text:
New approachesin improvingsensitivity and specificity ofPCR(immunePCRaptamer PCR).
Immuno-PCR is a group of hypersensitive methods for detecting antigens that combine the specificity of antibody recognition with antibodies and the sensitivity of PCR.
The method is based on the use of monoclonal antibodies linked to DNA. The antibody binds to the antigen, and then the amplification of the polymerase chain reaction exponentially amplifies the signal.
In order to increase the reliability of immuno-PCR, two different antibodies can be used that identify different epitopes of the same antigen. In this case, each of the antibodies is connected along a DNA chain with a different sequence of nucleotides, but they are nevertheless complementary to each other in a small area. These complementary regions serve as primers for the DNA polymerase in the first stage of the polymerase chain reaction.
The technology was created in 1992 and since then it has been repeatedly modified. For example, antibodies can be replaced with aptamers. In addition, unlike such analytical methods as ELISA and immunoimmunoassay immuno-PCR assay, in one experiment to determine many different antigens at once, because after binding of antibodies to antigens, these antibodies can easily be identified by unique oligonucleotide DNA sequences attached to antibodies.
Another important advantage of the immuno-PCR method is that the technology does not require working with dangerous radioactive material as in radioimmunoassay, does not require complex or expensive equipment, and at the same time it achieves the highest sensitivity, which allows recommending it to oncologists for early diagnosis of precancerous states. So, one of the types of immuno-PCR, called agglutination-PCR (ADAP), allows to detect from zepto- (10-21) to atto (10-18) moles of antibodies in 2 microliters of the sample. What makes it possible to identify, for example, autoantibodies of anti-thyroglobulin from human blood plasma with a 1000-fold increase in sensitivity in comparison with the current radioimmunoassay method.
Equipment required for mastering these methods, like SlipChip, can be made even in handicraft production, and even a cell phone with a built-in camera can be used for recording and evaluating results. Therefore, the technology can be implemented even in rural hospitals.
Aptamers are short (20–80mer), single-stranded DNA or RNA sequences or proteins that bind to target molecules with high affinity and specificity through their 3-dimensional structures. RNA sequences make up the majority of nucleic acid aptamers, perhaps because they can be synthesized by in vitro transcription in the laboratory and, with a 2′-OH, would potentially provide more diverse secondary structure than single-stranded DNA molecules. Nucleic acid aptamers are often identified using an iterative enrichment technique, where oligos or proteins with increased affinity and specificity to a target molecule are isolated from a sequence pool after several rounds of selection. Nucleic acid aptamers are selected in vitro based on affinity for the target molecule, which might be a protein, virus, or cell. SELEX (Systematic Evolution of Ligands by EXponential enrichment; see the sidebar) is one of the most common iterative enrichment methods used to Identify nucleic acid aptamers.
To obtain aptamers with specified properties, the SELEX technology was proposed (systematic evolution of ligands by exponential enrichment.) As a starting material in this method, an oligonucleotide library is used in which each oligonucleotide has common 3 'and 5' flanks in length 17-25 nucleotides, and the middle regions of 20-60 nucleotides in length are unique.This library can be synthesized as a single preparation of an oligonucleotide, in which in the middle part in each position it is equally probable Each of the four nucleotides is incubated with this molecule, which is usually fixed on a solid carrier, and the oligonucleotides that do not bind to the target are removed and the bound ones are amplified by PCR using common 3 'and 5' flanks. This cycle is repeated several times, as a result of which enrichment occurs with sequences having an affinity for the target molecule.
Finally, the aptamer molecules are cloned in the plasmids and individually tested for their properties. This technology allows to obtain aptamers for periods from two weeks to several months. The experience of using SELEX has shown that aptamers can be obtained for almost any target: proteins, polysaccharides, small organic molecules, viruses and whole cells.
Aptamers can be considered as analogs of monoclonal antibodies. Moreover, they have a number of important advantages over antibodies. Their preparation is much simpler, cheaper and faster than the preparation of monoclonal antibodies. They have a much smaller size, and therefore easier to penetrate into tissues and cells, may have higher affinity and specificity.
The results obtained using aptamers indicate the possibility of their use in biotechnology for the controlled expression of genes, as well as for diagnosis and therapy.
One of the most interesting achievements in this field of research is the creation of ribozymes with allosteric properties. In such constructions, the catalytic domain of the ribozyme is coupled to sequences of aptamer receptors interacting with regulatory molecules. In the presence of low molecular weight regulators, specific activation or inhibition of the enzymatic activity of the ribozyme can occur. Such hybrid structures are called aptazymov. Aptazim, which has RNA ligase activity, was activated 105 times in the presence of specific low molecular weight effectors. In a similar approach, ATP-dependent ribozymes were constructed.
Important results can be obtained by screening in vitro aptamers among a pool of fragments of natural RNA. Natural sequence libraries can be used to search for domains of nucleic acids that interact specifically with known molecules of biogenic origin, for example, proteins of retroviruses for which the target host RNA targets are unknown.


text:
After wining five in a row Bnei Yehuda has lost two and drawn one of its last three premier league games.
It would appear the Bnei Yehuda bandwagon is beginning to grind to a halt as Betar Jerusalem maintained its perfect record away from home with a 3-2 win in Herzliya Sunday night. After wining five in a row Bnei Yehuda has lost two and drawn one of its last three premier league games. Betar has now overtaken its Sunday night opponents and is third in the table, equal on points with Hapoel Tel Aviv, but behind the second-place team on goal difference. Betar dominated Bnei Yehuda for the entire first half and was only eventually slowed down by midfielders Maor Melikson's being sent off at the start of the second half. Bnei Yehuda, which was hosting Betar at its homeaway-from-home in Herzliya, missed its real home, Bloomfield Stadium, whose pitch is being resurfaced. The hosts couldn't take advantage of their one-man advantage and, despite creating numerous chances, didn't manage to equalize. Betar began the game well and seized the initiative from the first whistle. Ten minutes from the start striker Lior Asulin found himself totally free five meters from Bnei Yehuda's goal, but his awful shot went well wide of the mark. The hosts briefly breathed a sigh of relief, but two minutes later they were one goal down. Striker Jeff Tutuana's header was well saved by keeper Vincent Enyema, but Asulin easily headed the rebound in from the goal line. Betar continued to press forward and was rewarded with a second goal. Melikson dribbled his way into Bnei Yehuda's penalty box and passed the ball to Omri Afek whose powerful shot was deflected into the goal leaving Enyema helpless. Bnei Yehuda was fortunate to end the half only two goals behind. Thirty seconds into the half the hosts got on the board. Midfielder Asi Baldot was free inside Jerusalem's box and easily headed the ball from the corner into the net. Less then a minute after conceding the goal, Betar reclaimed its two-goal lead. Midfielder Barak Itzhaki ran clear of the Bnei Yehuda defense and beat the keeper with an accurate right-footed shot. The incidents kept coming and moments after scoring the goal, Betar found itself one man down. Melikson celebrated his team goal by jumping on the Stadium fences and, after receiving a yellow card earlier in the match, the referee had no choice but to show Melikson a second yellow and send him off. Bnei Yehuda pushed forward searching for goals, but couldn't beat the Betar defense until substitute Eli Biton scored in the 90th minute.

industry_corpus2: Sports


text: Our Brother Compatible Ink Cartridges for the Brother MFC-240C are ISO-9001 certified. Quality and Satisfaction are always Guaranteed! Best inkjet cartridge replacements and best value for your Brother MFC-240C. Why buy an OEM Brother LC51 ink-jet cartridge or a remanufactured ink cartridge for your Brother MFC-240C when you can get perfect quality out of a brand new generic LC51 inkjet cartridge at a fraction of the cost? We guarantee that they will print with the same high quality as your genuine Brother brand cartridges! 100% satisfaction guaranteed!

industry_corpus2: Computing & Telecommunications


text:
Exceptional food begins with exceptional ingredients, and exceptional ingredients begins with exceptional farmers. At Chameleon, we think local first. That means our menu is inspired by the flavours around us with a focus on community building and development by supporting our local friends.
Meet just a few of our extensive team of local suppliers that inspire our menu below.
Owned by our own member of the kitchen, Andrew Hinton, Roos Roots Farm is a 2.5 acre organic farm located in Maple Ridge BC. Growing a large variety of seasonal vegetables, fruits and cut flowers.
At Hopcott's Natural Beef, they grow high quality beef as nature intended, with an emphasis on natural grazing, environmental stewardship, and animal welfare. They do not use hormones, steroids, or antibiotics. They believe that healthy animals eating healthy feed will produce healthy, tasty meat. They also practice intensive pasturing. The cattle are moved often. This avoids damaging the grass through overgrazing, and ensures that the cattle always have plenty of fresh grass. Healthy Pastures, Happy Cows.
It takes a little longer and costs a little more, but we think it is worth it. We hope you agree.
Bruce's Market was opened on April 2, 1948 by Bruce and Elnora McEachern, and is still owned and operated by the McEachern family. They have been commercial fishermen for four generations and now operate a fleet of salmon gillnet boats, a processing plant, and our own smokehouses. Our seafood is delivered fresh daily and filleted by our team of Chefs.

