth trend with the establishment of a Polish branch office for recycling and waste in the capital Warsaw.
Headquartered in Bad Marienberg in Germany’s Westerwald, Vecoplan is a leading international specialist for environmental and recycling technologies – and thanks to the branch, the company can provide even faster support for its Polish customers.
Vecoplan has been successful in the Eastern European market for many years and in order to provide its Polish customers with even better customer care, the company has opened a branch in Warsaw.
Michael Lambert, CFO of Vecoplan and nominal CEO of the Polish operation.
The opening of the new branch is an important milestone for Vecoplan in its expansion of direct customer service in Eastern European markets.
Vecoplan Polska is responsible for machine and service sales, while technical development and project support is carried out by Application Technology at the German Headquarters, facilitating communication within the supply chain.
A leading manufacturer of machines and systems for the resources and recycling industry for shredding, conveying and reprocessing wood, biomass, plastics, paper and other recyclable materials such as domestic and industrial waste, Vecoplan currently has around 380 employees at locations in Germany, the US, UK, Spain and Poland.


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Our fav youtube show before we got netflix was 爱情保卫战, though it is slowly being replaced by another favorite 一转成双, which I was reassured by Mr Bear that would deliver violence on top of the volatile relationships ( I had to watch like 20+ blurry episodes before someone finally got slapped).
But of course 一转成双 does not have the erudite 涂磊, whom we cheekily nicknamed a nice foul word courtesy of the Canton dialect. He can toss 4 worded, 8 worded chinese idioms 蒺藜火毬-style at warring couples. Sounds very bombastic, but I cannot really understand them (possibly because my Mandarin is pretty shite).


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Many people, including the Governor of the Reserve Bank, Glen Stevens, have pointed out that global pessimism has meant that Australians currently see the glass as half empty rather than half full. This is, of course, despite Australia being relatively spared from the worst of the economic downturn so far. It is also the case in medical research, where there is widespread, and understandable, concern about future levels of funding remaining flat while costs continue to climb. However, it is important to recognize and celebrate the many good pieces of news we have had recently that are covered in this issue of The Edman.
We have previously reported our extremely good success rate in NHMRC grants in 2011 and this will continue to support us over the coming 3-5 years. We also have strong philanthropic support. Recently this has included receiving half the proceeds of the Susan Alberti Medical Research Foundation Signature Ball that raised $450,000 altogether, as well as several grants from a number of Trusts and Foundations, including the new 5Point Foundation. The latter is especially pleasing because it represents a new generation of charitable giving, with the Trust’s Founders being a group of successful business people in their early 40’s.
A further recent exciting event was the publicity associated with the description of a computer simulation of rhinovirus bound to a drug currently in human clinical trials. Rhinovirus is major cause of the common cold. This work was led by our Structural Biology Unit, headed by Michael Parker. A highlight of this work was its collaborative nature – including scientists at SVI and the biotech company Biota using the Australian Synchrotron at Clayton and by scientists from IBM and the University of Melbourne using the new IBM supercomputer recently installed at the University.
Another recent highlight was the award of an honorary Doctor of Laws to our esteemed John Holt Fellow, Professor Jack Martin. This recognition for Jack from his alma mater was a reward for a lifetime of achievement and a remarkable international reputation for research into diseases of bone. Other St Vincent’s campus alumni whose contribution was celebrated included Sir Peter Morris and Sir Marc Feldmann, both of whom have spent much of their careers in the UK. We are extremely fortunate to have Jack remain whole-heartedly involved in research at SVI: his presence is the best encouragement we can give to young researchers considering a career in medical research.
It is clear that gloomy global attitudes have not affected the performance of our researchers, who continue to work to find solutions for common disease that have serious effects on our health. Despite concern around future funding, we too should strive to see the glass as half full and when we have the chance make our voices heard about the value of medical research for the future health of Australia.
Steve Harris knew something was up when, the day after a bit of horseplay with his son, he saw a hand print-shaped bruise on his arm. “He was either the strongest 9 year old in the world, or there was something really wrong with me”, he says.