industry_corpus2: Agriculture & Fisheries


text:
Poutine is a delicious dish from Canada, made with french fries, gravy and cheese.
The original poutine is a wonderful french fry dish topped with Mozzarella cheese and gravy.
푸틴은 캐나다 대표 음식으로 바삭한 감자튀김에 감칠맛 나는 그레이비 소스와 모짜렐라 치즈, 다양한 토핑이 올라간 음식입니다. 감자튀김을 좋아하신다면 강추!
오리지널 푸틴은 특별한 토핑없이 감자튀김에 모짜렐라와 그레이비 소스를 올린 푸틴입니다.
This entry was posted in Food, Poutine and tagged cheese, French fries, gravy, poutine. Bookmark the permalink.

industry_corpus2: Hospitality & Catering


text:
Incumbent Queensland and Australian No.13 Josh McGuire has been named to replace injured superstar Jason Taumalolo at lock for the North Queensland Toyota Cowboys Round 3 showdown with the Cronulla Sharks at 1300SMILES Stadium on Saturday afternoon.
McGuire’s shift to lock is one of a number of changes made by head coach Paul Green with Ben Hampton, Jake Clifford and Corey Jensen all named to make their first NRL appearances of 2019.
Clifford will partner skipper Michael Morgan in the halves, with Te Maire Martin moving to fullback.
Jordan Kahu shifts from fullback to form a new centre pairing with Hampton, while Jensen has been named on the interchange.
Coen Hess returns to the starting side after moving to the bench in Round 2 and will partner Gavin Cooper in the second row.
Second-rower Shane Wright and teenage middle forward Peter Hola make their first appearances in Green’s 21-man squad for 2019, named in the reserves alongside centres Justin O’Neill and Enari Tuala.


text:
fter the successful debut in June 2010 Audi has extended the premium partnership with the Kieler Woche. The countdown to the sailing regatta is underway. In Kiel’s Schilksee district, at the Kiel Yacht-Club and at stage shows the automobile manufacturer based in Ingolstadt will expand its commitment through numerous additional activities.
The manner in which Audi showcased itself in its debut year will be retained in 2011. The Four Rings will visually shape the Kieler Woche on posters, in the center of the city, along the “Kiellinie” harbor promenade, on the official clothing, in the program booklet or on the turning marks of the regatta lanes. In addition, Audi in its role as mobility partner will again supply all the vehicles to the shuttle fleet. The organization of the official trailer service involves a major logistical feat. During the changes between the various boat classes the organizers last year counted more than 1,500 trailer movements within 40 hours that were performed by Audi Q7 and Audi A6 allroad models.
For its invited guests, Audi has put together an equally varied and exceptional offering this year. The project billed as “A dream comes true” will be continued. Customers from the Audi regions will again join professional sailors on board of a TP52 boat of the kind used in the Audi MedCup. The aim is clear: to win the German Ocean Sailing Championship as the Audi A1 Team did last year. Headed by skipper Tim Kröger, the TP52 will also contest other regattas with guests on board. World champion and federal German coach Roland Gäbler will do the same with his guests on a catamaran of the Tornado class. In addition, there are plans for following the regattas on ships and inflatable boats.
Sailing Team Germany will be able to celebrate a “small” birthday during the 2011 Kieler Woche. Exactly one year ago, the German National Sailing Team competed for the first time sporting the colors of its partner Audi, who supports the team with vehicles, among other things. The company, for example, makes personal cars available to the top sailors and pool cars for the trips to and from regattas and practice events.

industry_corpus2: Automobiles


text:
Looking at the world at 40.
« How many do you have?
What I did when I forgot my book.
I NEED my mental break at lunch. I prefer to read a book. It takes me away from the office and into another world. This is why I prefer to read Science Fiction or Fantasy novels as well. But I forgot my book yesterday and instead grabbed the book I had jus finished. I also forgot my breakfast and lunch in the fridge. At least I didn’t leave it on the counter.
But I still needed to do SOMETHING at lunch. I hate being bored during that time. Being bored on company time is bad enough. Being bored on my own time is somehow worse.
It’s a good thing I had two stitching projects with me. The down side is that I normally do something while stitching. Watch t.v. or a dvd or chat with people. Not an option in my cube. (I hate the lunch room.) So it was still a little tedious.
I worked on this little dragon. Maybe I’ll finish it soon and can post a picture of it completed.
I also need to update my Tardis Project. I have two items finished. In the stitching world there is something we call finished but not finished. The stitching is done but it hasn’t been turned into anything yet. I also made a good bit of progress on my Elegant Pumpkins. I’m still having trouble tracking down two of the colors. Once I get those photographed, I’ll be posting that update.
But in the meantime, here is a sample of the little dragon. The pattern is called Futurecast and it is by Teresa Wentzler. A lot of people hate Wentzler patterns because they tend to be ‘advanced’. They make massive use of blending two different colors and they use tons of partial cross stitches.
This is a free pattern on her website. It is designed so the stitcher can easily alter the color scheme to whatever he or she wants. I’m not blending two colors for every symbol. I’m just using one. So there is a little less subtlety. I may do so if I stitch it again. It’s not too big and the ease of swapping colors makes it a great pattern for stitching gifts. It is a good introduction on how to change colors on patterns and the partial stitches are kept to a minimum so it is also a good introduction to Teresa Wentzler patterns in general.
This entry was posted on June 1, 2012 at 8:59 am and is filed under Books, Food, Life with tags Advanced, Blending, Book, Books, Cross Stitch, Distraction, Dragon, Dragons, Forgetfulness, Get Away, Hobbies, Introduction, Lunch, Pumpkin, Pumpkins, Stitching, Tardis, Teresa Wentzler, update, Updates.	You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.

industry_corpus2: Literature & Emotions


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When people ask me “Don’t you get bored living all the way out there in the middle of no where?” my response is that I would love some days to be boring! There is always something to do, something happening, and barely time to sit down for a breather in our days let alone a chance to just do nothing, and for some reason where ever we live there is always some excitement, unfortunately not always excitement of the good kind.
We are lucky our local pub has a bit on – every now and then they will have a bit of a get together for the nearby stations whether it be during the day or night and there are always great events. The kids can run around and play while the bigger kids can have a drink and chat – get a few station blokes together and there are bound to be a few laughs.
Well we had a great night out for Easter this year, the kids had a ball there were lollies and prizes and everyone got something. The kids were entertained until quite late even little Willow done well, Dusty was certainly enjoying a few rums and probably the least keen to head home when I thought we should get home and get the kids to bed about 10.00pm. It’s about an hours drive home which was an interesting drive. I decided perhaps I should drive home and Dusty was pretty happy with this idea. We were driving along home driving cautiously but still at about 80km’s an hour, my concentration was on the road watching out for the many black cattle out on the road between the pub and home.
I only just noticed Dusty’s feet out the passenger side window and up towards the roof! ‘What are you doing?’ I yell out my open window to which I get the response ‘I get a better view up here’ – that I’m sure he did however most people would travel in the passenger seat but to Dusty the roof rack of the land cruiser wagon was much more exciting! Once he reaches through my window so I can hand him his rum can Dusty is set for his trip home well at least some of it til he decided to scramble back into the car once he finishes his drink and pass out for the rest of the drive home . . . with all four children now asleep I take my time and reach home around 11pm by the time we get the kids sorted Dusty and I probably made bed about 12.00pm.
Not long after going to bed I thought I heard the phone ringing by the time I fully woke up and realised it was in fact ringing the phone had stopped but only for a second and then it was ringing again. I jump up trying to work out who was calling us at 1.00am in the morning and to ring twice at this time its got to be important. Well it was the owner from the pub talking fairly quickly telling me to get Dusty to come back to the pub immediately and make sure he brings his gun, she continues on to mention a riot going on a police at least two hours away they are locked inside the pub. I look at Dusty and with four words “Pub, now, take gun” Dusty springs out of bed dressed with gun in hand ready to play super hero. As his running out the door I give him a brief run down and then he’s gone . . . well it’s 70km away, it’s dark, it’s going to take him at least an hour to get there. As I’m sitting up waiting to hear he got there and everything is ok not expecting a call for some time in about half an hour I get a call he is there everything is ok and he is waiting there until the police arrive.
He drove 70km in 26 minutes in the dark with cattle over the road . . . not a bad effort but not something I’d recommend trying again anytime soon that’s for sure. Luckily the headlights and a few gun shots in the air was enough to make people scatter and disappear there was a fair bit of damage to the pub and vehicles parked outside the pub but overall things ended up ok with everyone inside the pub safe. We might live further away out here but if you’re in trouble you can guarantee someone will get to you any time of day or night to help you out. One of the many reasons I love living in the bush.

industry_corpus2: Others


text:
One of the most popular Gator Tough™ Deluxe models, the 18 SC DLX accommodates all of the features that sportsmen demand in workhorse jonboats. Massive livewell capacity, large lockable storage and a 10° deadrise design that makes these performance hulls smooth running and faster on-plane. With over 30 gallons of capacity, the livewell has a place for baitfish, as well as large stripers or catfish.
Request a Quote on a Gator Tough 18 SC DLX.
Extra large 31 gallon livewell includes insulated lid, divider, and trim designed to hold a Plano® bait bucket.
Optional MinnKota® trolling motors are available in a selection of models. Ask your dealer for details.
The side console is the ultimate utility command center. Rugged, yet stylish, with plenty of room for optional gauges or Lowrance® electronics.

industry_corpus2: Manufacturing


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The number of times this has happened at my house is too numerous to mention. Eggs are so gross.
If you’ve ever wanted some custom artwork from me, I’ve set up a little Gumroad link to allow just such a transaction. Gumroad is a super easy and secure way to buy some art directly from the creator!


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The General Election finally finishes today in Thirsk and Malton, with the initial poll cancelled after the death of the UKIP candidate.
This has no doubt been frustrating for Anne McIntosh and her rival candidates, as a similar circumstance was for Sir Patrick Cormack in Staffordshire South in 2005. That was the first occurence since 1951, though this will be the eighth General Election since 1918 to have included a delayed poll due to the death of a candidate.
The House of Commons library paper explains the law.
But the current provisions are unnecessary. What is perhaps less appreciated is that they are also dangerous.
For example, imagine somebody with a very strong sense of grievance over a major political controversy was suicidal and had decided they wanted to take their own life. Were they validly nominated in the constituency of the Prime Minister or Leader of the Opposition before committing suicide as the campaign began, they could then remove a current or potential future PM from the House of Commons for the time that the new Parliament is prorogued.
For similar reasons, and perhaps a less fantastical scenario, the current system creates a completely unnecessary security risk against even the most obscure minor fringe candidates in the most high-profile seats. There were ten candidates in Witney at this election and fifteen in Sedgefield in 2005. There is an unnecessary risk in offering either organised terrorist groups or malicious individuals the chance to embarrass the British government and seize a significant publicity coup.
The law should be replaced before the next General Election, while there is plenty of time to remove these possibilities.
Of course, a similar outcome could result without any malicious motivation. It was very fortunate that Nigel Farage escaped injured from his plane crash on the morning of the election. Had that, as at at first feared, been a more tragic incident then the "Speaker seeking re-election" would then have still be seeking re-election to the House, probably in a few weeks time.
There are any number of alternatives which could replace the current legislation, avoiding these dangers.
The election could simply proceed, with provision made for it to be followed by a re-run if a deceased candidate were elected posthumously.
An alternative would be to make include provision for the Returning Officer to allow the party concerned to replace a candidate - solely in the event of a candidate's death, rather than allowing candidate substitutions to become a general rule - subject to their getting the relevant signatures to nominate the replacement. (Notices could be placed at all ballot stations if it was too late to print ballot papers; the loose ends in this scenario, such as for postal ballots, are rather better than the current system).
An alternative would be for the Returning Officer could be given discretion to determine whether the election could proceed, for example, based on whether the deceased candidate had any significant chance of victory. That could, for example, be a rule of thumb that the election would be postponed only if the deceased candidate's party were within 10-15% last time. If an outsider won a posthumous victory, again a by-election or re-run could be held.
Of course, if there was a very inconvenient outcome, the British tradition would be to find a way to fudge it. It is not much known that Sir Alec Douglas-Home was Prime Minister while neither a member of the Lords or the Commons, in a strange constitutional limbo, for a fortnight on renouncing his peerage on becoming PM in the Autumn of 1963.
So perhaps the Monarch could still invite a party leader who was not a member of the Commons to form a government, while they awaited their delayed General Election contest. But I can't see how they could speak in the Commons on the Queen's Speech.
More surprisingly (in something that would surely not be repeated today), Harold Wilson proceeded to make Patrick Gordon Walker his Foreign Secretary even after he lost his seat in Smethwick in October 1964 to the infamously racist Conservative campaign. Gordon Walker resigned after three months in the role only after also losing a hastily arranged Leyton by-election the following January.
This is *exactly* what I thought when I heard about the Thirsk & Malton scenario, but irritatingly failed to blog on. Yes, agreed.
The problem with your suggestions is the fact that electoral procedure in GEs doesn't reflect the existence of political parties, so it would actually be a major constitutional change. My preferred version would simply involve every candidate nominating a "second" at the time of nomination, who'd take over in the event of their untimely demise. Should the second die at any point, the candidate would be free to nominate a new one. So as long as they're not in the same car/plane, it'd all be fine. Mmmm, Classic British Fudge!
Rather than suicide, surely the more likely spoiler option is for a party to nominate a terminally ill person who is not expected to survive until election day.
In fact, the Committee debate you referred to considered this exact possibility, put forward by Philip Goodhart but rejected by the Minister.
It seemed to me in 2005 given the strength of feeling over Iraq among those most opposed to the war, one had exactly the circumstances where something like this was a potential danger, for example in Sedgefield or the seat of another prominent minister. But I thought it was perhaps even inadvisable and/or tasteless to discuss it publicly given that context.
The second/back-up point is a better proposal. As we do now have parties routinely on ballot papers, registered with Electoral Commission, etc, there has been some shift on that though your point remains correct.
Anthony Z's link from the 1968 debate is absolutely fascinating, though the attempt mooted whereby a group to bring about an indefinite series of postponements would be something else, and would no doubt then be dealt with by emergency legislation.
It is a good thing we now have made so much progress on peace in Northern Ireland. Something in this spirit could have been attempted in the early 1980s, around the time that Bobby Sands was elected while on hunger strike a month before his death. That led to legislation - the 1981 Representation of the People Act - barring prisoners serving more than one year from standing for Parliament. But that does not block all attempts by even very small splinter factions (whether in Ulster or elsewhere) to do something similar if this did not involve convicted prisoners.

industry_corpus2: Politics & Administration


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The village was mentioned in the 1086 Domesday record as Frecheltun. The name probably referred to land belonging to Frecla, tun being the Old English word for estate or homestead.
In 1615 a mill was built beside Freckleton marsh. In cold winters the mill pond froze and villagers would skate on it.
The road had a toll house on it which was a site of conflict during the English Civil War. The toll only ceased in the 1920s.
Freckleton has been a Christian place of worship since the 7th century. Following the Reformation, it was part of the Chester diocese. The Holy Trinity Parish Church was built in 1837.
In the 19th century the port was used for ship building. The villagers were kept busy providing sailcloth and ropes and these trades are reflected in the local street names.
The town has many military connections. During World War II many American forces were stationed at Warton Aerodrome and they lodged in the village.
The Freckleton Air Disaster in 1944 was a tragic local event. An aircraft attempted to land in bad weather but crashed into Holy Trinity School.
61 people died including 38 schoolchildren, two teachers and three air crew. Other victims were in a snack bar across the road from the school. The village still commemorates the loss each August.
The aerodrome was closed after the disaster and the site became the home of English Electric, now called BAE. It is the largest local employer of Freckleton residents.
Freckleton village has just over 6,000 residents and is known as a village of music and flowers. It is a lively community with plenty going on including a band which were the North West Area Champions in 2010.
In the centre of the village is the Holy Trinity Parish Church which has a monument and a mass grave for the victims of the Freckleton Air Disaster. There are three historic pubs, local shops, restaurants and a library.
The church has beautiful stained glass windows showing local parishioners and a lovely Jacobean pulpit. The tower had to be removed in 1976 and was replaced with a hexagonal bell cote.
Each year in June Freckleton holds a half marathon which has 700 runners. It started in 1965 and is now the oldest half-marathon in the UK.
In the first year Olympic contestant Ron Hill was invited to take part. Of course he won Freckleton's first marathon in a time of 65 minutes 44 seconds. He set a record time four years later of 64 minutes 45 seconds which still stands unbroken.
The Lancashire Coastal Walk runs through Freckleton from Silverdale. It is particularly popular with bird watchers. A shorter 2.5 mile walk was opened in 1999 and is known as the Lund Way.
Nearby Freckleton Marsh is an area of land with shared grazing rights. The marsh is the ideal breeding ground for birds including the rare Black Trailed Godwits.
The coastal resorts of Lytham St Annes and Blackpool are nearby and provide a host of attractions and entertainment.