Steve spent the next four months dealing with a diagnosis of, and treatment for, acute promyelocytic myeloid leukaemia (APML).
More than eight years after his diagnosis, Steve’s chances of relapsing now approach those of anyone else in the male population contracting the disease.
Steve visited SVI with a group from the Leukaemia Foundation in August to hear about SVI’s leukaemia research program, funded in part by the Foundation.
Steve was particularly interested to talk to Associate Professor Louise Purton, of SVI’s Stem Cell Regulation Unit, who has devoted a large part of her research career to investigating exactly what goes wrong in leukaemia and studying the pathways that can be exploited to treat it.
Louise explains that billions of cells are produced in our body each day, predominantly in the bone marrow. The non-blood cell types present in the marrow – collectively known as the bone marrow ‘microenvironment’ – help to control blood cell production from stem cells. Incomplete production or function of the different blood cell types, or problems arising in the function or composition of the non-blood cells that regulate blood cell production, can lead to disease.
help cure leukaemia, lymphoma and myeloma. To find out more information, visit www.lightthenight.com.au. If you would like to tour SVI, please contact us on (03) 9288 2480.
SVI researchers Dr Nicole Walsh and Associate Professor Helen Thomas and PhD student Suang Suang Koid, were given the opportunity to celebrate the achievements of women in science at a function held by the Parliamentary Friendship Group of Women in Science, Maths and Engineering at Parliament House in June. Thrilled by the invitation from Kelly O’Dwyer MP, Federal Member for Higgins, PhD student Suang made sure to introduce herself to a number of the luminaries in the room, including keynote speaker, Nobel Laureate Professor Elizabeth Blackburn AO FRS.
Michael Parker has been awarded the Federation of Asian and Oceanian Biochemists and Molecular Biologists Award for Research Excellence. The Award is granted annually to a distinguished biochemist or molecular biologist, based on work carried out predominantly within the region.
PhD student David Ascher was one of 115 young Australians awarded a prestigious 2012 Churchill Fellowship. The Fellowships are designed to provide an opportunity for Australians to travel overseas to conduct research in their chosen field that is not readily available in Australia. David’s Fellowship will allow him to travel to the UK and Spain to further his research into structure-guided drug design to develop new treatments for cancer.
Professor Michael Parker hit the headlines recently, with a flurry of media interest into his work on rhinovirus, the most frequent cause of the common cold.
Along with his collaborators, Michael’s research has enabled the structure and motion of the complete human rhinovirus to be simulated in 3D, on Australia’s fastest supercomputer, paving the way for new drug development.
Rhinovirus infection is linked to about 70 per cent of all asthma exacerbations with more than 50 per cent of these patients requiring hospitalisation.
A new antiviral drug to treat rhinovirus infections is being developed by Melbourne company Biota Holdings Ltd, targeted to those with existing conditions to whom the common cold poses a serious threat to their health.
Michael and his team have been working on the newly installed IBM Blue Gene/Q supercomputer at the University of Melbourne with computational biologists from IBM and the Victorian Life Sciences Computation Initiative (VLSCI). The researchers are using information on how the new drug works to create a 3D simulation of the complete rhinovirus.
“Supercomputer technology enables us to delve deeper in the mechanisms at play inside a human cell, particularly how drugs work at a molecular level. This work offers exciting opportunities for speeding up the discovery and development of new antiviral treatments and will hopefully save many lives around the world,” he says.
a Doctor of Laws from the University of Melbourne.
Jack received the honorary degree for his significant contribution to and association with the University of Melbourne throughout his career.
Jack’s career spans more than five decades, and has notably included his directorship of SVI from 1988 to 2001. Determined to understand why some cancer patients developdangerously elevated levels of calcium in their blood, Jack’s research began in the pioneering time of the recombinant DNA revolution. His great contribution to science has been in the advancement of contemporary understanding of calcium- regulating hormones, extensively developing modern concepts of bone cell biology.
One of his most outstanding contributions was the cloning of parathyroid hormone-related protein, which contributed to the understanding of bone metabolism and disorders such as osteoporosis and cancer spread to bone.
We live in a dangerous world. If it were not for our powerful immune systems, the bacteria, viruses, fungi, and parasites in our environment would make short work of us.