industry_corpus2: Travel & Geography


text:
I wake up this morning in an odd mood, and I can’t put my finger on it. Oh wait, that’s it. It’s only 46 degrees in the van. I try to stay snuggled in bed at least until the sun has cleared the eastern horizon but it’s not to be. The three amigos need a potty break and once that’s done there will be no more snuggling or dilly dallying or a leisure mug of coffee. They will want their breakfast and they will want it NOW. Ohhhhhkay. Your wish is my command you spoiled little wire and weiners.
The above taken care of we head out for a nice long walk. My moodiness isn’t lifting, but I do sense a need to move on. Maybe that’s it. Maybe we need to head farther north. Havasu isn’t too far and I do want to see Parker Dam. It’s a beautiful clear morning. I took a few photos on our walk.
Do you see the Tiki god lying on his back gazing heavenward?
Back from our walk I check the charge controller on the solar and it’s in float mode meaning the battery is fully charged and I can unhook the connections and put the panel away for a couple of days. Intending on doing just that one thing I end up putting away a couple more things, another thing or two and everything is all but loaded up. Put in the step stool I use at the side doors and we could leave if we wanted to.
Not wanting to head north without checking for boondocking sites I pour the last little bit of coffee that’s left in the thermos into my mug and drag the laptop out, hooking it up to my phone and use it as a hotspot. It appears there are at least three BLM sites on either end of Lake Havasu City, and I take some notes still not sure that I want to leave. I really like getting an earlier start on travel days, but since it isn’t that far, around 30 miles, we could still head out. And shoot, since I have to go into Parker to get water anyway we might as well just head out. I have liked it here—not THE WORST DAY—but the rest of it was nice and we had this particular area all to ourselves, but I am restless and just feel it’s time to move on.
Parker is an easy place to drive in and we get to the water kiosk with nary a problem. Next we go to McDonalds for some free Wi-Fi. I want to download a few things off Netflix to watch off-line. Wouldn’t you know—The signal is POOR and I can’t get a thing to download. Not. One. Single. Thing. Dang it. I fire up our Vome and we head north to Alaska. I mean Havasu.
North to Alaska, Hummm…Hope it is warmer than here. Actually it is not bad..the thermometer says 40ish but the south wind is blowing and spitting snow flakes when ever it wishes. Nothing is sticking but BURRR. If there are typos..I went to the eye doc. this morning, eyes are still dilated some so hard to see what I am typing. It is supposed to be nicer Wednesday, I think. I understand Havasue is very pretty but have never been there.
It was wonderful meeting you and Sam! Hope your travels are safe, and that we see you at the RTR next year!
You’re a much stronger woman than I am! If I woke up and the temp inside were 49 my body would be so stiff it would take me forever to move!! Hope you get to warmer temps!!
Ha! I didn’t want to write about THAT part! Warmer temps coming right up!


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Jaded Blossom: Michelle's 40th Birthday!!!!
Bought my stamps, no to hop!!
As usual you guys rock! Happy Birthday Michelle!
Happy Birthday Michelle. God bless you.
Can't wait to hop - I can only imagine that it will be a great celebration!!


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Summary: An introduction to historiography and the theory of counterfactuals.
Published: In w88 android (ed. Rasmus Dahlberg), q.v.

industry_corpus2: Subject Education


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What We’ve All Been Waiting For – Chanel Is Launching As E-Commerce!
Chanel is one of the last fashion brands standing that does not offer e-commerce on products other than cosmetics. It has upheld a strong standard of not allowing customers to shop its high-end product online.
Well looks like Chanel finally realized that in order to survive out there, you have to appeal to the masses, and as the masses grow, you have to make some serious decisions.
Bruno Pavlovsky, the French luxury house’s president of fashion, told WWD that it plans to launch e-commerce in some form by the end of next year. Although details on what products will be available, the company also plans to launch e-commerce sites for milliner Maison Michel, Barrie Knitwear and glove-maker Causse alongside its own.
Aside from licensed products like sunglasses, cosmetics, skincare and fragrances, Chanel is one of the very few luxury brands that has strategically not allowed their products to be sold online.
“Fashion is about clothing, and clothing you need to see, to feel, to understand,” Pavlovksy told Bloomberg in 2013. It’s also a luxury brand, and a hallmark of luxury is exclusivity. But it’s also probably more strategic than that. In Chanel’s case, most of its revenue comes from those licensed products, so it’s not necessarily worth it to make ready-to-wear available online when the customer base for it is so small.


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Malaki Seku Amen president of the California Urban Partnership with Khalil Ferguson at a rally at the State Capitol hold a flag with names of victims who were unarmed and killed by law enforcement. Photo by Russell Stiger Jr.
Assemblymember Shirley Weber speaks at a press rally before the police use of force bill AB 392 hearing. Photo by Russell Stiger Jr.
Authored by Assemblymember Shirley Weber (D-San Diego), the legislation aims to restrict the use of deadly force by police officers, which has ended the lives of more African Americans and Latinos in California than any other state in the nation. In 2017 alone, cops in California killed 172 civilians. Of that number, Latinos made up a disproportionate 47.1 percent and Blacks accounted for 15.1 percent.
Weber says her goal for introducing the bill, which has drawn wide and vocal opposition from police unions and law enforcement support groups, is to change the culture of policing in California and prioritize the sanctity of human life – not to victimize law enforcement.
Advocates of AB 392 from across the state – many of them social justice activists along with friends and family members of people injured or killed by police – came to Sacramento to witness the process and express their support. They filled the gallery of the Jesse Unruh room in the State Capitol and packed onto the main floor of the Assembly, many eyes full of tears as the moment called up memories of their loved ones.
Hamilton said she attended the rally on behalf of Yarber and his three daughters.
AB 392 calls for redefining the state’s existing legal measure of “reasonable” force, replacing it with the word “necessary.” Officers would only be allowed to use deadly force if there is no other option. It would also amend the California Penal Code regarding “justifiable homicides” by “peace officers,” opening cops up to more civil and criminal charges for killing citizens.
Weber and the bill’s co-author Assemblymember Kevin McCarty (D-Sacramento) say they studied data from other cities that employ similar police de-escalation tactics to prevent homicides and injuries. That information helped to inform the language, spirit and structuring of the bill. If passed, AB-392 would become the first law in the country to regulate police officers’ use of deadly force.
Assemblymember Reggie Jones-Sawyer (D-Los Angeles), chairman of the Public Safety Committee, presided over the meeting where Californians from all walks of life stepped up to the microphone to mostly affirm their support for AB 392. Only about a dozen people spoke up publicly against the bill.
As it makes its way through the legislature, AB 392 will likely face resistance already gathering from civic and political groups. Police unions across the state believe that the bill will put members of law enforcement at a disadvantage and place their lives in harm’s way.
“Anything that changes the word ‘reasonable’ is unreasonable,” said Assemblymember Tom Lackey (R-Palmdale) who spoke against the bill during the hearing and voted against it in committee.
Lackey, a former California Highway Patrol officer for nearly 30 years, posted on Twitter that he believes proponents of AB 392 don’t have a malicious intent in crafting the legislation. He insists, however, that it would be harmful to peace officers.
The committee hearing concluded two days of activities and advocacy ramping up to the big day. A march and rally Monday hosted by the American Civil Liberties Union of California was the highlight.
Family members of some of California’s most controversial and widely remembered victims of police violence – Oscar Grant, Sahleem Tindle, Mikel McIntyre, David Garcia, Stephon Clark, among many others – attended the rally held on the north steps of the State Capitol.

industry_corpus2: Law & Justice


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IndyStar is a rugged high-duty cycle excimer laser designed for fast pulse frequency applications as high as 2000 Hz. Based on proven ALMETA tube technology, the Semi-S2 certified IndyStar operates over many billion pulses at ultra-short 193 nm and 248 nm wavelengths. The IndyStar series is engineered to meet the highest demands in every aspect of an industrial laser.
Laser Power and Energy Meter (RoHS) compatible with LM- and PM-model thermopile and optical sensors with beam position display.


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We all know you can buy a dog ball launcher for a couple of pounds. But, how many times does the ball end of up falling out of the holder or loses it's rigidity over a short period of time? And, the cheap tennis ball that comes with a standard poor quality launcher is chewed up in seconds, and has potentially dangerous chemicals coating it. Plus, you have to swing your arm into positions it doesn't really like to bend to get any kind of distance on your throw.
So, here's to buying one launcher rather than buying two or three every couple of months and multiple packs of tennis balls every time you visit your local pet store!
The Chuckit Sport is the original dog ball launcher that paved the way for the many cheap flimsy rip-offs you can now find on the high streets.
The Chuckit Sport dog ball launcher is ergonomically shaped with a soft grip for the owners comfort and you can really feel the durability and rigidity when it's in your hand.
The Chuckit Sport dog ball launcher even comes with the award winning Chuckit Ultra Ball included for the perfect throw that is 100% safe for a dogs sensitive mouth and free from nasty chemicals or choking hazards.
The Chuckit Sport dog ball launcher and ultra balls design will allow you to throw 3x further than your average launcher, with less stress on your joints and is pawfect for tiring out those lively pooches!
Why not team this up with the Chuckit Max Glow Ball for the darker evening walks? We ship exclusively to the UK.


text: As a digital marketing agency, we offer full Social Media Agency services in Ible	Derbyshire to ensure you are able to communicate effectively on behalf of your business brand. As a major channel of business communication, we offer these services so you can harness and use social media as a means to get your message out there in a meaningful, fun and long-lasting, memorable manner. We can help connect your everyday marketing and in doing so open up new audiences and prospects for you and your brand.


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Imagine you could release yourself from negative thoughts.
How much better would your life be, if you could stop those nasty, self-loathing germs from ruminating in your mind.
If you could clear some headspace for positive and uplifting thoughts that would help you manifest the kind of life you truly want to lead.
How awesome would it be, if every negative situation in your life didn’t knock you sideways or leave a permanent scar? How great would it be, if you could simply rise above your circumstances and glide over the challenges in your life?
I bet that’s where you’d like to be, but I sense that it’s not where you’re at right now.
Listen, I don’t blame you. Let’s face it – life can be pretty tough.
The best plans often don’t work out, and even the best people can let you down, leaving you disappointed and upset.
It’s easy to get entangled in a web of negative thinking that can bring you down and make your mind spiral into a well of despair.
But it doesn’t have to be this way. And getting where you want to be is actually easier than you might think.
Here are three steps, grounded in spirituality, that will stop negative thinking from infecting your mind. If you use these steps, you will stop your negative thoughts and live a more abundant life. The Angels will also start to send you signs, like the number 555, to let you know you’re on the right track.
This may sound like a step in the opposite direction. But the only way you can start climbing out of that well of despair – is by descending right into its scary depths.
If you’re stuck in negative thoughts because your ex left you, accept that they no longer want to be in a relationship with you.
If you’re ruminating because you’ve lost a job, accept that you’re now unemployed.
If you’re not where you pictured your life to be at this point, accept that you’ve failed your own expectations.
It may sound harsh but, unfortunately, reality doesn’t always turn out the way we want it to be.
Sometimes this is because of actions that we’ve taken (or haven’t taken) while other times it’s due to challenging circumstances.
Sometimes we simply are where we are – in Universal terms, nothing has actually gone wrong – in fact, it’s our mind that’s burdened by our own high expectations of where we think we should be at.
But if we fight against our current circumstances, without accepting them, we’re at the risk of living in a state of fantasy or an idealized image of our own lives, instead of being fully present in what is.
When we try to feel better and happier from this frame of mind, it simply doesn’t work, because we haven’t accepted and examined the source of our own unhappiness.
It’s like telling yourself that you’re fine and happy, and that everything will work out, while deep down you’re torn by fear and despair.
People often complain that The Law of Attraction isn’t working for them, that they’re not able to manifest the things that they desire, no matter how hard they try to visualize that perfect scenario coming true.
This is because they haven’t fully acknowledged where they’re at.
They haven’t faced their reality head on.
Instead of facing the grim state of affairs that they’ve found themselves in, they’re trying to trick themselves and the Universe in believing that what’s really happening in their lives isn’t happening at all.
So, the first step you need to take in order to stop negative thoughts from occurring may sound counterproductive – but it’s the only way that any other method is going to work.
Accept that you’re having negative thoughts.
Accept that your life is not where you want it to be.
Accept that you haven’t accomplished that perfect ideal that you were striving for.
And accept that that’s completely ok.
Cry, if you need to. Have the courage to descend deep into that well of despair, in order to really face what’s going on.
Because everything is made up of energy. By completing this first step, you’ll be able to release a load of negative energy.
Crying, shouting and screaming has a lot of negative connotations, but what you’re effectively doing by releasing emotions this way, is that you’re releasing negative energy, instead of allowing it to fester inside you.
And, once you’ve completely accepted where you’re at right now, you can move onto these next two spiritual ways that will help you stop having negative thoughts.
Our culture is obsessed with the idea of ‘being happy 24/7’.
We see our friends posting amazing pictures on Facebook, where everyone is smiling and having an awesome time, and we want that, too.
We hear people bragging about their success, and we get jealous. We so often compare ourselves to others, experiencing ‘status anxiety’, a term coined by the modern philosopher Alain de Bottom in his documentary.
But when we’re obsessed with being, feeling and having more, we end up fighting our negative thoughts.
We try to get rid of them, dismiss them. We see negative thoughts as something undesirable, because we’re told that negative thinking limits our ability to manifest amazing things in our lives.
As a result, we don’t recognize our negative thoughts for what they really are.
Our negative thoughts are merely signals that something needs our attention.
This is similar to bodily pain which gets treated much in the same way as negative thoughts do.
What often happens in our culture is that when we experience bodily pain, we are given painkillers that simply numb that pain temporarily. We’re rarely told to really examine our lifestyle as the potential cause of that pain. We’re rarely encouraged to take responsibility for our own health and make important changes.
But bodily pain is not something that should be simply numbed. It is not something that we should run away from. Pain is merely a signal that something has gone wrong in the healthy functioning of your body. Just like a negative thought is a signal that something has gone wrong in the healthy functioning of your mind.
an emotional wound that you’ve suffered and is crying out to be healed.
In order to overcome negative thoughts, we need to recognize them as signals, pointing at something in our own minds that we need to examine.
So instead of trying to replace the negative thoughts with positive thinking (which is the equivalent of taking painkillers when you’ve got a broken leg, instead of getting an x-ray and a care plan), we need to recognize them as useful signals that something within us needs further examination.
So when you have a negative thought, write it down, and examine the reason for why you’re having it. Once you have it, take the necessary steps to rectify the problem.
For instance, if you have an intensely negative thought about your ex leaving you, you may need to work on raising your self-esteem. Try to examine the negative beliefs you hold about yourself and give yourself the attention that you wish your ex gave you.
And there’s one more thing you can do. In fact, this is the quickest and easiest way of releasing yourself from negative thoughts – but only if you practice it regularly.
You’ve accepted the reality of your situation. You’ve examined the source of your negative thoughts. Congratulations. That’s the hard bit.
Now is the time to let it all go.
The quickest spiritual way to stop negative thoughts from occurring is forgiveness. But – although forgiveness is quick and effective, you may have to overcome your own resistance to it first.
you’ve essentially done the hard work required for this final step that will, eventually, eliminate a lot of your negative thoughts.
And the first person you must forgive is not the person who ‘wronged’ you. The first person you need to forgive is yourself.
If you are not where you expected to be at this point in life, forgive yourself for the chances that you didn’t take, for the situations where you could have acted differently, for the ways in which you think you failed yourself.
For instance, if you feel cheated by another person, forgive yourself for trusting them and ignoring the warning signs. This is not to say that you are to blame for every situation. It’s simply that, when we are mad at someone for doing something to us, we’re actually mad at ourselves for allowing it to happen (whether or not we were powerless in that situation). And before we can forgive another person, we must forgive ourselves.
This is because the golden rule of do unto others as you would have them do unto you, applies to forgiveness, too. You cannot grant forgiveness to someone else before you have granted it to yourself.
Here is a self-forgiveness meditation by Unlock Your Life that you can try, if you’re struggling with this concept.
If you’re struggling with the concept of forgiving others, you may have some misinformed ideas about what forgiveness actually is.
bring justice to the situation where you ended up being hurt.
Forgiveness is simply the action that you need to take in order to release vast amounts of negative energy. You cannot go back and change the past, but, by forgiving someone else for something they did to you, you are releasing that hold that they still have over you.
Think about it this way, if you like. They did something awful to you, and yet – instead of letting it go, when you choose not to forgive, you’re actually allowing them to do it over and over again.
In other words, you can let someone enter your life, make a mess of things, and leave you in a complete turmoil. With your permission, you can allow them to leave a permanent scar.
Or – you can choose to forgive. By doing this, you soften the damage that they did to you, and release them, so that you can move on and live the kind of life you want and be the person you want to be.
And there you have it, 3 spiritual steps to stop negative thoughts. Please try them out and let me know what you think in the comments.