One of the most powerful elements of our defensive immune systems is the B cell. The Bcell produces antibodies when the body is subjected to infection. These antibodies either kill the infection-causing organism or make it prone to attack by other cells.
During development, B cells are sorted so that the body retains only those that will be effective. If this sorting goes wrong, and cells that recognise the body’s own tissues remain, autoimmune disease can result. Conversely, if too many cells are eliminated, the body’s immune system will not be able to destroy infectious agents. Recent research from SVI’s Molecular Genetics Unit has begun to explain how this fine balance is maintained.
The Unit has for some years focused on a protein called ASCIZ, which the group discovered whilelooking for genes that responded to DNA damage in yeast.
Subsequent research from the group has shown that ASCIZ is a surprising multi-tasker. While ASCIZ does play an important role in the way that the body repairs damage to DNA, which may be exploited to develop new cancer therapies, it is also essential for lung development in mice.
Associate Professor Jörg Heierhorst, his PhD student Sabine Jurado and colleagues have recently published a paper in the prestigious Journal of Experimental Medicine, showing that ASCIZ also has an unexpected role in helping to manage the development of B cells in the bone marrow during development.
of mice, the researchers were able to manipulate the number of B cells that developed.
He goes on to say that there are some rare cases of immune deficiency disorders in humans, similar to that seen in their mice. These disorders seem to affect B cells but not other immune cells, and the researchers plan to test if any of the patients with these disorders carry mutations in ASCIZ or DYNLL1.
While the group continues to focus on the potential of ASCIZ for improving cancer therapies, they will continue to examine the role of this surprising multi-tasker in immune cell as well as in lung development.
Are you curious to find out more about research at SVI? You are welcome to tour the laboratories, meet with our researchers and hear about the cutting edge of medical research into diseases that affect all Australians, including type 1 and 2 diabetes, heart disease, bone diseases such as arthritis and osteoporosis, Alzheimer’s Disease and cancer.
Tours take about an hour and can be tailored to suit your availability and interest in a particular disease.
In June, SVI examined the science of food, by hosting ‘Food Matters: You are what you eat,’ an exclusive evening for SVI 1000 Club members.
guests about current food trends, the Mediterranean diet and the effects of food on our health.
Tours of SVI ran before the event, giving guests an insight into the work that is being done into obesity and type 2 diabetes at the Institute.
All funds raised by the 1000 Club go towards the SVI Student Scholarship Fund.
This year marks the tenth anniversary of the founding of the SVI 1000 Club, which currently has 400 members. Support from 1000 Club members has helped increase the number of SVI Student Scholarships that can be offered at the Institute. The Scholarships help support students undertaking PhD and Honours studies. SVI’s young students are committed to a career of painstaking investigation into the intricacies of disease and illness. Support to help them achieve their goals is much appreciated.
If you would like to join the 1000 Club, please contact us on (03) 9288 2480.
Crown’s Palladium Ballroom radiated with glitz and glamour on Saturday 4 August for the 27th Susan Alberti Medical Research Foundation Signature Ball.
The evening was a spectacular success, raising in excess of $450,000 for research into type 1 diabetes, with 50 per cent of the funds raised directed towards SVI’s Islet Transplant Program. The remaining funds will go to the Juvenile Diabetes Research Foundation (JDRF).
Over 600 guests danced the night away to world-class performances by David Campbell, Chong Lim and his Big Band and The Aussie Boys.
Sue’s his 20 years of work researching type 1 diabetes and his shock at discovering three years ago that his 11 year old son Christopher had been diagnosed with the disease. This reinforced to guests the importance of supporting the vital research that SVI and JDRF are working on every day.
As the winner of the raffle, one lucky guest walked away with the keys to a 2012 Nissan Micro, while another successfully bid $9000 in the auction to secure the unique experience of a bike ride with Federal Opposition Leader, the Hon Tony Abbott MHR and the Hon Kevin Andrews MP.
SVI sincerely thanks Susan Alberti and her team for an unforgettable evening, an amazing fundraising effort and their ongoing commitment and support towards the Institute’s type 1 diabetes research.