industry_corpus2: Health & Medicine


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Did you ever dream of being a Disney Princess when you were growing up? Like many of you I’m sure, most of my formative years were spent watching Beauty and the Beast on repeat, wearing a Cinderella costume and desperately wanting to be “part of their world” like Ariel!
Enter Natasha Pitkanen…making our childhood dreams of feeling like a princess come true! Natasha, the star of our latest campaign, is the founder of Sydney based business Crowns & Wreaths creating stunning, handcrafted quartz and flower crowns. Each crown is unique and made especially for you, your crowning glory for any special occasion!
Having adorned heads on the runway, racetrack and even red carpet (not to mention my own fabulous Baby Shower 😉) Crowns & Wreaths is going from strength to strength and Natasha is now looking ahead at an extremely bright future!
Following our recent shoot I sat down with this budding (excuse the pun!) entrepreneur and got the inside track on her success..
What inspired you to start Crowns & Wreaths?
I started Crowns & Wreaths as a way of supporting myself through the final year of my Art Education degree. I'd always been extremely creative and an avid flower and crystal lover. For years I had been making headpieces for myself and friends every time we went to the races or to a fancy dress party and always received lots of compliments and so it occurred to me that there could be something more in this. So, I kind of fell into it, but looking back I think it had always been my destiny!
What does a normal work day look like for Crowns & Wreaths?
There is no normal day! Some days I wake up at 3:30am to get to the flower markets for a wedding or event I have coming up and I'll spend the morning prepping, de-thorning and arranging flowers. Other times I'm chipping away at my quartz crown orders well into the night. I’m happiest being creative and hands on, however running my own brand means I have to deal with all other facets of the business from replying to customer enquiries to updating our social media platforms to sending out orders….I spend way more time than I'd like to on admin!
What tech do you use?
My iPhone and a MacBook Air, I’m constantly on the go and need to have both of them with me at all times so that I can deal with anything that crops up…running your own business is a 24/7 job!!
What’s more important….Style or functionality?
As a creative I've always been more about style over function however since starting my own business I’ve learnt that functionality is also extremely important! That’s why I was so excited to discover Code Republic as finally there is an option out there where you don’t need to compromise! I often have to attend meetings with clients and so it’s important for me to look professional however I also want to maintain my own unique personal style as that’s also such a big part of my brand. I love that these bags are made in premium leather and the jewellery inspired hardware is such a great feminine detail for a laptop bag that I haven’t been able to find anywhere else.
Which Code Republic Bag do you wear?
I usually always go for black bags but once I’d seen Lisa in grey I had to have her! She’s perfect for me as the dove grey with rose gold hardware is so on trend right now and the tassel feature gives this bag such a unique feminine edge that is synonymous with my own brand. She pretty much goes with most of my wardrobe, so I use her for work in the day and then can easily transition into drinks at night!
I have a home studio in my apartment for my crystals and headbands- we are currently looking after two foster kittens so they're loving all the fun objects to play with! I've also just acquired the garage attached to our unit which I'll be using to store flowers. Each new wedding I take on is getting bigger & bigger so it's nice not to have to rent a space or beg family for their garage. It feels great to be expanding! The traditional office workspace is not compatible with my business, I need space for my creations and I also need to have the ability to work remotely as I’m pretty much “on call” 24/7. I love that I have the flexibility to catch up with friends for a coffee and be able to quickly reply to emails and update Instagram all at the same time!
I come from a family of entrepreneurs, all of us have or have had their own business. My mum was an artist, so she worked odd jobs to support herself between exhibitions and my Dad had a project management firm so that entrepreneurial spirit has been engrained in us all from a young age. I felt like their work ethic rubbed off on me, but my husband thinks I just don't like being told what to do!
To know your worth. It’s actually something I'm still learning.
This is a tough one as I come across new challenges all the time. It's been a huge challenge in itself learning how to run my own business. Every time I take on multiple jobs at one time, juggling brides and custom crown orders alongside the everyday tasks, I try to remind myself not to heap so much on my plate! When you love what you do it’s very hard to say no!
What do you do to forget about work? How do you recharge?
I like to travel down to the National Park with my husband for a day trip or catch up with family & friends. Travel is really important to me, both locally and overseas. I love discovering new places and it not only recharges my batteries but also inspires me creatively. Spending time with the important people in my life is also vital, they keep you grounded and also remind me what I’m working for.
What’s next for Crowns & Wreaths?
More staff! Now that we’re established, I’d love to be able to concentrate on the creative side, building the brand and our exposure. And ideally an international buying trip - finding new gems in foreign places would be the ultimate dream!


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By Madison Montana One advantage of short-selling is that an active investor can be profitable in a rising or falling market environment. In uncertain markets one can use shorting to hedge against long positions. This is particularly beneficial when Political, Market or Idiosyncratic Risk is present in the trading environment.
After a trader presses the sell button what actually happens?
A trader sell order goes to his/her broker. Then, the broker checks to see if the stock is in the trader’s account. If not, the broker classifies it as a “short-sell.” He then checks his company’s inventory of stocks to short and the subsequent amount of shares available. He identifies shares available either in the company’s inventory or a client account. At which time, he “lends” the shares to the trader and credits his/her account with the revenues from the sale. Now, the trader is “short” the stock. Note: This is laborious in theory, but it is all automated in real-time.
Why would you short a stock?
You believe that the stock is extended technically or that information is coming (or in existence) that will pressure the stock price and cause investors to take profits on their long positions. Such information could include: an analyst downgrade, bad earnings, tighter industry/government regulations, increased competition, change in management, global or macro conditions which could potentially impact the sector negatively and potentially your position; et’al.
Shorting a stock is very risky, and not suitable for all investors, as the market has an upward bias. A stock price could go up forever and could create unlimited liability to the short-seller, exceeding the capital in his/her trading account. Whereas, a trader that employs a long-only strategy caps his loss at the capital in his account.
Margin Trading: Short-Selling a stock involves using “borrowed money,” otherwise known as margin trading. If your account slips below the minimum margin level, one will be subject to a margin call and forced to put in more cash or liquidate the position. If a trader does not have the discipline, strict risk management rules, employ stops and a scaling methodology, margin requirements can become quite lofty. An alternative to shorting a stock is the employment of a put option strategy. Using put options achieves the same bias as the short seller, but with defined risk. Using options has seen an increase in volume growth over the past few years. However, employing puts strategies may not be suitable for all, as it has its own set of risks and learning curve.
“Short Squeeze” Risk phenomena: This occurs when a stock starts to rise and a large % of the stock’s float is short, the short-sellers will try to cover their positions simultaneously and the pressure of the buy orders forces the stock price to rise quickly to undefined levels. A few examples would be a dividend announcement (as the short-seller is required to pay the dividend), a positive announcement by the company, or a change of sentiment in the stock, sector or market.
High frequency, dark pools and algos are real and present in the market and once triggered, they can have a similar effect.
Capitulation by the buyers at specific price level.
Confirmation of Up Trend Extended on Multiple Time Frames for confirmation – Using longer term time frames for support and resistance levels, and identification of an up-trend that breaks below prior day/week/month lows and makes a new low.
Although stocks have the potential to go up forever we have seen several companies file for bankruptcy, leaving their investors holding the ball. Traders that understand the risks involved and the discipline that is required to short sell can make nice profits quickly in a declining market or stock price.
Thereby, short-selling is a great tool to have in any trading tool box, to profit when markets are down trending and to hedge long positions in an uncertain market. But, it is risky and requires discipline and an obedience of stops. As stated, this trading strategy requires strong discipline and the ability to assess market conditions in real-time. Risk is elevated when holding a short overnight, so know your time frame.
Personally, I enjoy a challenge, as taking on a short, keeps me in the game. Every day, I need to assess the market condition and what are the potential risks that may impact my position. Thanks for reading.
About Madison Montana: Manage funds for clients & self. Interested in quality stocks with liquidity. Enjoy ideas from $$ oriented & serious traders.

industry_corpus2: Finance & Economics


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At KB Book-Keeping we are experts in the use of accounting software and can help you to choose the right software for your business.
We also understand the many ways in which accounting software can save you time and money and give you access to essential financial information at the touch of a button.
As SAGE software specialists, we can also help you to get to grips with your accounting software. And with the introduction of cloud accounting software, we can offer an enhanced selection of options to help you reap the many rewards of outsourced accounting.


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Come take a look at this 3 bedroom 1 bath located in Duck Hills. It is near local schools, parks, and shopping. Could be a nice start up home for the right buyer.
I am interested in 208 Rosemont St, Duck Hills, MS 38925.

industry_corpus2: Real Estate & Construction


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How to prepare for winter.
Gritting and salting routesFind out how we keep your roads clear of ice and snow in winter.
Winter self-help (gritting the road)Find out how to grit your road.
Salt binsFind out where your nearest salt bin is or report a missing salt bin.
Read our Winter Operational Service Plan 2018-19 (PDF, 1.3MB) for more detail about how we maintain the roads in Hertfordshire during winter.

industry_corpus2: Transportation


text: Dress in style with these handmade Typewriter initial cufflinks. These cufflinks are made using high quality silver plated settings and a resin seal. They also come in a stylish gift box.