Generous contributions from SVI supporters allow the Institute to offer student scholarships to the best and brightest Honours and PhD students. In 2012, the Program is supporting one Honours and nine PhD students.
The essential research funding awarded annually by the National Health and Medical Research Council does not pay for cutting edge equipment that is often necessary to carry out the research. Support from our generous donors and from Trusts and Foundations makes these purchases possible. Since June, we have received $241,649 worth of funding for equipment purchases from six successful applications to Trusts and Foundations, including Perpetual Trustees, the LEW Carty Charitable Fund and the Angior Family Foundation. These funds will help to purchase vital equipment for research into osteoporosis, arthritis and breast cancer.
SVI supporters at the recent ‘From the Lab to London’ breakfast raised $15,000 to help support vital research at the Institute into diseases that affect all Australians.
On the eve of the Olympics, over 170 guests braved a chilly Melbourne morning to gather in the Olympic Room at the MCG and celebrate elite performance at SVI’s ‘From the Lab to London’ breakfast.
A group of six Olympians spoke with emotion about the highs and lows of being an elite performer, drawing parallels between the motivation and talent needed to perform at sport’s highest level as an athlete with that of elite medical researchers. Taking part were Olympians John Landy AC, CVO, MBE (Running, 1952, 1956), Simon Baker (Walking, 1984, 1988, 1992, 1996), Brett Maher (Basketball, 1996, 2000, 2004), Mark Turnbull OAM (Sailing, 2000), Matt Welsh (Swimming, 2000, 2004) and John Aloisi (Football, 2004), who entertained guests by sharing their Olympic experienceswith MC Leon Wiegard OAM (Water Polo, 1964, 1972).
SVI thanks its Major Event Partner, the Commonwealth Bank, Official Health Partner, Bupa and Community Partner, the City of Melbourne for their valuable contribution to this gold medal breakfast.


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Today’s Journal is brought to you first by Occupy Design, a project created by San Francisco-based designer, Jake Levitas.
As they state, Occupy Design creates “freely available visual tools around a common graphic language to unite the 99%. The project places an emphasis on producing infographics and icons to improve the communication of the movement’s messages and the data surrounding them across the world.” We love it when design gets active.
Plus check that logo, man. Tight.
Levitas and company also provide an Occupy Design Toolkit for designers who want to get involved. Now if only we knew some designers.
In concert with that theme, below is this week’s New Yorker cover, “Fighting Back,” by cartoonist Barry Blitt.


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Whether you are a new business or established organisation, you need to ensure you have adequate finance from the most suitable sources.
You also need to be able to review your financial picture to understanding your business stability.
Do you have too much short term debt?
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The US recognition of Guaido’s claim was followed by Canada, Saudi Arabia, Israel, the OAS, and a slew of Latin American countries including Brazil, Argentina, Chile, and Colombia. But Mexico and Spain, critical leaders in the Spanish-speaking world, withheld their support. In response to the US’ bold claim that Juan Guaidó is the legitimate President of Venezuela, President Maduro broke off all diplomatic with the US and gave US diplomats 72 hours to leave the country. Before the people and nations of the world and as constitutional president … I’ve decided to break diplomatic and political relations with the imperialist U.S. government,” Maduro said before an estimated one million supporters who surrounded the capital building.
Since assuming office two years ago, the Trump administration has made the government Venezuela (alongside Iran and North Korea) one of its significant targets of aggression and sanctions. For example, President Donald Trump increased sanctions on individuals and entities linked to the Maduro government, including sanctions on gold and oil trade, which are significant sources for the foreign currency of Venezuela. Additionally, Administration officials said further economic and diplomatic actions are on the table. “Everything is on the table, all options, but on the economic sphere, if you look at what we’ve done, there is still a tremendous amount of leverage in our toolbox,” said Secretary of State Mike Pompeo. Secretary Pompeo also refused to rule out US military action against Venezuela. “We have a host of options, we will take every single one of those options seriously, [The Maduro regime has] no immediate future, they will have no immediate livelihood, and they will have their days counted,” Pompeo added.


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