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I was a .NET developer from the betas of Framework v1 to .NET 4. At that point I transitioned to MacOS (at the time OSX) and a variety of non-Microsoft languages and platforms. The switch broadened my horizons while simultaneously making me really appreciate Microsoft’s efforts.
After nearly 10 years away from .NET I decided to create a small project and take some notes of my experience. I’m sure this post will be out of date rapidly.
I selected C# as my language since I’ve got the most experience with it. F# was calling but it was a distraction best saved for a later adventure.
As a strongly-typed, compiled language a capable IDE is imperative. Jetbrains won my heart with Resharper so I opted to use Rider rather than Visual Studio for Mac or VS Code.
Local development would be done via Docker containers. I’ve stopped installing development frameworks directly on my local machine. Instead I prefer Docker Compose and shell scripts for automating my local development experience. I take comfort in the ability to quickly get developing whenever I switch machines.
This seems to be a transition time with .NET Core. When I last worked with .NET you managed your code with Solution files (.sln) and Project files (.csproj). When I created a new project in Rider it produced both a project.json file and .sln/xproj files. The .NET Core documentation all revolves around global.json and project.json. So, I deleted the .sln and .xproj files. This made Rider very unhappy.
It turns out that Rider requires the .sln and .xproj files. It’s confusing to have two sets of files that appear to have the same purpose. Upon further research, I learned that project.json is being phased out completely. So the world is shifting back to MSBuild and csproj files. That’s fairly disheartening as I remember a lot of pain with merge conflicts and GUID wrangling in Project files. I hope the improvements they are making reduce the old pains.
Until Rider adds support for csproj files I’m stuck with both.
The .NET Tools include a watch command to listen for file system changes and re-run your tests or re-build your app. Unfortunately, the command is limited to a single project at a time. If you break your solution up into multiple projects you can’t issue a single command to watch for changes in all of the tests or source files.
I asked about this in the .NET Tools repo. The recommendation was to use MSBuild rather than dotnet test. That’s good advice considering the switch back to MSBuild. However, ider’s lack of support means that I can’t yet take advantage.
NuGet was in its infancy when I left the .NET world. My how things have changed. It now has a robust ecosystem of packages. It’s especially great to see Microsoft publishing their assemblies via NuGet.
I was thrown off by the package installation process. My expectation was that packages would default to a project-local install rather than globally in $HOME. I attempted to force packages to install locally but the best I could do was one local packages folder per project. This duplicates a lot of packages and is hard to manage with Docker volumes. There are several open issues related to this. I scrapped this approach and am installing globally. I can’t help but wonder if this will cause pain in the future.
I was also thrown off by dotnet restore vs using NuGet manually. I probably shouldn’t have installed the NuGet binary on my machine. I’ve removed it and only use the dotnet CLI.
I’m surprised that there is no command line to add the latest version of a package to your project. Something equivalent to npm install --save or yarn add. My process involves finding the package on nuget.org and then hand-editing project.json. Awkward.
It looks like the current state of things is to use StyleCop Analyzers. However the wiki page doesn’t leave me particularly excited. Coala has CSharpLintBear which uses mcs. I could try out Coala (but Python 3…) or running mcs myself. More work than I’m willing to invest right now.
Getting everything running in Docker was very easy. I was pleasantly surprised. I could even easily mount packages in a volume container like I would do with NodeJS modules.
I was interested in both Akka.Net and Orleans. Neither of them support .NET Core yet. 😔 Akka.Net has a branch for .NET Core, though. That’s a promising sign. Both projects also have Github issues listing the TODO items necessary for support. I’ve signed up for notifications on each of them.
I am optimistic about the future of .NET Core and non-Windows .NET development. These are definitely the very early days. There are some big changes looming that will cause quite a bit of churn to projects. I expect that things will feel more settled in 6–12 months.
Compared to frameworks in use with Ruby, Python and Node.js I find .NET’s patterns and practices to be more mature and consistent. Every non-functional concern I reviewed (ex. logging, monitoring, authorization) was well-considered and robust.


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The European Banking Federation recognises that the digitalisation of the economy questions the standard international taxation principle based on the concept of “Permanent Establishment”, which requires a physical presence.
Such a challenge definitely needs to be addressed in a consistent and coherent way and from a global perspective. The efforts of the OECD in order to elaborate comprehensive solutions need to be supported much more than short term reactions with possibly unintended negative consequences for the European economy.
European banks are fully taxed according to prevailing international standards and, due to applicable regulations, their taxable profits arise where the real economic activity is undertaken. Any additional taxes for European banks would eventually affect their ability to compete globally and to finance the European economy and households.
It is the EBF’s understanding that Article 3(4)(b) of the proposed Directive on the common system of a digital services tax (DST) on revenues resulting from the provision of certain digital services contains an exemption for “the supply by a trading venue or a systematic internaliser of any of the services referred to in points (1) to (9) of Section A of Annex I to Directive 2014/65/EU (MiFID)”. However, we are concerned that this exemption appears to be limited in scope, especially since it applies only to trading venues that are regulated under MiFID. Consequently, any venues which are not regulated by MiFID, including all third country venues, would remain under the scope of the DST. This would appear to bring into scope non-MiFID instruments where they are traded via such venues.
If a DST were introduced in the EU as an interim measure, then a clear exemption must be provided not only ad hoc for payments, trading venues or crowdfunding, but for all types of financial and banking services. In respect of the latter, consideration should notably be given to the list of activities subject to mutual recognition in Annex 1 of the CRD IV. We urge the Council to carefully consider the wording of this exemption to avoid any legal uncertainty and ensure that it is future-proof.
As an alternative for ensuring that only large digital service providers would be subject to the DST, the EBF recommends that the calculation of the thresholds should only take into account the activities and commissions targeted by the taxation, and not the global turnover of companies.


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The search for effective products to combat the ravages of ageing has gathered pace alongside the rapidly expanding population of wealthy older people not prepared to accept the fate of their parents.
In the past, anyone aged 60 or more, was expected to disappear quietly into gardening or bridge clubs.
Today’s rising generation of older people wants the same treatment, lifestyle and choices as are on offer to much younger people, and that includes looking younger too.
The pitfalls of unregulated cosmetic surgery have been made all too clear by the growing number of women with leaking breast implants or anti-wrinkle fillers, which have set into concrete lumps under their skin.
The rejection of such risky measures to reduce the effects of age is fuelling a much more considered push to find products that have a biological, anti-ageing effect well beyond the simple moisturisers marketed since the beginning of the 20th century.
We are now seeing the advent of cosmeceuticals or “interventional cosmetics” – that is, compounds which have a biological effect, but which have so far managed to stay the right side of the line which divides them from medicines, which necessarily are much more closely regulated and expensive to develop, and require a licence to be sold.
The growth of the new class of cosmeceuticals is being driven by serious investment in laboratory research by companies such as L’Oreal, Unilever, Proctor & Gamble, Boots, and now Fujifilm.
Results are sent out for peer review, and if the science is considered sufficiently robust, the findings are published in research journals in the same way as news of advances in any other branch of science or medicine.
L’Oreal the world’s largest cosmetics company which employs 3,400 scientists and is sponsoring research projects in universities around the world, is leading the field, with studies to investigate skin cell regeneration, gene expression, the processes of burn repair and skin pigmentation.
Its researchers are even predicting they will soon be able to demonstrate how to turn off the genes involved in greying hair.
Unilever has recently published research showing the nature of the link between high blood sugar, obesity and premature skin-wrinkling, while Proctor & Gamble has published clinical trials favourably comparing its new cosmetic with retinoic acid, a vitamin A derivative, which was previously the only really effective anti-wrinkle agent, but one which had the unfortunate side-effect of causing skin-thinning.
Even Boots the Chemists, best-known in Britain for its chain of more than 2,000 high streets pharmacy stores, is not being left behind in the new age of skin science, and is investing heavily in laboratory research.
It was arguably the BBC which gave the nascent field of cosmeceutical research its biggest boost, when in 2007 its science programme Horizon, showed a skeptical female senior doctor being confronted with research evidence that a Boots produce also had better skin-smoothing properties than retinoic acid.
If the BBC was endorsing an anti-wrinkle cream on a respected science programme despite its strict brief to remain commercially neutral, people not unreasonably assumed that it had a biological effect.
Nevertheless, there remain substantial hurdles to cosmeceutical development. It is one thing persuading people to apply skin smoothing agents, but quite another to convince them that long term use of dietary supplements will make their skin younger than it might otherwise have looked.
L’Oreal’s cosmeceutical product Inneov has never been launched in the UK.(1) principally because we don’t have the networks of cosmeceutical pharmacists that exist elsewhere in the world.
Far more likely then, that the next step will be disseminating more results from long-term studies demonstrating benefit, at the same time as promoting cosmeceutical yoghourt drinks or something similar, containing the magic youth-promoting compounds.
Getting this nascent field off the ground however, will depend completely on producing the research findings showing such products work.

industry_corpus2: Biopharmaceuticals


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Doors are the entrance into your home. They are Home renovations available at Nook's Homes. There are two on display at once, and the selection changes daily.
Each selection costs 4,000 Bells.


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I make a difference. I am a creative connector and I freely serve others to get unstuck from their pain or apathy.
I inspire people to be their own hero and say YES to the “call to adventure” to live happier in the present.
I change people’s lives. With laser like focus I serve as a catalyst for students to figure out their purpose (sva-dharma).
I save people time in healing their pain.
I wake people up to the power of change – their ability to choose to be happy, in order to love themselves, love their day, love their lives.
I grow and contribute to others growth.
I encourage authenticity and vulnerability.
I step into my divine feminine power to express myself with confidence.
I take away people’s pain, short cut it, prevent it where possible, help them make that quantum leap to happiness.
I hold space for immersion into deep self-study and personal growth through Alchemy of Yoga Teacher Training Programs.
My writing is reaching more people than ever with new insights that will INSPIRE and teach.
I enjoy my life more because I make time for my partner, family/friends, fun and adventure!
I have a spiritual partner who shares my ideals and deep love for life. I am in love and happy. My relationship is a source of bliss.
I practice meditation daily and it enriches every aspect of my life.
I am healthy baby momma in 2015-2016.
What Do I Say YES To?
Using technology to stay connected but not so much that it takes over. Avoid email, fb, twitter, pinterest in first 30 minutes of each day. Take one day off per week, long weekend per month.
Removing all negative people from my life!!


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Basement waterproofing, crawl space encapsulation, crawl space repair and winterization, concrete repair and more in Carmel! FREE estimates!
I have water coming up through our finished basement floor. I would like to schedule an appointment.
Patio dropped from last step in back yard.
I want to purchase a home in Carmel that has multiple moist spots around the cove joint. It appears that one corner has also been repaired with epoxy or hydraulic cement. To meet my needs, I must be able to finish the basement into an office so I require it be bone dry.
I have a leak basement storage room and repair!
My driveway needs lifted under the garage door.
Since 2008, Master Service Companies has been your trusted provider for basement, crawl space and concrete repair services. If you are noticing damaged concrete on your property, musty smells or mold growth in your crawl space or a wet, leaky basement, Master Service Companies has the trusted products and craftsmanship to complete your repairs correctly the first time. Our team of knowledgeable contractors also offers prompt, efficient servicing and exemplary customer care. Call today to schedule your FREE, no obligation estimate to improve the value, curb appeal and safety of your Carmel property!
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Some of the most recognizable works of art on the planet are oil paintings with animals featured in them. Animal painting is considered to be an important genre to the art world, and by looking at some of these, it's no wonder as to why that is.
To highlight a few of the most talented animal art painters in the world, check out George Stubbs, as he has various works that are extremely impressive such as A Lion Attacking a Horse, Whistlejacket, and A Horse Frightened by a Lion. Don't forget about Ducks by Willem Maris, or The Morning in a Pine Forest by Russian artists Ivan Shishkin and Konstantin Savitsky. Still Life with Three Puppiesby Paul Gauguin is another good one.
It is no doubt that animal oil paintings will continue to grow in popularity as who doesn't love a painting with animals in it?

industry_corpus2: Film & Entertainment


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An attractive remuneration package would be provided commensurate with the qualification and experiences of the selected candidate.
All applications will be treated with strict confidential. Please note only short listed candidates will be notified afterwards.


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I hope with this comparison review to help you with a decision on your next purchase of quality Binoculars!
There are many ideas of what the best hunting binoculars are. And depending on your budget those ideas can be very wide-ranging ! There are many options in sport optics these days and choosing the right ones can be a chore. I have become a huge fan of Vortex optics over the past several years. Not just for the midrange pricing, but because you get a top of the line quality optic for a mid range price !
Vortex Diamondback Roof prism 10×42 Binocular.
I had an older pair of Nikon Monarch Binoculars that were very high quality and the price I paid was unbeatable!. After all it’s hard to argue with free. Those binoculars were given to me several years ago, and I loved them ! The crystal clear sight picture was amazing! But as things sometimes happen, they were lost when caught in a storm on the lake. I tried and tried with no luck to recover them.
At first, I decided to order my 10×42 Monarchs on Amazon and started browsing through the store. As I did so I was thinking about how impressed I had been with my Vortex Diamondback rifle scope I had purchased the year before. It is a fantastic scope with awesome glass and field of view!
The more I thought about it the more interested I became. So I went back and looked at the Vortex offering for about an hour. When I looked through the binoculars the sight picture was awesome, the field of view was good and the crispness of the images was fantastic so I purchased them. I was hoping all the way home that I didn’t make a mistake, and I would find out that I didn’t in short order!
I love the Vortex Diamondbacks! I have hunted with them for a year now and I really have nothing but good to say.I feel that they perform on par with the Nikon Monarch Binoculars with one major difference. They cost about $100 less.
My first impressions of the Vortex line of optics left me impressed!
And my impression of the Nikon Monarch Binoculars had sent me looking for another pair when mine were lost.! So my field testing part of this comparison ends up a tie in everything but price and I think the Nikons are a little nicer cosmetically in my opinion. But that wasn’t exactly one of my criteria. The flip down lens caps are a nice touch over the Vortex, but there are some not so great reviews and complaints on the lens caps.
10x magnification and 42mm objective lenses, these Diamondback binoculars are the workhorse of Vortex lineup; known for impressive optical quality and durability.
Dielectric, fully multi-coated lenses transmit more light and clearer, brighter images. A field of view that is one of the largest in its class helps you efficiently glass your surroundings and identify your target.
A sleek, short hinge design with rubber armor and thumb indents leaves more room for your hands creating an easier, secure, non-slip grip.
Multi-position eye cups twist up for adjustable eye relief. A right eye diopter accomodates for focal differences in your eyes.
Argon purging and rubber armor provide enhanced waterproof and fogproof performance in extreme weather conditions.
Warranty – Unconditional lifetime V.I.P. warranty. No proof needed and transferable.
What’s in the box?Rainguard Eyepiece Cover, Tethered Objective Lens Covers, Comfort Neckstrap, Deluxe Molded Carrycase.
All MONARCH 5 binoculars are now built with Nikon’s premium ED (Extra-Low Dispersion) Glass for a sharper, clearer and more brilliant field of view.
Almost an ounce lighter than its predecessor, the new MONARCH 5 is even easier to bring along on your next adventure.
Fully Multicoated Eco-Glass Lenses provide a high light transmittance across the entire visible light spectrum.
It is equipped with user-friendly features such as Turn-and-Slide Rubber Eyecups, a Smooth Central Focus Knob and Flip Down Lens Caps.
The differences between the Vortex and Nikon offerings are small in nature. I really like the caps on the Nikons but they have gotten a few less than good reviews. I like the styling of the Nikon Monarchs, but that wasn’t a big issue for me. If that is an issue with you, you may want to consider the Nikon Binos. My biggest concern other than glass and clarity at all ranges is that the ones I purchase have a rubberized (or quiet) coating. And that is true of both. That was important to me for those accidental times when your range finder or grunt tube bumps against your binoculars when in the field. And I believe both are great in that department.
The controls Feel great on both pair. I will note that the Vortex Binoculars controls are a little tighter than the Nikon controls, but I actually like that. And they may not be much of a difference considering my Nikons were a couple of years old when I got them.
The best binocular in this review has 2 very closely matched offerings that perform very well ! I loved my Nikons and one of the guys I know really loves his. But I love the new Vortex binoculars that are about a year and a half old now too. If I had to pick one difference other than the cosmetics,I would say that it would be the size. The Vortex binoculars are just a tiny bit smaller. If that is a big deal for you, you might want to take that into consideration. .
I would give the Vortex Diamondback Roof prism 10×42 Binoculars the nod. Since all things are pretty much equal, I’ll base this solely on the price difference. Since the fancier styling isn’t a concern for me, I can do other things with an extra $100.
Thank you for checking my comparison review ! These are my opinions and like anything else, opinions may vary. But I don’t see enough difference in the function, clarity, reliability and warranty to warrant an extra $100 on the Monarchs. They are both very, very good products and in fact it would have been easier to have picked a couple of other brands, because Nikon and Vortex both make an excellent product.
If you have any further questions or comments, I would appreciate it if you would leave them below in the comments section.
If you found the content helpful, sign up for the WILD WERX news letter for more great content ! Thank You !
Next Post:Deer Hunting Super Tactics-Hunting On The Edge.
Very wonderful contrast, I also like the outdoor binocular very much. The most common way I use them is when my friends drive and we can better observe nature. One thing that impressed me was that we went to Yellowstone Park together to see the colored lake. A binocular we scrambled to use. It’s really fun. Once I was careless, I threw the telescope to my brother. He didn’t catch it and it fell to the ground. The front lens fell out. We have never used it again. So I plan to get a new one, but not too expensive. Thank you for sharing. I think I would like to choose Nikon.
Not a bad choice at allRaino!
These binoculars are actually pretty closely matched with the performance edge . The Vortex Binos are the better price, but it’s hard to go wrong with either!
Nikon is a brand that has proven itself over the years when it comes to lenses and optics. There’s no doubt that they also make some kickass binoculars.
But Vortex is also a pretty decent item and it can provide you all the optical needs you demand in hunt. If you have the money and you’re willing to invest in a good binocular, I would advise going with Nikon. If you want to pay less but STILL achieve great quality, then you can always buy a Vortex.
Everyone will always have their favorites for whatever reason, and theres nothing wrong with that!

industry_corpus2: Sports


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@robertcc @jerry Indeed. Madness, I say!
@m4iler @jerry Someone set themselves up for a terrible day when they made that array.